Abstract:
:Coincident with an increase in the water permeability of toad urinary bladder induced by serosal hypertonicity, a transformation of the ridge-like surface structures of the granular cells into individual microvillous structures occurs. This study was initiated to establish whether the transformation is mediated by the cytoskeletal network and, thus, can be prevented by disruption of microtubule-microfilament function with colchicine or cytochalasin B (CB). Scanning electron microscopy revealed the characteristic branching ridges on granular cells of control bladder incubated with colchicine or CB. In contrast, transformation of ridges to discrete microvilli was observed in experimental bladders exposed to serosal hypertonicity alone or in combination with either colchicine or CB. These results suggest that the mechanism underlying hypertonicity-induced surface changes which are associated with increased water permeability does not involve either microtubules or microfilaments.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Dratwa M,LeFurgey A,Tisher CCdoi
10.1007/BF00217226subject
Has Abstractpub_date
1984-01-01 00:00:00pages
585-91issue
3eissn
0302-766Xissn
1432-0878journal_volume
236pub_type
杂志文章abstract::To investigate the mechanisms whereby bone cells absorb organic bone-matrix components during endochondral bone development, rat humeri were examined, employing horseradish peroxidase as a soluble protein tracer. Intravenously-injected peroxidase filled the osteoid layer and penetrated into the osteocyte lacunae and c...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219233
更新日期:1985-01-01 00:00:00
abstract::The fan-shaped body is the largest substructure of the central complex in Drosophila melanogaster. Two groups of large-field neurons that innervate the fan-shaped body, viz., F1 and F5 neurons, have recently been found to be involved in visual pattern memory for "contour orientation" and "elevation" in a rut-dependent...
journal_title:Cell and tissue research
pub_type: 杂志文章
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abstract::We compare the ultrastructure of the gerbil sublingual gland as seen after cryofixation followed by substitution with osmium tetroxide, with the more familiar appearance of material processed by glutaraldehyde-osmium chemical fixation. After primary cryofixation of fresh salivary glands, the nuclei of the mucous cells...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219075
更新日期:1987-11-01 00:00:00
abstract::In previous studies the differentiation of the epithelium in the human hard palate has been described stereologically using parameters expressed per unit tissue volume. Since single epithelial cells represent the true biological units of this tissue, it became necessary to estimate the absolute size of such cells in o...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216577
更新日期:1981-01-01 00:00:00
abstract::Purinergic P2X receptors associated with the parasympathetic nerves supplying human bladder smooth muscle (detrusor) are implicated in control of detrusor contractility. The relative abundance of all seven subtypes colocalised with synaptic vesicles on parasympathetic nerves was examined in specimens from normal adult...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-003-0788-z
更新日期:2003-12-01 00:00:00
abstract::To identify structures involved in the translocation of the synaptic vesicles towards the presynaptic membrane, an ultrastructural study has been undertaken by means of (1) the E-PTA stain and (2) the HMM-labeling procedure. Using serial sections of E-PTA stained nervous tissue, especially those made in transversal an...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219841
更新日期:1975-06-27 00:00:00
abstract::Golgi- and fluorescence-histochemical studies in the chicken shown the presence of a sharply delimited group of aminergic neurons beneath the floor of the fourth ventricle at the mesen-metencephalic boundary. According to the observations reported in other avian species a homology can be established between the mammal...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216221
更新日期:1982-01-01 00:00:00
abstract::The acrosome is a special organelle that develops from the Golgi apparatus and the endolysosomal compartment in the spermatids. Centromere protein E (CENP-E) is an essential kinesin motor in chromosome congression and alignment. This study is aimed at investigating the roles and mechanisms of kinesin-7 CENP-E in the f...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-020-03341-3
更新日期:2020-11-25 00:00:00
abstract::Fibres growing from neurons of explanted dorsal root ganglia from 10 day chick embryos were transected and subsequently observed by light and electron microscopy after periods of a few to fifty minutes. Changes immediately proximal and distal to the cut together with alterations further away from the site of injury on...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219562
更新日期:1978-07-10 00:00:00
abstract::In the atherosclerotic plaque, smooth muscle cells (SMC) acquire an inflammatory phenotype. Resistin and fractalkine (CX3CL1) are found in human atheroma and not in normal arteries. CX3CL1 and CX3CR1 are predominately associated with SMC. We have questioned whether resistin has a role in the expression of CX3CL1 and C...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-012-1510-9
更新日期:2013-01-01 00:00:00
abstract::The formation of secretory granules in chronically hypersecretory melanotrophs in the rat pituitary was studied. Hypersecretion was induced by treatment with the dopamine antagonist haloperidol (1.5 mg/kg daily for 7 days), which releases the normal neural dopaminergic inhibition of secretion from the melanotroph. Mor...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00319432
更新日期:1994-02-01 00:00:00
abstract::The maternal-fetal interface, a chimeric structure, is formed when fetal cytotrophoblasts (CTBs) from the placenta invade the uterine wall and its resident vasculature. In preeclampsia (PE), interstitial and endovascular invasion are often shallow, and fewer spiral arterioles are breached in toto. Our previous work ha...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0428-0
更新日期:2007-09-01 00:00:00
abstract::Antibodies against laminin (LN), fibronectin (FN), collagen type IV (Col IV), neural cell adhesion molecule (N-CAM), T-61 antigen, actin, tubulin and neurofilament protein were injected into the eyes of quail embryos (Coturnix coturnix japonica) of different ages. Twenty h after injection, the heads of the embryos wer...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217320
更新日期:1987-09-01 00:00:00
abstract::Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have revealed the molecular characteristics of human neuroblastomas, including abnormalities at genome, epigenome and transcriptome levels. However...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-018-2796-z
更新日期:2018-05-01 00:00:00
abstract::To study the biosynthesis and intracellular migration of glycoproteins in the adrenal gland, adult mice were injected intravenously with L-(3H)-fucose and killed from 10 min to 14 days after injection. Semi-thin sections of the adrenal glands were then processed for radioautography. Incorporation of labeled fucose occ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00232246
更新日期:1979-11-01 00:00:00
abstract::In the present study, we used ultrastructural cytochemistry to analyze the distribution of nuclear and cytoplasmic nucleic acids and polysaccharides, and electron spectroscopic imaging to map the element phosphorus in immature erythroid cells taken from two amphibians, the diploid Bufo ictericus and the tetraploid Odo...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00305791
更新日期:1994-10-01 00:00:00
abstract::Exposure to maternal diabetes during fetal growth is a risk factor for the development of type II diabetes (T2D) in later life. Discovery of the mechanisms involved in this association should provide valuable background for therapeutic treatments. Early embryogenesis involves epigenetic changes including histone modif...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-017-2583-2
更新日期:2017-06-01 00:00:00
abstract::To further evaluate the role of autonomic ganglia in the regulation of pelvic visceral activity, the neural elements in the major pelvic ganglion of the male rat have been studied with histochemixal and electron microscopic techniques. The principal findings are that the ganglion is composed of cholinergic and adrener...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00231994
更新日期:1975-05-27 00:00:00
abstract::Steroid hormones intervene in the structural and functional regulation of neuronal processes during development and thus determine brain differentiation. The effects of estrogens are mediated by two transcription factors, namely estrogen receptor α (ER-α) and estrogen receptor β (ER-β), that regulate the expression of...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-014-2023-5
更新日期:2015-02-01 00:00:00
abstract::In situ hybridisation and immunohistochemistry analyses have shown that the Ciona intestinalis tumour necrosis factor alpha gene (CiTNFalpha), which has been previously cloned and sequenced, is expressed either during the inflammatory pharynx response to lipopolysaccharide (LPS) or during the swimming larval phase of ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-010-0993-5
更新日期:2010-08-01 00:00:00
abstract::The amniotic epithelium constitutes a diffusion barrier controlling the passage of solutes and water between the amniotic cavity and maternal circulation. With the present immunocytochemical approach, we have shown that several major components of the cyto-skeleton, i.e., actin, alpha-actinin, spectrin and ezrin, are ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00318194
更新日期:1991-11-01 00:00:00
abstract::A gelsolin-related protein was isolated from seminal vesicles of the annelid Lumbricus terrestris. Compared with the isoforms of the gelsolin-related protein previously found in the muscle of the annelid body wall, the isolated protein was assigned to the first isoform (EWAM-P1) because of its electrophoretic mobility...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0561-9
更新日期:2008-04-01 00:00:00
abstract::Enzyme-histochemical methods were used to study the metabolic activity of specialized ependyma of the ventrolateral walls and floor of the third ventricle in young male and female rats during the "critical period" of sexual differentiation of the hypothalamus (one week after birth). Histochemical tests were conducted ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220328
更新日期:1976-10-13 00:00:00
abstract::The freshwater polyp Hydra magnipapillata has a primitive nervous system that produces at least three distinct classes of neuropeptides: various peptides having the C-terminal sequence Arg-Phe-NH2 (the Hydra-RFamide family), Leu-Trp-NH2 (the Hydra-LWamide family), and a single peptide having the C-terminal sequence Ly...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410000240
更新日期:2000-08-01 00:00:00
abstract::Transgenic rats for the murine Ren-2 gene display high blood pressure, low circulating levels of angiotensin II, and high renin content in the adrenal glands. Moreover, transgenic rats possess an increased aldosterone secretion (maximal from 6 to 18 weeks of age), paralleling the development of hypertension. To invest...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00305774
更新日期:1994-10-01 00:00:00
abstract::It is known that human and animal fibroblasts are able to induce the retraction of a fibrin clot. In the present study the correlation between (i) fibrin-fibroblasts during growth, (ii) the number of actin stress-lines in mouse fibroblasts during growth in culture, and (iii) the sensitivity of actin stress-lines to a ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218485
更新日期:1982-01-01 00:00:00
abstract::Zebrafish (Danio rerio) is widely used as an animal model to understand the pathophysiology of cardiovascular diseases. Here, we present the adult cardiac phenotype of weak atrium, myh6-/-, which carry mutations in the zebrafish atrial myosin heavy chain. Homozygous mutants survive to adulthood and are fertile despite...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-019-03044-4
更新日期:2019-11-01 00:00:00
abstract::The functional expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and MAdCAM-1 in the choroid plexus is indicative of a role of this structure in the communication of the immune system with the central nervous system (CNS). In order to gain further insight into the pos...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410051287
更新日期:1999-05-01 00:00:00
abstract::Striated rootlets in ciliated cells are conical banded structures composed of longitudinally aligned filaments. The formation of striated rootlets during ciliognesis in the human oviduct epithelium was studied by electron microscopy. Primitive rootlets appeared at the proximal side of basal bodies before or at the sam...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050905
更新日期:1997-10-01 00:00:00
abstract::Antibodies raised against the cystic fibrosis transmembrane regulator protein (CFTR) were used to localize CFTR in intestinal tissues of piglets and mice. Positive staining for CFTR was detected in goblet cells of both species. A second population of epithelial cells of unknown phenotype was also labeled by anti-CFTR ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050531
更新日期:1996-02-01 00:00:00