Abstract:
:Tenidap is a structurally novel antirheumatic agent with anti-inflammatory and analgesic properties. Previous studies have shown that tenidap is able to inhibit the production and action of cytokines such as interleukin-1, interleukin-6 (IL-6) and tumour necrosis factor alpha. However, the mechanisms by which tenidap inhibits cytokine synthesis are not yet known. We investigated in the human astrocytoma cell line U373 whether tenidap inhibits IL-6 synthesis by inhibition of certain signal transduction processes leading to IL-6 synthesis. Cells were stimulated with different substances which have previously been shown to activate protein kinase A or C, reactive oxygen intermediates as well as transcription factors such as nuclear factor kappa B and AP-1 and which all result in IL-6 synthesis. Tenidap was a very potent inhibitor of IL-6 synthesis independent of the stimuli used, suggesting an inhibitory mechanism other than inhibition of a certain signal transduction pathway. Since IL-6 has been shown to be involved in the etiopathology of Alzheimer's disease and since the use of nonsteroidal anti-inflammatory drugs appears to be of therapeutical benefit, it is concluded that tenidap should be tested in clinical trials in order to determine whether it may be useful for the treatment of Alzheimer's disease.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Lieb K,Fiebich BL,Hüll M,Berger M,Bauer Jdoi
10.1007/s004410050810subject
Has Abstractpub_date
1997-05-01 00:00:00pages
251-7issue
2eissn
0302-766Xissn
1432-0878journal_volume
288pub_type
杂志文章abstract::The present study continues a previous investigation on the median eminence (EM) (Krisch et al., 1978). In rats with high levels of neurohormones (LHRH, vasopressin) a limited immunohistochemical labeling of perivascular tanycyte processes can be observed surrounding capillaries in the marginal region of the organum v...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233891
更新日期:1978-12-29 00:00:00
abstract::Rainbow trout (Oncorhynchus mykiss) were exposed to ion-poor (soft) water to test the hypothesis that naturally induced proliferation of branchial chloride cells causes a thickening of the blood-to-water diffusion barrier. This was achieved by using a combination of scanning and transmission electron-microscopic techn...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050622
更新日期:1996-07-01 00:00:00
abstract::Mesenchymal stromal cells (MSCs), especially those lying close to cartilage defects, are an important cell source for cartilage regeneration. We hypothesize that a larger number of MSCs might become available, if the bone marrow in the immediate vicinity of the subchondral bone is stimulated for MSCs in advance of the...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-010-1020-6
更新日期:2010-09-01 00:00:00
abstract::Chorionic binucleate cells (BNC) occur in several ruminants including cow, deer, goat and sheep. They migrate through the chorionic tight junction to fuse with uterine epithelial cells and discharge their granules into maternal connective tissue. We have compared the BNC of near-term, resin-embedded, ovine and bovine ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00331380
更新日期:1994-12-01 00:00:00
abstract::Caveolae or membrane vesicles are commonly observed in smooth and skeletal muscle as well as in working heart muscle. Using sections of fixed tissue and replicas of freeze-cleaved material, we show in this study that caveolae are also very numerous in sinus node cells of the rabbit, and to a lesser degree, in the atri...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00234869
更新日期:1980-01-01 00:00:00
abstract::Pulmonary neuroepithelial bodies (NEBs) are extensively innervated organoid groups of neuroendocrine cells that lie in the epithelium of intrapulmonary airways. Our present understanding of the morphology of NEBs is comprehensive, but direct physiological studies have so far been challenging because the extremely diff...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-005-1111-y
更新日期:2005-07-01 00:00:00
abstract::Regenerated adrenocortical nodules were obtained by implanting fragments of the capsular tissue of excised adrenal glands into the musculus gracilis of rats (Belloni et al. 1990). Five months after the operation, operated rats showed a normal basal blood level of corticosterone, but a very low concentration of circula...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00318136
更新日期:1991-07-01 00:00:00
abstract::Four groups of male rats were exercised for periods of 2, 4, 6, and 8 weeks with controls in each group. As a result of chronic exercise there was an increase in the width of the zona fasciculata of the adrenal cortex. Also, there was an increase in the number and size of the mitochondria, and an increase in the quant...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215882
更新日期:1976-05-06 00:00:00
abstract::The pineal gland structure and ultrastructure in the Northern (Blarina brevicauda) and Southern short-tailed shrew (Blarina carolinensis) are described by light and electron microscopy. Results observed were similar to other mammals of Insectivora described previously, specifically, the hedgehog (Erinaceus europaeus) ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2897-8
更新日期:2018-12-01 00:00:00
abstract::Numerous macrophages were found aggregated in the lamina propria at the tips of villi in the small intestine of guinea pigs. These macrophages extended their pseudopodia into the epithelial lining and internalized fragments of effete enterocytes in their phagosomes. The epithelium of the villus tips was found to be in...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF02913723
更新日期:1993-03-01 00:00:00
abstract::Changes in the ultrastructure of the toad epidermis during the moulting cycle are described on the basis of 17 skin preparations fixed in consecutive phases of the cycle. Our previous light microscopical findings that morphological changes are mainly restricted to a short period prior to and after shedding are confirm...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221703
更新日期:1975-06-24 00:00:00
abstract::A culture technique for the in vitro growth and differentiation of antennal cells of Mamestra brassicae is described. The morphology of the growing cells is described. At least five morphological cell types can be distinguished in the cultures. Neuronal cells (type A) were characterized morphologically and immunocytoc...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050884
更新日期:1997-08-01 00:00:00
abstract::During developmental critical periods, external stimuli are crucial for information processing, acquisition of new functions or functional recovery after CNS damage. These phenomena depend on the capability of neurons to modify their functional properties and/or their connections, generally defined as "plasticity". Al...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-011-1293-4
更新日期:2012-07-01 00:00:00
abstract::The central fat body of the ovoviviparous cockroach Nauphoeta cinerea was studied during the first reproductive cycle of the female by means of light microscopy, autoradiography and electron microscopy. Comparative studies in larval stages were also undertaken. The fat body of Nauphoeta contains a large amount of lipi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219785
更新日期:1978-04-28 00:00:00
abstract::By use of the immunofluorescence technique TSH-, LH- and ACTH-cells were localized in the hypophysis of tadpoles of Xenopus laevis. The first signs of the activity of these cells were observed in early stages of the development, i.e., stage 39 for ACTH, and stage 42 for TSH and LH. ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216218
更新日期:1982-01-01 00:00:00
abstract::The effects of radiotherapy on neuropeptide expression in the rat larynx were studied. Irradiation was given for five days, 6 or 8 Gray daily. Ten days after the end of irradiation, the larynx, the laryngeal nerves and different ganglia related to the larynx were dissected out from irradiated and control animals and p...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00300691
更新日期:1995-01-01 00:00:00
abstract::A detailed chronological electron-microscopic study of the bone remodeling sequence has been performed in the rat based on a previously described model (Tran Van et al. 1982) in which the remodeling activity is synchronized. This allowed the observation of the cellular and extracellular events during the bone remodeli...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214682
更新日期:1982-01-01 00:00:00
abstract::Kidneys of 2 to 10 day-old rats of Wistar and Sprague-Dawley strains were fixed with glutaraldehyde by retrograde vascular perfusion and then prepared for observation in TEM and SEM. In addition methacrylate casts of differentiating glomerular capillaries were examined by SEM. Although the glomerular vascular pattern ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233959
更新日期:1980-01-01 00:00:00
abstract::The European shore crab Carcinus maenas and the common hermit crab Pagurus bernhardus are members of the sister taxa Brachyura and Anomura (together forming the taxon Meiura) respectively. Both species share similar coastal marine habitats and thus are confronted with similar environmental conditions. This study sets ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-012-1353-4
更新日期:2012-04-01 00:00:00
abstract::Variations in gene expression patterns represent a powerful source of evolutionary innovation. In a rodent living about 70 million years ago, a genomic accident led an immune formyl peptide receptor (FPR) gene to hijack a vomeronasal receptor regulatory sequence. This gene shuffling event forced an immune pathogen sen...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-020-03393-5
更新日期:2021-01-16 00:00:00
abstract::Research in mammals has established the existence of a neuronal network that lies within the hypothalamus and that regulates energy homeostasis. However, it is unknown whether this system has been evolutionarily conserved. The objective of the present study was therefore to examine the influence of the agouti-related ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-003-0755-8
更新日期:2003-08-01 00:00:00
abstract::Survival of mesenchymal stem cells (MSCs) against oxidative stress and inflammation is vital for effective stem cell therapy. The reactive oxygen species (ROS) result in apoptosis and release of inflammatory mediators. Adipose-derived stem cells (ASCs) have shown promise for stem cell therapy owing to their anti-infla...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2857-3
更新日期:2018-10-01 00:00:00
abstract::Previously, we showed that synchronous autophagy occurred in the corpora allata during the declining phase of juvenile hormone synthesis in mated adult females of the cockroach Diploptera punctata. At the onset of this process, conspicuous whorl-like autophagosomes were often observed. Each consisted of a ribosome-con...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050764
更新日期:1997-02-01 00:00:00
abstract::The pituitary gland is first evident in rainbow trout two weeks before hatching. Differentiation of prolactin and ACTH cells is not marked until 3-4 days after hatching when the follicular arrangement of the prolactin cells become apparent. There is no difference in the time of development of either prolactin or ACTH ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00209283
更新日期:1978-05-29 00:00:00
abstract::Apart from the known hypothalamic controls, which have been well documented, a myriad of compounds both endogenous and exogenous have proved effective in influencing secretion of prolactin (PRL). Recent studies have shown that somatostatin (SRIF), when injected intra-atrially as a bolus, is able to inhibit PRL secreti...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222371
更新日期:1983-01-01 00:00:00
abstract::The fan-shaped body is the largest substructure of the central complex in Drosophila melanogaster. Two groups of large-field neurons that innervate the fan-shaped body, viz., F1 and F5 neurons, have recently been found to be involved in visual pattern memory for "contour orientation" and "elevation" in a rut-dependent...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0781-2
更新日期:2009-06-01 00:00:00
abstract::The elaboration and distribution of newly formed proteins in the striated muscle of 21-day-old mice were investigated by quantitative radioautography at intervals between 2 and 240 min after intravenous injection of tritiated leucine. In radioautographs, the localization and the relative label concentration were compa...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00209040
更新日期:1978-10-17 00:00:00
abstract::The regeneration of the vallate papilla in the rat was studied by both light and electron microscopy. The papillae were excised and regeneration was studied at time intervals of 3 to 45 days. It was found that the vallate papilla is capable of regeneration after both partial and total papillectomies. The regenerated p...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00225338
更新日期:1978-10-30 00:00:00
abstract::A quantitative evaluation of putative amino acid neurotransmitters in sea pansy polyps by high-performance liquid chromatography indicates that the taurine content exceeds that of other amino acids by a 100-fold. The cellular source of this taurine was investigated by immunohistochemistry with two polyclonal antisera ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050800
更新日期:1997-04-01 00:00:00
abstract::Large granular lymphocytes (LGL) comprise a natural defense system in the liver and exert an inhibitory effect on tumor cell metastasis. In order to demonstrate the maturation of LGL in the liver from the morphological aspect, we evaluated electron-microscopically the frequency of 0.2 micron vesicles (rod-cored and "e...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00354799
更新日期:1994-04-01 00:00:00