Role of AMPA receptors in synaptic plasticity.

Abstract:

:The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the principal molecular units for fast excitatory synaptic transmission in the central nervous system. The glutamate-mediated transmission efficiency of synaptic AMPA receptors is influenced by their subunit composition (GluR-A to GluR-D), post-transcriptional and post-translational modifications, the number of synaptic AMPA receptors, and auxiliary proteins. Functional AMPA receptors are located predominantly in the post-synapse but are also found at extra-synaptic sites and occasionally in the pre-synapse. Thus, many factors influence the tasks of AMPA receptors in neuronal signal transmission. At hippocampal synaptic connections, AMPA receptor functions have been well studied in vitro and in the mouse; however, it is unlikely that these observations can be generalized to all glutamatergic synapses in the brain.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Sprengel R

doi

10.1007/s00441-006-0275-4

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

447-55

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

326

pub_type

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