Novel mechanisms of tube-size regulation revealed by the Drosophila trachea.

Abstract:

:The size of various tubes within tubular organs such as the lung, vascular system and kidney must be finely tuned for the optimal delivery of gases, nutrients, waste and cells within the entire organism. Aberrant tube sizes lead to devastating human illnesses, such as polycystic kidney disease, fibrocystic breast disease, pancreatic cystic neoplasm and thyroid nodules. However, the underlying mechanisms that are responsible for tube-size regulation have yet to be fully understood. Therefore, no effective treatments are available for disorders caused by tube-size defects. Recently, the Drosophila tracheal system has emerged as an excellent in vivo model to explore the fundamental mechanisms of tube-size regulation. Here, we discuss the role of the apical luminal matrix, cell polarity and signaling pathways in regulating tube size in Drosophila trachea. Previous studies of the Drosophila tracheal system have provided general insights into epithelial tube morphogenesis. Mechanisms that regulate tube size in Drosophila trachea could be well conserved in mammalian tubular organs. This knowledge should greatly aid our understanding of tubular organogenesis in vertebrates and potentially lead to new avenues for the treatment of human disease caused by tube-size defects.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Zuo L,Iordanou E,Chandran RR,Jiang L

doi

10.1007/s00441-013-1673-z

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

343-54

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

354

pub_type

杂志文章,评审
  • Localization of monoamines in the forebrain of two salmonid species, with special reference to the hypothalamo-hypophysial system.

    abstract::In the salmon and trout aminergic cell bodies were found in the nucleus recessus lateralis (NRL) and the nucleus recessus posterioris (NRP), both of which are situated near the third ventricle. Three cell types could be distinguished. Type 1 produces a green and type 2 a yellow fluorescence. The former type probably c...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00219556

    authors: Terlou M,Ekengren B,Hiemstra K

    更新日期:1978-07-10 00:00:00

  • Cytochemical variations in the nucleolus during spermiogenesis in man and monkey.

    abstract::The fine structure, nature and fate of the components of the nucleolus were studied in young (steps 1, 2), intermediate (steps 3, 4, 5) and mature spermatids (steps 6, 7, 8) of man and monkey, by use of several cytochemical techniques (alcoholic PTA; sodium tungstate: EDTA; HAPTA; nuclease-gold complexes; NOR silver s...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00305735

    authors: Dadoune JP,Alfonsi MF,Fain-Maurel MA

    更新日期:1991-04-01 00:00:00

  • Somatotrophs and lactotrophs in the anterior pituitary of fetal and neonatal rats. Electron-microscopic immunocytochemical identification.

    abstract::The ultrastructure of immunoreactive somatotrophs and lactotrophs in pituitaries of fetal rats at 19, 20 and 21 days of gestation and on the day of birth was studied. Somatotrophs, first detectable at 19 days of gestation, undergo only minor modifications before reaching the structure described for adults. In particul...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00213955

    authors: Hemming FJ,Dubois MP,Dubois PM

    更新日期:1986-01-01 00:00:00

  • Insect UV-, and green-photoreceptor membranes studied by the freeze-fracture technique.

    abstract::The membranes of the microvilli of UV- and green-photoreceptors of the ant Myrmecia gulosa have been studied with the freeze-fracture technique. Both inner fracture faces, the cytoplasmic P-face and the extracellular E-face, are covered by globular particles. The P-face particles appear to be randomly distributed, occ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00218715

    authors: Nickel E,Menzel R

    更新日期:1976-12-10 00:00:00

  • Ultastructural localization of polysaccharides in the vacuolar system of an established cell line.

    abstract::Polysaccharides in the vacuolar system of an established line of monkey kidney epithelial cells, were investigated by high resolution radioautography following incorporation of 3H-fucose and by the periodic acid-thiosemicarbazide-silver proteinate staining method. Significant amounts of glycogen and glycoproteins were...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00225345

    authors: Knecht E,Hernández J

    更新日期:1978-10-30 00:00:00

  • Apoptosis in cardiac development.

    abstract::Cell degeneration, as a phenomenon accompanying developmental processes, was originally described over a century ago. Apoptosis, a term introduced approximately three decades ago, has occupied investigators particularly with respect to cell and tissue kinetics, emphasizing its role in the disposal of supernumerary, ma...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审

    doi:10.1007/s004410000227

    authors: Poelmann RE,Molin D,Wisse LJ,Gittenberger-de Groot AC

    更新日期:2000-07-01 00:00:00

  • Union is strength: matrix elasticity and microenvironmental factors codetermine stem cell differentiation fate.

    abstract::Stem cells are an attractive cellular source for regenerative medicine and tissue engineering applications due to their multipotency. Although the elasticity of the extracellular matrix (ECM) has been shown to have crucial impacts in directing stem cell differentiation, it is not the only contributing factor. Many res...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审

    doi:10.1007/s00441-015-2190-z

    authors: Lv H,Li L,Zhang Y,Chen Z,Sun M,Xu T,Tian L,Lu M,Ren M,Liu Y,Li Y

    更新日期:2015-09-01 00:00:00

  • Morphological changes in the zonula adhaerens during embryonic development of chick retinal pigment epithelial cells.

    abstract::Retinal pigment epithelial cells from chicks at various stages of development were examined by transmission electron microscopy to determine how the adult form of the zonula adhaerens, composed of subunits termed zonula adhaerens complexes, is acquired. During early stages of development, between embryonic day 4 and e...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF01740771

    authors: Sandig M,Kalnins VI

    更新日期:1990-03-01 00:00:00

  • Specialized contacts between sarcolemma and sarcoplasmic reticulum at the ends of muscle fibers in the diaphragm of the rat.

    abstract::An electron-microscopic study of the myotendinous portion of the diaphragm in the Wistar rat has shown that at the ends of muscle fibers, longitudinally oriented invaginations and peripheral furrows of the sarcolemma establish specialized contacts with individual sacs of the sarcoplasmic reticulum. The construction of...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00251058

    authors: Andreev DP,Wassilev WA

    更新日期:1986-01-01 00:00:00

  • Cotton rat (Sigmodon hispidus) develops metabolic disorders associated with visceral adipose inflammation and fatty pancreas without obesity.

    abstract::Obesity induces metabolic disorders such as type 2 diabetes, hypertension, and cardiovascular diseases and has become a global health concern. Recent studies imply that fat accumulation in nonadipose tissue correlates with metabolic disorders. However, there are no suitable animal models to evaluate this phenomenon. T...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-018-2908-9

    authors: Nakamura T,Ichii O,Irie T,Kouguchi H,Sotozaki K,Chihara M,Sunden Y,Nagasaki KI,Tatsumi O,Elewa YHA,Kon Y

    更新日期:2019-02-01 00:00:00

  • Isolation of taste buds from the foliate papillae of the rabbit.

    abstract::A method to isolate taste buds from the foliate papillae of the rabbit tongue is described. The method comprises (a) separation of the epidermis from the dermal layer after treatment with dilute acetic acid, and (b) mechanical removal of the taste buds from the epithelium with the use of a surgical needle. The procedu...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00229216

    authors: Albrecht J,Brouwer JN,Wiersma A

    更新日期:1984-01-01 00:00:00

  • Visualization of the retino-hypothalamic projection in the rat by cobalt precipitation.

    abstract::The technique of cobalt sulfide precipitation combined with Timm's sulfide-silver method for intensification of heavy metals was used to delineate the retino-hypothalamic projection of the rat. Freshly isolated rat brains were dissected and a solution of cobaltous chloride was applied to one of the cut optic nerves. S...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00219728

    authors: Mason CA,Lincoln DW

    更新日期:1976-04-28 00:00:00

  • Quantitative microscopy of mole rat eosinophil granule morphology.

    abstract::Mole rat bone marrow cells and peritoneal eosinophils are used to study granule morphological maturation by quantitative microscopy. The bulk eosinophil granule content is pre-stored in unique granular structures known as crystalloid or secondary granules. Mole rat eosinophil granules exhibit the basic structure of an...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-015-2189-5

    authors: Amihai D,Meilijson I,Terkel J,Hammel I

    更新日期:2015-10-01 00:00:00

  • Sex differences in pituitary LH storage and release in LHRH-stimulated pubertal rats. A correlative immunohistochemical and radioimmunoassay study.

    abstract::This study investigates the relationship between pituitary LHRH responsiveness and the depletion of LH in pubertal rats. The anterior pituitaries of 7-week-old rats of both sexes were stimulated for a maximum of 24 h with either a continuous, or pulsatile exposure to LHRH in vitro. Immunohistochemical examination reve...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00218057

    authors: Watanabe YG

    更新日期:1986-01-01 00:00:00

  • Cell differentiation during early development of Nassarius reticulatus L. (Gastropoda, Prosobranchia). II. Morphological changes of nuclei and nucleoi.

    abstract::In Nassarius reticulatus the nuclei and nucleoli undergo important morphological changes from the zygote to the 16-cell stage. In the zygote and in the trefoil (2-cell) and 4-cell stage, several agranular, fibrillar nucleolus-like bodies 1 mum diameter are present in the interphase nucleus. Granular nucleoli first app...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00215313

    authors: Schmekel L,Fioroni P

    更新日期:1976-05-13 00:00:00

  • Culture of human pituitary prolactin and growth hormone cells.

    abstract::Fragments of pituitary tissue obtained from a total of 37 patients with either breast cancer, diabetic retinopathy, galactorrhea, or acromegaly were dissociated into single cell suspensions prior to cell culture. Release of human growth hormone (hGH) and human prolactin (hPRL) into the culture medium was measured by r...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00219803

    authors: Snyder J,Hymer WC,Wilfinger WW

    更新日期:1978-08-16 00:00:00

  • Subsurface cisterns and lamellar bodies in the granule cells of the guinea-pig fascia dentata.

    abstract::Subsurface cisterns (SSC's) and less frequent lamellar bodies (LB's) were identified in the granule cells of the guinea-pig fascia dentata. Both structures, composed of flattened or collapsed agranular cisterns, are continuous with the regular rough endoplasmic reticulum and occasionally connected with each other form...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF01258502

    authors: Kolde G,Themann H

    更新日期:1982-01-01 00:00:00

  • Mosquito trypsin: immunocytochemical localization in the midgut of blood-fed Aedes aegypti (L.).

    abstract::A polyclonal antibody was raised against trypsin purified from the midgut of blood-fed Aedes aegypti. Using this antibody and our modification of the peroxidase-antiperoxidase immunocytochemical reaction, strong activity was found in the lumen of the midgut at the light-microscopical level. The activity was localized ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00218082

    authors: Graf R,Raikhel AS,Brown MR,Lea AO,Briegel H

    更新日期:1986-01-01 00:00:00

  • The ecdysis of hair mechanoreceptors in crayfish.

    abstract::The fine structure of hair mechanoreceptors in crayfish during moulting was investigated with special attention to the interface apparatus between cuticular hairs and sensory cells: the chorda. The chordae are lost with old exuviae at every moulting. They are drawn out from a moulting canal at the tip of the new hair....

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00214236

    authors: Kouyama N,Shimozawa T

    更新日期:1984-01-01 00:00:00

  • Extracellular glycosaminoglycans (GAG) released by chick embryonic fibroblasts. A possible involvement of surface receptors.

    abstract::Administration of Concanavalin A (Con A) to cultured skin fibroblasts derived from chick embryos at two developmental stages produce variations in the relative concentration of individual glycosaminoglycan (GAG) secreted by the cells. This effect is different: at 7 days (increase of hyaluronic acid and dermatan sulpha...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00217295

    authors: Evangelisti R,Bodo M,Caruso A,Becchetti E,Carinci P

    更新日期:1984-01-01 00:00:00

  • Immunocytological and FISH analysis of pole cell formation and soma elimination of germ line-limited chromosomes in the chironomid Acricotopus lucidus.

    abstract::In the chironomid Acricotopus lucidus, germ line-soma differentiation becomes evident with the formation of the pole cells and the elimination of the germ line-limited chromosomes (Ks) from the future somatic nuclei of the embryo. Unlike in Drosophila, the early nuclear divisions do not proceed synchronously in A. luc...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410000270

    authors: Staiber W

    更新日期:2000-11-01 00:00:00

  • Melanophore death and disappearance produces color metamorphosis in the polychromatic Midas cichlid (Cichlasoma citrinellum).

    abstract::We describe the histological basis of color metamorphosis in the polychromatic Midas cichlid, Cichlasoma citrinellum. Eight percent of the individuals in a natural population transform from gray with black markings to orange, simultaneously losing their ability to adjust coloration in response to background and social...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00221733

    authors: Dickman MC,Schliwa M,Barlow GW

    更新日期:1988-07-01 00:00:00

  • Occurrence of neurotrophin receptors and transmitters in the developing Xenopus gut.

    abstract::The ontogeny of gut innervation in the anuran amphibian Xenopus laevis was studied using immunohistochemistry on sections of whole larvae from NF stages 38-52. Immunoreactivity to acetylated tubulin confirmed the presence of nerve fibres as early as stages 38-39. Actin immunoreactivity was found at stage 41, indicatin...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410100423

    authors: Holmberg A,Hägg U,Fritsche R,Holmgren S

    更新日期:2001-10-01 00:00:00

  • Fine structure of rabbit ear chondrocytes in vitro and after autotransplantation.

    abstract::Chondrocytes were isolated enzymatically from rabbit ear cartilage, grown in vitro or as autotransplants for 1, 2 or 5 weeks and then examined by transmission electron microscopy. A confluent monolayer formed rapidly in vitro and the cells later grew in multiple overlapping layers, producing thick sheets of cartilagin...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00227600

    authors: Thyberg J,Hinek A

    更新日期:1977-05-31 00:00:00

  • The ultrastructure of the mid-gut cells of Nasonia vitripennis (Walker) (Hymenoptera, Pteromalidae).

    abstract::The ultrastructure of the mid-gut cells of female Nasonia vitripennis is described. The mid-gut consists of a uniform, single-cell epithelium. The cells of different gut regions were analysed using morphometric techniques in order to determine any differences in the components. The structure of the cells is described ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00221084

    authors: Davies I,King PE

    更新日期:1977-02-09 00:00:00

  • Use of microarrays to find novel regulators of periodontal ligament fibroblast differentiation.

    abstract::Periodontal regeneration requires the coordinated movement and differentiation of several cell types in order to re-establish the cementum, periodontal ligament (PDL), and alveolar bone. Cells in culture are often used as model systems for mature tissues, although they may represent expanded progenitor cell population...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-006-0282-5

    authors: Lallier TE,Spencer A

    更新日期:2007-01-01 00:00:00

  • The fine structure of identified electrotonic synapses following increased coupling resistance.

    abstract::Gap junctions exist in the septa between the segments of the lateral giant axons in the ventral nerve cord of the crayfish Procambarus. A large increase in the resistance (uncoupling) of these gap junctions was brought about by mechanical injury to the axonal segments. Both thin sections and freeze-fracture preparatio...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00217847

    authors: Hanna RB,Pappas GD,Bennett MV

    更新日期:1984-01-01 00:00:00

  • The histological architecture of the auditory organs in the parasitoid fly Ormia ochracea.

    abstract::Gravid females of the parasitoid fly species Ormia ochracea (Diptera: Tachinidae) rely on their sense of hearing to detect and localize their hosts, field crickets of the genus Gryllus. As in any hearing insect species, the fly's auditory system consists of a rather complex cascade of mechanical and physiological mech...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410000257

    authors: Robert D,Willi U

    更新日期:2000-09-01 00:00:00

  • Three-dimensional architecture of the tubular endocytic apparatus and paramembranous networks of the endoplasmic reticulum in the rat visceral yolk-sac endoderm.

    abstract::The three-dimensional architecture of the tubular endocytic apparatus and the endoplasmic reticulum in the rat yolk-sac endoderm was investigated after loading with horseradish peroxidase-conjugated concanavalin A by intrauterine administration. After 30 min, small vesicles (50-150 nm in diameter), small tubules (80-1...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00414178

    authors: Ichimura T,Hatae T,Sakurai T,Ishida T

    更新日期:1994-11-01 00:00:00

  • Midbrain-derived neural stem cells: from basic science to therapeutic approaches.

    abstract::Neural stem cells (NSCs) are a subtype of tissue-specific progenitor cells capable of extended self-renewal and the ability to generate all major cell types of nervous tissue, such as neurons, astroglia and oligodendroglial cells. Recent studies suggest that salient patterning in anterior-posterior and dorsal-ventral ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审

    doi:10.1007/s00441-004-0923-5

    authors: Storch A,Sabolek M,Milosevic J,Schwarz SC,Schwarz J

    更新日期:2004-10-01 00:00:00