Plasticity and regulatory mechanisms of Hox gene expression in mouse neural crest cells.

Abstract:

:In amniotes, the developmental potentials of neural crest cells differ between the cranium and the trunk. These differences may be attributable to the different expression patterns of Hox genes between cranial and trunk neural crest cells. However, little is known about the factors that control Hox genes expression in neural crest cells. The present data demonstrate that retinoic acid (RA) treatment and the activation of Wnt signaling induce Hoxa2 and Hoxd9 expression, respectively, in mouse mesencephalic neural crest cells, which never express Hox genes in vivo. Furthermore, Wnt signaling suppresses the induction of Hoxa2. We also demonstrate that these factors participate in the maintenance of Hoxa2 and Hoxd9 expression in mouse trunk neural crest cells. Our results suggest that RA and Wnt signaling function as environmental factors that regulate the expression of Hoxa2 and Hoxd9 in mouse neural crest cells.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Ishikawa S,Ito K

doi

10.1007/s00441-009-0827-5

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

381-91

issue

3

eissn

0302-766X

issn

1432-0878

journal_volume

337

pub_type

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