Cotton rat (Sigmodon hispidus) develops metabolic disorders associated with visceral adipose inflammation and fatty pancreas without obesity.

Abstract:

:Obesity induces metabolic disorders such as type 2 diabetes, hypertension, and cardiovascular diseases and has become a global health concern. Recent studies imply that fat accumulation in nonadipose tissue correlates with metabolic disorders. However, there are no suitable animal models to evaluate this phenomenon. This study investigated the characteristics of metabolic disorders found in cotton rat (Sigmodon hispidus). Blood biochemical examinations revealed that cotton rats, predominantly males, developed hyperinsulinemia, hyperglycemia, and dyslipidemia when fed a normal diet. The islets increased in size through β-cell hyperplasia, which was associated with serum insulin level in both sexes, strongly indicating insulin resistance. In male cotton rats, oxidative stress was observed in β cells, and macrophage infiltration into the visceral white adipose tissue was reported, both of which were associated with serum insulin level without visceral obesity. In contrast, female cotton rats developed hyperinsulinemia without histopathological changes that were reported in males. Adipocytes were found to be accumulated in the pancreas but not in the liver of both sexes during aging. Pancreatic fat accumulation was associated with the serum insulin level only in females. Taken together, cotton rats developed metabolic disorders associated with visceral fat inflammation in the absence of obesity. In addition, pancreatic ectopic fat may also be related to the early stages of these conditions. Thus, the cotton rat may serve as a novel and useful model for metabolic disorders characterized by visceral adipose inflammation and ectopic fat accumulation in the pancreas without obesity.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Nakamura T,Ichii O,Irie T,Kouguchi H,Sotozaki K,Chihara M,Sunden Y,Nagasaki KI,Tatsumi O,Elewa YHA,Kon Y

doi

10.1007/s00441-018-2908-9

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

483-492

issue

2

eissn

0302-766X

issn

1432-0878

pii

10.1007/s00441-018-2908-9

journal_volume

375

pub_type

杂志文章
  • Ontogeny of the GnRH systems in zebrafish brain: in situ hybridization and promoter-reporter expression analyses in intact animals.

    abstract::The ontogeny of two gonadotropin-releasing-hormone (GnRH) systems, salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), was investigated in zebrafish (Danio rerio). In situ hybridization (ISH) first detected sGnRH mRNA-expressing cells at 1 day post-fertilization (pf) anterior to the developing olfactory organs. Subseq...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-006-0279-0

    authors: Palevitch O,Kight K,Abraham E,Wray S,Zohar Y,Gothilf Y

    更新日期:2007-02-01 00:00:00

  • Neurosecretion in the sinus gland of the fiddler crab, Uca pugnax.

    abstract::The ultrastructure of the sinus gland of the fiddler crab, Uca pugnax, was investigated and found to be similar to that in other crustaceans. Five types of neurosecretory axon terminals were tentatively identified on the basis of the size, shape, and electron density of granules within the axons. Release of neuro-secr...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00222805

    authors: Silverthorn SU

    更新日期:1975-12-29 00:00:00

  • The effects of type 1 diabetes on the hypothalamic, pituitary and testes axis.

    abstract::Type 1 diabetes is an autoimmune disorder characterized by a lack of insulin production by the beta cells of the pancreas. This lack of insulin causes a variety of systemic effects on whole-body metabolism. Poorly managed type 1 diabetes can lead to cardiovascular disease, diabetic neuropathy, and diabetic retinopathy...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审

    doi:10.1007/s00441-012-1387-7

    authors: Schoeller EL,Schon S,Moley KH

    更新日期:2012-09-01 00:00:00

  • A histological and electron-microscopic study of the cell types involved in rejection of skin allografts in ammocoetes.

    abstract::The rejection of skin allografts by the larval lamprey, Lampetra reissneri, was studied by light- and electron-microscopy, with particular attention to the cell types involved in the reaction. In all allografts, melanophores were destroyed within 20-60 days (the mean survival time, 36 +/- 12 days). Neither the epiderm...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00222182

    authors: Fujii T,Hayakawa I

    更新日期:1983-01-01 00:00:00

  • Phenotypic modulation of parietal epithelial cells of Bowman's capsule in culture.

    abstract::The origin of cobblestone-like polygonal cells (the most numerous in renal glomerular cell culture) remains controversial; they could be either dedifferentiated podocytes or parietal epithelial cells (PECs) of Bowman's capsule. Poor cellular outgrowth from glomeruli devoid of Bowman's capsule (decapsulated glomeruli) ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410100380

    authors: Yaoita E,Kurihara H,Sakai T,Ohshiro K,Yamamoto T

    更新日期:2001-06-01 00:00:00

  • Quantum dots for quantitative imaging: from single molecules to tissue.

    abstract::Since their introduction to biological imaging, quantum dots (QDs) have progressed from a little known, but attractive, technology to one that has gained broad application in many areas of biology. The versatile properties of these fluorescent nanoparticles have allowed investigators to conduct biological studies with...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审

    doi:10.1007/s00441-014-2087-2

    authors: Vu TQ,Lam WY,Hatch EW,Lidke DS

    更新日期:2015-04-01 00:00:00

  • Beyond vessels: occurrence and regional clustering of vascular endothelial (VE-)cadherin-containing junctions in non-endothelial cells.

    abstract::The genes encoding transmembrane glycoproteins of the cadherin family, i.e., the Ca(2+)-dependent cell-cell adhesion molecules, are typically expressed in cell-type- or cell-lineage-specific patterns. One of them, vascular endothelial (VE)-cadherin, is widely considered to be specific for vascular endothelia in which ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审

    doi:10.1007/s00441-008-0718-1

    authors: Boda-Heggemann J,Régnier-Vigouroux A,Franke WW

    更新日期:2009-01-01 00:00:00

  • Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth.

    abstract::In humans, pathogenesis in cyclosporine A (CsA)-induced gingival overgrowth (GO) includes the accumulation of extracellular matrix (ECM) constituents, viz., collagen type-1 and type-3 and proteoglycans, in subgingival connective tissue. However, whether this increase is associated with alterations of molecules pivotal...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-006-0200-x

    authors: Dannewitz B,Edrich C,Tomakidi P,Kohl A,Gabbert O,Eickholz P,Steinberg T

    更新日期:2006-09-01 00:00:00

  • Fine structure of the pineal organ in the troglobytic fish, Typhlichthyes subterraneous (Pisces: Amblyopsidae).

    abstract::The pineal organ of the blind, cave-dwelling fish, Typhlichythyes subterraneous, was examined with both light and electron microscopes. Like the eyes, the pineal in this troglobytic species was found to be regressed. Two cell types, photoreceptor and supportive cells, were described in the pineal epithelium. Although ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00233895

    authors: McNulty JA

    更新日期:1978-12-29 00:00:00

  • ChAT and NOS in human myenteric neurons: co-existence and co-absence.

    abstract::Most myenteric neurons contain one of the two generating enzymes for major excitatory and inhibitory neurotransmitters: choline acetyltransferase (ChAT) or neuronal nitric oxide synthase (NOS). Two minor groups of myenteric neurons contain either both enzymes or neither. Our study had two aims: (1) to compare the prop...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-009-0852-4

    authors: Beck M,Schlabrakowski A,Schrödl F,Neuhuber W,Brehmer A

    更新日期:2009-10-01 00:00:00

  • The association between increasing levels of O-GlcNAc and galectins in the liver tissue of hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus).

    abstract::Post-translational glycosylation of proteins with O-linked β-N-acetylglucosamine (O-GlcNAcylation) and changes of galectin expression profiles are essential in many cellular stress responses. We examine this regulation in the liver tissue of hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus) repr...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-020-03185-x

    authors: Jariwala KA,Sherazi AA,Tazhitdinova R,Shum K,Guevorguian P,Karagiannis J,Staples JF,Timoshenko AV

    更新日期:2020-07-01 00:00:00

  • Migration of cranial neural crest cells to the pharyngeal arches and heart in rat embryos.

    abstract::The existence of a neural crest cell migration pathway from occipital levels of the hindbrain into the heart was suspected in mammalian embryos because it had previously been identified in avian embryos and because the Di George anomaly, an association between craniofacial and cardiac malformations, is most easily exp...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00338048

    authors: Fukiishi Y,Morriss-Kay GM

    更新日期:1992-04-01 00:00:00

  • Morphogenesis of tight junctions in the peritoneal mesothelium of the mouse embryo.

    abstract::The peritoneal mesothelium of mouse embryos (12 to 18 day of gestation) was studied by freeze-fracture and in sections in order to reveal the initial formation of the tight junctions. Freeze-fracture observations showed three types of tight junctions. Type I consists of belt-like meshworks of elevations on the P face ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00232008

    authors: Suzuki F,Nagano T

    更新日期:1979-05-18 00:00:00

  • Effects of colchicine on the ultrastructure of mouse taste buds.

    abstract::Effect of colchicine on the ultrastructure of taste bud cells was studied in the mouse. In untreated mice microtubules were abundant throughout the entire cytoplasm of type-III cells, but only in the apical cytoplasm of type-I cells. After 2 h of colchicine treatment, no microtubules were observed in any taste bud cel...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00214555

    authors: Takeda M,Suzuki Y,Shishido Y

    更新日期:1985-01-01 00:00:00

  • Co-existence and origin of peptidergic and adrenergic nerves in the guinea pig uterus. Retrograde tracing and immunocytochemistry, effects of chemical sympathectomy, capsaicin treatment and pregnancy.

    abstract::The occurrence and distribution of peptidergic nerves in the guinea pig uterus was studied by means of immunocytochemistry using numerous neuropeptide anti-sera. Neuropeptide Y (NPY)-immunoreactive (IR) nerves were the most abundant, whereas substance P (SP)-, calcitonin gene-related peptide (CGRP)-, and neurokinin A ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00226501

    authors: Alm P,Lundberg LM

    更新日期:1988-01-01 00:00:00

  • Detrusor smooth muscle cells of the guinea-pig are functionally coupled via gap junctions in situ and in cell culture.

    abstract::Intercellular communication between smooth muscle cells is crucial for contractile behaviour in normal and pathologically altered urinary bladder. Since the study of coupling is difficult in situ, we established cell cultures of bladder smooth muscle cells to analyse coupling mechanisms. Microinjection of Lucifer yell...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-002-0559-2

    authors: Neuhaus J,Wolburg H,Hermsdorf T,Stolzenburg JU,Dorschner W

    更新日期:2002-08-01 00:00:00

  • Development and retention of phenotypically specialized cells in pituitary allografts in the hamster (Mesocricetus auratus).

    abstract::We used immunohistochemistry to identify cells present in pituitary allografts in the hamster. Hypophyses removed from neonatal hamsters or adenohypophyses removed from adult females were placed beneath renal capsules of hypophysectomized adult females. Serum PRL, LH, and GH concentrations were measured at two, five a...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00215467

    authors: Campbell GT,Wagoner J,Colosi P,Soares MJ,Talamantes F

    更新日期:1988-01-01 00:00:00

  • Ultrastructure of the salivary bladder of the nine-banded armadillo.

    abstract::The nine-banded armadillo possesses a salivary bladder which is a dilated portion of the main duct of the submandibular gland at its origin. The wall of the bladder is composed of an epithelium, a submucosa and a thick coat of skeletal muscle. The ultrastructure of the epithelium reveals that it is complex and consist...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00219609

    authors: Ruby JR,Allen ER

    更新日期:1976-06-28 00:00:00

  • Quadruple colocalization of calretinin, calcitonin gene-related peptide, vasoactive intestinal peptide, and substance P in fibers within the villi of the rat intestine.

    abstract::Double-labeling immunofluorescent histochemistry demonstrates that calretinin, a calcium-binding protein, coexists with calcitonin gene-related peptide, vasoactive intestinal peptide, and substance P in the fibers innervating the lamina propria of the rat intestinal villi. An acetylcholinesterase histochemical stain r...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00318366

    authors: Isaacs KR,Winsky L,Strauss KI,Jacobowitz DM

    更新日期:1995-06-01 00:00:00

  • Adaptation-dependent plasticity of rod bipolar cell axon terminal morphology in the rat retina.

    abstract::We chose synaptic terminals of rat rod bipolar cells as a model system to study activity-related changes in the overall morphology and the fine structure of synaptic sites. Using confocal laser scanning microscopy in conjunction with three-dimensional reconstruction and electron microscopy, we examined the effect of l...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410051174

    authors: Behrens UD,Kasten P,Wagner HJ

    更新日期:1998-11-01 00:00:00

  • A scanning electron microscopic study of the rat liver sinusoid: endothelial and Kupffer cells.

    abstract::The surface ultrastructure of Kupffer cells in the rat liver has been studied by scanning electron microscopy (SEM). The results demonstrate that Kupffer cells are both significantly different and clearly distinct from endothelial cells. Kupffer cells have neither pores (and/or "sieve plates") nor fenestrations, all o...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00223015

    authors: Motta P

    更新日期:1975-12-10 00:00:00

  • Differential Akt activation in the photoreceptors of normal and rd1 mice.

    abstract::Retinitis pigmentosa is a blinding disease in which unknown mechanisms cause the degeneration of retinal photoreceptors. The retinal degeneration (rd1) mouse is a relevant model for this condition, since it carries a mutation also found in some forms of retinitis pigmentosa. To understand the degenerative process in t...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-004-1046-8

    authors: Johnson LE,van Veen T,Ekström PA

    更新日期:2005-05-01 00:00:00

  • Aquaporin expression is downregulated in a murine model of colitis and in patients with ulcerative colitis, Crohn's disease and infectious colitis.

    abstract::Colitis is associated with alterations in electrolyte and water transport. These changes give rise to some of the symptoms experienced by patients with colitis. Alterations in fluid flux may also contribute to increased susceptibility to mucosal injury. Recently, endogenous water channel proteins (aquaporins; AQPs), h...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-004-0932-4

    authors: Hardin JA,Wallace LE,Wong JF,O'Loughlin EV,Urbanski SJ,Gall DG,MacNaughton WK,Beck PL

    更新日期:2004-11-01 00:00:00

  • Effect of synthetic peptides derived from SCO-spondin conserved domains on chick cortical and spinal-cord neurons in cell cultures.

    abstract::SCO-spondin is a newly identified protein, strongly expressed in the subcommissural organ (SCO), an ependymal differentiation of the brain. When secreted into the cerebrospinal fluid at the entrance to the Sylvian aqueduct, it condenses and forms Reissner's fiber. Several conserved domains have previously been charact...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410051132

    authors: Monnerie H,Dastugue B,Meiniel A

    更新日期:1998-09-01 00:00:00

  • Complex relationships between the pineal organ and the medial habenular nucleus-pretectal region of the mouse as revealed by S-antigen immunocytochemistry.

    abstract::S-antigen-immunoreactive pinealocytes located in the deep portion of the pineal organ of inbred and wild pigmented mice give rise to long, beaded processes penetrating into the habenular and pretectal regions. In addition, the medial habenular nuclei and the pretectal area contain S-antigen-immunoreactive perikarya, w...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00313528

    authors: Korf HW,Sato T,Oksche A

    更新日期:1990-09-01 00:00:00

  • Synaptic organization of the indoleamine-accumulating neurons in the cyprinid retina.

    abstract::The distribution and synaptic connections of the indoleamine-accumulating neurons in the retinae of the goldfish and carp were studied by means of fluorescence and electron microscopy. The indoleamine-accumulating neurons were visualized after intravitreal injection and uptake of the indoleamine 5,6-dihydroxytryptamin...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:

    authors: Holmgren-Taylor I

    更新日期:1983-01-01 00:00:00

  • Seasonal changes in the fine structure of the accessory sex gland in the mole (Talpa europaea).

    abstract::The mole has a single pair of accessory sex organs with features of both the prostate and the seminal vesicle, for which the term prostate gland is not appropriate. Seasonal changes occuring in this gland were related to four periods: a) the quiescence period, b) the maturation period, c) the active period and d) the ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00218718

    authors: Aumüller G,Greenberg J

    更新日期:1976-12-10 00:00:00

  • A steroid hormone affects sodium channel expression in Manduca central neurons.

    abstract::Neuronal differentiation is characterized by stereotypical sequences of membrane channel and receptor acquisition. This is regulated by the coordinated interactions of a variety of developmental mechanisms, one of which is the control by steroid hormones. We have used the metamorphosis of the holometabolous insect, Ma...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-006-0175-7

    authors: Börner J,Puschmann T,Duch C

    更新日期:2006-07-01 00:00:00

  • In vitro differentiation of hypothalamic magnocellular neurons of guinea pigs.

    abstract::The development of neurophysin-oxytocin and neurophysin-vasopressin containing neurons of the guinea pig was studied in vitro. Supraoptic (SO) and paraventricular (PV) nuclei were explanted from guinea pig foetuses at the 40th day of gestation and cultured in Maximov slides for nearly fifty days. The cultures were obs...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00233269

    authors: Marson AM,Privat A

    更新日期:1979-01-01 00:00:00

  • Immunohistochemical demonstration of renin in the juxtaglomerular apparatus of three Bufo species.

    abstract::The cellular localization of renin was examined in the kidneys of some amphibians of the genus Bufo by immunoperoxidase and immunofluorescence techniques with an antiserum to renin isolated from the submandibular gland of the mouse. Immunoreactivity could be demonstrated in the media cells of the afferent arterioles (...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00219248

    authors: Lamers AP,Verhofstad AA,Stadhouders AM,Michelakis AM

    更新日期:1985-01-01 00:00:00