Abstract:
:Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have revealed the molecular characteristics of human neuroblastomas, including abnormalities at genome, epigenome and transcriptome levels. However, neuroblastoma initiation mechanisms and even its origin are long-standing mysteries. In this review article, we summarize the current knowledge about normal development of putative neuroblastoma sources, namely sympathoadrenal lineage of neural crest cells and Schwann cell precursors that were recently identified as the source of adrenal chromaffin cells. A plausible origin of enigmatic stage 4S neuroblastoma is also discussed. With regard to the initiation mechanisms, we review genetic abnormalities in neuroblastomas and their possible association to initiation mechanisms. We also summarize evidences of neuroblastoma initiation observed in genetically engineered animal models, in which epigenetic alterations were involved, including transcriptomic upregulation by N-Myc and downregulation by polycomb repressive complex 2. Finally, several in vitro experimental methods are proposed that hopefully will accelerate our comprehension of neuroblastoma initiation. Thus, this review summarizes the state-of-the-art knowledge about the mechanisms of neuroblastoma initiation, which is critical for developing new strategies to cure children with neuroblastoma.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Tsubota S,Kadomatsu Kdoi
10.1007/s00441-018-2796-zsubject
Has Abstractpub_date
2018-05-01 00:00:00pages
211-221issue
2eissn
0302-766Xissn
1432-0878pii
10.1007/s00441-018-2796-zjournal_volume
372pub_type
杂志文章,评审abstract::We have previously demonstrated that tooth size is determined by dental mesenchymal factors. Exogenous bone morphogenetic protein (BMP)4, Noggin, fibroblast growth factor (FGF)3 and FGF10 have no effect on tooth size, despite the expressions of Bmp2, Bmp4, Fgf3, Fgf10 and Lef1 in the dental mesenchyme. Among the wingl...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-011-1224-4
更新日期:2011-09-01 00:00:00
abstract::Filamentous intranuclear rodlets were found in a majority of cells in a bronchiolar neuroepithelial body of a rabbit. These rodlets appear to be similar to structures that have been described primarily in neural tissues. They are composed of large bundles of microfibrils made up of smaller subbundles. No close associa...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00210521
更新日期:1981-01-01 00:00:00
abstract::Human endothelial progenitor cells (EPCs) were isolated from cord blood samples and enriched by magnetic activated cell sorting method based on the CD133 marker. Cells were incubated with different doses of bacterial lipopolysaccharide, ranging from 2, 5, 10, 50, 100, 200, 250, 500, to 1000 µg/ml, for 48 h. The cell s...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-020-03405-4
更新日期:2021-01-18 00:00:00
abstract::The fine structure of hair mechanoreceptors in crayfish during moulting was investigated with special attention to the interface apparatus between cuticular hairs and sensory cells: the chorda. The chordae are lost with old exuviae at every moulting. They are drawn out from a moulting canal at the tip of the new hair....
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214236
更新日期:1984-01-01 00:00:00
abstract::Apart from the characteristic and progressive motor- and movement-related problems, Parkinson's disease (PD) patients also suffer from several non-motor symptoms, including gastrointestinal dysfunction. The fact that the enteric nervous system (ENS) controls motility and that one of the typical PD hallmarks, α-synucle...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-018-2856-4
更新日期:2018-07-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are increasingly being reported as occurring in a variety of tissues. Although MSCs from human bone marrow are relatively easy to harvest, the isolation of rodent MSCs is more difficult, thereby limiting the number of experiments in vivo. To determine a suitable cell source, we isolated r...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0308-z
更新日期:2007-03-01 00:00:00
abstract::Transmission electron microscopy was used to study the effects of proteolytic enzymes (collagenase, trypsin, clostripain), the calcium chelator ethyleneglycol-bis-(beta-aminoethyl ether) N,N,N',N'-tetraacetic acid (EGTA), and the calcium ionophore A 23187 on substrate adhesion and fine structure of chondrocytes and fi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00228443
更新日期:1984-01-01 00:00:00
abstract::The structure of the compound eyes of adult Cicindela tranquebarica Herbst was examined by use of light, scanning, and transmission electron microscopy. Each ommatidium of these photopic eyes is eucone and has a "subcorneal layer" situated between the corneal lens and crystalline cone. A distal rhabdomere consisting o...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233613
更新日期:1980-01-01 00:00:00
abstract::In model experiments with the use of horseradish peroxidase (HRP), two pathways of transport of substances to the adenohypophysis were studied, as well as the distribution of the tracer in the latter organ. The first pathway allows the tracer to penetrate from the intercellular milieu of the median eminence below the ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214248
更新日期:1984-01-01 00:00:00
abstract::Prolonged secretory stimulation of the exocrine pancreas in the rat by in vivo infusion of caerulein leads to a rapid degranulation of the organ associated with a progressive reduction in the size of the zymogen granules. During the first six to twelve hours of stimulation Golgi complexes are enlarged and several stru...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00224474
更新日期:1976-01-28 00:00:00
abstract::Corneal fibroblasts, major cellular components of the corneal stroma, are loosely arrayed between collagen lamellae. They play an important role in the metabolic and physiological homeostasis mechanisms by which the cornea is kept transparent. This paper deals with the demonstration of the gap junctions between the co...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215533
更新日期:1987-08-01 00:00:00
abstract::Among heterogeneous S100β-protein-positive (S100β-positive) cells, star-like cells with extended cytoplasmic processes, the so-called folliculo-stellate cells, envelop hormone-producing cells or interconnect homophilically in the anterior pituitary. S100β-positive cells are known, from immunohistochemistry, to emerge ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-015-2256-y
更新日期:2016-02-01 00:00:00
abstract::Immunocytochemistry using antibodies against Met-enkephalin and Leu-enkephalin has demonstrated a group of large enkephalin-immunoreactive neurons in the nucleus of the rostral mesencephalic tegmentum (mRMT) of two teleost fish. Salmo gairdneri and Salmo salar. Injections of cobalt-lysine in the medial optic tectum re...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00305731
更新日期:1991-04-01 00:00:00
abstract::Neural lobes of rats subjected to dehydration by drinking 2% saline for four days were examined electron microscopically and compared to untreated controls. The ultrastructure of the blood vessels and the tissues surrounding them were examined and it was found that, although few exocytotic figures could be seen in eit...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221710
更新日期:1975-06-24 00:00:00
abstract::Placenta-derived stem cells (PDSCs) have gained interest as an alternative source of stem cells for regenerative medicine because of their potential for self-renewal and differentiation and their immunomodulatory properties. Although many studies have characterized various PDSCs biologically, the properties of the sel...
journal_title:Cell and tissue research
pub_type: 临床试验,杂志文章
doi:10.1007/s00441-011-1249-8
更新日期:2011-10-01 00:00:00
abstract::The distribution of the molluscan cardioexcitatory tetrapeptide FMRFamide (Phe-Met-Arg-Phe-NH2) in the brain of the cloudy dogfish, Scyliorhinus torazame, was examined by immunocytochemistry. FMRFamide-like immunoreactivity was demonstrated to occur extensively in various regions of the dogfish brain, except for the c...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00398072
更新日期:1991-08-01 00:00:00
abstract::We compared the bone regeneration potentials of autologous cultured osteoblasts and of bone-marrow-derived autologous MSCs in combination with allogeneic cancellous bone granules in a rabbit radial defect model. Radial shaft defects over 15 mm were made in 26 New Zealand white rabbits. The animals underwent insertion ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-011-1272-9
更新日期:2012-02-01 00:00:00
abstract::The maternal-fetal interface undergoes dynamic changes that promote successful development of the embryo/fetal allograft during pregnancy. This immune privilege of the conceptus is mediated through local and systemic cellular responses. In species in which endometrial decidualization accompanies pregnancy, unique immu...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-015-2315-4
更新日期:2016-01-01 00:00:00
abstract::Sipunculans, a small phylum of coelomated marine worms closely related to polychaete annelids, lack a true circulatory system. We have previously shown that the sipunculan Themiste petricola can form a cellular clot, without congealing, of cell-free coelomic fluid. The clot is formed by the aggregation of large granul...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0912-9
更新日期:2010-03-01 00:00:00
abstract::The distribution of P2X(2) purine receptor subunit immunoreactivity has been investigated in the mouse gastrointestinal tract. Immunoreactivity occurred in intraganglionic laminar endings (IGLEs) associated with myenteric ganglia throughout the gastrointestinal tract. In the esophagus, IGLEs supplied every myenteric g...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-003-0715-3
更新日期:2003-05-01 00:00:00
abstract::MN9, a monoclonal antibody raised against mouse spermatozoa, specifically recognizes the equatorial segment of sperm head in several mammalian species, including humans. Colloidal gold-immuno-electron microscopy of mouse spermatozoa has shown that the antigen is localized in the space between the outer and inner acros...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00645047
更新日期:1992-12-01 00:00:00
abstract::A total of 20 Golgi-impregnated cone horizontal cells of Nannacara anomala (Cichlidae) were studied in alternating semi- and ultrathin sections in order to examine their connections with the overlying square mosaic of equal double and central single cones. Cone horizontal cells exhibiting three types of processes: (a)...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220825
更新日期:1976-11-24 00:00:00
abstract::An indirect immunofluorescence study of the frozen sections of the spleen of an anuran amphibian, Xenopus laevis, showed that lymphocytes bearing a small amount of immunoglobulin (Ig) were localized mostly in the white pulp of non-immunized toads. There were fewer fluorescent cells in the red pulp. In the toads hyperi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218363
更新日期:1982-01-01 00:00:00
abstract::Tissue lectins appear to be involved in a broad range of physiological processes, as reflected for the members of the family of galectins by referring to them as adhesion/growth-regulatory effectors. In order to clarify the significance of galectin presence, key challenges are to define their binding partners and the ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2931-x
更新日期:2019-03-01 00:00:00
abstract::Vitrification of biological specimens in liquid nitrogen can be achieved under high pressure (2,100 bars). This procedure obviates the use of aldehyde fixation and cryoprotection (glycerol). The present work demonstrates its applicability to the freeze-etching of mammalian brain tissue. Freeze-fracture repicas from ra...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00237626
更新日期:1980-01-01 00:00:00
abstract::Neural stem cells (NSCs) are a subtype of tissue-specific progenitor cells capable of extended self-renewal and the ability to generate all major cell types of nervous tissue, such as neurons, astroglia and oligodendroglial cells. Recent studies suggest that salient patterning in anterior-posterior and dorsal-ventral ...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-004-0923-5
更新日期:2004-10-01 00:00:00
abstract::Angiotensin II (AII) is present in the mammalian ovary and has been correlated with atresia in follicles. Since the theca interna may be one site at which atresia is initiated, we wished to determine whether AII exerts an effect on theca interna from explanted ovarian follicles of hamsters. Hamsters were sacrified on ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00338068
更新日期:1992-04-01 00:00:00
abstract::The immunocytochemical localization of bovine oviduct-specific glycoproteins was investigated by light and electron microscopy. Using monoclonal antibodies (MAbs) specific for bovine oviductal glycoproteins, 3 regions (fimbriae, ampulla, and isthmus) of the epithelium in the bovine oviduct we studied during the follic...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00327983
更新日期:1993-10-01 00:00:00
abstract::The organization of the neuropeptide Y (NPY)-immunoreactive system in the forebrain, pineal organ and retina of a biweekly spawning fish (Fundulus heteroclitus) was investigated. Immunoreactivity was encountered in neurons of the nucleus olfactoretinalis, in the large population of neurons in the floor of the telencep...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050541
更新日期:1996-02-01 00:00:00
abstract::During normal development of many vertebrate species, substantial numbers of neurons in the central and peripheral nervous system undergo naturally occurring (or programmed) cell death. For example, approximately 50% of spinal motoneurons degenerate and die at a time when these cells are establishing synaptic connecti...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050690
更新日期:1996-11-01 00:00:00