Abstract:
:The comparatively simple Caenorhabditis elegans intestine fulfills many of the complex functions of the mammalian digestive tract, liver, and fat tissues, while also having roles in pathogen defense, immunity, and longevity. In this review, we describe the structure of the C. elegans gut and how it develops from the embryonic precursor E. We examine what is currently known about how the animal's microbial diet is moved through the intestinal lumen, and how its enzymatic functions contribute to physiology and metabolism. The underlying gene regulatory networks behind both development and physiology are also described. Finally, we consider recent studies that examine metabolism and digestion and describe emerging areas for future work.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Dimov I,Maduro MFdoi
10.1007/s00441-019-03036-4subject
Has Abstractpub_date
2019-09-01 00:00:00pages
383-396issue
3eissn
0302-766Xissn
1432-0878pii
10.1007/s00441-019-03036-4journal_volume
377pub_type
杂志文章,评审abstract::During normal development of many vertebrate species, substantial numbers of neurons in the central and peripheral nervous system undergo naturally occurring (or programmed) cell death. For example, approximately 50% of spinal motoneurons degenerate and die at a time when these cells are establishing synaptic connecti...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050690
更新日期:1996-11-01 00:00:00
abstract::Glycoproteins rich in mannosyl or glucosyl residues were analyzed in the subcommissural organ (SCO) and the pineal organ of the sheep (Ovis aries). By use of concanavalin A labelled with fluorescein isothiocyanate, fluorescent material was found both in ependymal and hypendymal cells of the SCO. In the pineal organ, e...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218562
更新日期:1986-01-01 00:00:00
abstract::Normal development, function and repair of the sensory epithelia in the inner ear are all dependent on gap junctional intercellular communication. Mutations in the connexin genes GJB2 and GJB6 (encoding CX26 and CX30) result in syndromic and non-syndromic deafness via various mechanisms. Clinical vestibular defects, h...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-014-2029-z
更新日期:2015-06-01 00:00:00
abstract::Although several studies have shown a dysregulation of microRNA (miRNA) expression profiles in cutaneous melanoma, there has been little research on the miRNA machinery itself. In this study, we investigated the mRNA expression profiles of different miRNA machinery components in primary cutaneous malignant melanoma (P...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-012-1446-0
更新日期:2012-10-01 00:00:00
abstract::This report demonstrates that the administration of testosterone (T) or 11-ketotestosterone (11-KT) to sexually immature (8 wks old) male platyfish (Xiphophorus maculatus) of early- and late-maturing genotypes affects the synthesis and/or release of luteinizing hormone-releasing hormone (LHRH), as assessed by immunocy...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218552
更新日期:1986-01-01 00:00:00
abstract::The present electron microscopic autoradiographic study includes a quantitative analysis of osteoclasts in vitro using tritiated leucin as a protein tracer. A significant increase in the grain density over the ruffled border and the underlying resportion zone was demonstrated two hours post pulse whereas the grain den...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219726
更新日期:1976-04-28 00:00:00
abstract::During the first postnatal weeks of the developing rodent retina, rhodopsin can be detected in a number of neuron-like cells in the inner retina. In the present study, we aim to characterize the morphology, number and staining characteristics of this peculiar population. Misplaced rhodopsin-positive cells (MRCs) were ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1788-2
更新日期:2014-04-01 00:00:00
abstract::The morphology and histology of the tibial auditory system of the New Zealand weta, Hemideina crassidens, are described. The groups of acoustic sensilla conform closely to the subgenual organ, intermediate organ and crista acoustica of the Tettigoniidae. Each prothoracic tibia bears two thick (40-100 micrometers) tymp...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233584
更新日期:1981-01-01 00:00:00
abstract::Correlations between the presence of surface coat and immobilization antigen of Paramecium tetraurelia were studied. Supravital, partial removal of the surface coat resulted in accelerated response of monobacterially and axenically grown cells to the homologous antiserum. Ciliates pretreated with trypsin or pronase (0...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219984
更新日期:1977-07-11 00:00:00
abstract::Iron loading of hepatocytes was followed through the stages (1-7) of metamorphosis in lamprey (Petromyzon marinus L.) using light- and electron-microscopic histochemistry. Iron is present in ferric and ferrous forms in the hepatocytes of larval lampreys in levels that can only be detected in the electron microscope. D...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217405
更新日期:1983-01-01 00:00:00
abstract::Wnts are secreted glycoproteins that play multiple roles in early development, including the differentiation of precursor cells. During this period, gradients of Wnts and other morphogens are formed and regulate the differentiation and migration of neural progenitor cells. Afterwards, Wnt signalling cascades participa...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-014-1996-4
更新日期:2015-01-01 00:00:00
abstract::Dexamethasone (Dex) regulates osteoblastic and adipocytic differentiation in mesenchymal progenitor cells through regulation of Wnt/β-catenin signaling. To elucidate the regulatory mechanisms underlying the effects of Dex, we examine the expression of Axin2, which is an intracellular inhibitor of Wnt/β-catenin signali...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1696-5
更新日期:2013-12-01 00:00:00
abstract::In Streetsia challengeri left and right eyes have fused and become a single cylindrical photoreceptor, which occupies the basal half of a forward directed head projection. This unusual compound eye consists of approximately 2500 ommatidia, which are arranged in such a way that the animal has almost circumferential vis...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00225542
更新日期:1978-01-17 00:00:00
abstract::Neurotrophins NGF, BDNF, NT-3, and NT-4/5 are members of the neurotrophin family of proteins, which support the survival and induce differentiation of vertebrate neurons. We have studied the effects of neurotrophins on growth cones of embryonic sensory neurons. BDNF and NT-4/5 cause growth cone collapse and transient ...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s004410050933
更新日期:1997-11-01 00:00:00
abstract::In this study, we focus on the specific contribution of β integrin-like protein to adhesion-mediated events in molluscan larval cells in culture that could not have been investigated within the whole animal. An analysis of disturbances to cell-substratum adhesion, caused by the integrin receptor inhibiting Arg-Gly-Asp...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-015-2122-y
更新日期:2015-08-01 00:00:00
abstract::Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cell (MSC) characterized by multi-lineage differentiation making it an attractive choice for tissue regeneration. However, before DPSCs can be used for cell-based therapy, we have to understand their biological properties in response to intrinsic and extrin...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-014-1799-7
更新日期:2014-05-01 00:00:00
abstract::We have examined the cortex of the teleost (Brachydanio rerio) egg before and during exocytosis of cortical granules by scanning, transmission, and freeze-fracture electron microscopy. In the unactivated egg, the P-face of the plasma membrane exhibits a random distribution of intramembranous particles, showing a densi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00398079
更新日期:1991-08-01 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) was found extensively in the small intestine of both non-mammalian and mammalian vertebrates using radioimmunoassay and immunocytochemistry. By radioimmunoassay, the levels of CGRP in rats, mice, chickens, bullfrogs and rainbow trout were found to range from 91.5 to 419.1 ng/g ti...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00223142
更新日期:1989-10-01 00:00:00
abstract::Caprine preantral follicles within ovarian fragments were cryopreserved in the absence or presence of 0.5 M sucrose with or without 1 M dimethyl sulfoxide and/or 1 M ethylene glycol (EG). After being thawed, they were washed in minimum essential medium with or without 0.3 M sucrose. Histological analysis of follicle i...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0193-5
更新日期:2006-09-01 00:00:00
abstract::The octavo-lateral efferent system of several anuran species was studied by means of retrograde transport of horseradish peroxidase. This system is organized similarly in all larval anurans and in all adult aglossids. All have two groups of efferent neurons in the nucleus reticularis medialis between the VIIIth and th...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214812
更新日期:1982-01-01 00:00:00
abstract::In amniotes, the developmental potentials of neural crest cells differ between the cranium and the trunk. These differences may be attributable to the different expression patterns of Hox genes between cranial and trunk neural crest cells. However, little is known about the factors that control Hox genes expression in...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0827-5
更新日期:2009-09-01 00:00:00
abstract::Previous studies have indicated the importance of basement membrane components both for cellular differentiation in general and for the barrier properties of cerebral microvascular endothelial cells in particular. Therefore, we have examined the expression of basement membrane proteins in primary capillary endothelial...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-002-0604-1
更新日期:2002-10-01 00:00:00
abstract::The dorsal integument of the girdle of the chiton Mopalia muscosa is covered by a chitinous cuticle about 0.1 mm in thickness. Within the cuticle are fusiform spicules composed of a central mass of pigment granules surrounded by a layer of calcium carbonate crystals. Tapered, curved chitinous hairs with a groove on th...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221498
更新日期:1982-01-01 00:00:00
abstract::The three-dimensional ultrastructure of the pineal body of the rat is described on the basis of freeze-fractured preparations. The pineal capsule consists of irregular cells with very flat and perforated processes. Through these openings, extremely branched canaliculi, extending to almost every pineal cell, communicat...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00238052
更新日期:1979-09-02 00:00:00
abstract::Electron-microscopic studies of lymphoid tissues from bovine fetuses and from calves disclosed a non-lymphoid cell type in the thymus-dependent zones of secondary lymphoid tissues and in the thymus that is distinguishable from reticulum cells, epithelial and endothelial cells, and macrophages. Based on morphological a...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00213735
更新日期:1984-01-01 00:00:00
abstract::Neurosecretory pathways were examined in normal male rats by the use of the immunoperoxidase technique for the localization of neurophysin in Bouin-fixed, deparaffinized sections. Using this technique two projections of extrahypothalamic neuorosecretory fibers can be traced to the sites of origin of the choid plexuses...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00232829
更新日期:1977-03-01 00:00:00
abstract::Structures identified as subsurface cisterns (SSC's) were found in neurons of the paraventricular nuclei of the rat hypothalamus. They appeared as cytoplasmic organelles consisting most often of stacks of parallel cisterns apposed to the neuronal plasmalemma. These SSC's were located in the interneurons of the parvoce...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00236138
更新日期:1979-06-27 00:00:00
abstract::The adenohypophysial primordium of Xenopus laevis tadpoles at stages 33/34 to 46 (Nieuwkoop and Faber, 1956) were examined immunohistologically for alpha-MSH, beta-MSH and ACTH. beta-MSH was demonstrated from stage 37/38 onwards, and alpha-MSH from stage 39. No signs of ACTH production were detected. alpha-MSH and bet...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00231955
更新日期:1977-05-16 00:00:00
abstract::Ultrastructural studies of pancreatic islets have suggested that crinophagy provides a possible mechanism for intracellular degradation of insulin in the insulin-producing B-cells. In the present study, a quantitative estimation of crinophagy in mouse pancreatic islets was attempted by morphometric analysis of lysosom...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00213820
更新日期:1988-04-01 00:00:00
abstract::Previous immunochemical investigations have demonstrated various opioid peptides in the pancreas. However, controversies exist related to the cellular localization of these peptides in the endocrine pancreas. Therefore, the guinea pig endocrine pancreas was immunohistochemically investigated for the presence of opioid...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00318454
更新日期:1990-02-01 00:00:00