Splenic white pulp as a thymus-independent area in the African clawed toad, Xenopus laevis.

Abstract:

:An indirect immunofluorescence study of the frozen sections of the spleen of an anuran amphibian, Xenopus laevis, showed that lymphocytes bearing a small amount of immunoglobulin (Ig) were localized mostly in the white pulp of non-immunized toads. There were fewer fluorescent cells in the red pulp. In the toads hyperimmunized with human gamma globulin (HGG), cells with strong cytoplasmic fluorescence increased significantly in the outer part of the white pulp. Electron microscopy of spleens from these toads showed that plasma cells at different stages of maturation were abundant in the white pulp, whereas in the red pulp, a smaller number of maturer plasma cells were observed. These results indicate that, in contrast with its mammalian counterpart, the splenic white pulp of this anuran is the site where thymus-independent lymphocytes commence blast formation and transformation into plasma cells.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Obara N,Tochinai S,Katagiri C

doi

10.1007/BF00218363

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

327-35

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

226

pub_type

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