Expression of heat-shock protein 47 in mouse liver.


:Expression of heat-shock protein 47 in intact and fibrotic liver and in hepatic constituent cells was investigated in mice. Immunohistochemical study of intact liver and Western blot analysis of the protein from isolated liver cells revealed that stellate cells and smooth muscle cells of interlobular vessels, but not hepatocytes, Kupffer cells, or endothelial cells, expressed heat-shock protein 47. The protein was found in both vitamin-A-storing stellate cells and myofibroblast-like cells. The amount of the protein in cultured stellate cells was reduced by dexamethasone but was not regulated by quercetin, transforming growth factor beta, interferon gamma, or retinoic acid. In CCl4-treated or bile-duct-ligated mouse liver, the number of cells positive for heat-shock protein 47 markedly increased in the centrilobular area or around the periportal area, respectively, and the level of heat-shock protein 47 also increased.


Cell Tissue Res


Cell and tissue research


Kawada N,Kuroki T,Kobayashi K,Inoue M,Nakatani K,Kaneda K,Nagata K




Has Abstract


1996-05-01 00:00:00












  • Postnatal expression and denervation induced up-regulation of aquaporin-5 protein in rat sweat gland.

    abstract::The evolution of aquaporin-5 (AQP5) expression during postnatal development has not been defined in the sweat gland. Previous studies have suggested that AQP isoforms in several peripheral targets are regulated by a neural mechanism. We have examined, in rat sweat glands, the expression of AQP5 during postnatal develo...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Ma L,Huang YG,He H,Deng YC,Zhang HF,Che HL,Tian JY,Zhao G

    更新日期:2007-07-01 00:00:00

  • Zonation of the optical environment and zonation in the rhabdom structure within the eye of the backswimmer, Notonecta glauca.

    abstract::In the compound eye of Notonecta glauca, the backswimmer, there is a small ventral region in which the rhabdoms differ in structure from those in the other parts of the eye. Here, among other unusual features, there is a special orientation of the microvilli of the central rhabdomeres, i.e., in most of the median eye ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Schwind R

    更新日期:1983-01-01 00:00:00

  • An electron microscopic study of Babesia microti invading erythrocytes.

    abstract::Intracellular sporozoan parasites invade the host cell through the invagination of the plasma membrane of the host and a vacuole is formed which accommodates the entering parasite. The vacuole may disappear and the invaginated membrane of the host then becomes closely apposed to that of the parasite's own membrane. As...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Rudzinska MA,Trager W,Lewengrub SJ,Gubert E

    更新日期:1976-06-28 00:00:00

  • Development of nNOS-positive preganglionic sympathetic neurons in the rat thoracic spinal cord.

    abstract::To gain a better understanding of the neuroplasticity of sympathetic neurons during postnatal ontogenesis, the distribution of neuronal nitric oxide synthase (nNOS) immunoreactivity was studied in sympathetic preganglionic neurons (SPN) in the spinal cord (Th2 segment) of female Wistar rats at different ages (newborn,...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Moiseev KY,Romanova IV,Masliukov AP,Masliukov PM

    更新日期:2019-02-01 00:00:00

  • Fibrosis and inflammation are greater in muscles of beta-sarcoglycan-null mouse than mdx mouse.

    abstract::The Sgcb-null mouse, with knocked-down β-sarcoglycan, develops severe muscular dystrophy as in type 2E human limb girdle muscular dystrophy. The mdx mouse, lacking dystrophin, is the most used model for Duchenne muscular dystrophy (DMD). Unlike DMD, the mdx mouse has mild clinical features and shows little fibrosis in...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Gibertini S,Zanotti S,Savadori P,Curcio M,Saredi S,Salerno F,Andreetta F,Bernasconi P,Mantegazza R,Mora M

    更新日期:2014-05-01 00:00:00

  • Neuronal background of activation of estivated snails, with special attention to the monoaminergic system: a biochemical, physiological, and neuroanatomical study.

    abstract::Osmotic stimulation activates both estivated and inactivated specimens of Helix pomatia and increases their central arousal. High-pressure liquid chromatography has shown that, during activation, the level of both serotonin and dopamine decreases in the central nervous system (CNS) but increases in the foot and heart,...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Hernádi L,Vehovszky A,Gyori J,Hiripi L

    更新日期:2008-02-01 00:00:00

  • Estrogenic stimulation of ovarian follicular maturation in diabetes (db/db) mutant mice: restoration of euglycemia prevents hyperlipidemic cytoatrophy.

    abstract::The diabetes (db/db) mutation (leptin-receptor defect) induces a hyperglycemic-hyperinsulinemic endometabolic environment that promotes hypercytolipidemic ovarian involution in C57BL/KsJ mice, resulting in reproductive sterility and eventual organoatrophy. The effectiveness of low-dose (1.0 microg/sc/3.5 day intervals...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Garris DR

    更新日期:2004-11-01 00:00:00

  • To serve and to protect: the role of decidual innate immune cells on human pregnancy.

    abstract::The maternal-fetal interface undergoes dynamic changes that promote successful development of the embryo/fetal allograft during pregnancy. This immune privilege of the conceptus is mediated through local and systemic cellular responses. In species in which endometrial decidualization accompanies pregnancy, unique immu...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Zhang J,Dunk C,Croy AB,Lye SJ

    更新日期:2016-01-01 00:00:00

  • Scanning electron-microscopic study of lens fibers of the pig.

    abstract::Whole pigs lenses were fixed, critical-point dried and fractured, and the internal surfaces examined with a scanning electron microscope. At various locations from the equator to the center of the lens four types of fibers can be distinguished. The superficial fibers have small interdigitations. Cortical lens fibers, ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Hoyer HE

    更新日期:1982-01-01 00:00:00

  • Scanning electron microscopic analysis of the linings of the fourth ventricle in the domestic fowl.

    abstract::Surface features of the ependymal linings of the fourth ventricle in the fowl were analyzed employing the scanning electron microscope (SEM). On the floor of the median sulcus, each ependymal cell has a solitary cilium, whereas on both sides of the sulcus, cilia are so densely distributed that the details of the under...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Hirunagi K,Yasuda M

    更新日期:1979-03-09 00:00:00

  • Expression of PU.1 and terminal differentiation of alveolar macrophages in newborn rats.

    abstract::PU.1, which is a transcription factor, promotes the terminal differentiation of alveolar macrophages (AMs). Its expression is regulated by granulocyte/macrophage colony-stimulating factor (GM-CSF). In this study of AMs in newborn rats, we performed immunohistochemical staining, acid phosphatase staining, reverse trans...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Iwabuchi H,Kawasaki T,Yamamoto T,Uchiyama M,Nakata K,Naito M

    更新日期:2007-07-01 00:00:00

  • Two different types of dynorphin-A-immunoreactive terminals in rat substantia nigra.

    abstract::The opioid peptide dynorphin A (1-17) is the third transmitter identified in the striatonigral projection, the other two being gamma-aminobutyric acid (GABA) and substance P. The ultrastructural features of the dynorphinergic terminals in substantia nigra/pars reticulata were studied using pre-embedding immunocytochem...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Riesenberg R,Nitsch C

    更新日期:1990-07-01 00:00:00

  • Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule.

    abstract::The wall of the seminiferous tubule in rodents consists of an inner layer of myoid cells covered by an outer layer of endothelial cells. Myoid cells are a type of smooth muscle cell containing α-actin filaments arranged in two independent layers that contract when stimulated by endothelin-1. The irregular surface reli...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Losinno AD,Sorrivas V,Ezquer M,Ezquer F,López LA,Morales A

    更新日期:2016-08-01 00:00:00

  • The hypothalamo-choroidal tract. I. Immunohistochemical demonstration of neurophysin pathways to telencephalic choroid plexuses and cerebrospinal fluid.

    abstract::Neurosecretory pathways were examined in normal male rats by the use of the immunoperoxidase technique for the localization of neurophysin in Bouin-fixed, deparaffinized sections. Using this technique two projections of extrahypothalamic neuorosecretory fibers can be traced to the sites of origin of the choid plexuses...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Brownfield MS,Kozlowski GP

    更新日期:1977-03-01 00:00:00

  • Topographic, morphologic and developmental characterization of the nucleus loci coerulei in the chicken. A Golgi and fluorescence-histochemical study.

    abstract::Golgi- and fluorescence-histochemical studies in the chicken shown the presence of a sharply delimited group of aminergic neurons beneath the floor of the fourth ventricle at the mesen-metencephalic boundary. According to the observations reported in other avian species a homology can be established between the mammal...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Guglielmone R,Panzica GC

    更新日期:1982-01-01 00:00:00

  • Skin-derived multipotent stromal cells--an archrival for mesenchymal stem cells.

    abstract::Progenitor stem cells have been identified, isolated and characterized in numerous tissues and organs. However, their therapeutic potential and the use of these stem cells remain elusive except for a few progenitor cells from bone marrow, umbilical cord blood, eyes and dental pulp. The use of bone marrow-derived hemat...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Vishnubalaji R,Al-Nbaheen M,Kadalmani B,Aldahmash A,Ramesh T

    更新日期:2012-10-01 00:00:00

  • Proteomics of post-translational modifications of mammalian spermatozoa.

    abstract::It is hard to fathom that one of the most highly differentiated cells in the body, the spermatozoon, spends over half of its developmental life without the capacity for nuclear protein biosynthesis. This is even more incredible when considering that protein synthesis is switched off long before the sperm is mature. As...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Baker MA

    更新日期:2016-01-01 00:00:00

  • Neuroendocrine cells within colorectal tumours induced by dimethylhydrazine. An immunocytochemical study.

    abstract::Colorectal adenocarcinomas were induced in male Wistar rats, by weekly subcutaneous administration of 1,2-dimethylhydrazine, classified according to the degree of differentiation and submitted to immunocytochemistry for the peptides cholecystokinin (CCK), gastrin, gastric inhibitory polypeptide (GIP), glucagon, neurot...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Johnston CF,O'Neill AB,O'Hare MM,Buchanan KD

    更新日期:1986-01-01 00:00:00

  • Well-organized spheroids as a new platform to examine cell interaction and behaviour during organ development.

    abstract::We present an experimental method allowing the production of three-dimensional organ-like structures, namely microtissues (MTs), in vitro without the need for exogenous extracellular matrix (ECM) or growth factors. Submandibular salivary glands (embryonic day ED14), kidneys (ED13) and lungs (ED13) were harvested from ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Bécavin T,Kuchler-Bopp S,Kökten T,Huck O,Messaddeq N,Lesot H,Deveaux E,Benkirane-Jessel N,Laetitia K

    更新日期:2016-12-01 00:00:00

  • Distribution of the extended family of protein kinase C isoenzymes in fetal organs of mice: an immunohistochemical study.

    abstract::Using isoenzyme-specific antisera, we have studied the distribution of protein kinase C isoforms in fetal mouse organs at the developmental age of 17 days. Two different sets of antibodies, produced by different manufacturers, were employed in this study. The specificity of the antisera was tested by immunoblotting ex...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Bareggi R,Grill V,Zweyer M,Narducci P,Martelli AM

    更新日期:1995-06-01 00:00:00

  • Ultrastructure of the nongranulated cells and morphology of the extracellular spaces in the pars distalis of adult and pouch-young tammar wallabies (Macropus eugenii).

    abstract::Differentiated nongranulated (folliculo-stellate) cells were observed in the centre and periphery of the cords of cells in the pars distalis of the adult tammar wallaby (Macropus eugenii). The nongranulated cells formed follicles containing a small lumen: the cell apices were joined by junctional complexes including z...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Leatherland JF,Renfree MB

    更新日期:1982-01-01 00:00:00

  • Intraepithelial inclusions resembling human biondi bodies in the choroid plexus of an aged chimpanzee.

    abstract::Complex intracellular inclusion bodies of the Biondi type were observed in the choroidal epithelium (choroid plexus of the lateral ventricle) of a 43-year-old male chimpanzee. The specific components of these inclusions are bundles of filaments 8-15 nm in diameter, which are associated with lipid droplets and a wide v...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Oksche A,Liesner R,Tigges J,Tigges M

    更新日期:1984-01-01 00:00:00

  • Complex-type glycoproteins synthesized in the subcommissural organ of mammals. Light- and electron-microscopic investigations by use of lectins.

    abstract::The secretory activity in the subcommissural organ (SCO) of the sheep and cow was examined by means of lectin histochemistry and cytochemistry. Among the various lectins tested. Concanavalin A (Con A) revealed glycoproteins rich in mannosyl residues in the rough endoplasmic reticulum of ependymal and hypendymal cells....

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Meiniel A,Molat JL,Meiniel R

    更新日期:1988-08-01 00:00:00

  • The aminergic innervation of the pituitary gland in the roach Leuciscus rutilus.

    abstract::Fluorescent (aminergic) fibers were demonstrated by the Falck-Hillarp technique in all parts of the neurohypophysis (NH) in the roach (Leuciscus rutilus). The fibers are very thin and few in number in the rostral (RNH) and proximal neurohypophysis (PNH) but slightly more numerous in the NH adjacent to the pars interme...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Ekengren B

    更新日期:1975-01-01 00:00:00

  • The development and maintenance of smooth muscle in control and aneurogenic amphibians (Ambystoma).

    abstract::Ultrastructural investigations showed that development and maintenance of smooth muscle was similar in control and aneurogenic amphibian larvae. This applies to both multi-unit and unitary smooth muscles. The gut musculature displayed a regional variation in smooth muscle morphology and a variety of intermuscular appo...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Tweedle CD

    更新日期:1976-02-12 00:00:00

  • Ultrastructural and morphometric study of the lung of the European salamander, Salamandra salamandra L.

    abstract::Ultrastructural and morphometric investigations were performed on the lung of the European salamander, Salamandra salamandra L. Folds of first and second order are covered with a ciliated epithelium containing goblet cells. The respiratory surface of the lung is lined by a single type of cell which, in amphibians, com...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Goniakowska-Witalińska L

    更新日期:1978-07-27 00:00:00

  • The enteric nervous system in PD: gateway, bystander victim, or source of solutions.

    abstract::Apart from the characteristic and progressive motor- and movement-related problems, Parkinson's disease (PD) patients also suffer from several non-motor symptoms, including gastrointestinal dysfunction. The fact that the enteric nervous system (ENS) controls motility and that one of the typical PD hallmarks, α-synucle...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Shannon K,Vanden Berghe P

    更新日期:2018-07-01 00:00:00

  • Light- and electron-microscopic studies on the secretory cytology of the adenohypophysis of the Japanese quail, Coturnix coturnix japonica.

    abstract::The effects of thyroidectomy, adrenalectomy, and castration on the pars distalis of male Japanese quail, and of injection of LH-RH on sexually inactive females, were investigated by light and electron microscopy. Correlation between light and electron microscopy was attained by use of alternate thin and thick sections...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Mikami S,Kurosu T,Farner DS

    更新日期:1975-06-09 00:00:00

  • Distribution of peptidyl-glycine alpha-amidating monooxygenase immunoreactivity in the brain, pituitary and islet organ of the anglerfish (Lophius americanus).

    abstract::Peptidyl-glycine alpha-amidating monooxygenase (PAM; EC is an enzyme that catalyzes conversion of glycine-extended peptides to alpha-amidated bioactive peptides. Two peptides that are processed at their carboxyl-termini by this enzyme are neuropeptide Y and anglerfish peptide Y, both of which possess a C-te...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: McDonald JK,Klein K,Noe BD

    更新日期:1995-04-01 00:00:00

  • Immunocytochemical localization of oviduct-specific glycoproteins in the oviductal epithelium from cows at follicular and luteal phases.

    abstract::The immunocytochemical localization of bovine oviduct-specific glycoproteins was investigated by light and electron microscopy. Using monoclonal antibodies (MAbs) specific for bovine oviductal glycoproteins, 3 regions (fimbriae, ampulla, and isthmus) of the epithelium in the bovine oviduct we studied during the follic...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Abe H,Numazawa C,Abe M,Onodera M,Katsumi A

    更新日期:1993-10-01 00:00:00