Expression of heat-shock protein 47 in mouse liver.


:Expression of heat-shock protein 47 in intact and fibrotic liver and in hepatic constituent cells was investigated in mice. Immunohistochemical study of intact liver and Western blot analysis of the protein from isolated liver cells revealed that stellate cells and smooth muscle cells of interlobular vessels, but not hepatocytes, Kupffer cells, or endothelial cells, expressed heat-shock protein 47. The protein was found in both vitamin-A-storing stellate cells and myofibroblast-like cells. The amount of the protein in cultured stellate cells was reduced by dexamethasone but was not regulated by quercetin, transforming growth factor beta, interferon gamma, or retinoic acid. In CCl4-treated or bile-duct-ligated mouse liver, the number of cells positive for heat-shock protein 47 markedly increased in the centrilobular area or around the periportal area, respectively, and the level of heat-shock protein 47 also increased.


Cell Tissue Res


Cell and tissue research


Kawada N,Kuroki T,Kobayashi K,Inoue M,Nakatani K,Kaneda K,Nagata K




Has Abstract


1996-05-01 00:00:00












  • Variation in serotonergic and dopaminergic neuronal survival in the central nervous system of adult Drosophila.

    abstract::Loss of serotonergic and dopaminergic neurons may have serious implications for normal brain function. Drosophila models of neurodegenerative diseases utilize the short life-span and simple anatomy of the fly to characterize the molecular and genetic processes characteristic of each dysfunctional state. In fly embryon...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Sykes PA,Norman HS,Condron BG

    更新日期:2004-09-01 00:00:00

  • Calbindin immunoreactivity in the enteric nervous system of larval and adult zebrafish (Danio rerio).

    abstract::Calbindin is a calcium-binding protein, commonly found in certain subpopulations of the enteric nervous system in mammals. Recently, calbindin-immunoreactive enteric neurons have also been demonstrated in shorthorn sculpin (Myoxocephalus scorpius). In the present study, calbindin immunoreactivity has been investigated...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Olsson C

    更新日期:2011-04-01 00:00:00

  • Histogenesis of the pituitary in rainbow trout (Salmo gairdneri) in different ambient salinities with particular reference to the rostral pars distalis.

    abstract::The pituitary gland is first evident in rainbow trout two weeks before hatching. Differentiation of prolactin and ACTH cells is not marked until 3-4 days after hatching when the follicular arrangement of the prolactin cells become apparent. There is no difference in the time of development of either prolactin or ACTH ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Shen AC,Leatherland JF

    更新日期:1978-05-29 00:00:00

  • Effect of alpha-fluoromethylhistidine-evoked histamine depletion on ultrastructure of endocrine cells in acid-producing mucosa of stomach in mouse, rat and hamster.

    abstract::The oxyntic mucosa of the mammalian stomach is rich in endocrine cells, such as ECL cells, A-like cells, somatostatin cells, D1/P cells and, in some species, enterochromaffin cells. The various endocrine cell types can be distinguished on the basis of their characteristic cytoplasmic granules and vesicles. The ECL cel...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Andersson K,Zhao CM,Chen D,Sundler F,Hâkanson R

    更新日期:1996-12-01 00:00:00

  • Identification of M2 macrophages in anterior pituitary glands of normal rats and rats with estrogen-induced prolactinoma.

    abstract::Macrophages are present throughout the anterior pituitary gland. However, the features and function of macrophages in the gland are poorly understood. Recent studies have indicated that there are two main macrophage classes: M1 (classically activated) and M2 (alternatively activated). In this study, we examine whether...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Fujiwara K,Yatabe M,Tofrizal A,Jindatip D,Yashiro T,Nagai R

    更新日期:2017-05-01 00:00:00

  • Afferent and efferent connections of the sexually dimorphic medial preoptic nucleus of the male quail revealed by in vitro transport of DiI.

    abstract::The medial preoptic nucleus of the Japanese quail is a testosterone-sensitive structure that is involved in the control of male copulatory behavior. The full understanding of the role played by this nucleus in the control of reproduction requires the identification of its afferent and efferent connections. In order to...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Balthazart J,Dupiereux V,Aste N,Viglietti-Panzica C,Barrese M,Panzica GC

    更新日期:1994-06-01 00:00:00

  • Identification and characterization of an antimicrobial peptide, lysozyme, from Suncus murinus.

    abstract::Lysozyme is one of the most prominent antimicrobial peptides and has been identified from many mammalian species. However, this enzyme has not been studied in the order Insectivora, which includes the most primitive placental mammals. Here, we done the lysozyme cDNA from Suncus murinus (referred to as suncus, its labo...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Takemi S,Ojima S,Tanaka T,Sakai T,Sakata I

    更新日期:2019-06-01 00:00:00

  • Neurohormones as putative circadian clock output signals in the central nervous system of two cricket species.

    abstract::Antisera to the neuropeptides corazonin (Crz) and crustacean cardioactive peptide (CCAP) and to the diapause hormone (DH) react with small sets of neurones in the cephalic ganglia of the crickets Dianemobius nigrofasciatus and Allonemobius allardi. The distribution of their immunoreactivities is similar in the two spe...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Sehadová H,Shao QM,Sehnal F,Takeda M

    更新日期:2007-04-01 00:00:00

  • Morphological changes during ontogeny of the canine proximal colon.

    abstract::The development of the canine proximal colon from the completion of organogenesis through 43 days after birth was studied using light microscopy, immunofluorescence and electron microscopy. During this period the tunica muscularis increased in thickness from 42+/-6 microm in animals midway through the gestation period...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Ward SM,Torihashi S

    更新日期:1995-10-01 00:00:00

  • Regeneration of the flatworm Prosthiostomum siphunculus (Polycladida, Platyhelminthes).

    abstract::Fueled by the discovery of head regeneration in triclads (planarians) two and a half centuries ago, flatworms have been the focus of regeneration research. But not all flatworms can regenerate equally well and to obtain a better picture of the characteristics and evolution of regeneration in flatworms other than plana...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Schadt T,Prantl V,Grosbusch AL,Bertemes P,Egger B

    更新日期:2020-11-07 00:00:00

  • Ultrastructural tracer studies on the permeability of the Malpighian tubule of the pill millipede, Glomeris marginate (Villers).

    abstract::The electron-dense tracers ferritin, and iron-dextran, and the protein horseradish peroxidase, have been used to investigate the ultrastructural basis of permeability in the upper and lower segments of the Malpighian tubules of Glomeris marginata. All these materials were able to cross the basal lamina and enter the t...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Johnson IT,Riegel JA

    更新日期:1977-09-05 00:00:00

  • Specialized contacts between sarcolemma and sarcoplasmic reticulum at the ends of muscle fibers in the diaphragm of the rat.

    abstract::An electron-microscopic study of the myotendinous portion of the diaphragm in the Wistar rat has shown that at the ends of muscle fibers, longitudinally oriented invaginations and peripheral furrows of the sarcolemma establish specialized contacts with individual sacs of the sarcoplasmic reticulum. The construction of...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Andreev DP,Wassilev WA

    更新日期:1986-01-01 00:00:00

  • Neurochemical characterization of nervous elements innervating the body wall of earthworms (Lumbricus, Eisenia): immunohistochemical and pharmacological studies.

    abstract::The distribution and chemical neuroanatomy of nervous elements and certain pharmacological-physiological characteristics of the innervation of the body wall in earthworms are described. Solitary sensory bipolar cells can be found among the epithelial cells. These bipolar cells contain serotonin, tyrosine hydroxylase, ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Csoknya M,Takács B,Koza A,Dénes V,Wilhelm M,Hiripi L,Kaslin J,Elekes K

    更新日期:2005-09-01 00:00:00

  • Immuno-cytochemical demonstration, in the external region of the amphibian median eminence, of separate vasotocinergic and mesotocinergic nerve fibres.

    abstract::By means of single and double immuno-enzyme cytochemical staining techniques, it was shown that the external region of the amphibian median eminence contains separate vasotocinergic and mesotocinergic nerve fibres. Moreover, it was demonstrated that the vasotocinergic fibres also contain neurophysin. In animals in whi...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Dierickx K,Vandesande F

    更新日期:1977-02-02 00:00:00

  • Developmental changes at the node and paranode in human sural nerves: morphometric and fine-structural evaluation.

    abstract::Developmental alterations of paranodal fiber segments have not been investigated systematically in human nerve fibers at the light- and electron-microscopic level. We have therefore analyzed developmental changes in the fine structure of the paranode in 43 human sural nerves during the axonal growth period up to 5 yea...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Bertram M,Schröder JM

    更新日期:1993-09-01 00:00:00

  • Vascular endothelium in atherosclerosis.

    abstract::Their strategic location between blood and tissue and their constitutive properties allow endothelial cells (EC) to monitor the transport of plasma molecules, by employing bidirectional receptor-mediated and receptor-independent transcytosis and endocytosis, and to regulate vascular tone, cellular cholesterol and lipi...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Sima AV,Stancu CS,Simionescu M

    更新日期:2009-01-01 00:00:00

  • The Canoe protein is necessary in adherens junctions for development of ommatidial architecture in the Drosophila compound eye.

    abstract::Rhabdomeres of the Drosophila melanogaster canoemisl mutant ommatidia were twisted, branched, and often fused to each other. A considerable proportion of rhabdomeres were found to have fallen below the retinal basement membrane. Electron-microscopic observations of the mutant ommatidia revealed that microvilli, the su...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Matsuo T,Takahashi K,Suzuki E,Yamamoto D

    更新日期:1999-12-01 00:00:00

  • Significance of the peri-insular extracellular matrix for islet isolation from the pancreas of rat, dog, pig, and man.

    abstract::The presence and distribution in the peri-insular region of extracellular matrix, and in particular basement membrane, was investigated in a comparative study comprising pancreata of rat, dog, pig, and man. Basement membrane markers, collagen type-IV and laminin, were determined immunohistochemically. Additional infor...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: van Deijnen JH,Hulstaert CE,Wolters GH,van Schilfgaarde R

    更新日期:1992-01-01 00:00:00

  • Immunocytochemical localization of serotonin in the reptilian lung.

    abstract::The distribution of serotonin-immunoreactive cells in the lung of 4 species of reptiles was investigated. Serotonin-containing cells were found forming groups in the interconnecting septa in all 4 species studied, and also as solitary cells in Testudo graeca and Mauremys caspica. Serotonin-containing cells were also l...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Pastor LM,Ballesta J,Perez-Tomas R,Marin JA,Hernandez F,Madrid JF

    更新日期:1987-06-01 00:00:00

  • Pregnancy reduces noradrenaline but not neuropeptide levels in the uterine artery of the guinea-pig.

    abstract::Using histochemical, immunohistochemical and biochemical techniques, noradrenaline-, neuropeptide Y-, vasoactive intestinal polypeptide-, substance P- and calcitonin gene-related peptide-containing nerve fibres were studied in the uterine artery of virgin, progesterone-treated and pregnant guinea-pigs. Morphological c...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Mione MC,Cavanagh JF,Lincoln J,Milner P,Burnstock G

    更新日期:1990-03-01 00:00:00

  • Comparative analysis of ABCG2-expressing and label-retaining cells in mouse submandibular gland.

    abstract::The submandibular gland (SMG) is a tissue that can be regenerated in a tissue injury model and that has adult stem cells capable of self-renewal and differentiation into functional cells. We have analyzed the localization of label-retaining cells (LRCs), which are putative progenitor cells, by using the BrdU-labeling ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Kim YJ,Kwon HJ,Shinozaki N,Hashimoto S,Shimono M,Cho SW,Jung HS

    更新日期:2008-10-01 00:00:00

  • Distribution of short neuropeptide F and its receptor in neuronal circuits related to feeding in larval Drosophila.

    abstract::Four forms of short neuropeptide F (sNPF1-4), derived from the gene snpf, have been identified in Drosophila and are known to act on a single G-protein-coupled receptor (sNPFR). Several functions have been suggested for sNPFs in Drosophila, including the regulation of feeding and growth in larvae, the control of insul...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Carlsson MA,Enell LE,Nässel DR

    更新日期:2013-09-01 00:00:00

  • Sigma receptor 1 modulates ER stress and Bcl2 in murine retina.

    abstract::Sigma receptor 1 (σR1), a non-opiate transmembrane protein located on endoplasmic reticulum (ER) and mitochondrial membranes, is considered to be a molecular chaperone. Marked protection against cell death has been observed when ligands for σR1 have been used in in vitro and in vivo models of retinal cell death. Mice ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Ha Y,Shanmugam AK,Markand S,Zorrilla E,Ganapathy V,Smith SB

    更新日期:2014-04-01 00:00:00

  • Immunohistochemical characterization of chicken pituitary cells containing the vasotocin VT2 receptor.

    abstract::Research in mammals has demonstrated a variety of regulatory effects of vasopressin and oxytocin on endocrine functions of the anterior pituitary gland. Less evidence is available regarding the hypophysiotropic action of arginine vasotocin (AVT) comprising vasopressic and oxytocic activities in birds. Some hypophysiot...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Jurkevich A,Berghman LR,Cornett LE,Kuenzel WJ

    更新日期:2008-08-01 00:00:00

  • Distribution of neurons with high-affinity uptake sites for GABA in the myenteric plexus of the guniea-pig, rat and chicken.

    abstract::The occurrence of neurons possessing high-affinity uptake sites for GABA was studied in the myenteric plexus of the guinea-pig ileum, caecum, and proximal and distal colon, the rat proximal colon, and the chicken gizzard with the use of 3H-GABA and autoradiography. Experiments were carried out on plexuses that had bee...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Saffrey MJ,Marcus N,Jessen KR,Burnstock G

    更新日期:1983-01-01 00:00:00

  • FoxO3a suppression and VPS34 activity are essential to anti-atrophic effects of leucine in skeletal muscle.

    abstract::Our aim is to gain insight into the mechanisms underlying the anti-atrophic effects of leucine, namely, the way that this amino acid can restrain the up-regulation of MuRF1 and Mafbx/Atrogin-1 in muscle atrophy. Male rats received dietary leucine supplementation for 1-3 days, during which time their hind limbs were im...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Baptista IL,Silvestre JG,Silva WJ,Labeit S,Moriscot AS

    更新日期:2017-08-01 00:00:00

  • Ultrastructural immunocytochemical localization of neurophysin and vasopressin in the median eminence and posterior pituitary of the guinea pig.

    abstract::With the use of tissue prepared by freeze-substitution and the unlabelled antibody enzyme technique, neurophysin and vasopressin were localized at the ultrastructural level in the pofterior pituitary and median eminence of the guinea pig. In the posterior pituitary neurophysin was found in the large neurosecretory gra...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Silverman AJ,Zimmerman EA

    更新日期:1975-06-13 00:00:00

  • Scanning electron microscopic study of spermatozoa from gossypol-treated rats.

    abstract::Spermatozoa from the cauda epididymidis of gossypol-treated rats exhibit distinctive departures from the morphology of spermatozoa from control rats: wrinkled and disorganized cell membrane in the head and tail regions, cell membrane missing from segments of the tail midpiece and principal piece regions, malformed hea...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Bozek SA,Jensen DR,Tone JN

    更新日期:1981-01-01 00:00:00

  • Demonstration of a somatostatin-like activity in retinal cells of the rat.

    abstract::A somatostatin-like substance is demonstrated by light microscopic immunohistochemistry (PAP-method) in perikarya and cell processes of the retina of adult and infant rats. These perikarya are identified according to their size, arrangement and distribution. Each of the first two neuronal orders (receptors, bipolar ce...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Kirsch B,Leonhardt H

    更新日期:1979-01-01 00:00:00

  • Projection of ventrolateral medullary (A1) catecholamine neurons toward nucleus tractus solitarii.

    abstract::The distribution and interconnections of brainstem catecholamine cell groups thought to be important in cardiovascular control were studied using histochemical and ultrastructural techniques in the rabbit. Lesions and microinjections of horseradish peroxidase (HRP) were made in the nucleus tractus solitarii in the dor...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Blessing WW,Furness JB,Costa M,West MJ,Chalmers JP

    更新日期:1981-01-01 00:00:00