Abstract:
:The effects, on the maternal mammary gland, of diets containing similar lipid percentages but differing in composition of polyunsaturated fatty acids (PUFA) have been assessed in rats during pregnancy and lactation. For this purpose, tuna fish oil (an n-3-PUFA-enriched oil) and corn oil (an n-6-PUFA-enriched oil) were included in diets at ratios such that the caloric inputs were the same as that of the control diet. As expected, the maternal diet affected the tissue composition of dams. Unexpectedly, only the tuna fish oil diet had an effect on pup growth, being associated with the pups being underweight between the ages of 11 and 21 days. The maternal mammary gland of rats fed the tuna fish oil diet displayed two main modifications: the size of cytoplasmic lipid droplets was increased when compared with those in control rats and the mammary epithelium showed an unusual formation of multilayers of cells. These results show that the tuna fish oil diet, during pregnancy and lactation, exerts specific effects on mammary cells and on the formation of lipid droplets. They suggest that this maternal diet affects the functioning of the mammary tissue.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Delpal S,Pauloin A,Hue-Beauvais C,Berthelot V,Schmidely P,Ollivier-Bousquet Mdoi
10.1007/s00441-012-1523-4subject
Has Abstractpub_date
2013-03-01 00:00:00pages
453-64issue
3eissn
0302-766Xissn
1432-0878journal_volume
351pub_type
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