Abstract：
:Expression of heat-shock protein 47 in intact and fibrotic liver and in hepatic constituent cells was investigated in mice. Immunohistochemical study of intact liver and Western blot analysis of the protein from isolated liver cells revealed that stellate cells and smooth muscle cells of interlobular vessels, but not hepatocytes, Kupffer cells, or endothelial cells, expressed heat-shock protein 47. The protein was found in both vitamin-A-storing stellate cells and myofibroblast-like cells. The amount of the protein in cultured stellate cells was reduced by dexamethasone but was not regulated by quercetin, transforming growth factor beta, interferon gamma, or retinoic acid. In CCl4-treated or bile-duct-ligated mouse liver, the number of cells positive for heat-shock protein 47 markedly increased in the centrilobular area or around the periportal area, respectively, and the level of heat-shock protein 47 also increased.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Kawada N,Kuroki T,Kobayashi K,Inoue M,Nakatani K,Kaneda K,Nagata Kdoi
10.1007/s004410050594subject
Has Abstractpub_date
1996-05-01 00:00:00pages
341-6issue
2eissn
0302-766Xissn
1432-0878journal_volume
284pub_type
杂志文章abstract：:Ependymal cells and their junctional complexes in the area postrema of the rat were studied in detail by tracer experiments using horseradish peroxidase (HRP) and colloidal lanthanum and by freeze-etch techniques, in addition to routine electron microscopy. The ependyma of the area postrema is characterized as flatten...
journal_title：Cell and tissue research
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