Abstract:
:Notch signaling is evolutionarily conserved from Drosophila to human. It plays critical roles in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the adult brain. Notch functions greatly depend on careful regulation and cross-talk with other regulatory mechanisms. Deregulation of Notch signaling is involved in many neurodegenerative diseases and brain disorders. Here, we summarize the fundamental role of Notch in neuronal development and specification and discuss how epigenetic regulation and pathway cross-talk contribute to Notch function. In addition, we cover aberrant alterations of Notch signaling in the diseased brain. The aim of this review is to provide an insight into how Notch signaling works in different contexts to control neurogenesis and its potential effects in diagnoses and therapies of neurodegeneration, brain tumors and disorders.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Zhang R,Engler A,Taylor Vdoi
10.1007/s00441-017-2641-9subject
Has Abstractpub_date
2018-01-01 00:00:00pages
73-89issue
1eissn
0302-766Xissn
1432-0878pii
10.1007/s00441-017-2641-9journal_volume
371pub_type
杂志文章,评审abstract::Injection of wheat-germ agglutinin-horseradish peroxidase conjugate (WGA-HRP) into the superior cervical ganglion (SCG) of the rat results in accumulation of WGA-HRP in sympathetic postganglionic neurons in the contralateral SCG. The sympathetic pathways involved and the mechanism underlying the labeling were investig...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00327745
更新日期:1990-10-01 00:00:00
abstract::The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin brain-derived neurotr...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
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abstract::The vascularization of the hypothalamo-adenohypophysial region of the toad Bufo bufo (L.) (Amphibia, Anura) was studied by means of light- and scanning electron microscopy. Special attention was given to the portal vascular system of the median eminence and the pars distalis. Course and arrangement of these vessels ar...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00223268
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abstract::Immunocytochemistry was used to determine if photoperiod and/or sex have any effect on the pattern of the luteinizing hormone-releasing hormone (LHRH) system in the brain of the Japanese quail. Immunopositive perikarya were found within three major areas of the brain: the rostral paraolfactory lobe, the preoptic, and ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222289
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00238658
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216433
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00318179
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220391
更新日期:1978-11-20 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章,评审
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journal_title:Cell and tissue research
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222116
更新日期:1975-08-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220184
更新日期:1975-10-13 00:00:00
abstract::Angiotensin II (AII) is present in the mammalian ovary and has been correlated with atresia in follicles. Since the theca interna may be one site at which atresia is initiated, we wished to determine whether AII exerts an effect on theca interna from explanted ovarian follicles of hamsters. Hamsters were sacrified on ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00338068
更新日期:1992-04-01 00:00:00
abstract::The course of the Nervus connectivus (N.c.), its branches, and synaptic connections within the frontal ganglion (FG) were investigated electron microscopically after cobalt iontophoresis of the N.c. The subsequent treatment of ultrathin sections with Timm's method was found to be very suitable for identifying the smal...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00235172
更新日期:1979-01-01 00:00:00
abstract::Ontogenetic differentiation of the human thymus was investigated in 50 embryos by means of light and electron microscopic methods in an attempt to clarify the morphogenesis of the complicated microecology of thymic tissue. At the 8th gestational week (g.w.), the primordium of the thymus contains almost exclusively und...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00237813
更新日期:1980-01-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-010-0944-1
更新日期:2010-05-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-011-1265-8
更新日期:2012-03-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00225557
更新日期:1985-01-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219611
更新日期:1976-06-28 00:00:00
abstract::Intracerebroventricular (ICV) injection of melanin-concentrating hormone (MCH) influences feeding behavior in the goldfish and exerts an anorexigenic action in goldfish brain, unlike its orexigenic action in mammals. Despite a growing body of knowledge concerning MCH function in mammals, the role of MCH in appetite ha...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0347-5
更新日期:2007-05-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章,评审
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更新日期:2019-09-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219720
更新日期:1976-04-28 00:00:00
abstract::Live Merkel cells in the skin and hair follicles are known to incorporate a fluorescence dye, quinacrine, which has been utilized to identify and dissect the cells for experiments. Quinacrine fluorescence of the cells is, however, quickly lost and quinacrine-stained Merkel cells soon become difficult to identify in ti...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-002-0688-7
更新日期:2003-03-01 00:00:00
abstract::Sipunculans, a small phylum of coelomated marine worms closely related to polychaete annelids, lack a true circulatory system. We have previously shown that the sipunculan Themiste petricola can form a cellular clot, without congealing, of cell-free coelomic fluid. The clot is formed by the aggregation of large granul...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0912-9
更新日期:2010-03-01 00:00:00
abstract::The postnatal development of brush cells in the distal segment of the common bile duct of the rat was examined with respect to cell number and immunoreactivity for liver fatty acid-binding protein (L-FABP). The brush cells, distinguishable from the principal cells by scanning electron microscopy, first appeared in the...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00318592
更新日期:1991-12-01 00:00:00
abstract::Employing electron-microscopic methods that help retain polyanionic materials, we describe the extracellular coverings of a sea urchin (Lytechinus variegatus) throughout ontogeny. The surface of the embryo is covered by a two-layered cuticle (commonly called the hyaline layer), which in turn is covered by a granular l...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218028
更新日期:1985-01-01 00:00:00
abstract::Putative neural stem cells have been identified within the enteric nervous system (ENS) of adult rodents and cultured from human myenteric plexus. We conducted studies to identify neural stem cells or progenitor cells within the submucosa of adult human ENS. Jejunum tissue was removed from adult human subjects undergo...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-011-1130-9
更新日期:2011-05-01 00:00:00
abstract::The effect of phenylthiourea (PTU) on the pigment epithelium and the photoreceptor cells in the developing retina of Haplochromis burtoni was studied by electron microscopy. In the retinal pigment epithelium of 6-day old embryos, both types of melanin granule (spindle-shaped and rod-shaped) are already found. PTU inhi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219054
更新日期:1977-03-09 00:00:00
abstract::The circadian timing system is a neural network consisting of the hypothalamic suprachiasmatic nucleus, aided by the retina, other hypothalamic nuclei, autonomic regions of the spinal cord, sympathetic ganglia and the pineal gland. Extensive studies conducted over the last two decades have unravelled the principal ite...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s004410050652
更新日期:1996-09-01 00:00:00
abstract::The morphology and histology of the tibial auditory system of the New Zealand weta, Hemideina crassidens, are described. The groups of acoustic sensilla conform closely to the subgenual organ, intermediate organ and crista acoustica of the Tettigoniidae. Each prothoracic tibia bears two thick (40-100 micrometers) tymp...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233584
更新日期:1981-01-01 00:00:00