Abstract：
:Beta-catenin is a multi-functional molecule that is involved in both cell-cell adhesion and signaling. We analyzed changes in beta-catenin gene expression during mouse molar tooth development by in situ hybridization. Prominent up-regulation of the expression of this gene was evident exclusively in the enamel knot at the early cap stage. During the cap and bell stages, the enamel knot, inner dental epithelium, and differentiating stratum intermedium expressed the beta-catenin gene more strongly than other parts of the enamel organ. During these stages, the strength of the gene expression changed heterogeneously within the inner dental epithelium and stratum intermedium. However, the heterogeneity was not evident at the late bell stage, when the cells in the inner dental epithelium had differentiated into ameloblasts at the cusp tip. No spatiotemporal change in beta-catenin gene expression was apparent in the dental papilla except for the cells that differentiated into odontoblasts, which became negative for the expression of the gene after their differentiation. Thus, the up-regulated expression of the beta-catenin gene was strongly associated with epithelial morphogenesis. These findings raise the possibility that the up-regulation of the gene expression and the stabilization of the protein by Wnt signaling play a role in the regulation of the activities of beta-catenin in tooth morphogenesis.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Obara N,Suzuki Y,Takeda Mdoi
10.1007/s00441-005-0136-6keywords:
subject
Has Abstractpub_date
2006-07-01 00:00:00pages
197-201issue
1eissn
0302-766Xissn
1432-0878journal_volume
325pub_type
杂志文章abstract：:In three species of teleosts - carp Cyprinus carpio; grass carp Ctenopharyngodon idella; and crucian carp Carassius auratus - the caudal neurosecretory system displays small, medium-sized and large neurons. Urotensin I (UI)-immunoreactive and UI-nonreactive neurons were found in all three groups; in general, the numbe...
journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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