Abstract：
:Putative neural stem cells have been identified within the enteric nervous system (ENS) of adult rodents and cultured from human myenteric plexus. We conducted studies to identify neural stem cells or progenitor cells within the submucosa of adult human ENS. Jejunum tissue was removed from adult human subjects undergoing gastric bypass surgery. The tissue was immunostained, and confocal images of ganglia in the submucosal plexus were collected to identify protein gene product 9.5 (PGP 9.5) - immunoractive neurons and neuronal progenitor cells that coexpress PGP 9.5 and nestin. In addition to PGP-9.5-positive/nestin-negative neuronal cells within ganglia, we observed two other types of cells: (1) cells in which PGP 9.5 and nestin were co-localized, (2) cells negative for both PGP 9.5 and nestin. These observations suggest that the latter two types of cells are related to a progenitor cell population and are consistent with the concept that the submucosa of human adult ENS contains stem cells capable of maintenance and repair within the peripheral nervous system.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Azan G,Low WC,Wendelschafer-Crabb G,Ikramuddin S,Kennedy WRdoi
10.1007/s00441-011-1130-9subject
Has Abstractpub_date
2011-05-01 00:00:00pages
217-25issue
2eissn
0302-766Xissn
1432-0878journal_volume
344pub_type
杂志文章abstract：:Fibres growing from neurons of explanted dorsal root ganglia from 10 day chick embryos were transected and subsequently observed by light and electron microscopy after periods of a few to fifty minutes. Changes immediately proximal and distal to the cut together with alterations further away from the site of injury on...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219562
更新日期：1978-07-10 00:00:00
abstract：:The enteric nervous system (ENS) controls gastrointestinal functions. In large mammals' intestine, it comprises an inner (ISP) and outer (OSP) submucous plexus and a myenteric plexus (MP). This study quantifies enteric neurons in the ISP, OSP, and MP of the pig ascending (AC) and descending colon (DC) using the HuC/D,...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-020-03286-7
更新日期：2020-09-23 00:00:00
abstract：:Taste buds and the peripheral nerves innervating them are two important components of the peripheral gustatory system. They require appropriate connections for the taste system to function. Neurotrophic factors play crucial roles in the innervation of peripheral sensory organs and tissues. Both brain-derived neurotrop...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-009-0833-7
更新日期：2009-09-01 00:00:00
abstract：:An electron-microscopic study of the myotendinous portion of the diaphragm in the Wistar rat has shown that at the ends of muscle fibers, longitudinally oriented invaginations and peripheral furrows of the sarcolemma establish specialized contacts with individual sacs of the sarcoplasmic reticulum. The construction of...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00251058
更新日期：1986-01-01 00:00:00
abstract：:Single Golgi impregnated visual cells and their axons were treated from the retina to the first synaptic layer (lamina) in serial electron microscopic sections. This analysis of the retina-lamina projection was undertaken in the upper dorso-median eye region which is known to be involved in the perception of polarized...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218590
更新日期：1975-11-17 00:00:00
abstract：:In order to compare the functional state of the anterior pituitary of spontaneously hypertensive rats (SHR) with that of nonmotensive Wistar Kyoto rats (WKR), the anterior pituitary was examined by morphometry and autoradiography at the level of electron microscopy. The relative number and the relative volume of thyro...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237005
更新日期：1979-10-01 00:00:00
abstract：:Light and electron microscopic studies, including the use of the vital dyes trypan blue and acridine orange, indicate that the topical application of precocene II rapidly triggers degenerative processes in the corpora allata (CA) leading within a few days to the virtual disappearance of the parenchymal cells of these ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00234326
更新日期：1979-11-01 00:00:00
abstract：:Myosin and actin were localized by indirect immunofluorescence microscopy using specific antibodies prepared in rabbits against highly purified gizzard myosin and actin. A strong fluorescence staining with both antibodies was observed in rat corneal epithelial cells, anterior lens epithelial cells, rod inner segments,...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221771
更新日期：1977-07-19 00:00:00
abstract：:Enzymatic activities of calcium-magnesium dependent adenosine triphosphatase (Ca-ATPase) and nonspecific alkaline phosphatase (ALPase) were localized at the initial calcification sites of dentin and enamel of rat incisor teeth using electron-microscopic cytochemistry. Ca-ATPase was localized in the Golgi cisternae, cy...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221856
更新日期：1986-01-01 00:00:00
abstract：:The dental follicle is an ectomesenchymal tissue that surrounds developing tooth germ and that contains osteoblastic-lineage-committed stem/progenitor cells. We examined the osteogenic potential of human dental follicle cells (hDFC) by microarray analysis. We first compared the characteristics of hDFC with those of hu...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1477-6
更新日期：2012-11-01 00:00:00
abstract：:Early in postnatal life, the first wave of spermatogenesis is accompanied by an initial wave of germ cell apoptosis. This may reflect an adjustment in the number of germ cells that can be adequately maintained by Sertoli cells. Two major pathways (intrinsic and extrinsic) are involved in the process of caspase activat...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0186-4
更新日期：2006-09-01 00:00:00
abstract：:The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the principal molecular units for fast excitatory synaptic transmission in the central nervous system. The glutamate-mediated transmission efficiency of synaptic AMPA receptors is influenced by their subunit composition (GluR-A to GluR-D...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-006-0275-4
更新日期：2006-11-01 00:00:00
abstract：:Follicular dendritic cells (FDCs) are immune accessory cells found in the follicles of secondary lymphoid organs where they promote B cell maturation in germinal centers (GCs) that develop following antigen exposure. Recently, we published a method for isolating functional murine FDCs in high purity. We reasoned that ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0566-4
更新日期：2008-04-01 00:00:00
abstract：:A total of 20 Golgi-impregnated cone horizontal cells of Nannacara anomala (Cichlidae) were studied in alternating semi- and ultrathin sections in order to examine their connections with the overlying square mosaic of equal double and central single cones. Cone horizontal cells exhibiting three types of processes: (a)...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00220825
更新日期：1976-11-24 00:00:00
abstract：:The fine structure, nature and fate of the components of the nucleolus were studied in young (steps 1, 2), intermediate (steps 3, 4, 5) and mature spermatids (steps 6, 7, 8) of man and monkey, by use of several cytochemical techniques (alcoholic PTA; sodium tungstate: EDTA; HAPTA; nuclease-gold complexes; NOR silver s...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00305735
更新日期：1991-04-01 00:00:00
abstract：:An immunohistochemical study for islet amyloid polypeptide (IAPP) was made on the gastrointestinal (GI) tract and pancreas of man and rat, using antisera raised against a synthetic peptide of C-terminal human IAPP (24-37) and a synthetic peptide of rat IAPP (18-37). A large number of IAPP-immunoreactive cells were fou...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00305236
更新日期：1990-12-01 00:00:00
abstract：:The effects of dexamethasone on the ability of cells enzymatically isolated from 21-day fetal rat calvaria to produce cartilage in vitro has been investigated. Primary cultures of single-cell suspensions of rat calvaria were grown for up to 28 days in vitro in alpha-minimal essential medium containing 15% fetal bovine...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00224728
更新日期：1989-04-01 00:00:00
abstract：:The stem cells with their distinct ability of self-renewal and differentiation are considered an innovation in wound healing. However, there is lack of studies comparing the differential effect of the type and administration route of stem cells in the wound healing context. Thus, the current study has been designed to...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-018-2879-x
更新日期：2018-11-01 00:00:00
abstract：:The number of cells comprising biological structures represents fundamental information in basic anatomy, development, aging, drug tests, pathology and genetic manipulations. Obtaining unbiased estimates of cell numbers, however, was until recently possible only through stereological techniques, which require specific...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-015-2127-6
更新日期：2015-04-01 00:00:00
abstract：:The intestine, which is exposed to nutrition and to food-derived antigens and microbes including viruses and bacteria, might be an important site for the immune response. Crucial structural and functional differences exist between the small and large intestine, regional differences even having been demonstrated within...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-003-0706-4
更新日期：2003-07-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410051100
更新日期：1998-07-01 00:00:00
abstract：:A reversible breakdown of the blood-aqueous barrier in the iridial processes of rabbits has been induced by arachidonic acid as demonstrated by the passage of horseradish peroxidase at places through the tight junctions. Freeze-fracture images reveal very discontinuous P-face ridges. However, the analysis of complemen...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00213948
更新日期：1986-01-01 00:00:00
abstract：:With the use of tissue prepared by freeze-substitution and the unlabelled antibody enzyme technique, neurophysin and vasopressin were localized at the ultrastructural level in the pofterior pituitary and median eminence of the guinea pig. In the posterior pituitary neurophysin was found in the large neurosecretory gra...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221777
更新日期：1975-06-13 00:00:00
abstract：:The papillary muscle of the cat heart's right ventricle has not been studied previously with quantitative ultrastructural techniques despite its wide use for functional studies. This tissue was perfusion-fixed, processed for electron microscopy, and morphometric techniques were used to assess the ultrastructural chara...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216200
更新日期：1983-01-01 00:00:00
abstract：:Morphological changes in the disconnected neuro-intermediate lobe were studied in the lizard, Anolis carolinensis from the 2nd to the 14th post-operative day using a threefold aldehyde fixative (Rodríguez, 1969). Two phases of colour change capacity were exhibited: Phase I started immediately after the transection, la...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237724
更新日期：1979-06-08 00:00:00
abstract：:Autoradiograms of mouse pituitaries were prepared 30 min after injection of 3H-dexamethasone (3HDM), 3H-corticosterone (3HB) and 3H-cortexolone (3HS) either alone or in the presence of competing unlabelled steroids. 3H-dexamethasone accumulated in cell nuclei of both the pars distalis and the pars nervosa but not in t...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00236423
更新日期：1979-08-01 00:00:00
abstract：:The Sgcb-null mouse, with knocked-down β-sarcoglycan, develops severe muscular dystrophy as in type 2E human limb girdle muscular dystrophy. The mdx mouse, lacking dystrophin, is the most used model for Duchenne muscular dystrophy (DMD). Unlike DMD, the mdx mouse has mild clinical features and shows little fibrosis in...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-014-1854-4
更新日期：2014-05-01 00:00:00
abstract：:The distribution of gap junctions (nexuses) in various parts of the small and large intestines of the guinea-pig was studied using the freeze-fracture technique and in thin sections. The percentage area of smooth muscle cell surface occupied by gap junctions varies from 0.50% in the circular muscle of the duodenum to ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00209987
更新日期：1981-01-01 00:00:00
abstract：:Fixed cerebral vesicles of mouse foetuses were fractured and examined with the scanning electron microscope. This method provides a study of the three dimensional developmental features of the pseudostratified columnar epithelium up to the formation of the early cortex plate. Matrix cells are a cell population of homo...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219466
更新日期：1975-11-12 00:00:00
abstract：:We have developed a simple and reliable method of preserving antigen immunoreactivity with concomitant excellent retention of the cell ultrastructure. Using this method, we have been able to follow the origin and developmental stages of nuage accumulations within the nurse cell/oocyte syncytium in the ovary of the fru...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-011-1145-2
更新日期：2011-04-01 00:00:00
