Abstract：
:Angiogenesis, the growth of new blood vessels, is required for a variety of normal proliferative processes. Furthermore, angiogenesis is well established as also playing an important role in neoplastic growth and metastasis. Numerous regulators of angiogenesis have been identified and characterized over the last few decades. Among these, vascular endothelial growth factor (VEGF)-A appears especially important in several pathophysiological processes. Several VEGF inhibitors have been approved, by the US Food and Drug Administration, for the treatment of tumors or age-releted macular degeneration. This review examines the various mouse tumor models in which VEGF inhibitors have been tested and the lessons learned from these studies.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Crawford Y,Ferrara Ndoi
10.1007/s00441-008-0675-8subject
Has Abstractpub_date
2009-01-01 00:00:00pages
261-9issue
1eissn
0302-766Xissn
1432-0878journal_volume
335pub_type
杂志文章,评审abstract：:Filamentous intranuclear rodlets were found in a majority of cells in a bronchiolar neuroepithelial body of a rabbit. These rodlets appear to be similar to structures that have been described primarily in neural tissues. They are composed of large bundles of microfibrils made up of smaller subbundles. No close associa...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210521
更新日期：1981-01-01 00:00:00
abstract：:Obesity induces metabolic disorders such as type 2 diabetes, hypertension, and cardiovascular diseases and has become a global health concern. Recent studies imply that fat accumulation in nonadipose tissue correlates with metabolic disorders. However, there are no suitable animal models to evaluate this phenomenon. T...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-018-2908-9
更新日期：2019-02-01 00:00:00
abstract：:Beta-defensin 103 (DEFB103) shares little homology with 8 other members of the bovine beta-defensin family and in other species DEFB103 protein has diverse functions, including antimicrobial activity, a chemoattractant for dendritic cells, enhancing epithelial wound repair and regulating hair colour. Expression of the...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-015-2258-9
更新日期：2016-02-01 00:00:00
abstract：:In the stalk-eyed fly Cyrtodiopsis whitei (Diopsidae; Diptera), the relatively long optic nerve develops within the tight lumen of a very short eyestalk. Axonal growth is generally considered in terms of path finding, selective fasciculation, and towing. Physical forces that are necessary for axon lengthening are gene...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-005-1142-4
更新日期：2005-09-01 00:00:00
abstract：:Elastic cartilage-derived cells cultured two-dimensionally with FGF2 and corticosteroid produce gel-type masses that become mature cartilage when injected into a subcutaneous pocket. This unique method has previously been clinically applied for treatments of nasal augmentation. However, the components of the gel-type ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0438-y
更新日期：2007-09-01 00:00:00
abstract：:Two different fixative procedures (immersion and perfusion) and four different fixative solutions were used in order to obtain the best preservation of the brush cells of the common bile duct of the rat. The results indicate that only perfusion fixation through the common bile duct is suitable, independent of the fixa...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210353
更新日期：1981-01-01 00:00:00
abstract：:Dorsal root ganglia of chick embryos were cultured for one to four weeks on Maximow-slides. Puromycin was added to cultures for a pulse of 30' in a dose of 100 mug/ml medium. Particular interest was given to the ultrastructural features of the glia-neuron relations. Puromycin caused a shrinkage of the glial processes ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00225762
更新日期：1975-07-23 00:00:00
abstract：:The application of autologous dermal fibroblasts has been shown to improve burn wound healing. However, a major hurdle is the availability of sufficient healthy skin as a cell source. We investigated fetal dermal cells as an alternative source for cell-based therapy for skin regeneration. Human (hFF), porcine fetal (p...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-015-2293-6
更新日期：2016-04-01 00:00:00
abstract：:The chemical nature of the thickened plasma membrane of cornified cells in stratified squamous epithelium was investigated in comparison with that in noncornified epithelium. Localizations of transglutaminase, molecular weight 92,000 daltons, and detection of epidermal cysteine proteinase inhibitor were effected with ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215516
更新日期：1987-08-01 00:00:00
abstract：:The effect of phenylthiourea (PTU) on the pigment epithelium and the photoreceptor cells in the developing retina of Haplochromis burtoni was studied by electron microscopy. In the retinal pigment epithelium of 6-day old embryos, both types of melanin granule (spindle-shaped and rod-shaped) are already found. PTU inhi...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219054
更新日期：1977-03-09 00:00:00
abstract：:Synaptogyrins are conserved components of the exocytic apparatus and function as regulators of Ca(2+)-dependent exocytosis. The synaptogyrin family comprises three isoforms: two neuronal (synaptogyrin-1 and -3) and one ubiquitous (synaptogyrin-2) form. Although the expression patterns of the exocytic proteins synaptot...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1629-3
更新日期：2013-09-01 00:00:00
abstract：:In the pond snail Lymnaea stagnalis, the growth regulating system consists of (1) about 200 neuroendocrine light green cells, located in four clusters in the cerebral ganglia, and (2) the paired canopy cells, located in the lateral lobes. These cells express genes encoding the molluscan insulin-related peptides (MIPs)...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00384739
更新日期：1992-07-01 00:00:00
abstract：:Interstitial cells of Cajal (ICCs) are believed to be a major element in generating the spontaneous rhythm of the gastrointestinal tract. A prominent problem in the study of these cells has been the difficulty in observing them in intact tissues. We used the lipophilic dye DiI to stain ICCs in the submucosal-circular ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410051058
更新日期：1998-05-01 00:00:00
abstract：:In Syrian hamsters (Mesocricetus auratus), oxytocin (OXT) activity within the medial preoptic-anterior hypothalamus (MPOA-AH) and the ventromedial hypothalamus (VMH) plays an important role in the expression of sexual receptivity. Immunocytochemical analysis with OXT-specific antibodies was used to identify the distri...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050993
更新日期：1998-02-01 00:00:00
abstract：:alpha-Smooth muscle (alpha SM) actin of endothermic vertebrates is selectively recognized by the monoclonal antibody anti-alpha SM-1. Immunoreactivity to this antibody has been shown to be localized in the NH2-terminal sequence Ac-EEED (Chaponnier et al. 1994). Among terrestrial ectothermic vertebrates, two amphibian ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00417867
更新日期：1995-09-01 00:00:00
abstract：:An immunohistochemical staining technique with the D2-40 antibody was undertaken to examine the functional and morphological features of lymphatic networks in tissue sections and whole-mount preparations of normal nasal mucosa and ethmoid sinus mucosa. In normal nasal mucosa, most lymphatic vessels were found in the s...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0337-7
更新日期：2007-03-01 00:00:00
abstract：:In vitro incubation of autonomic nerves with vinblastine sulphate (1 times 10(-4) M) caused a disappearance of microtubules within 15 min; during the following 15 min paracrystalline arrays appeared within the axons. An increase in the abundance of microfilaments was also observed, but these did not appear to arise fr...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00220136
更新日期：1976-02-25 00:00:00
abstract：:The globiferous pedicellariae of Psammechinus miliaris are described. Two fixation methods giving minimal distortion and rapid tissue hardening were adapted for soft tissue preparation for scanning electron microscopy. The pedicellarial valves are covered by a microvillous epithelium. The outer valve epithelial microv...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00220184
更新日期：1975-10-13 00:00:00
abstract：:Although the cerebrospinal fluid-contacting neurons of the avian paraventricular organ exhibit considerable amounts of catecholamines, they show no tyrosine hydroxylase immunoreactivity. In the quail embryo, the development of these neurons has been studied using the paraformaldeyde-glutaraldeyde method for the fluore...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00307970
更新日期：1995-07-01 00:00:00
abstract：:Changes in the ultrastructure of the toad epidermis during the moulting cycle are described on the basis of 17 skin preparations fixed in consecutive phases of the cycle. Our previous light microscopical findings that morphological changes are mainly restricted to a short period prior to and after shedding are confirm...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221703
更新日期：1975-06-24 00:00:00
abstract：:Induction of HIF-1α by oxygen limitation promotes increased phosphorylation and catalytic depression of mitochondrial pyruvate dehydrogenase (PDH) and an enhanced glycolytic poise in cells. Cobalt chloride and desferrioxamine are widely used as mimics for hypoxia because they increase the levels of HIF-1α. We evaluate...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1517-2
更新日期：2013-01-01 00:00:00
abstract：:This study provides information on the rates of DNA synthesis, sites of DNA synthesis, and DNA content of the avian salt gland during the osmotic stressing (plasma membrane synthesis) and destressing (plasma membrane turnover) cycle, in an effort to better understand the relationship of cell turnover to the initial ev...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00214782
更新日期：1982-01-01 00:00:00
abstract：:As luminal fluid moves from the seminiferous tubule and enters the rete testis, its protein concentration declines from approximately 6 mg/ml to 1 mg/ml. It was therefore suggested that protein is either 1) utilized by the spermatozoa, 2) transported across the epithelium of the terminal segment of the seminiferous tu...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00213810
更新日期：1983-01-01 00:00:00
abstract：:The presence and distribution in the peri-insular region of extracellular matrix, and in particular basement membrane, was investigated in a comparative study comprising pancreata of rat, dog, pig, and man. Basement membrane markers, collagen type-IV and laminin, were determined immunohistochemically. Additional infor...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318700
更新日期：1992-01-01 00:00:00
abstract：:Using in vitro autoradiography, binding sites of 125I-ANP (atrial natriuretic peptide) were localized in the rat placenta, visceral yolk sac, and decidua at 16, 18, and 20 days of gestation. There was diffuse binding over the labyrinthine region of the placenta and an intense binding over the decidual gland and viscer...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00302744
更新日期：1993-05-01 00:00:00
abstract：:The vertebrate limb is a powerful model system for studying the cellular and molecular interactions that determine morphological pattern during embryonic development. Recent advances in our understanding of these interactions have shed new light on the molecular mechanisms of vertebrate limb development, evolution and...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s004410051261
更新日期：1999-04-01 00:00:00
abstract：:Vesicular transport involves SNARE (soluble- N-ethylmaleimide-sensitive-factor-attachment-protein-receptor) proteins on transport vesicles and on target membranes. Syntaxin 13 is a SNARE enriched in brain, associated with recycling endosomes; its overexpression in PC12 cells promotes neurite outgrowth. This suggests a...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-002-0600-5
更新日期：2002-08-01 00:00:00
abstract：:The structure of the two integumental layers comprising the carapace of female D. magna was examined at several points through the molt cycle. The epicuticle and procuticle are simple in organisation; pore canalsare absent but intracuticular fibres are present, forming complexes with invaginations of the epidermal pla...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00214213
更新日期：1976-06-14 00:00:00
abstract：:The acrosome is a special organelle that develops from the Golgi apparatus and the endolysosomal compartment in the spermatids. Centromere protein E (CENP-E) is an essential kinesin motor in chromosome congression and alignment. This study is aimed at investigating the roles and mechanisms of kinesin-7 CENP-E in the f...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-020-03341-3
更新日期：2020-11-25 00:00:00
abstract：:Tenidap is a structurally novel antirheumatic agent with anti-inflammatory and analgesic properties. Previous studies have shown that tenidap is able to inhibit the production and action of cytokines such as interleukin-1, interleukin-6 (IL-6) and tumour necrosis factor alpha. However, the mechanisms by which tenidap ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050810
更新日期：1997-05-01 00:00:00
