Abstract:
:Variations in gene expression patterns represent a powerful source of evolutionary innovation. In a rodent living about 70 million years ago, a genomic accident led an immune formyl peptide receptor (FPR) gene to hijack a vomeronasal receptor regulatory sequence. This gene shuffling event forced an immune pathogen sensor to transition into an olfactory chemoreceptor, which thus moved from sensing the internal world to probing the outside world. We here discuss the evolution of the FPR gene family, the events that led to their neofunctionalization in the vomeronasal organ and the functions of immune and vomeronasal FPRs.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Boillat M,Carleton A,Rodriguez Idoi
10.1007/s00441-020-03393-5subject
Has Abstractpub_date
2021-01-16 00:00:00eissn
0302-766Xissn
1432-0878pii
10.1007/s00441-020-03393-5pub_type
杂志文章abstract::Autophagy (cellular self-consumption) is an adaptive stress response and an important aspect of adaption to mechanical loading. If mechanical forces are associated with autophagy regulation in periodontal ligament (PDL) fibroblasts is still unknown. The aim of this study was to analyze the influence of force magnitude...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-019-03063-1
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abstract::The effects of radiotherapy on neuropeptide expression in the rat larynx were studied. Irradiation was given for five days, 6 or 8 Gray daily. Ten days after the end of irradiation, the larynx, the laryngeal nerves and different ganglia related to the larynx were dissected out from irradiated and control animals and p...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00300691
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abstract::Beta-catenin is a multi-functional molecule that is involved in both cell-cell adhesion and signaling. We analyzed changes in beta-catenin gene expression during mouse molar tooth development by in situ hybridization. Prominent up-regulation of the expression of this gene was evident exclusively in the enamel knot at ...
journal_title:Cell and tissue research
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doi:10.1007/s00441-005-0136-6
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216728
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abstract::Angiogenesis, the growth of new blood vessels, is required for a variety of normal proliferative processes. Furthermore, angiogenesis is well established as also playing an important role in neoplastic growth and metastasis. Numerous regulators of angiogenesis have been identified and characterized over the last few d...
journal_title:Cell and tissue research
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abstract::Nitric oxide and various neuropeptides in the myenteric plexus regulate esophageal motility. We sought colocalization of nitric oxide synthase and neuropeptides in frozen sections of mid-portion of smooth-muscled opossum esophagus using NADPH-diaphorase activity to mark the synthase and immunoreactivity to detect pept...
journal_title:Cell and tissue research
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
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更新日期:2010-11-01 00:00:00
abstract::The amniotic epithelium constitutes a diffusion barrier controlling the passage of solutes and water between the amniotic cavity and maternal circulation. With the present immunocytochemical approach, we have shown that several major components of the cyto-skeleton, i.e., actin, alpha-actinin, spectrin and ezrin, are ...
journal_title:Cell and tissue research
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doi:10.1007/BF00318194
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abstract::Many noctuid moth species perceive ultrasound via tympanic ears that are located at the metathorax. Whereas the neural processing of auditory information is well studied at the peripheral and first synaptic level, little is known about the features characterizing higher order sound-sensitive neurons in the moth brain....
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1749-9
更新日期:2014-02-01 00:00:00
abstract::The tyrosine kinase proteins (Trk), encoded by the trk family of proto-oncogenes, mediate, in mammals, the action of neurotrophins, a family of growth factors acting on the development and maintenance of the nervous system. Neurotrophins and their specific receptors, TrkA, TrkB and TrkC, seem to be phylogenetically we...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410000342
更新日期:2001-03-01 00:00:00
abstract::Teleost fish exhibit extraordinary cognitive skills that are comparable to those of mammals and birds. Kin recognition based on olfactory and visual imprinting requires neuronal circuits that were assumed to be necessarily dependent on the interaction of mammalian amygdala, hippocampus, and isocortex, the latter being...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-020-03378-4
更新日期:2021-01-30 00:00:00
abstract::The epithelial surface of the taste disc on the fungiform papillae of the frog was studied by means of freeze-fracture and conventional electron microscopy. The plasma membrane of the apical process of taste receptor cells was found to exhibit a uniform population of 10-nm intramembrane particles on its fracture face ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216883
更新日期:1982-01-01 00:00:00
abstract::The effect of phenylthiourea (PTU) on the pigment epithelium and the photoreceptor cells in the developing retina of Haplochromis burtoni was studied by electron microscopy. In the retinal pigment epithelium of 6-day old embryos, both types of melanin granule (spindle-shaped and rod-shaped) are already found. PTU inhi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219054
更新日期:1977-03-09 00:00:00
abstract::In amniotes, the developmental potentials of neural crest cells differ between the cranium and the trunk. These differences may be attributable to the different expression patterns of Hox genes between cranial and trunk neural crest cells. However, little is known about the factors that control Hox genes expression in...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0827-5
更新日期:2009-09-01 00:00:00
abstract::Morphologically the large intestine of the nutria resembles that of other caviomorphs, notably the guinea pig. The cecum is voluminous: it contributes 8.6% of the total intestinal length and 12.7% of the total intestinal surface area (considering the surface enlargement factor). It contains 27-32% of the wet ingesta a...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214387
更新日期:1988-05-01 00:00:00
abstract::TFF-peptides (formerly P-domain peptides, trefoil factors) are typical secretory products of mucin-producing cells and seem to influence the rheological properties of mucous gels. Here, localization studies of TFF-peptides in human salivary glands are presented. Expression studies (polymerase chain reaction) revealed ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004419900087
更新日期:1999-10-01 00:00:00
abstract::Transplantation of ligament-tissue-derived stem cells has become a promising approach in the repair of injured ligament. Neovascularization plays an important role in ligament healing and remodeling. Recently, human umbilical-cord-blood-derived CD34+ cells have been reported to contribute to neoangiogenesis. Therefore...
journal_title:Cell and tissue research
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doi:10.1007/s00441-015-2250-4
更新日期:2015-12-01 00:00:00
abstract::To identify and describe ovarian follicles committed to undergo follicular degeneration (atresia), immature rats were primed with pregnant mare serum gonadotropin (PMSG). After PMSG treatment, preovulatory follicles develop but subsequently degenerate. Prior to the appearance of pyknotic nuclei (Stage I of atresia), d...
journal_title:Cell and tissue research
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doi:10.1007/BF00233727
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abstract::To investigate the mechanisms whereby bone cells absorb organic bone-matrix components during endochondral bone development, rat humeri were examined, employing horseradish peroxidase as a soluble protein tracer. Intravenously-injected peroxidase filled the osteoid layer and penetrated into the osteocyte lacunae and c...
journal_title:Cell and tissue research
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doi:10.1007/BF00219233
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abstract::Neurotrophins signal via a dual-receptor system comprising receptor tyrosine kinases, the Trks, and a tumor necrosis factor (TNF) receptor like molecule, p75. Interest in these receptors was spurred on by the finding that they are employed by their neurotrophin ligands to activate opposing cellular mechanisms. Signall...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
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更新日期:2001-08-01 00:00:00
abstract::Nerve growth factor (NGF) induces morphological and physiological changes in cultured pancreatic beta-cells, including the extension of neurite-like processes. This latter effect is potentiated by dibutyryl cAMP (dbcAMP). beta-cells cultured under these conditions maintain their immunoreactivity to insulin and gamma-a...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410100411
更新日期:2001-09-01 00:00:00
abstract::Neurotrophins NGF, BDNF, NT-3, and NT-4/5 are members of the neurotrophin family of proteins, which support the survival and induce differentiation of vertebrate neurons. We have studied the effects of neurotrophins on growth cones of embryonic sensory neurons. BDNF and NT-4/5 cause growth cone collapse and transient ...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s004410050933
更新日期:1997-11-01 00:00:00
abstract::The existence of the surface-connected canalicular system (SCCS) has been demonstrated in semithick sections of the frog thrombocytes by the use of a high voltage electron microscope. The SCCS of the thrombocytes in Rana catesbeiana and Rana nigromaculata consists of numerous canaliculi and vesicles with a diameter of...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00237001
更新日期:1979-10-01 00:00:00
abstract::The presence of melatonin is demonstrated in the pineal gland, the retina and the Harderian gland in some mammalian and non-mammalian vertebrates, using a specific fluorescence labelled antibody technique. Four different potent antibodies against melatonin have been used and compared. In the pineal gland of hamsters, ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233830
更新日期:1981-01-01 00:00:00
abstract::Two different monoclonal antibodies raised against choline acetyltransferase were used, together with preembedding immunocytochemical techniques, to visualize the possible cholinergic innervation of the supraoptic and paraventricular nuclei of the rat hypothalamus. Light microscopy confirmed the presence of a group of...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220024
更新日期:1988-10-01 00:00:00
abstract::Following castration, the nucleus of the dark cells of the subcortical portions of the collecting tubules in the rat kidney showed two types of morphological alterations: 1) Decomposition of the nuclear membrane in a circumscribed area. This phenomenon is independent of the sex of the animal and becomes more frequent ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220204
更新日期:1980-01-01 00:00:00
abstract::Previous studies have identified Dogiel type II neurons with cell bodies in the myenteric plexus of guinea-pig ileum to be intrinsic primary afferent neurons. These neurons also have distinctive electrophysiological characteristics (they are AH neurons) and 82-84% are immunoreactive for calbindin. They are the only ca...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410100395
更新日期:2001-07-01 00:00:00
abstract::Antibodies against laminin (LN), fibronectin (FN), collagen type IV (Col IV), neural cell adhesion molecule (N-CAM), T-61 antigen, actin, tubulin and neurofilament protein were injected into the eyes of quail embryos (Coturnix coturnix japonica) of different ages. Twenty h after injection, the heads of the embryos wer...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217320
更新日期:1987-09-01 00:00:00