Abstract：
:Nucleoside di-phosphate kinase enzyme (NDPK) isoforms, encoded by the nm23 family of genes, may be involved in various cellular differentiation and proliferation processes. We have therefore analyzed the expression of nm23-M1, -M2, -M3, and -M4 during embryonic mouse development. In situ hybridization data has revealed the differential expression of nm23 mRNA during organogenesis. Whereas nm23-M1 and -M3 are preferentially expressed in the nervous and sensory systems, nm23-M2 mRNA is found ubiquitously. Irrespective of the developmental state studied, nm23-M4 mRNA is only expressed at low levels in a few embryonic organs. In the cerebellum and cerebral cortex, nm23-M1, -M2, and -M3 are present in the neuronal differentiation layer, whereas nm23-M4 mRNA is distributed in the proliferating layer. Thus, nm23 mRNA is differentially expressed, and the diverse NDPK isoforms are sequentially involved in various developmental processes.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Amrein L,Barraud P,Daniel JY,Pérel Y,Landry Mdoi
10.1007/s00441-005-0036-9keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
365-78issue
3eissn
0302-766Xissn
1432-0878journal_volume
322pub_type
杂志文章abstract：:In the salmon and trout aminergic cell bodies were found in the nucleus recessus lateralis (NRL) and the nucleus recessus posterioris (NRP), both of which are situated near the third ventricle. Three cell types could be distinguished. Type 1 produces a green and type 2 a yellow fluorescence. The former type probably c...
journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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更新日期：1990-12-01 00:00:00
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pub_type： 杂志文章,评审
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