Abstract:
:The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the principal molecular units for fast excitatory synaptic transmission in the central nervous system. The glutamate-mediated transmission efficiency of synaptic AMPA receptors is influenced by their subunit composition (GluR-A to GluR-D), post-transcriptional and post-translational modifications, the number of synaptic AMPA receptors, and auxiliary proteins. Functional AMPA receptors are located predominantly in the post-synapse but are also found at extra-synaptic sites and occasionally in the pre-synapse. Thus, many factors influence the tasks of AMPA receptors in neuronal signal transmission. At hippocampal synaptic connections, AMPA receptor functions have been well studied in vitro and in the mouse; however, it is unlikely that these observations can be generalized to all glutamatergic synapses in the brain.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Sprengel Rdoi
10.1007/s00441-006-0275-4subject
Has Abstractpub_date
2006-11-01 00:00:00pages
447-55issue
2eissn
0302-766Xissn
1432-0878journal_volume
326pub_type
杂志文章,评审abstract::Most myenteric neurons contain one of the two generating enzymes for major excitatory and inhibitory neurotransmitters: choline acetyltransferase (ChAT) or neuronal nitric oxide synthase (NOS). Two minor groups of myenteric neurons contain either both enzymes or neither. Our study had two aims: (1) to compare the prop...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0852-4
更新日期:2009-10-01 00:00:00
abstract::In the compound eye of the locust, Locusta, the cross-sectional area of the rhabdoms increases at "dusk" by 4.7-fold due to the rapid assembly of new microvillar membrane, and decreases at "dawn" by a corresponding amount as a result of pinocytotic shedding from the microvilli. The rhabdoms at night have more and long...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214807
更新日期:1982-01-01 00:00:00
abstract::The ultrastructural immunohistochemical localization of gamma aminobutyric acid (GABA) and its regulating enzymes, L-glutamate decarboxylase (GAD) and gamma aminobutyrate-alpha-ketoglutarate transaminase, was determined utilizing an immunogold post-embedding protocol in pancreatic exocrine tissue. Within the acinar ce...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00213841
更新日期:1988-04-01 00:00:00
abstract::Intracellular sporozoan parasites invade the host cell through the invagination of the plasma membrane of the host and a vacuole is formed which accommodates the entering parasite. The vacuole may disappear and the invaginated membrane of the host then becomes closely apposed to that of the parasite's own membrane. As...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219605
更新日期:1976-06-28 00:00:00
abstract::The effect of copulation on the rat coagulating gland (anterior prostate) was studied. At 4 to 6 h after the beginning of copulation the coagulating glands of rats that had produced copulatory plugs were nearly empty of secretion. Ultrastructurally, the coagulating gland has large cisternae of rough endoplasmic reticu...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221773
更新日期:1977-07-19 00:00:00
abstract::The alimentary system of Habrotrocha rosa is composed of the alimentary channel, five digestive glands and another gland which is in close relation to the intestinal syncytium. After the present investigation, the alimentary channel can be divided into sections which clearly differ from each other, these are: oral cav...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00209138
更新日期:1978-06-08 00:00:00
abstract::The smooth muscle of rabbit portal vein was studied by electron microscopy with particular emphasis on the mechanical linkage between the muscle cells and on the distribution of connective tissue. The media of this vein is composed of inner circular and outer longitudinal muscle layers which are orientated almost perp...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00237614
更新日期:1980-01-01 00:00:00
abstract::The origin and renewal of the argentaffin cells in the pyloric glands of hamsters were studied by flash, cumulative and pulse labelling autoradiography with 3H-thymidine. The argentaffin cells were identified by the Diazo Method using Fast Red B Salt. By flash labelling autoradiography, it was shown that the argentaff...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222771
更新日期:1977-06-20 00:00:00
abstract::The fine structure of luminal surface of clearly identified portions of uriniferous tubules has been studied by scanning electron microscopy to elucidate some controversies concerning the topography of certain surface formations. The results show a characteristic pattern of the luminal surface in the region of Henle's...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215128
更新日期:1976-02-06 00:00:00
abstract::In an attempt to determine the neural control of pancreatic D cells, the pancreatic islets of the domestic fowl were examined electron microscopically from 1 to 28 days after abdominal vagotomy. Exocytotic release of many secretory granules from D cells occurred one day after vagotomy. Rough endoplasmic reticulum deve...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233732
更新日期:1980-01-01 00:00:00
abstract::Hepatic peroxisomes in human embryos with a menstrual age of 6 and 7 weeks have been examined via catalase cytochemistry. In the younger sample, the organelles show no catalase activity, their matrix being pale and coarsely reticular. In the 7-week specimen, the peroxisome population consists of catalase-positive and ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00323574
更新日期:1993-04-01 00:00:00
abstract::The reaction of nerve endings in the median eminence of the rat to zinc iodide-osmium tetroxide (ZIO) staining was examined electron microscopically under normal and experimental conditions. The experimental condition of catecholamine exhaustion in the nerve endings was induced by the administration of H44/68 and rese...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220316
更新日期:1976-10-13 00:00:00
abstract::Normal development, function and repair of the sensory epithelia in the inner ear are all dependent on gap junctional intercellular communication. Mutations in the connexin genes GJB2 and GJB6 (encoding CX26 and CX30) result in syndromic and non-syndromic deafness via various mechanisms. Clinical vestibular defects, h...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-014-2029-z
更新日期:2015-06-01 00:00:00
abstract::To identify anterior pituitary cell types containing GnRH binding sites and to study the internalization process of this peptide by target cells under physiological conditions, autoradiography was performed on rat anterior pituitaries removed at specific time intervals (2-60 min) after intravenous injection of mono-ra...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216482
更新日期:1987-06-01 00:00:00
abstract::During normal development of many vertebrate species, substantial numbers of neurons in the central and peripheral nervous system undergo naturally occurring (or programmed) cell death. For example, approximately 50% of spinal motoneurons degenerate and die at a time when these cells are establishing synaptic connecti...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050690
更新日期:1996-11-01 00:00:00
abstract::The medial preoptic nucleus is a sexually dimorphic structure whose cytoarchitecture, afferent and efferent connections, and functions have been previously described. No detailed ultrastructural study has, however, been performed to date. Here we describe the ultrastructural organization of this important preoptic str...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00318164
更新日期:1995-03-01 00:00:00
abstract::Our immunocytochemical investigation of the magnocellular neuroendocrine system in the goldfish hypothalamus reveals enkephalin (ENK)-containing neurons interspersed among the vasotocin (VT)- and isotocin (IT)-containing neurons of the preoptic nucleus. The perikarya of the ENK, VT, and IT neurons do not show distinct...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00236894
更新日期:1979-08-03 00:00:00
abstract::Cortisone-treated Buffalo rats have been parabiosed with untreated controls of the same age. The optical and electron microscopy, including histochemistry, of costal cartilage of these rats has been compared with that in single cortisone treated rats, single controls, and control parabiosed with control rats, at 14 an...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00223122
更新日期:1978-05-18 00:00:00
abstract::The etiologic basis of Parkinson's disease (PD), the second most common age-related neurodegenerative disorder, is unknown. Recent epidemiological and experimental studies indicate that exposure to environmental agents, including a number of agricultural chemicals, may contribute to the pathogenesis of this disorder. ...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-004-0937-z
更新日期:2004-10-01 00:00:00
abstract::As luminal fluid moves from the seminiferous tubule and enters the rete testis, its protein concentration declines from approximately 6 mg/ml to 1 mg/ml. It was therefore suggested that protein is either 1) utilized by the spermatozoa, 2) transported across the epithelium of the terminal segment of the seminiferous tu...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00213810
更新日期:1983-01-01 00:00:00
abstract::Neural stem and progenitor cells produce one of the most remarkable organs in nature, the human brain. Among neural stem cell progeny, post-mitotic neurons are likewise remarkably diverse. Single-cell transcriptomic approaches are now cataloging a long-sought-after molecular taxonomy of neuronal diversity in the brain...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-017-2728-3
更新日期:2018-01-01 00:00:00
abstract::This study aimed to characterize porcine Achilles tendon (PAT) in terms of its structural components, vascularity, and resident tendon cells. We found that PAT is composed of a paratenon sheath, a core of fascicles, and an endotenon/interfascicular matrix (IFM) that encases the fascicle bundles. We analyzed each of th...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-020-03379-3
更新日期:2021-01-26 00:00:00
abstract::We previously described the presence of MHC class II (HLA-DR) antigens, structurally similar to those on lymphoid cells and bearing the genetically-appropriate allotypic determinants, on human adrenocortical cells in the zona reticularis of normal glands. We now report a similar expression by granulosa-lutein cells (G...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00309876
更新日期:1990-11-01 00:00:00
abstract::Rat blood monocytes contain granules of two types, primary and secondary granules, which can be distinguished on morphological grounds. Secondary granules have a halo between the limiting membrane and the matrix; primary granules have no halo and are generally more elongate than the secondary granules. In addition, th...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00226665
更新日期:1977-11-30 00:00:00
abstract::Back-labeling of regenerated electromotor neurons in the teleost Sternarchus albifrons was performed to test the hypothesis that, in regenerated spinal cord, incorrectly located electromotor neurons are eliminated because their axons do not reach the correct target area (electric organ). In each cross section examined...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217166
更新日期:1985-01-01 00:00:00
abstract::Islet amyloid peptide (or diabetes-associated peptide), the major component of pancreatic islet amyloid found in type-2 diabetes, has been identified by electron-microscopic immunocytochemistry in pancreatic B-cells from five non-diabetic human subjects, and in islets from five type-2 diabetic patients. The greatest d...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221649
更新日期:1989-07-01 00:00:00
abstract::The dorsal root ganglion (DRG) and dorsal horn of the spinal cord are areas through which primary afferent information passes enroute to the brain. Previous studies have reported that, during normal neuronal activity, the regional distribution of a second messenger, diacylglycerol (DG), which is derived from phosphoin...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0219-z
更新日期:2006-10-01 00:00:00
abstract::Exposure to nicotine in smoking contributes to most unexplained male infertility but the mechanisms remain to be fully elucidated. Zinc (Zn) is an essential trace element in normal growth, development and reproduction. Zinc oxide nanoparticles (ZnONPs) are well-known antioxidants. Therefore, this work was designed to ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2909-8
更新日期:2019-02-01 00:00:00
abstract::Sipunculans, a small phylum of coelomated marine worms closely related to polychaete annelids, lack a true circulatory system. We have previously shown that the sipunculan Themiste petricola can form a cellular clot, without congealing, of cell-free coelomic fluid. The clot is formed by the aggregation of large granul...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0912-9
更新日期:2010-03-01 00:00:00
abstract::The pancreatic endocrine tissue of Fugu rubripes rubripes consists of numerous round principal islets (Brockmann bodies) of various sizes scattered around the gall-bladder. The endocrine cells are divided into A-, B-, D-, and Ff-cells. Each cell type was identified by comparing thick and thin sections in both light an...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222157
更新日期:1976-10-29 00:00:00