Abstract:
:Numerous macrophages were found aggregated in the lamina propria at the tips of villi in the small intestine of guinea pigs. These macrophages extended their pseudopodia into the epithelial lining and internalized fragments of effete enterocytes in their phagosomes. The epithelium of the villus tips was found to be infiltrated with numerous lymphocytes. They possessed electron-dense granules characteristic of natural killer cells, and actively interdigitated with the enterocytes. The latter were either fragmented or extensively lost in their basal cytoplasm, often leaving an attenuated apical cytoplasm of the cell. Immunohistochemical labeling using bromodeoxyuridine demonstrated that at 96 h after its administration, immunolabeled nuclei were encountered in the cytoplasm of macrophages in the lamina propria at the villus tips. These findings suggest that in the guinea pig, effete enterocytes are not simply exfoliated into the lumen, but are damaged by intraepithelial lymphocytes possessing a natural killer cytotoxicity, and subsequently phagocytosed by subepithelial macrophages.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Han H,Iwanaga T,Uchiyama Y,Fujita Tdoi
10.1007/BF02913723subject
Has Abstractpub_date
1993-03-01 00:00:00pages
407-16issue
3eissn
0302-766Xissn
1432-0878journal_volume
271pub_type
杂志文章abstract::Membrane-coating granules of the epithelium of the hamster cheek pouch displayed a lamellated internal structure consisting of alternating thick and thin electron dense bands separated by translucent bands of equal width. The repeat distance of the contents was 8.5 nm +/- sd. 0.7 nm and the thickness of the major elec...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00224374
更新日期:1978-02-24 00:00:00
abstract::The ultrastructural organization of the axons of retinula cells of the eye of the wax moth Galleria mellonella are described. The axons traverse an appreciable distance between the basement membrane of the retina and the lamina ganglionaris of the optic lobe of the brain. The optic tract was reconstructed from serial ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00232837
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00331380
更新日期:1994-12-01 00:00:00
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
pub_type: 杂志文章
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journal_title:Cell and tissue research
pub_type: 杂志文章
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abstract::Overexpression of type XIII collagen molecules with an 83-amino-acid residue in-frame deletion of part of the ectodomain leads to fetal lethality in Col13a1COL2del transgenic mice. We characterize here the functional disturbances in the cardiovascular system of mouse fetuses overexpressing mutant type XIII collagen. D...
journal_title:Cell and tissue research
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-016-2396-8
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0440-4
更新日期:2007-09-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:1994-11-01 00:00:00
abstract::In an attempt to identify pancreatic islet cells emitting formaldehyde-induced fluorescence (FIF), the pancreatic islets of the domestic fowl were studied by combined fluorescence, ultrastructural, silver-impregnation and immunohistochemical methods in the same section or in consecutive semi-thin and ultra-thin sectio...
journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
abstract::The maternal-fetal interface undergoes dynamic changes that promote successful development of the embryo/fetal allograft during pregnancy. This immune privilege of the conceptus is mediated through local and systemic cellular responses. In species in which endometrial decidualization accompanies pregnancy, unique immu...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
abstract::Light and electron microscopic autoradiography has been employed to define the neuroanatomical patterns of uptake and binding of radiolabelled L-dopa in the endocrine hypothalamus of the rat. A dorsomedial continuum of arcuate and periventricular neurons selectively sequester 3HL-dopa 20 min following its intraventric...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233675
更新日期:1978-12-14 00:00:00
abstract::To identify and describe ovarian follicles committed to undergo follicular degeneration (atresia), immature rats were primed with pregnant mare serum gonadotropin (PMSG). After PMSG treatment, preovulatory follicles develop but subsequently degenerate. Prior to the appearance of pyknotic nuclei (Stage I of atresia), d...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233727
更新日期:1980-01-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410051058
更新日期:1998-05-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218954
更新日期:1987-12-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-002-0646-4
更新日期:2003-01-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00319368
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journal_title:Cell and tissue research
pub_type: 杂志文章
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journal_title:Cell and tissue research
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更新日期:2005-09-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00224474
更新日期:1976-01-28 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215517
更新日期:1987-08-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004419900142
更新日期:2000-02-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00384739
更新日期:1992-07-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00210146
更新日期:1981-01-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:2000-06-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221380
更新日期:1976-10-06 00:00:00