Abstract:
:Expression of heat-shock protein 47 in intact and fibrotic liver and in hepatic constituent cells was investigated in mice. Immunohistochemical study of intact liver and Western blot analysis of the protein from isolated liver cells revealed that stellate cells and smooth muscle cells of interlobular vessels, but not hepatocytes, Kupffer cells, or endothelial cells, expressed heat-shock protein 47. The protein was found in both vitamin-A-storing stellate cells and myofibroblast-like cells. The amount of the protein in cultured stellate cells was reduced by dexamethasone but was not regulated by quercetin, transforming growth factor beta, interferon gamma, or retinoic acid. In CCl4-treated or bile-duct-ligated mouse liver, the number of cells positive for heat-shock protein 47 markedly increased in the centrilobular area or around the periportal area, respectively, and the level of heat-shock protein 47 also increased.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Kawada N,Kuroki T,Kobayashi K,Inoue M,Nakatani K,Kaneda K,Nagata Kdoi
10.1007/s004410050594subject
Has Abstractpub_date
1996-05-01 00:00:00pages
341-6issue
2eissn
0302-766Xissn
1432-0878journal_volume
284pub_type
杂志文章abstract::Ependymal cells and their junctional complexes in the area postrema of the rat were studied in detail by tracer experiments using horseradish peroxidase (HRP) and colloidal lanthanum and by freeze-etch techniques, in addition to routine electron microscopy. The ependyma of the area postrema is characterized as flatten...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00235058
更新日期:1979-09-03 00:00:00
abstract::Many lung diseases result in fibrotic remodelling. Fibrotic lung disorders can be divided into diseases with known and unknown aetiology. Among those with unknown aetiology, idiopathic pulmonary fibrosis (IPF) is a common diagnosis. Because of its progressive character leading to a rapid decline in lung function, it i...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-016-2543-2
更新日期:2017-03-01 00:00:00
abstract::Tactile hairs on the locust thorax can be divided into two classes by their external morphology and their central projection pattern: Short hairs, 10--100 micrometer in length, which are assembled in distinct plates and rows, and long hairs, 100--800 micrometer in length, which are distributed all over the body and ar...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00234546
更新日期:1981-01-01 00:00:00
abstract::Homeostatic cell turnover has been extensively characterized in mammals. In their adult tissues, lost or aging differentiated cells are replenished by a self-renewing cohort of stem cells. The stem cells have been particularly well studied in the intestine and are clearly identified by the expression of marker genes i...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-017-2692-y
更新日期:2017-12-01 00:00:00
abstract::Mytilus mussels are characterized by annually repeated reproduction which is associated with subsequent growth, morphogenesis, breakdown and redevelopment of the gonad and reproductive tract into mantle mesenchyme. We present a description of the expression of the male-associated polypeptide (MAP; see Mikhailov et al....
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410051204
更新日期:1998-12-01 00:00:00
abstract::It is clear that the well-described phenomenon of epithelial-mesenchymal transition (EMT) plays a pivotal role in embryonic development, wound healing, tissue regeneration, organ fibrosis and cancer progression. EMTs have been classified into three subtypes based on the functional consequences and biomarker context in...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-011-1227-1
更新日期:2012-01-01 00:00:00
abstract::Although the secretory products of the hypothalamo-neurohypophyseal system are not glycoproteins, synthesis and migration of these macromolecules occur within its secretory neurons. After being labeled with 3H-fucose in the Golgi apparatus, newly synthesized glycoproteins migrate to secretion granules, lysosomes and t...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00234755
更新日期:1980-01-01 00:00:00
abstract::Eosinophils are innate immune leukocytes found in relatively low numbers within the blood. Terminal effector functions of eosinophils, deriving from their capacity to release their content of tissue-destructive cationic proteins, have historically been considered primary effector mechanisms against specific parasites,...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-010-1049-6
更新日期:2011-01-01 00:00:00
abstract::The azygos vein of the rat can be divided into three regions: The proximal cardiac region, where the wall is composed of two and sometimes three layers of cardiac muscle and a thin discontinuous layer of smooth muscle cells. Vascular casts of this region demonstrate layers of capillaries closely following the orientat...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221867
更新日期:1986-01-01 00:00:00
abstract::A tissue-engineered heart valve can be an alternative to a prosthetic valve in heart valve replacement; however, it is not fully efficient in terms of long-lasting functionality, as leaflets in engineered valves do not possess the trilayered native leaflet structure. Previously, we developed a flat, trilayered, orient...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-020-03241-6
更新日期:2020-11-01 00:00:00
abstract::Complex carbohydrates in secretory granules and at the apical cell surface of mouse gastric mucoid cells were studied during embryogenesis and in the early postnatal period by various cytochemical methods; the periodic acid-thiocarbohydrazide-silver proteinate (PA-TCH-SP) and tannic acid-uranyl acetate (TA-UA) procedu...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214559
更新日期:1985-01-01 00:00:00
abstract::Ossification of calvariae from day-21 rat fetuses was reinvestigated by electron microscopy using different fixation techniques (glutaraldehyde/OsO4, tannic acid, ruthenium red, K-pyroantimonate). An osteoid layer with scattered mineral deposits was found at the mineralization front. Directly beyond this layer, a shee...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00318693
更新日期:1992-01-01 00:00:00
abstract::By a regular immunoperoxidase method, alpha-1-proteinase inhibitor (Api) was demonstrated in pancreatic islets in individuals with and without genetic deficiency of Api. Subsequently a double immunoperoxidase method, with two different chromogens (diaminobenzidine-brown and 4-chloro-1-naphthol-blue), was applied on th...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218078
更新日期:1986-01-01 00:00:00
abstract::Surface features of the ependymal linings of the fourth ventricle in the fowl were analyzed employing the scanning electron microscope (SEM). On the floor of the median sulcus, each ependymal cell has a solitary cilium, whereas on both sides of the sulcus, cilia are so densely distributed that the details of the under...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233562
更新日期:1979-03-09 00:00:00
abstract::Identified dorsal unpaired median (DUM) neurones of the locust Locusta migratoria were stained intracellularly with large amounts of cobalt to reveal their extensive peripheral branching patterns. Two neurones of the suboesophageal ganglion were studied as well as several neurones of thoracic ganglia. The peripheral b...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050970
更新日期:1997-12-01 00:00:00
abstract::Phenotype transition of vascular smooth muscle cells (VSMCs) is implicated in vascular diseases. Angiotensin-converting enzyme 2 (ACE2) is a perspective cardiovascular target due to its ability of converting angiotensin (Ang II) to Ang (1-7). Our group recently showed that ACE2 can regulate the function of endothelial...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-020-03259-w
更新日期:2020-12-01 00:00:00
abstract::The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is thought to regulate crucial cellular functions such as mitosis, apoptosis, migration, differentiation and communication between organelles as a scaffold protein. These diverse functions are modulated by the tyrosine/serine phosphorylation status of P...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-016-2508-5
更新日期:2017-06-01 00:00:00
abstract::By using an antiserum raised against a crustacean beta-pigment-dispersing hormone (PDH), the distribution and chemical neuroanatomy of PDH-like immunoreactive neurons was investigated in the central nervous system of the gastropod snails, Helix pomatia and Lymnaea stagnalis. The number of immunoreactive cells in the H...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410051240
更新日期:1999-02-01 00:00:00
abstract::PU.1, which is a transcription factor, promotes the terminal differentiation of alveolar macrophages (AMs). Its expression is regulated by granulocyte/macrophage colony-stimulating factor (GM-CSF). In this study of AMs in newborn rats, we performed immunohistochemical staining, acid phosphatase staining, reverse trans...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0405-7
更新日期:2007-07-01 00:00:00
abstract::In cattle, the oviduct plays a major role in the reproductive process; however, molecular control of oviduct receptivity to the embryo is poorly understood. A model for receptivity based on size of the pre-ovulatory follicle (POF) was used to compare oviductal morphology, cellular proliferation, and candidate transcri...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-017-2666-0
更新日期:2017-11-01 00:00:00
abstract::Cestodes (tapeworms) are a derived, parasitic clade of the phylum Platyhelminthes (flatworms). The cestode body wall represents an adaptation to its endoparasitic lifestyle. The epidermis forms a non-ciliated syncytium, and both muscular and nervous system are reduced. Morphological differences between cestodes and fr...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-002-0687-8
更新日期:2003-03-01 00:00:00
abstract::Fragments of pituitary tissue obtained from a total of 37 patients with either breast cancer, diabetic retinopathy, galactorrhea, or acromegaly were dissociated into single cell suspensions prior to cell culture. Release of human growth hormone (hGH) and human prolactin (hPRL) into the culture medium was measured by r...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219803
更新日期:1978-08-16 00:00:00
abstract::In Rana temporaria tadpoles, fluorescent fibres appear in the prospective eminentia mediana, the pars intermedia and the pars distalis at Gosner's stage 25. During prometamorphosis the amount of fluorescent material increases around the developing primary capillary plexus in the eminentia mediana. In the pars intermed...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220236
更新日期:1976-09-01 00:00:00
abstract::The distributions within the coeliac ganglion of different chemically coded subgroups of noradrenaline neurons, and the relationships between these neurons and nerve fibres projecting to the ganglion from the intestine, have been assessed quantitatively by use of an immunohistochemical double-staining method. Noradren...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218395
更新日期:1986-01-01 00:00:00
abstract::The true surface of rabbit spinal ganglion neurons has been made directly accessible to scanning electron-microscope observation after removal of both the connective tissue and satellite cells that normally cover it. The neuronal surface is characterized by a profusion of slender projections whose shapes have been det...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00297502
更新日期:1990-04-01 00:00:00
abstract::Osteogenic differentiation is a tightly regulated process realized by progenitor cell osteoblasts. Notch signaling pathway plays a critical role in skeletal development and bone remodeling. Controversial data exist regarding the role of Notch activation in promoting or preventing osteogenic differentiation. This study...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-019-03130-7
更新日期:2020-01-01 00:00:00
abstract::The fine structure of synapses, their distribution and arrangement in the ventral nerve cord of Peripatoides leuckarti (phylum Onychophora) is described. The asymmetric synaptic junctions show a well developed synaptic cleft (300 A) and pre- and subsynaptic electron dense apposition. They frequently show an array of p...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00224940
更新日期:1978-01-31 00:00:00
abstract::The expression of the gene for vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM) in the human gastrointestinal tract was studied by in situ hybridization and Northern blotting for PHM/VIP mRNA and immunocytochemistry using specific antisera against the bioactive peptides PHM and VIP. In th...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00306108
更新日期:1994-05-01 00:00:00
abstract::Distribution of microtubules and other cytoskeletal filaments in growing skeletal muscle cells (myotubes) was studied in vitro by fluorescence microscopy using fluorescin-labeled antibodies and phalloidin, a specific antiactin drug. In the distal elongating tips of myotubes, microtubules were the major cytoskeletal el...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214368
更新日期:1988-05-01 00:00:00
abstract::The distribution of estradiol-concentrating cells in the pituitary of the platyfish, Xiphophorus maculatus, is studied after the injection of 3H estradiol-17 beta by thaw-mount autoradiography. Autoradiograms prepared 2-8 h after the injection show nuclear concentration of radioactivity in certain cells of the rostral...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00234188
更新日期:1979-05-25 00:00:00