Disease modeling in genetic kidney diseases: zebrafish.

Abstract:

:Growing numbers of translational genomics studies are based on the highly efficient and versatile zebrafish (Danio rerio) vertebrate model. The increasing types of zebrafish models have improved our understanding of inherited kidney diseases, since they not only display pathophysiological changes but also give us the opportunity to develop and test novel treatment options in a high-throughput manner. New paradigms in inherited kidney diseases have been developed on the basis of the distinct genome conservation of approximately 70 % between zebrafish and humans in terms of existing gene orthologs. Several options are available to determine the functional role of a specific gene or gene sets. Permanent genome editing can be induced via complete gene knockout by using the CRISPR/Cas-system, among others, or via transient modification by using various morpholino techniques. Cross-species rescues succeeding knockdown techniques are employed to determine the functional significance of a target gene or a specific mutation. This article summarizes the current techniques and discusses their perspectives.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Schenk H,Müller-Deile J,Kinast M,Schiffer M

doi

10.1007/s00441-017-2593-0

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

127-141

issue

1

eissn

0302-766X

issn

1432-0878

pii

10.1007/s00441-017-2593-0

journal_volume

369

pub_type

杂志文章,评审
  • Thy-1 is an in vivo and in vitro marker of liver myofibroblasts.

    abstract::Thy-1, a glycophosphatidylinositol-linked glycoprotein of the outer membrane leaflet, has been described in myofibroblasts of several organs. Previous studies have shown that, in fetal liver, Thy-1 is expressed in a subpopulation of ductular/progenitor cells. The aim of this study has been to investigate whether the l...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-007-0437-z

    authors: Dudas J,Mansuroglu T,Batusic D,Saile B,Ramadori G

    更新日期:2007-09-01 00:00:00

  • Biological and bioinformatical approaches to study crosstalk of long-non-coding RNAs and chromatin-modifying proteins.

    abstract::Long-non-coding RNA (lncRNA) regulates gene expression through transcriptional and epigenetic regulation as well as alternative splicing in the nucleus. In addition, regulation is achieved at the levels of mRNA translation, storage and degradation in the cytoplasm. During recent years, several studies have described t...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审

    doi:10.1007/s00441-014-1885-x

    authors: Backofen R,Vogel T

    更新日期:2014-06-01 00:00:00

  • The origin of the dendritic reticulum cell. An experimental enzyme-histochemical and electron microscopic study on the rabbit spleen.

    abstract::To obtain more information concerning the origin of dendritic reticulum cells, the development of germinal centers in the spleens of rabbits was investigated by conventional light microscopy, enzyme histochemistry, and electron microscopy. Washed sheep erythrocytes were used as antigen. Splenic tissue was examined on ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00237632

    authors: Heusermann U,Zurborn KH,Schroeder L,Stutte HJ

    更新日期:1980-01-01 00:00:00

  • An electron microscopic study of Babesia microti invading erythrocytes.

    abstract::Intracellular sporozoan parasites invade the host cell through the invagination of the plasma membrane of the host and a vacuole is formed which accommodates the entering parasite. The vacuole may disappear and the invaginated membrane of the host then becomes closely apposed to that of the parasite's own membrane. As...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00219605

    authors: Rudzinska MA,Trager W,Lewengrub SJ,Gubert E

    更新日期:1976-06-28 00:00:00

  • A steroid hormone affects sodium channel expression in Manduca central neurons.

    abstract::Neuronal differentiation is characterized by stereotypical sequences of membrane channel and receptor acquisition. This is regulated by the coordinated interactions of a variety of developmental mechanisms, one of which is the control by steroid hormones. We have used the metamorphosis of the holometabolous insect, Ma...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-006-0175-7

    authors: Börner J,Puschmann T,Duch C

    更新日期:2006-07-01 00:00:00

  • A freeze-fracture study of perinatal changes of intramembranous particles in microvilli of absorptive cells in mouse small intestine.

    abstract::Perinatal changes in the appearance of intramembranous particles (IMPs) of microvilli of enterocytes were analyzed quantitatively. In both the jejunum and the ileum, the IMP density on the P-face showed no significant changes from day 17 of gestation to day 5 of postnatal life. It increased between day 5 and day 12, r...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00212224

    authors: Arima T,Yamamoto T

    更新日期:1983-01-01 00:00:00

  • Distribution of ionocytes in the saccular epithelium of the inner ear of two teleosts (Oncorhynchus mykiss and Scophthalmus maximus).

    abstract::The saccular membranes of trout (Oncorhynchus mykiss) and turbot (Scophthalmus maximus) were examined to characterize specialized epithelial cells that might be responsible for ion exchange. The approach for localizing cell types was new for this tissue, as observations were made with a stereomicroscope and a light mi...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410050851

    authors: Mayer-Gostan N,Kossmann H,Watrin A,Payan P,Boeuf G

    更新日期:1997-07-01 00:00:00

  • Co-existence and origin of peptidergic and adrenergic nerves in the guinea pig uterus. Retrograde tracing and immunocytochemistry, effects of chemical sympathectomy, capsaicin treatment and pregnancy.

    abstract::The occurrence and distribution of peptidergic nerves in the guinea pig uterus was studied by means of immunocytochemistry using numerous neuropeptide anti-sera. Neuropeptide Y (NPY)-immunoreactive (IR) nerves were the most abundant, whereas substance P (SP)-, calcitonin gene-related peptide (CGRP)-, and neurokinin A ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00226501

    authors: Alm P,Lundberg LM

    更新日期:1988-01-01 00:00:00

  • Lead nitrate and gadolinium chloride administration modify hepatocyte cell surfaces.

    abstract::Modifications of hepatocyte cell surface were determined after single i.v. injection to rats of Pb(NO(3))(2) (known to induce liver hyperplasia followed by apoptosis) or GdCl(3) (known to induce proliferation of parenchymal cells and Kupffer cell depletion) or administration of GdCl(3) 24 h before Pb(NO(3))(2) injecti...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-003-0708-2

    authors: Pagliara P,Chionna A,Carlà EC,Caforio S,Dini L

    更新日期:2003-04-01 00:00:00

  • Fine structure of seminiferous tubules from prenatally irradiated rats.

    abstract::The ultrastructure of the seminiferous tubules was studied in rats that had been subjected to whole body irradiation on the 19th day of gestation. The seminiferous tubules from 3 months-old irradiated animals are devoid of germ cells and contain only Sertoli cells. Compared with controls of the same age, the seminifer...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00218294

    authors: Abreu I,David-Ferreira JF

    更新日期:1982-01-01 00:00:00

  • Functional morphology of the primary olfactory centers in the brain of the hermit crab Coenobita clypeatus (Anomala, Coenobitidae).

    abstract::Terrestrial hermit crabs of the genus Coenobita display strong behavioral responses to volatile odors and are attracted by chemical cues of various potential food sources. Several aspects of their sense of aerial olfaction have been explored in recent years including behavioral aspects and structure of their periphera...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-020-03199-5

    authors: Polanska MA,Kirchhoff T,Dircksen H,Hansson BS,Harzsch S

    更新日期:2020-06-01 00:00:00

  • Effect of salt loading and salt deprivation on the vasopressin and oxytocin content of the median eminence and the neural lobe in adrenalectomized rats.

    abstract::In adrenalectomized rats the influence of salt loading or salt deprivation on the vasopressin and oxytocin content of the median eminence (ME) and the neural lobe (NL) was studied by means of various methods: morphometric and microphotometric analysis of aldehyde fuchsin-stained sections of ME and NL; immunohistochemi...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审

    doi:10.1007/BF00215904

    authors: Mink D,Lang RE,Ostermann E,Bock R

    更新日期:1986-01-01 00:00:00

  • Immune complexes of E. coli antigens and maternal IgG in the bursa of Fabricius.

    abstract::The bursa of Fabricius of the chicken is known to be both a primary lymphoid organ and a secondary lymphoid tissue. Bursal follicles are equipped with antigen-trapping follicle-associated epithelium. However, bioactive antigens such as protein and bacteria have not been detected in the bursal parenchyma. By immunopero...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-013-1701-z

    authors: Sonoda K,Noguchi K,Ekino S

    更新日期:2013-12-01 00:00:00

  • Location of neurons projecting to the hypophysial stalk--median eminence in ring doves (Streptopelia roseogrisea).

    abstract::The median eminence/pituitary stalk represents the final common pathway for fibers from neurons that project to the pituitary gland. We have used the lipophilic fluorescent tracer 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) to determine the location of neurons projecting to the median emin...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00304513

    authors: Knapp R,Silver R

    更新日期:1995-04-01 00:00:00

  • Ultrastructural and cytochemical features of SV 40 transformed hypothalamic cell lines.

    abstract::A continuous cell line was previously obtained by Simian Virus (SV) 40 transformation of primary cultures of dissociated mouse fetal hypothalami. One clone from this cell line has been previously shown to possess some of the ultrastructural features, immunological properties and synthesizing capacities of magnocellula...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00219699

    authors: Tixier-Vidal A,De Vitry F

    更新日期:1976-08-16 00:00:00

  • Expression and cell-specific localization of the cholecystokinin B/gastrin receptor in the human stomach.

    abstract::Gastrin stimulates gastric acid secretion by acting on the cholecystokinin B/gastrin receptor (CCK-BR). The localization of this receptor at the cellular level showed conflicting results in animal studies and has not been described in man by immunohistochemistry. The aim of the present study is to characterize the pre...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004419900114

    authors: Kulaksiz H,Arnold R,Göke B,Maronde E,Meyer M,Fahrenholz F,Forssmann WG,Eissele R

    更新日期:2000-02-01 00:00:00

  • Uptake and transport of copolymer biodegradable microspheres by rabbit Peyer's patch M cells.

    abstract::In this study, we demonstrate the role of M cells in uptake of poly(D-L-lactic-co-glycolic acid) (PLGA) microspheres and transport into rabbit Peyer's patches. Microspheres 1 to 10 microns in diameter composed of 50:50 lactic acid:glycolic acid were instilled into intestinal segments containing jejunal or ileal Peyer'...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00318501

    authors: Ermak TH,Dougherty EP,Bhagat HR,Kabok Z,Pappo J

    更新日期:1995-02-01 00:00:00

  • Localization of monoamines in the forebrain of two salmonid species, with special reference to the hypothalamo-hypophysial system.

    abstract::In the salmon and trout aminergic cell bodies were found in the nucleus recessus lateralis (NRL) and the nucleus recessus posterioris (NRP), both of which are situated near the third ventricle. Three cell types could be distinguished. Type 1 produces a green and type 2 a yellow fluorescence. The former type probably c...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00219556

    authors: Terlou M,Ekengren B,Hiemstra K

    更新日期:1978-07-10 00:00:00

  • Immunohistochemical localization of urotensin I and other neuropeptides in the caudal neurosecretory system of three species of teleosts and two species of elasmobranchs.

    abstract::In three species of teleosts - carp Cyprinus carpio; grass carp Ctenopharyngodon idella; and crucian carp Carassius auratus - the caudal neurosecretory system displays small, medium-sized and large neurons. Urotensin I (UI)-immunoreactive and UI-nonreactive neurons were found in all three groups; in general, the numbe...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00212550

    authors: Yamada C,Yamada S,Ichikawa T,Kobayashi H

    更新日期:1986-01-01 00:00:00

  • GABA and glutamate-like immunoreactivity at synapses received by dorsal unpaired median neurones in the abdominal nerve cord of the locust.

    abstract::Dorsal unpaired median (DUM) neurones in the abdominal ganglia of the locust were impaled with microelectrodes and some were injected intracellularly with horseradish peroxidase so that their synapses could be identified in the electron microscope. Simultaneous recordings from DUM neurones in different abdominal gangl...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00307805

    authors: Pflüger HJ,Watson AH

    更新日期:1995-05-01 00:00:00

  • Developmental patterns of proteoglycan-containing extracellular matrix in perineuronal nets and neuropil of the postnatal rat brain.

    abstract::The extracellular matrix is involved in various morphogenetic processes which are accompanied by changes in its physicochemical properties and spatial organization. In the adult brain it contributes to cellular communication and the regulation of neuronal activity. The present study deals with the postnatal appearance...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410050790

    authors: Köppe G,Brückner G,Brauer K,Härtig W,Bigl V

    更新日期:1997-04-01 00:00:00

  • The influence of luteinizing hormone-releasing hormone (LHRH) on the process of protein and/or peptide secretion characterized by the formation of granular vesicles in mammalian pinealocytes. Comparative in vitro study.

    abstract::In the present study, the effect of LHRH on the process of protein and/or peptide secretion characterized by the formation of granular vesicles has been studied by means of an in vitro system in the pinealocytes of three different species of rodents. LHRH has a strong influence on the activity of this process. However...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00216426

    authors: Haldar-Misra C,Pévet P

    更新日期:1983-01-01 00:00:00

  • Immunohistochemical evidence for the presence of tryptophan hydroxylase in the brains of insects as revealed by sheep anti-tryptophan hydroxylase polyclonal antibody.

    abstract::Immediately following the discovery of tryptophan hydroxylase in Drosophila, we demonstrated the presence of tryptophan hydroxylase in the brain of the beetle Harmonia axyridis (Coleoptera: Coccinellidae). However, whether tryptophan hydroxylase is present in the brains of other insects is still a matter of discussion...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-008-0596-6

    authors: Bao X,Tian X,Zhao Z,Qu Y,Wang B,Zhang J,Liu T,Yang L,Lv J,Song C

    更新日期:2008-06-01 00:00:00

  • The 180-kD component of the neural cell adhesion molecule N-CAM is involved in cell-cell contacts and cytoskeleton-membrane interactions.

    abstract::N-CAM180, the molecular form of the three neural cell adhesion molecules (N-CAM) with the largest cytoplasmic domain, is accumulated at sites of cell-cell contact (cell bodies, neurites, growth cones) in cultures of neuroblastoma and cerebellum. At these sites the cytoskeleton-membrane linker protein brain spectrin an...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00214676

    authors: Pollerberg GE,Burridge K,Krebs KE,Goodman SR,Schachner M

    更新日期:1987-10-01 00:00:00

  • Scanning electron-microscopic study of lens fibers of the pig.

    abstract::Whole pigs lenses were fixed, critical-point dried and fractured, and the internal surfaces examined with a scanning electron microscope. At various locations from the equator to the center of the lens four types of fibers can be distinguished. The superficial fibers have small interdigitations. Cortical lens fibers, ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00217281

    authors: Hoyer HE

    更新日期:1982-01-01 00:00:00

  • Development and retention of phenotypically specialized cells in pituitary allografts in the hamster (Mesocricetus auratus).

    abstract::We used immunohistochemistry to identify cells present in pituitary allografts in the hamster. Hypophyses removed from neonatal hamsters or adenohypophyses removed from adult females were placed beneath renal capsules of hypophysectomized adult females. Serum PRL, LH, and GH concentrations were measured at two, five a...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00215467

    authors: Campbell GT,Wagoner J,Colosi P,Soares MJ,Talamantes F

    更新日期:1988-01-01 00:00:00

  • Sigma receptor 1 modulates ER stress and Bcl2 in murine retina.

    abstract::Sigma receptor 1 (σR1), a non-opiate transmembrane protein located on endoplasmic reticulum (ER) and mitochondrial membranes, is considered to be a molecular chaperone. Marked protection against cell death has been observed when ligands for σR1 have been used in in vitro and in vivo models of retinal cell death. Mice ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-013-1774-8

    authors: Ha Y,Shanmugam AK,Markand S,Zorrilla E,Ganapathy V,Smith SB

    更新日期:2014-04-01 00:00:00

  • Demonstration of the granular layer and the fate of the hyaline layer during the development of a sea urchin (Lytechinus variegatus).

    abstract::Employing electron-microscopic methods that help retain polyanionic materials, we describe the extracellular coverings of a sea urchin (Lytechinus variegatus) throughout ontogeny. The surface of the embryo is covered by a two-layered cuticle (commonly called the hyaline layer), which in turn is covered by a granular l...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00218028

    authors: Cameron RA,Holland ND

    更新日期:1985-01-01 00:00:00

  • Lysosomes and pancreatic islet function. A quantitative estimation of crinophagy in the mouse pancreatic B-cell.

    abstract::Ultrastructural studies of pancreatic islets have suggested that crinophagy provides a possible mechanism for intracellular degradation of insulin in the insulin-producing B-cells. In the present study, a quantitative estimation of crinophagy in mouse pancreatic islets was attempted by morphometric analysis of lysosom...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00213820

    authors: Schnell AH,Swenne I,Borg LA

    更新日期:1988-04-01 00:00:00

  • The Canoe protein is necessary in adherens junctions for development of ommatidial architecture in the Drosophila compound eye.

    abstract::Rhabdomeres of the Drosophila melanogaster canoemisl mutant ommatidia were twisted, branched, and often fused to each other. A considerable proportion of rhabdomeres were found to have fallen below the retinal basement membrane. Electron-microscopic observations of the mutant ommatidia revealed that microvilli, the su...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004419900107

    authors: Matsuo T,Takahashi K,Suzuki E,Yamamoto D

    更新日期:1999-12-01 00:00:00