Studies on intracellular transport of secretory proteins in the rat exocrine pancreas. IV. Stimulation by in vivo infusion of caerulein.

Abstract:

:Prolonged secretory stimulation of the exocrine pancreas in the rat by in vivo infusion of caerulein leads to a rapid degranulation of the organ associated with a progressive reduction in the size of the zymogen granules. During the first six to twelve hours of stimulation Golgi complexes are enlarged and several structural forms of multivesicular bodies are found indicating a lysosomal degradation of membrane material in the Golgi area. Maximum secretory activity is obtained after a 24 hour infusion, Golgi complexes appear fragmented, the secretory granules measure only 1/3 to 1/4 their normal size. Thereafter, in spite of a continuous stimulation, the exocrine cells regranulate progressively up to 72 hours of infusion. This regranulation is associated with massive enlargement of the Golgi complexes.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Bieger W,Martin-Achard A,Bassler M,Kern HF

doi

10.1007/BF00224474

keywords:

subject

Has Abstract

pub_date

1976-01-28 00:00:00

pages

435-53

issue

4

eissn

0302-766X

issn

1432-0878

journal_volume

165

pub_type

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