Abstract:
:N-CAM180, the molecular form of the three neural cell adhesion molecules (N-CAM) with the largest cytoplasmic domain, is accumulated at sites of cell-cell contact (cell bodies, neurites, growth cones) in cultures of neuroblastoma and cerebellum. At these sites the cytoskeleton-membrane linker protein brain spectrin and actin are also accumulated. Brain spectrin copurifies with N-CAM180 by immunoaffinity chromatography and binds specifically to N-CAM180 but not to N-CAM140 or N-CAM120 in a solid-phase binding test. These observations indicate an association of N-CAM180 with the cytoskeleton in vivo. This association may underlie the reduced lateral mobility of N-CAM180 in the surface membrane compared to N-CAM140 (Pollerberg et al. 1986). Together with the fact that N-CAM180 is only expressed after termination of neuron migration in vivo (Persohn and Schachner, unpublished) these results suggest a role for N-CAM180 in stabilization of cell contacts.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Pollerberg GE,Burridge K,Krebs KE,Goodman SR,Schachner Mdoi
10.1007/BF00214676subject
Has Abstractpub_date
1987-10-01 00:00:00pages
227-36issue
1eissn
0302-766Xissn
1432-0878journal_volume
250pub_type
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