Abstract:
:SCO-spondin is a newly identified protein, strongly expressed in the subcommissural organ (SCO), an ependymal differentiation of the brain. When secreted into the cerebrospinal fluid at the entrance to the Sylvian aqueduct, it condenses and forms Reissner's fiber. Several conserved domains have previously been characterizedin SCO-spondin, e.g., thrombospondin type 1 repeats (TSRs), low-density lipoprotein receptor (LDLr) type A repeats, and epidermal-growth-factor-like domains, which are potent sites of protein-protein interaction. To clarify the role of this protein on neuronal development, we have tested the effect of oligopeptides, the sequences of which include highly conserved amino acids of TSRs, LDLr type A repeats and a potent site of attachment to proteoglycan, on cortical and spinal-cord neurons in primary cell cultures. One of these peptides (WSGWSSCSRSCG), corresponding to a SCO-spondin TSR sequence, markedly increases adhesivity and neuritic outgrowth of cortical neurons and induces an opposite effect on cortical and spinal-cord neuronal aggregation. These effects are specific, as no response is observed with the scrambled sequence of this peptide. Another peptide (WGPCSVSCG) is only slightly active on adhesivity and neuritic outgrowth of cortical neurons and has no effect on spinal-cord neurons. Peptides derived from other conserved domains of SCO-spondin are not effective under our experimental conditions. Thus, SCO-spondin may be responsible for at least a part of the effects previously observed on neuronal cells cultured in the presence of Reissner's fiber. In addition, SCO-spondin seems to interfere with neuronal development and/or axonal guidance during ontogenesis of the central nervous system in modulating side-to-side interactions and neuritic outgrowth.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Monnerie H,Dastugue B,Meiniel Adoi
10.1007/s004410051132subject
Has Abstractpub_date
1998-09-01 00:00:00pages
407-18issue
3eissn
0302-766Xissn
1432-0878journal_volume
293pub_type
杂志文章abstract::The fine structure of Heterophrys marina (Centrohelidia, Heliozoa) is described with special reference to centroplast structure, morphogenesis and "behavior" of kinetocysts (= axopodial granules which perform saltatory movement), and formation of organic spicules in a new type of organelle located in the plasma membra...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222116
更新日期:1975-08-01 00:00:00
abstract::iASPP (inhibitory member of the ASPP family), the conserved key inhibitor of p53, is overexpressed and plays an important oncogenetic role in many human cancers. However, its function in cervical cancer remains unknown. The objective of this study was to investigate the expression and clinical relevance of iASPP in ce...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1569-y
更新日期:2013-05-01 00:00:00
abstract::The structure of the compound eyes of adult Cicindela tranquebarica Herbst was examined by use of light, scanning, and transmission electron microscopy. Each ommatidium of these photopic eyes is eucone and has a "subcorneal layer" situated between the corneal lens and crystalline cone. A distal rhabdomere consisting o...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233613
更新日期:1980-01-01 00:00:00
abstract::Variations in gene expression patterns represent a powerful source of evolutionary innovation. In a rodent living about 70 million years ago, a genomic accident led an immune formyl peptide receptor (FPR) gene to hijack a vomeronasal receptor regulatory sequence. This gene shuffling event forced an immune pathogen sen...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-020-03393-5
更新日期:2021-01-16 00:00:00
abstract::The isolated perfused heart model was used to examine the structure of rat cardiac capillaries and their permeability to macromolecules of various sizes. Haemoglobin (diameter 6.4 nm) and catalase (10.4 nm) did not cross the endothelium but remained on the luminal side. Cytochrome C (3 nm) and horseradish peroxidase (...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00213826
更新日期:1988-04-01 00:00:00
abstract::Thyroid glands of 7 to 21 day-old chick embryos were examined by electron microscopy using freeze-fracture and thin-section preparations. The primitive follicle lumen first appears between two adjacent epithelial cells in 8 day-old embryos, and is formed in the region of a focal tight junction (macula occludens). The ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00234830
更新日期:1979-04-30 00:00:00
abstract::Ultrastructural investigations showed that development and maintenance of smooth muscle was similar in control and aneurogenic amphibian larvae. This applies to both multi-unit and unitary smooth muscles. The gut musculature displayed a regional variation in smooth muscle morphology and a variety of intermuscular appo...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00227048
更新日期:1976-02-12 00:00:00
abstract::The cardiovascular system is the first functional organ in the vertebrate embryo, and many organs start to develop adjacent to cells of the cardiovascular system. Endothelial cells (EC) form the inner cell lining of blood vessels and represent the major cell type that interacts with developing organs. On the one hand,...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-003-0739-8
更新日期:2003-10-01 00:00:00
abstract::Exposure of adult brown bullheads Ictalurus nebulosus (120-450 g) to environmental hypercapnia (2% carbon dioxide in air) and subsequent recovery caused transient changes in whole body net sodium flux (JnetNa+) and net chloride flux (JnetCl-) resulting largely from changes in whole body sodium influx (JNa+in) and chlo...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00319161
更新日期:1992-06-01 00:00:00
abstract::New genome-editing approaches, such as the CRISPR/Cas system, have opened up great opportunities to insert or delete genes at targeted loci and have revolutionized genetics in model organisms like the zebrafish. The Cre-loxp recombination system is widely used to activate or inactivate genes with high spatial and temp...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2798-x
更新日期:2018-04-01 00:00:00
abstract::Tenidap is a structurally novel antirheumatic agent with anti-inflammatory and analgesic properties. Previous studies have shown that tenidap is able to inhibit the production and action of cytokines such as interleukin-1, interleukin-6 (IL-6) and tumour necrosis factor alpha. However, the mechanisms by which tenidap ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050810
更新日期:1997-05-01 00:00:00
abstract::The fine structure and primary sensory projections of sensilla located in the labial-palp pit organ of the cotton bollworm Helicoverpa armigera (Insecta, Lepidoptera) are investigated by scanning electron and transmission electron microscopy combined with confocal laser scanning microscopy. The pit organ located on th...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1657-z
更新日期:2013-09-01 00:00:00
abstract::The expression patterns of three microtubule-associated proteins (MAP1A, MAP1B, and MAP2A&B) were investigated in the developing optic tectum. Expression of MAP1B and middle-molecular-weight peptide of neurofilament (NF-M) was first observed in the same mesencephalic cells on day 3 of incubation, indicating that neuro...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-003-0796-z
更新日期:2003-12-01 00:00:00
abstract::The distribution of immunoreactive thyrotropin-releasing hormone (TRH) in the forebrain and hypophysis of Rana catesbeiana was studied by means of specific radioimmunoassay and immunohistochemistry based on peroxidase-antiperoxidase (PAP) techniques. A relatively high concentration of immunoassayable TRH is present in...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00212220
更新日期:1983-01-01 00:00:00
abstract::The ultrastructural changes induced by the topical application of retinol acetate on hamster cheek pouch epithelium were evaluated using stereological analysis. Electron micrographs were prepared of the basal and superficial regions of the nucleated cell layer of the epithelium obtained from 3 treated and 3 control an...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214783
更新日期:1982-01-01 00:00:00
abstract::The regression of atretic oocytes in Perca fluviatilis was studied by histochemical, light and electron microscopic methods. The course of regression can be divided into three stages, the first two comprising the dissolution of the atretic oocyte and its phagocytosis by the granulosa cells of the follicular epithelium...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00209978
更新日期:1981-01-01 00:00:00
abstract::S-antigen-immunoreactive pinealocytes located in the deep portion of the pineal organ of inbred and wild pigmented mice give rise to long, beaded processes penetrating into the habenular and pretectal regions. In addition, the medial habenular nuclei and the pretectal area contain S-antigen-immunoreactive perikarya, w...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00313528
更新日期:1990-09-01 00:00:00
abstract::The effects of dexamethasone on the ability of cells enzymatically isolated from 21-day fetal rat calvaria to produce cartilage in vitro has been investigated. Primary cultures of single-cell suspensions of rat calvaria were grown for up to 28 days in vitro in alpha-minimal essential medium containing 15% fetal bovine...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00224728
更新日期:1989-04-01 00:00:00
abstract::The general ultrastructure of the electrocyte, the basic unit of the electric organs of Electrophorus electricus, is analyzed. Presented herein are detailed observations of the syncytial surface, its fibrillar coat, invaginations of the plasma membrane and synaptic terminals. Using Thiéry's method glycogen granules we...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220681
更新日期:1976-11-10 00:00:00
abstract::Activities of the H+, K(+)-ATPase and the Na+, K+, ATPase have been localized in the morphologically heterogeneous oxyntic cell lineage of adult bovine abomasal mucosa, by means of K(+)-dependent paranitrophenylphosphatase (K(+)-pNPPase) histochemistry. At the light- and electron-microscopic level, only members of the...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050583
更新日期:1996-05-01 00:00:00
abstract::Cestodes (tapeworms) are a derived, parasitic clade of the phylum Platyhelminthes (flatworms). The cestode body wall represents an adaptation to its endoparasitic lifestyle. The epidermis forms a non-ciliated syncytium, and both muscular and nervous system are reduced. Morphological differences between cestodes and fr...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-002-0687-8
更新日期:2003-03-01 00:00:00
abstract::To investigate the mechanisms whereby bone cells absorb organic bone-matrix components during endochondral bone development, rat humeri were examined, employing horseradish peroxidase as a soluble protein tracer. Intravenously-injected peroxidase filled the osteoid layer and penetrated into the osteocyte lacunae and c...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219233
更新日期:1985-01-01 00:00:00
abstract::Stem cells are an attractive cellular source for regenerative medicine and tissue engineering applications due to their multipotency. Although the elasticity of the extracellular matrix (ECM) has been shown to have crucial impacts in directing stem cell differentiation, it is not the only contributing factor. Many res...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-015-2190-z
更新日期:2015-09-01 00:00:00
abstract::Glial cell line-derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote dopamine uptake within midbrain dopaminergic neurons. Since its discover...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-020-03287-6
更新日期:2020-10-01 00:00:00
abstract::The rejection of skin allografts by the larval lamprey, Lampetra reissneri, was studied by light- and electron-microscopy, with particular attention to the cell types involved in the reaction. In all allografts, melanophores were destroyed within 20-60 days (the mean survival time, 36 +/- 12 days). Neither the epiderm...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222182
更新日期:1983-01-01 00:00:00
abstract::A monoclonal antibody (Mab) developed against a partially purified bursal protein extract was found to bind specifically to a single cell type in the cortico-medullary border region of the chicken bursa of Fabricius. These cells were microscopically similar to the bursal secretory dendritic-like cells. A product with ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-004-0910-x
更新日期:2004-09-01 00:00:00
abstract::A technique for organotypic in vitro culture with serum-free medium was tested for its appropriateness to mimic normal odontogenesis in the cichlid fish Hemichromis bimaculatus and the zebrafish Danio rerio. Serial semithin sections were observed by light microscopy to collect data on tooth patterning and transmission...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-004-1036-x
更新日期:2005-09-01 00:00:00
abstract::Ultrastructural and morphometric investigations were performed on the lung of the European salamander, Salamandra salamandra L. Folds of first and second order are covered with a ciliated epithelium containing goblet cells. The respiratory surface of the lung is lined by a single type of cell which, in amphibians, com...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222429
更新日期:1978-07-27 00:00:00
abstract::Call-Exner bodies are present in ovarian follicles of a range of species including human and rabbit, and in a range of human ovarian tumors. We have also found structures resembling Call-Exner bodies in bovine preantral and small antral follicles. Hematoxylin and eosin staining of single sections of bovine ovaries has...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410051298
更新日期:1999-05-01 00:00:00
abstract::Exposure to maternal diabetes during fetal growth is a risk factor for the development of type II diabetes (T2D) in later life. Discovery of the mechanisms involved in this association should provide valuable background for therapeutic treatments. Early embryogenesis involves epigenetic changes including histone modif...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-017-2583-2
更新日期:2017-06-01 00:00:00