Ultrastructural alterations of the pancreatic D cell in the domestic fowl following vagotomy.

Abstract:

:In an attempt to determine the neural control of pancreatic D cells, the pancreatic islets of the domestic fowl were examined electron microscopically from 1 to 28 days after abdominal vagotomy. Exocytotic release of many secretory granules from D cells occurred one day after vagotomy. Rough endoplasmic reticulum developed and formed an arrangement of concentric whorls in the cytoplasm of D cells after axotomy. The altered D cells were also characterized by the occurrence of many peculiar dense bodies in the apical cytoplasm at all time periods studied. These bodies varied in shape and size, containing several round vesicles. The D cells were extensively depleted of granules after the longer time periods following vagotomy. The present results provide new morphological evidence for the vagus-nerve control of D cells, which may regulate the activity of islet cells.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Watanabe T,Fujioka T

doi

10.1007/BF00233732

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

171-4

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

211

pub_type

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