Abstract：
:Long-non-coding RNA (lncRNA) regulates gene expression through transcriptional and epigenetic regulation as well as alternative splicing in the nucleus. In addition, regulation is achieved at the levels of mRNA translation, storage and degradation in the cytoplasm. During recent years, several studies have described the interaction of lncRNAs with enzymes that confer so-called epigenetic modifications, such as DNA methylation, histone modifications and chromatin structure or remodelling. LncRNA interaction with chromatin-modifying enzymes (CME) is an emerging field that confers another layer of complexity in transcriptional regulation. Given that CME-lncRNA interactions have been identified in many biological processes, ranging from development to disease, comprehensive understanding of underlying mechanisms is important to inspire basic and translational research in the future. In this review, we highlight recent findings to extend our understanding about the functional interdependencies between lncRNAs and CMEs that activate or repress gene expression. We focus on recent highlights of molecular and functional roles for CME-lncRNAs and provide an interdisciplinary overview of recent technical and methodological developments that have improved biological and bioinformatical approaches for detection and functional studies of CME-lncRNA interaction.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Backofen R,Vogel Tdoi
10.1007/s00441-014-1885-xsubject
Has Abstractpub_date
2014-06-01 00:00:00pages
507-26issue
3eissn
0302-766Xissn
1432-0878journal_volume
356pub_type
杂志文章,评审abstract：:The cellular response of non-neuronal elements of the pyramidal cell layer of the rat hippocampus, especially the area CA3, was observed electron microscopically following destruction of this formation by means of intraventricular administration of kainic acid (KA). The neuroglial cell types responding to the KA-induc...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00238652
更新日期：1981-01-01 00:00:00
abstract：:Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have revealed the molecular characteristics of human neuroblastomas, including abnormalities at genome, epigenome and transcriptome levels. However...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-018-2796-z
更新日期：2018-05-01 00:00:00
abstract：:Whether an axon will regenerate after it is cut depends on the balance between the intrinisic ability of the axon to regrow and the permissiveness of the environment surrounding it. The permissiveness of the environment is determined by the glial cells at the site of injury, and in the CNS both oligodendrocytes and as...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s004410050943
更新日期：1997-11-01 00:00:00
abstract：:Ependymal cells and their junctional complexes in the area postrema of the rat were studied in detail by tracer experiments using horseradish peroxidase (HRP) and colloidal lanthanum and by freeze-etch techniques, in addition to routine electron microscopy. The ependyma of the area postrema is characterized as flatten...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00235058
更新日期：1979-09-03 00:00:00
abstract：:Vitrification of biological specimens in liquid nitrogen can be achieved under high pressure (2,100 bars). This procedure obviates the use of aldehyde fixation and cryoprotection (glycerol). The present work demonstrates its applicability to the freeze-etching of mammalian brain tissue. Freeze-fracture repicas from ra...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237626
更新日期：1980-01-01 00:00:00
abstract：:Stereological studies showed that treatment of normal adult human adrenocortical cells in primary culture with ACTH or cyclic-AMP for 2 days results in similar increases in the volume of cells, of the mitochondrial and "membrane space" compartments and of the surface area of the smooth endoplasmic reticulum and mitoch...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218169
更新日期：1978-07-05 00:00:00
abstract：:A somatostatin-like substance is demonstrated by light microscopic immunohistochemistry (PAP-method) in perikarya and cell processes of the retina of adult and infant rats. These perikarya are identified according to their size, arrangement and distribution. Each of the first two neuronal orders (receptors, bipolar ce...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00235169
更新日期：1979-01-01 00:00:00
abstract：:Scanning electrom microscopy of the ventricular surface of the pars ventralis of the tuber cinereum of the frog Rana temporaria shows that it can be divided in (1) a dorsolateral area, characterized by the presence of very numerous large, solid, bulbous protrusions (2) a medial area, where the large bulbous structures...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00231997
更新日期：1975-05-27 00:00:00
abstract：:The European shore crab Carcinus maenas and the common hermit crab Pagurus bernhardus are members of the sister taxa Brachyura and Anomura (together forming the taxon Meiura) respectively. Both species share similar coastal marine habitats and thus are confronted with similar environmental conditions. This study sets ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1353-4
更新日期：2012-04-01 00:00:00
abstract：:Follicular dendritic cells (FDCs) are immune accessory cells found in the follicles of secondary lymphoid organs where they promote B cell maturation in germinal centers (GCs) that develop following antigen exposure. Recently, we published a method for isolating functional murine FDCs in high purity. We reasoned that ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0566-4
更新日期：2008-04-01 00:00:00
abstract：:Thyroid hormone (TH) plays an important role in regulating ovarian development. However, the mechanism involved remains unclear. Evidence suggests that glucose is essential for ovarian development, and its uptake is mediated by several glucose transporter proteins (Glut). We have investigated the effects of TH on Glut...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-016-2453-3
更新日期：2016-11-01 00:00:00
abstract：:Andersen's syndrome (AS) is a rare autosomal disorder that has been defined by the triad of periodic paralysis, cardiac arrhythmia, and developmental anomalies. AS has been directly linked to over 40 different autosomal dominant negative loss-of-function mutations in the KCNJ2 gene, encoding for the tetrameric strong ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-017-2696-7
更新日期：2018-02-01 00:00:00
abstract：:Guanosine triphosphatase (GTPase) activity was studied histo- and cytochemically in the rod outer segments of the rat retina by means of a newly developed method. Differences in the distribution pattern of the enzyme activity exist within the outer segment: the activity is more intense at the tip of the rod outer segm...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217416
更新日期：1983-01-01 00:00:00
abstract：:During tooth development, the inner and outer enamel epithelia fuse by mitotic activity to produce a bilayered epithelial sheath termed Hertwig's epithelial root sheath (HERS). The epithelial rests of Malassez (ERM) are the developmental residues of HERS and remain in the adult periodontal ligament (PDL). Although the...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-010-1076-3
更新日期：2010-12-01 00:00:00
abstract：:The expression of the gene for vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM) in the human gastrointestinal tract was studied by in situ hybridization and Northern blotting for PHM/VIP mRNA and immunocytochemistry using specific antisera against the bioactive peptides PHM and VIP. In th...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00306108
更新日期：1994-05-01 00:00:00
abstract：:Caprine preantral follicles within ovarian fragments were cryopreserved in the absence or presence of 0.5 M sucrose with or without 1 M dimethyl sulfoxide and/or 1 M ethylene glycol (EG). After being thawed, they were washed in minimum essential medium with or without 0.3 M sucrose. Histological analysis of follicle i...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0193-5
更新日期：2006-09-01 00:00:00
abstract：:Loss of wild-type p53 activity is thought to be a major predictor of failure to respond to radiotherapy and chemotherapy in various human cancers. This assumption is largely based on some cell-death studies in p53-knockout mice and on correlations of p53 status assessed by immunochemistry or single-strand conformation...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s004410051072
更新日期：1998-06-01 00:00:00
abstract：:VIP-containing neurons were localized in lungs from dogs, cat, and human subjects by means of the indirect immunofluorescence technique. Nerve fibers and terminals were observed in the smooth muscle layer and glands of airways, and within the walls of pulmonary and bronchial vessels, especially at the medial-adventiti...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210505
更新日期：1981-01-01 00:00:00
abstract：:Transplantation of a small fragment of the ileum beneath the kidney capsule in syngenic mice results in the formation of a cyst lined with proliferating intestinal epithelium. The duration of the cell cycle in the epithelium was determined (using tritiated thymidine and the FLM method) as 14.5 h, as compared with 11.5...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221125
更新日期：1977-02-02 00:00:00
abstract：:The distribution and nature of 125I-atrial natriuretic peptide binding sites have been examined in the brain and pituitary gland of the toad, Bufo marinus, using tissue section autoradiography, affinity cross-linking and electrophoresis, guanylyl cyclase assays and molecular analysis of natriuretic peptide receptor C ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410000266
更新日期：2000-10-01 00:00:00
abstract：:In several animal species, galanin occurs in pancreatic nerves and inhibits insulin secretion. However, the presence and action of galanin in the human pancreas have not been established. Therefore, we examined the presence and nature of human pancreatic galanin-like immunoreactive material (GLIR) and the effects of g...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00313963
更新日期：1991-05-01 00:00:00
abstract：:The effects of high dose injections of corticotropin-releasing hormone (CRH) on the adrenal cortex of hypophysectomized rats were studied at the light- and electron-microscopical levels. Adrenocortical atrophy induced by hypophysectomy could be reduced by daily i.p. injection of 10 micrograms (3 nmol) CRH given for 3 ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00297501
更新日期：1990-04-01 00:00:00
abstract：:Using anti-carp-gonadotropic-gamma-globulin, the indirect immunofluorescence technique was applied to sections of the pituitary of 12 teleost species. From the investigated species, the Poeciliinae, and especially the black molly, showed a distinct localization of fluorescent cells in the mesoadenohypophysis. Strong f...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00224328
更新日期：1976-03-16 00:00:00
abstract：:Steroid hormones intervene in the structural and functional regulation of neuronal processes during development and thus determine brain differentiation. The effects of estrogens are mediated by two transcription factors, namely estrogen receptor α (ER-α) and estrogen receptor β (ER-β), that regulate the expression of...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-014-2023-5
更新日期：2015-02-01 00:00:00
abstract：:The skeletal body muscle of vertebrates is derived from segmentally arranged mesodermal structures, the somites. Only the dorsal epithelial half of the somite, the dermomyotome, gives rise to muscle cells during normal development. Head muscle takes its origin from the somites, the unsegmented paraxial head mesoderm a...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s004410051281
更新日期：1999-04-01 00:00:00
abstract：:Three sites of somatostatin-synthesizing perikarya, or a related antigen, were determined by immunofluorescence in the hypothalamus of the tadpole, Alytes obstetricans (Amphibia, Anura). Two sites of neurosecretory perikarya were localized in the preoptic nuclei of the anterior hypothalamus; the axons extended either ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00224373
更新日期：1978-02-24 00:00:00
abstract：:Calbindin is a calcium-binding protein, commonly found in certain subpopulations of the enteric nervous system in mammals. Recently, calbindin-immunoreactive enteric neurons have also been demonstrated in shorthorn sculpin (Myoxocephalus scorpius). In the present study, calbindin immunoreactivity has been investigated...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-011-1135-4
更新日期：2011-04-01 00:00:00
abstract：:The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) comprise a group of four homologous and potent growth factors that includes GDNF, neurturin (NRTN), artemin (ARTN), and persephin (PSPN). The survival, growth, and mitotic activities of the GFLs are conveyed by a single receptor tyrosine kina...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-020-03235-4
更新日期：2020-10-01 00:00:00
abstract：:Comparing the distribution of cytoplasmic particles and organelles between different experimental conditions can be challenging due to the heterogeneous nature of cell morphologies. The border-to-border distribution method was created to enable the quantitative analysis of fluorescently labeled cytoplasmic particles a...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-015-2265-x
更新日期：2016-02-01 00:00:00
abstract：:The location of the perikarya of LH-RH neurons in the rat hypothalamus and their pathways to the median eminence were studied by immunohistochemistry and radioimmunoassay after placing stereotaxic electrolytic lesions in several parts of the hypothalamus. The principal location of the cell somata was found to be in th...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00234184
更新日期：1979-05-25 00:00:00
