Abstract：
:The maternal-fetal interface undergoes dynamic changes that promote successful development of the embryo/fetal allograft during pregnancy. This immune privilege of the conceptus is mediated through local and systemic cellular responses. In species in which endometrial decidualization accompanies pregnancy, unique immune cell niches are found. Many studies have addressed the enigmatic roles of uterine (u)NK cells as killers and helpers because they are frequently found in the uterine lining and decidua of normal and pathological pregnancies. Accumulating evidence indicates that uNK cells are induced and transformed by sensing signals within their microenvironment to both protect the mother from the fetal allograft and support the fetus during its development. Here, we review the mechanisms that modulate these functions of uNK cells during pregnancy. We suggest that uNK cells must be tightly regulated in order to serve these two roles and support a healthy pregnancy.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Zhang J,Dunk C,Croy AB,Lye SJdoi
10.1007/s00441-015-2315-4subject
Has Abstractpub_date
2016-01-01 00:00:00pages
249-265issue
1eissn
0302-766Xissn
1432-0878pii
10.1007/s00441-015-2315-4journal_volume
363pub_type
杂志文章,评审abstract：:Kruppel-like factor 4 (KLF4) is a zinc-finger-type transcription factor with a restricted expression pattern during skeletal development. We have previously shown that KLF4 represses osteoblast mineralization concomitant with a down-regulation in the expression of a number of osteoblastic genes, both in vivo and in vi...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-014-1931-8
更新日期：2014-10-01 00:00:00
abstract：:Dietary restriction (DR) retards physical growth, resulting in small body size, reduced liver weight and reduced number of hepatocytes in rats. We examined the effects of DR on proliferation and apoptosis of hepatocytes during development and explained these changes subcellularly using immunohistochemistry for bromode...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004419900126
更新日期：2000-03-01 00:00:00
abstract：:The solute carrier (SLC) group of membrane transport proteins includes about 400 members organized into more than 50 families. The SLC family that comprises nucleoside-sugar transporters is referred to as SLC35. One of the members of this family is SLC35F1. The function of SLC35F1 is still unknown; however, recent stu...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-019-03008-8
更新日期：2019-08-01 00:00:00
abstract：:S-antigen-immunoreactive pinealocytes located in the deep portion of the pineal organ of inbred and wild pigmented mice give rise to long, beaded processes penetrating into the habenular and pretectal regions. In addition, the medial habenular nuclei and the pretectal area contain S-antigen-immunoreactive perikarya, w...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00313528
更新日期：1990-09-01 00:00:00
abstract：:The epithelial surface of the taste disc on the fungiform papillae of the frog was studied by means of freeze-fracture and conventional electron microscopy. The plasma membrane of the apical process of taste receptor cells was found to exhibit a uniform population of 10-nm intramembrane particles on its fracture face ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216883
更新日期：1982-01-01 00:00:00
abstract：:Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have revealed the molecular characteristics of human neuroblastomas, including abnormalities at genome, epigenome and transcriptome levels. However...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-018-2796-z
更新日期：2018-05-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217176
更新日期：1985-01-01 00:00:00
abstract：:Angiotensin II (AII) is present in the mammalian ovary and has been correlated with atresia in follicles. Since the theca interna may be one site at which atresia is initiated, we wished to determine whether AII exerts an effect on theca interna from explanted ovarian follicles of hamsters. Hamsters were sacrified on ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00338068
更新日期：1992-04-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-008-0744-z
更新日期：2009-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218078
更新日期：1986-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217578
更新日期：1985-01-01 00:00:00
abstract：:In mouse hepatocytes, the gap junctional proteins connexin32 (Cx32) and connexin26 (Cx26) are expressed in the same gap junctional plaque. Expression of the major Cx32 protein is downregulated during liver regeneration and cholestasis. Here we have analyzed the acute-phase response (after experimental inflammation) an...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410000177
更新日期：2000-04-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216728
更新日期：1981-01-01 00:00:00
abstract：:The pineal organ of the blind, cave-dwelling fish, Typhlichythyes subterraneous, was examined with both light and electron microscopes. Like the eyes, the pineal in this troglobytic species was found to be regressed. Two cell types, photoreceptor and supportive cells, were described in the pineal epithelium. Although ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00233895
更新日期：1978-12-29 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00297553
更新日期：1993-01-01 00:00:00
abstract：:We have previously shown that mice deficient in the gene for the myelin-associated glycoprotein (MAG) develop normal myelin in the peripheral nerves, but show axon and myelin degeneration at eight months of age, suggesting that MAG is involved in the maintenance of axon-Schwann cell integrity. The search for molecules...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050727
更新日期：1997-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-020-03199-5
更新日期：2020-06-01 00:00:00
abstract：:SEPTIN9 (SEPT9) is a filament-forming protein involved in numerous cellular processes. We have used a conditional knock out allele of Sept9 to specifically delete Sept9 in T-cells. As shown by fluorescence-activated cell sorting, loss of Sept9 at an early thymocyte stage in the thymus results in increased numbers of d...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1618-6
更新日期：2013-06-01 00:00:00
abstract：:The fine structure and primary sensory projections of sensilla located in the labial-palp pit organ of the cotton bollworm Helicoverpa armigera (Insecta, Lepidoptera) are investigated by scanning electron and transmission electron microscopy combined with confocal laser scanning microscopy. The pit organ located on th...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1657-z
更新日期：2013-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00227032
更新日期：1977-05-10 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218017
更新日期：1985-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00222805
更新日期：1975-12-29 00:00:00
abstract：:In the present study, the effect of LHRH on the process of protein and/or peptide secretion characterized by the formation of granular vesicles has been studied by means of an in vitro system in the pinealocytes of three different species of rodents. LHRH has a strong influence on the activity of this process. However...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216426
更新日期：1983-01-01 00:00:00
abstract：:Light and electron microscopy of the hypothalamic ventricle in neonatal rats demonstrate morphological specializations of the ventricular wall at the level of the premammillary region of the third ventricle. The morphological features are: (1) A ventricular recess that we have called the "hypothalamic dorso-lateral re...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00214672
更新日期：1987-10-01 00:00:00
abstract：:Electron microscopy of the rat lymph node disclosed reticular cells in close association with bundles of collagenous fibrils 30-45 nm in diameter, and electron lucent "amorphous" substances surrounded by microfibrils 11 nm in diameter, with junctional complexes. The amorphous substances, distinctly revealed by orcein ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210522
更新日期：1981-01-01 00:00:00
abstract：:Agitation of villi evokes reflexes that affect the motility of the guinea-pig small intestine. NK1 receptor endocytosis was used to investigate the possible involvement of tachykinins acting on neuronal NK1 receptors in these reflexes. Segments of guinea-pig ileum were incubated at 37 degrees C in Krebs physiological ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410051032
更新日期：1998-04-01 00:00:00
abstract：:Exposure to nicotine in smoking contributes to most unexplained male infertility but the mechanisms remain to be fully elucidated. Zinc (Zn) is an essential trace element in normal growth, development and reproduction. Zinc oxide nanoparticles (ZnONPs) are well-known antioxidants. Therefore, this work was designed to ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-018-2909-8
更新日期：2019-02-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00381893
更新日期：1992-10-01 00:00:00
abstract：:The fine structure of Heterophrys marina (Centrohelidia, Heliozoa) is described with special reference to centroplast structure, morphogenesis and "behavior" of kinetocysts (= axopodial granules which perform saltatory movement), and formation of organic spicules in a new type of organelle located in the plasma membra...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00222116
更新日期：1975-08-01 00:00:00
abstract：:The fine structural organization of a cortical filament layer in normal locomoting Amoeba proteus was demonstrated using improved fixation and embedding techniques. Best results were obtained after application of PIPES-buffered glutaraldehyde in connection with substances known to prevent the depolymerization of F-act...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215699
更新日期：1982-01-01 00:00:00
