Abstract:
:Neurotrophins signal via a dual-receptor system comprising receptor tyrosine kinases, the Trks, and a tumor necrosis factor (TNF) receptor like molecule, p75. Interest in these receptors was spurred on by the finding that they are employed by their neurotrophin ligands to activate opposing cellular mechanisms. Signalling via Trk receptors promotes the survival of embryonic neurons, whereas activation of p75 can trigger apoptosis. However, this antagonistic view is an oversimplification. It is more accurate to refer to this system as a signalling network in which ligands, receptors and their intracellular target proteins are linked by balanced biochemical interactions. This article reviews recent advances in our understanding of these molecular mechanisms which critically determine many cell-type-specific responses to neurotrophins. Emphasis is given to the formation of receptor complexes, the generation of receptor diversity by alternative splicing and the influence exerted by the local membrane environment on neurotrophin signalling.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Dechant Gdoi
10.1007/s004410100378keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
229-38issue
2eissn
0302-766Xissn
1432-0878journal_volume
305pub_type
杂志文章,评审abstract::Periderm granules in the support cells of regenerating feathers of mature male Jungle Fowls were studied ultrastructurally and histochemically. Histochemical results showed the absence of carbohydrate and lipid, and the presence of protein in the periderm granules. The periderm granules were measured at successive lev...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220749
更新日期:1978-09-05 00:00:00
abstract::The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is thought to regulate crucial cellular functions such as mitosis, apoptosis, migration, differentiation and communication between organelles as a scaffold protein. These diverse functions are modulated by the tyrosine/serine phosphorylation status of P...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-016-2508-5
更新日期:2017-06-01 00:00:00
abstract::Transplantation of ligament-tissue-derived stem cells has become a promising approach in the repair of injured ligament. Neovascularization plays an important role in ligament healing and remodeling. Recently, human umbilical-cord-blood-derived CD34+ cells have been reported to contribute to neoangiogenesis. Therefore...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-015-2250-4
更新日期:2015-12-01 00:00:00
abstract::Besides its function at cholinergic synapses, acetylcholinesterase (AChE) exerts structural functions on neural differentiation, independent of its enzymatic activity. To elucidate such functions, we have previously heterologously expressed AChE in histotypic retinal reaggregates, revealing strong effects on their his...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410100444
更新日期:2001-11-01 00:00:00
abstract::Pituitary somatotrops were localized in four species from the genus Oncorhynchus using an antiserum to chum salmon (Oncorhynchus keta) growth hormone. The antiserum cross-reacted specifically with the acidophils in the caudal pars distalis of all species tested. Corroborative immunodiffusion studies were also conducte...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218126
更新日期:1983-01-01 00:00:00
abstract::Early in postnatal life, the first wave of spermatogenesis is accompanied by an initial wave of germ cell apoptosis. This may reflect an adjustment in the number of germ cells that can be adequately maintained by Sertoli cells. Two major pathways (intrinsic and extrinsic) are involved in the process of caspase activat...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0186-4
更新日期:2006-09-01 00:00:00
abstract::Rat blood monocytes contain granules of two types, primary and secondary granules, which can be distinguished on morphological grounds. Secondary granules have a halo between the limiting membrane and the matrix; primary granules have no halo and are generally more elongate than the secondary granules. In addition, th...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00226665
更新日期:1977-11-30 00:00:00
abstract::Subsurface cisterns (SSC's) and less frequent lamellar bodies (LB's) were identified in the granule cells of the guinea-pig fascia dentata. Both structures, composed of flattened or collapsed agranular cisterns, are continuous with the regular rough endoplasmic reticulum and occasionally connected with each other form...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF01258502
更新日期:1982-01-01 00:00:00
abstract::The pituitary gland is first evident in rainbow trout two weeks before hatching. Differentiation of prolactin and ACTH cells is not marked until 3-4 days after hatching when the follicular arrangement of the prolactin cells become apparent. There is no difference in the time of development of either prolactin or ACTH ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00209283
更新日期:1978-05-29 00:00:00
abstract::Changes in the frequency of endocrine cells are evidence of intestinal adaptation to germ-free (GF) status. Not only the distribution of these cells along the intestine, but also the differences in intracellular content of these regulatory peptides may be explored to explain functional and structural aspects of GF int...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410000323
更新日期:2001-03-01 00:00:00
abstract::Brain injuries trigger physiological reactions which are mediated by a number of cytokines including interleukin-6 (IL-6), ciliary neurotrophic factor (CNTF), and leukemia inhibitory factor (LIF). Astrocytes and microglia, the protagonists in these traumatic responses, are known to secrete a variety of paracrine signa...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-002-0624-x
更新日期:2002-11-01 00:00:00
abstract::The expression of corticosteroids and regional expression 16 (CR16) and neural Wiscott-Aldrich syndrome protein (N-WASP) was studied in the testes of men with idiopathic azoospermia by (1) immunohistochemistry and Western blot to detect the expression of CR16 and N-WASP protein, (2) reverse transcription with the poly...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-011-1159-9
更新日期:2011-06-01 00:00:00
abstract::Stellate cells in the rabbit adenohypophysis were observed electron microscopically under normal and experimental conditions such as lactation, thyroidectomy, adrenalectomy, or castration. In control animals stellate cells had a scanty cytoplasm surrounding the nucleus and possessed slender processes extending between...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00234784
更新日期:1980-01-01 00:00:00
abstract::Using anti-carp-gonadotropic-gamma-globulin, the indirect immunofluorescence technique was applied to sections of the pituitary of 12 teleost species. From the investigated species, the Poeciliinae, and especially the black molly, showed a distinct localization of fluorescent cells in the mesoadenohypophysis. Strong f...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00224328
更新日期:1976-03-16 00:00:00
abstract::The globiferous pedicellariae of Psammechinus miliaris are described. Two fixation methods giving minimal distortion and rapid tissue hardening were adapted for soft tissue preparation for scanning electron microscopy. The pedicellarial valves are covered by a microvillous epithelium. The outer valve epithelial microv...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220184
更新日期:1975-10-13 00:00:00
abstract::Serine proteases, cysteine proteases, aspartic proteases and matrix metalloproteinases play an essential role in extracellular matrix remodeling and turnover through their proteolytic action on collagens, proteoglycans, fibronectin, elastin and laminin. Proteases can also act on chemokines, receptors and anti-microbia...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-012-1390-z
更新日期:2013-02-01 00:00:00
abstract::The kidney is an organ involved in cross talk with many human organs. The link between the immune system and the kidney has been studied in some detail, although data precisely elucidating their interaction are sparse, in particular with regard to the function of the kidney filter apparatus. Current research suggests ...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-017-2635-7
更新日期:2017-07-01 00:00:00
abstract::Two dozen hybrid clones were produced by fusion of diploid embryonic stem (ES) cells positive for green fluorescent protein (GFP) with tetraploid fibroblasts derived from DD/c and C57BL-I(I)1RK mice. Cytogenetic analysis demonstrated that most cells from these hybrid clones contained near-hexaploid chromosome sets. Ad...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-010-0987-3
更新日期:2010-06-01 00:00:00
abstract::The inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular Ca2+ release channel responsible for mobilizing stored Ca2+. Three different receptor types have been molecularly cloned, and their genes have been classified into a family. The gene for the type 1 receptor (IP3R1) is predominantly expressed in cereb...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00307790
更新日期:1995-05-01 00:00:00
abstract::Adult male Branta canadensis maxima were collected from a nonmigratory feral population during their premolt, molt and postmolt phases. Lean dry weight of the pectoralis muscle decreased significantly (p less than or equal to 0.0001) during molt, as a result of disuse atrophy. Histochemical analysis revealed that the ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215763
更新日期:1987-03-01 00:00:00
abstract::To examine the morphological evidence of the nature of hormone release from castration cells the author gonadectomized neonatal male and female rats. Twenty-eight days after the operation the animals were pretreated with estrogen, progesterone, or estrogen and progesterone in combination, every other day for one week,...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218301
更新日期:1982-01-01 00:00:00
abstract::To determine whether lipid-secreting cells have cytosolic Ca2+ concentration ([Ca2+]c)-related secretory mechanisms, morphological changes and intracellular calcium dynamics of Harderian glands of guinea pigs stimulated by secretagogue were studied by electron microscopy and Fura-2/AM digital image analysis. Control g...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00327979
更新日期:1993-10-01 00:00:00
abstract::The occurrence of neurons possessing high-affinity uptake sites for GABA was studied in the myenteric plexus of the guinea-pig ileum, caecum, and proximal and distal colon, the rat proximal colon, and the chicken gizzard with the use of 3H-GABA and autoradiography. Experiments were carried out on plexuses that had bee...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217417
更新日期:1983-01-01 00:00:00
abstract::Most myenteric neurons contain one of the two generating enzymes for major excitatory and inhibitory neurotransmitters: choline acetyltransferase (ChAT) or neuronal nitric oxide synthase (NOS). Two minor groups of myenteric neurons contain either both enzymes or neither. Our study had two aims: (1) to compare the prop...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0852-4
更新日期:2009-10-01 00:00:00
abstract::The surface coat of the electrocyte of the main electric organ of Electrophorus electricus was studied using cytochemical methods (periodic acid-silver methanamine, periodic acid-chromic acid-silver methenamine, periodic acid-thiosemicarbazide-silver proteinate, Concanavalin A - horseradish peroxidase, ruthenium red, ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00226622
更新日期:1977-09-26 00:00:00
abstract::"White pigment cells" are derived from melanophore precursors and contain both melanophore-specific and iridophore-specific pigment organelles. Whereas melanophores differentiate in the wild type regenerating tail, white pigment cells appear in the regenerating tail in the periodic albino mutant (a(p)/a(p)) of Xenopus...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-015-2133-8
更新日期:2015-09-01 00:00:00
abstract::Previous light-microscopic and ultra-immunohistochemical tracer studies revealed the existence of an independent local immune response of the simian oral mucosa. This local response is attributed to the presence of minor salivary gland (MSG) duct-related lymphoid tissue. Semithin sections from a total of 263 Epon-embe...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217578
更新日期:1985-01-01 00:00:00
abstract::Sections of glutaraldehyde-OsO4-fixed, plastic-embedded rat incisor enamel were left untreated, stained, decalcified (1% formic acid in 10% sodium citrate), or decalcified-stained. The presence of apatite crystals was monitored with electron diffraction. After brief decalcification and staining, apatite crystals and m...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215908
更新日期:1986-01-01 00:00:00
abstract::Light and electron microscopy of the hypothalamic ventricle in neonatal rats demonstrate morphological specializations of the ventricular wall at the level of the premammillary region of the third ventricle. The morphological features are: (1) A ventricular recess that we have called the "hypothalamic dorso-lateral re...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214672
更新日期:1987-10-01 00:00:00
abstract::The cellular response of non-neuronal elements of the pyramidal cell layer of the rat hippocampus, especially the area CA3, was observed electron microscopically following destruction of this formation by means of intraventricular administration of kainic acid (KA). The neuroglial cell types responding to the KA-induc...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00238652
更新日期:1981-01-01 00:00:00