Abstract：
:During normal development of many vertebrate species, substantial numbers of neurons in the central and peripheral nervous system undergo naturally occurring (or programmed) cell death. For example, approximately 50% of spinal motoneurons degenerate and die at a time when these cells are establishing synaptic connections with their target muscles in the chick, mouse, rat, and human. It is generally thought that the survival of developing motoneurons depends on access to trophic molecules. Motoneurons that survive the period of programmed cell death may also die following injury in the developing or adult animal. Increasing evidence suggests that glial-cell-line-derived neurotrophic factor (GDNF) plays a physiological and/or pharmacological role in the survival of various neuronal cell types, including motoneurons. In this paper, we review the survival and growth-promoting effects of GDNF on spinal motoneurons during the period of programmed cell death and following injury.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Houenou LJ,Oppenheim RW,Li L,Lo AC,Prevette Ddoi
10.1007/s004410050690subject
Has Abstractpub_date
1996-11-01 00:00:00pages
219-23issue
2eissn
0302-766Xissn
1432-0878journal_volume
286pub_type
杂志文章abstract：:To gain a better understanding of the neuroplasticity of sympathetic neurons during postnatal ontogenesis, the distribution of neuronal nitric oxide synthase (nNOS) immunoreactivity was studied in sympathetic preganglionic neurons (SPN) in the spinal cord (Th2 segment) of female Wistar rats at different ages (newborn,...
journal_title：Cell and tissue research
pub_type： 杂志文章
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1979-05-25 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1997-07-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1980-01-01 00:00:00
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journal_title：Cell and tissue research
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更新日期：1997-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1999-02-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
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更新日期：2006-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1995-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1749-9
更新日期：2014-02-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216742
更新日期：1981-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1987-08-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1980-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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journal_title：Cell and tissue research
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更新日期：1984-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1977-02-09 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00209140
更新日期：1978-06-08 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1977-11-23 00:00:00
