Molecular interactions between neurotrophin receptors.

Abstract:

:Neurotrophins signal via a dual-receptor system comprising receptor tyrosine kinases, the Trks, and a tumor necrosis factor (TNF) receptor like molecule, p75. Interest in these receptors was spurred on by the finding that they are employed by their neurotrophin ligands to activate opposing cellular mechanisms. Signalling via Trk receptors promotes the survival of embryonic neurons, whereas activation of p75 can trigger apoptosis. However, this antagonistic view is an oversimplification. It is more accurate to refer to this system as a signalling network in which ligands, receptors and their intracellular target proteins are linked by balanced biochemical interactions. This article reviews recent advances in our understanding of these molecular mechanisms which critically determine many cell-type-specific responses to neurotrophins. Emphasis is given to the formation of receptor complexes, the generation of receptor diversity by alternative splicing and the influence exerted by the local membrane environment on neurotrophin signalling.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Dechant G

doi

10.1007/s004410100378

keywords:

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

229-38

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

305

pub_type

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