Notch: an interactive player in neurogenesis and disease.

Abstract:

:Notch signaling is evolutionarily conserved from Drosophila to human. It plays critical roles in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the adult brain. Notch functions greatly depend on careful regulation and cross-talk with other regulatory mechanisms. Deregulation of Notch signaling is involved in many neurodegenerative diseases and brain disorders. Here, we summarize the fundamental role of Notch in neuronal development and specification and discuss how epigenetic regulation and pathway cross-talk contribute to Notch function. In addition, we cover aberrant alterations of Notch signaling in the diseased brain. The aim of this review is to provide an insight into how Notch signaling works in different contexts to control neurogenesis and its potential effects in diagnoses and therapies of neurodegeneration, brain tumors and disorders.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Zhang R,Engler A,Taylor V

doi

10.1007/s00441-017-2641-9

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

73-89

issue

1

eissn

0302-766X

issn

1432-0878

pii

10.1007/s00441-017-2641-9

journal_volume

371

pub_type

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