Abstract：
:We investigated the binding characteristics of two monoclonal antibodies, 4F3 and 3F8, which in the retina specifically stain Müller cells, both with protein blots and immunohistochemically in sections of various regions of the central nervous system of neonatal and adult cats and rats. Clear differences emerged between the two antibodies. In addition, some species-specific as well as developmental differences within the staining pattern of each individual antibody were evident. The epitopes recognized by 4F3 lay mainly in the 57-63 kDa range. Histologically, 4F3 labelled mainly glia cells: oligodendrocytes and astrocytes in optic nerve, astrocytes in neocortex and cerebellum, Bergmann glia in the cerebellum and radial glia in neonatal animals. This was confirmed by double-immunofluorescence with the astrocyte marker GFAP. By contrast, 3F8 epitopes lay mainly in the 47-49 kDa range. Histologically, 3F8 labelled oligodendrocytes in the optic nerve, but only neurons in cerebellum and neocortex as confirmed by double-labelling with neuronal markers. Neither 4F3 nor 3F8 recognized GFAP or vimentin. These results clearly indicate (1) that the two antibodies identify new epitopes/molecules, (2) that the antigens are not retina-specific, and (3) that Müller cells share epitopes with other glial cells as well as with neurons outside the retina.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Distler C,Bronzel M,Paas I,Wahle Pdoi
10.1007/s004410050887subject
Has Abstractpub_date
1997-09-01 00:00:00pages
411-26issue
3eissn
0302-766Xissn
1432-0878journal_volume
289pub_type
杂志文章abstract：:This work describes the origin and development of about 200 tension receptor cells located around the anterior attachment site of the locust ovipositor muscle and their migration to their final position on the muscle fibres. The locust ovipositor muscle is the only insect system in which more than 100 tension receptor...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0498-z
更新日期：2007-12-01 00:00:00
abstract：:The thoracic legs of the moth Manduca sexta acquire a new form and develop a new complement of sensory organs and muscles during metamorphosis from larva to adult. Because of our interest in the reorganization of neural circuitry and the acquisition of new behaviors during metamorphosis, we are characterizing sensory ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318442
更新日期：1990-02-01 00:00:00
abstract：:Apoptosis is a form of programmed cell death that occurs in neurons during development of the nervous system and may also be a prominent form of neuronal death in chronic neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Recent findings also implicate apoptosis in neuronal degeneration after is...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s004419900154
更新日期：2000-07-01 00:00:00
abstract：:The expression patterns of three microtubule-associated proteins (MAP1A, MAP1B, and MAP2A&B) were investigated in the developing optic tectum. Expression of MAP1B and middle-molecular-weight peptide of neurofilament (NF-M) was first observed in the same mesencephalic cells on day 3 of incubation, indicating that neuro...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-003-0796-z
更新日期：2003-12-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00307817
更新日期：1995-05-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-010-1052-y
更新日期：2010-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00343944
更新日期：1994-06-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1498-1
更新日期：2012-12-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219793
更新日期：1977-04-07 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-008-0675-8
更新日期：2009-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00302960
更新日期：1992-02-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00234830
更新日期：1979-04-30 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00236423
更新日期：1979-08-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-015-2315-4
更新日期：2016-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318822
更新日期：1994-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s004410050652
更新日期：1996-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215891
更新日期：1986-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410000240
更新日期：2000-08-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00222429
更新日期：1978-07-27 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217226
更新日期：1984-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00231405
更新日期：1977-01-24 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1630-x
更新日期：2013-07-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218972
更新日期：1975-12-02 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0543-y
更新日期：2008-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF02913723
更新日期：1993-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0405-7
更新日期：2007-07-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210469
更新日期：1981-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-010-0934-3
更新日期：2010-04-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s004410051281
更新日期：1999-04-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216347
更新日期：1985-01-01 00:00:00
