Abstract：
:The peritoneal mesothelium of mouse embryos (12 to 18 day of gestation) was studied by freeze-fracture and in sections in order to reveal the initial formation of the tight junctions. Freeze-fracture observations showed three types of tight junctions. Type I consists of belt-like meshworks of elevations on the P face and of shallow grooves on the E face. No tight junctional particle can be seen either on the elevations or in the grooves. Type II shows rows of discontinuous particles on the elevations on the P face. Type III consists of strands forming ridges on the P face. On the E face, the grooves of Type II and III appear to be narrower and sharper than those of Type I. Quantitatively, Type I junctions are most numerous during the early stages (day 12-13) of embryonic development, while Type III junctions become more common in the later stages, and are the only type seen by day 18. Observations on sections, however, fail to distinguish between the three types. The results suggest that an initial sign of tight junction formation is close apposition of the two cell membranes in the junctional domain, without tight junctional particles. Later, the particles appear to be incorporated in the tight junctions and the strands form by fusion of the particles.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Suzuki F,Nagano Tdoi
10.1007/BF00232008subject
Has Abstractpub_date
1979-05-18 00:00:00pages
247-60issue
2eissn
0302-766Xissn
1432-0878journal_volume
198pub_type
杂志文章abstract：:Connective tissue microfibrils were observed in tissues prepared with methods believed to minimize the loss of tissue components. The eyes of C57BL/6J mice were fixed with glutaraldehyde followed by either freeze substitution, or embedding in glycol methacrylate, a water-miscible embedding medium, after limited or no ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318486
更新日期：1995-02-01 00:00:00
abstract：:We investigated the binding characteristics of two monoclonal antibodies, 4F3 and 3F8, which in the retina specifically stain Müller cells, both with protein blots and immunohistochemically in sections of various regions of the central nervous system of neonatal and adult cats and rats. Clear differences emerged betwe...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050887
更新日期：1997-09-01 00:00:00
abstract：:Putative neural stem cells have been identified within the enteric nervous system (ENS) of adult rodents and cultured from human myenteric plexus. We conducted studies to identify neural stem cells or progenitor cells within the submucosa of adult human ENS. Jejunum tissue was removed from adult human subjects undergo...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-011-1130-9
更新日期：2011-05-01 00:00:00
abstract：:By use of the indirect immunofluorescence technique a small group of large somatostatin-positive neurons is described in the subependymal area of the anterior paraventricular thalamus of the male rat. Retrograde-tracing experiments suggest that they project to areas outside the blood-brain barrier. ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215212
更新日期：1986-01-01 00:00:00
abstract：:Nerves containing the calcium-binding protein calretinin have been reported in several organs but not in female reproductive organs and associated ganglia. This study was undertaken to determine if nerves associated with the uterus contain calretinin and the source(s) of calretinin-synthesizing nerves in the rat (are ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004419900071
更新日期：1999-10-01 00:00:00
abstract：:Electron microscopy of the rat lymph node disclosed reticular cells in close association with bundles of collagenous fibrils 30-45 nm in diameter, and electron lucent "amorphous" substances surrounded by microfibrils 11 nm in diameter, with junctional complexes. The amorphous substances, distinctly revealed by orcein ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210522
更新日期：1981-01-01 00:00:00
abstract：:The distribution pattern of adrenergic fibres innervating the ocular choroid membrane of the chicken was studied by means of fluorescence and electron microscopy. In addition, the origin of these fibres was investigated after superior cervical ganglionectomy. Adrenergic axons reach the choroid, partly forming the peri...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00213222
更新日期：1982-01-01 00:00:00
abstract：:The termination of intrafusal muscle fibres was studied in muscle spindles of the tenuissimus muscle of the Chinese hamster. Most nuclear chain fibres terminated within the spindle capsule. The nuclear bag- and nuclear chain fibres that extended beyond the limit of the spindle capsule terminated in the endomysial conn...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218663
更新日期：1983-01-01 00:00:00
abstract：:The brood pouch of the male pipefish (Syngnathus schlegeli) is a ventral organ located on the tail, with the anterior region closely associated with the genital pore. The embryos in the pouch are attached to highly vascularized placenta-like tissue which seals the pouch folds from inside during incubation. The epithel...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410051220
更新日期：1999-01-01 00:00:00
abstract：:DBA/2J (D2) mice develop a form of progressive pigmentary glaucoma with increasing age. We have compared retinal cell populations of D2 mice with those in control C57BL/6J mice to provide information on retinal histopathology in the D2 mouse. The D2 mouse retina is characterized by a reduction in retinal thickness cau...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-004-1062-8
更新日期：2005-04-01 00:00:00
abstract：:The notion that teeth contain stem cells is based on the well-known repairing ability of dentin after injury. Dental stem cells have been isolated according to their anatomical locations, colony-forming ability, expression of stem cell markers, and regeneration of pulp/dentin structures in vivo. These dental-derived s...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-007-0467-6
更新日期：2008-01-01 00:00:00
abstract：:The distribution and abundance of nitric oxide synthase (NOS)-containing neurons and their terminals in the gastrointestinal tract of the guinea-pig were examined in detail using NADPH diaphorase histochemistry and NOS immunohistochemistry. NOS-containing cell bodies were found in the myenteric plexus throughout the g...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00303090
更新日期：1994-07-01 00:00:00
abstract：:The meninges of albino Wistar rat embryos, aged between the 11th embryonic day (ED) and birth, were sectioned using a specially constructed device. This technique permits optimal microanatomical preservation of all tissues covering the convexity of the brain: skin, muscle, cartilage or bone, and the meninges. At ED11,...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221652
更新日期：1989-07-01 00:00:00
abstract：:The choroid plexus from the lateral ventricles of 18-day chick embryos was cultivated as an organ in medium 199 until the degeneration of the stroma. Selected plexuses forming an empty epithelial sac were then incubated with enzyme-treated human immunoglobulin (5S-antibody) and with native human immunoglobulin (7S-ant...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237886
更新日期：1980-01-01 00:00:00
abstract：:In marine cartilaginous fish, reabsorption of filtered urea by the kidney is essential for retaining a large amount of urea in their body. However, the mechanism for urea reabsorption is poorly understood due to the complexity of the kidney. To address this problem, we focused on elephant fish (Callorhinchus milii) fo...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-015-2234-4
更新日期：2015-12-01 00:00:00
abstract：:In amniotes, the developmental potentials of neural crest cells differ between the cranium and the trunk. These differences may be attributable to the different expression patterns of Hox genes between cranial and trunk neural crest cells. However, little is known about the factors that control Hox genes expression in...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-009-0827-5
更新日期：2009-09-01 00:00:00
abstract：:Considerable evidence indicates that the state of ocular connective tissues and their response in glaucomatous disease affect the degree of glaucoma damage. Both experimental and clinical data suggest that improved diagnostic and prognostic information can be derived from the assessment of the mechanical responsivenes...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-013-1603-0
更新日期：2013-08-01 00:00:00
abstract：:The spatial localisation of insulin-like growth-factor-binding protein-2 (IGFBP-2) and its mRNA was investigated during larval and post-larval developmental stages of the gilthead seabream ( Sparus aurata) by immunohistochemistry and in situ hybridisation with specific antisera and riboprobes. During larval developmen...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-004-0952-0
更新日期：2005-01-01 00:00:00
abstract：:The expression of the gene for vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM) in the human gastrointestinal tract was studied by in situ hybridization and Northern blotting for PHM/VIP mRNA and immunocytochemistry using specific antisera against the bioactive peptides PHM and VIP. In th...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00306108
更新日期：1994-05-01 00:00:00
abstract：:Over the past decade, adult stem cells have attracted great attention because of their ability to potentially regenerate desired tissues or entire organs. With the emergence of nanomaterial-based gene therapy, adult stem cells have been considered as a proper tool for the biomedical field. In this study, we utilized o...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-015-2235-3
更新日期：2015-12-01 00:00:00
abstract：:Antibodies raised against the cystic fibrosis transmembrane regulator protein (CFTR) were used to localize CFTR in intestinal tissues of piglets and mice. Positive staining for CFTR was detected in goblet cells of both species. A second population of epithelial cells of unknown phenotype was also labeled by anti-CFTR ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050531
更新日期：1996-02-01 00:00:00
abstract：:Proteins participating in vesicular docking and fusion have been identified in the nervous system. Such proteins appear to be important for the molecular regulation of exocytosis also in non-neuronal cells. The enterochromaffin-like (ECL) cells of the gastric acid-secreting (oxyntic) mucosa secrete histamine and chrom...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050960
更新日期：1997-12-01 00:00:00
abstract：:A technique has been developed to obtain viable, isolated and enriched populations of gastrin cells (G-cells) from the rat stomach. Restricted tissue samples from a small area of the pyloric antrum known to be particularly rich in G-cells, were sequentially digested with pronase followed by mechanical agitation, to re...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00236409
更新日期：1979-08-01 00:00:00
abstract：:The supraependymal cells (SEC) are a normal component of the wall of the cerebral ventricles. In the hypothalamic area of the third ventricle they are restricted, in healthy animals, to the ependymal projection of the hypophyseotropic area. Here the SEC show great polymorphism. In addition to bipolar, multipolar and s...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215308
更新日期：1976-05-13 00:00:00
abstract：:Neurons displaying FMRFamide(Phe - Met - Arg - Phe - NH2)-like immunoreactivity have recently been implicated in neural plasticity in salmon. We now extend these findings by describing the extent of the FMRF-like immunoreactive (FMRF-IR) system in the brain, retina and olfactory system of sockeye salmon parr using the...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00313518
更新日期：1990-09-01 00:00:00
abstract：:To investigate the uptake and transport patterns of variously sized particles in Peyer's patches (PPs) of calves, intestinal loops were created in four newborn and two 2-month-old calves, and the loops were inoculated with various particles, including carbon black, fluorescein isothiocyanate (FITC)-labeled latex, FITC...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-009-0793-y
更新日期：2009-07-01 00:00:00
abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is the latest member of the vasoactive intestinal polypeptide (VIP) family of neuropeptides present in nerve fibres in many peripheral organs. Using double immunohistochemistry, with VIP as a marker for intrinsic innervation and calcitonin-gene related peptide...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004419900124
更新日期：2000-01-01 00:00:00
abstract：:Growing numbers of translational genomics studies are based on the highly efficient and versatile zebrafish (Danio rerio) vertebrate model. The increasing types of zebrafish models have improved our understanding of inherited kidney diseases, since they not only display pathophysiological changes but also give us the ...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-017-2593-0
更新日期：2017-07-01 00:00:00
abstract：:The pituitary gland is first evident in rainbow trout two weeks before hatching. Differentiation of prolactin and ACTH cells is not marked until 3-4 days after hatching when the follicular arrangement of the prolactin cells become apparent. There is no difference in the time of development of either prolactin or ACTH ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00209283
更新日期：1978-05-29 00:00:00
abstract：:We have tested the suggestion that the reported increase, in hypoxic rats, in the number of lung endocrine cells immunoreactive for the regulatory peptide CGRP is caused by an accumulation of peptide within the cells which renders them more detectable, rather than by a real increase in proliferation. The incorporation...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00338049
更新日期：1992-04-01 00:00:00
