Abstract：
:Although cartilage is considered to be devoid of innervation, axons occur in the perichondrium and during development in cartilage canals, thereby having a relatively close spatial relationship to chondroblasts and chondrocytes. The present study locates the source of the sensory innervation of the femoral cartilaginous epiphyses of young rats and investigates whether the neuropeptide calcitonin gene-related peptide (CGRP) can influence chondrocytes. Retrograde tracing from the distal femoral epiphysis of young rats with Fast Blue (FB) showed labelled neuronal profiles in the L2-L5 dorsal root ganglia. Sample countings indicated that 50% of the FB-labelled neuronal profiles were located at the L3 level and 25% at the L4 level. The labelled neurones had diameters of 15-40 microm, with a peak at 25-30 microm. Immunohistochemistry showed that about 50% of the FB-labelled profiles contained CGRP. Together with the finding that CGRP influences bone cells to generate the second messenger cAMP, this result suggested the hypothesis that chondrocytes might be similarly influenced by CGRP. However, stimulation of cartilage slices with CGRP in vitro followed by an assay of the cAMP content did not provide support for this hypothesis. We conclude that primary sensory neurones containing CGRP project to the perichondrium and to cartilage canals of growing cartilage, and that exogenous CGRP does not elevate the cAMP content of cartilage slices in vitro.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Edoff K,Grenegård M,Hildebrand Cdoi
10.1007/s004419900142keywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
193-200issue
2eissn
0302-766Xissn
1432-0878journal_volume
299pub_type
杂志文章abstract：:Two types of horizontal cells, H1 and H2, were classified using the Golgi technique on flat mounts of the retina of the frog. Cell type H1 possesses rather short, thick dendrites; the diameter of its dendritic field ranges from 40-90 micrometers. H2-cell displays long and thin dendrites; the diameter of its dendritic ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216747
更新日期：1981-01-01 00:00:00
abstract：:A culture technique for the in vitro growth and differentiation of antennal cells of Mamestra brassicae is described. The morphology of the growing cells is described. At least five morphological cell types can be distinguished in the cultures. Neuronal cells (type A) were characterized morphologically and immunocytoc...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050884
更新日期：1997-08-01 00:00:00
abstract：:Frozen sections of growing terminal follicles of the locust ovary were incubated with an ecdysteroid-specific rabbit antibody and the bound antibody visualised by the use of FITC-labelled goat-anti-rabbit antiserum. A bright fluorescence was seen in the cytoplasm of the follicle cells in terminal follicles with a leng...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00220391
更新日期：1978-11-20 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410100395
更新日期：2001-07-01 00:00:00
abstract：:For the study of the hypothalamo-hypophysial system of Xenopus laevis tadpoles, hypothalamic lesions were made by means of the electrocoagulation technique. Lesioning of the ventral region of the preoptic nucleus resulted in a decrease of the number of ACTH cells in the pars distalis of the pituitary gland and in a di...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219304
更新日期：1976-06-11 00:00:00
abstract：:In the present study, we have analyzed the direct effects of cytokines, which mediate the acute-phase response in liver, on connexin expression and gap-junctional intercellular communication in immortalized MHSV12 mouse hepatocytes. When these cells were stimulated for 24 h with interleukin 1 and interleukin 6, the am...
journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1998-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00223109
更新日期：1977-07-15 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-017-2583-2
更新日期：2017-06-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219841
更新日期：1975-06-27 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410051209
更新日期：1999-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
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更新日期：2016-09-01 00:00:00
abstract：:The interstitial cells of Cajal (ICCs) are important mediators of gastrointestinal (GI) motility because of their role as pacemakers in the GI tract. In addition to their function, ICCs are also structurally distinct cells most easily identified by their ultra-structural features and expression of the tyrosine kinase ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1434-4
更新日期：2012-08-01 00:00:00
abstract：:Post-translational modification of histone proteins, such as the methylation of lysine and arginine residues, influences the higher order of chromatin and leads to gene activation or silencing. Histone methyltransferases or demethylases actively add or remove various methylation marks in a cell-type-specific and conte...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-014-1842-8
更新日期：2014-06-01 00:00:00
abstract：:R*-cells of the digestive gland of Carcinus maenas have been investigated functionally and morphologically. A comparison of the capacity of separated cell suspensions to synthesize glycogen gave support to the hypothesis that R and R* cells belong to the same cell line. The unexpected observation of R* cells in gastri...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318696
更新日期：1992-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1720-9
更新日期：2014-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219605
更新日期：1976-06-28 00:00:00
abstract：:Fueled by the discovery of head regeneration in triclads (planarians) two and a half centuries ago, flatworms have been the focus of regeneration research. But not all flatworms can regenerate equally well and to obtain a better picture of the characteristics and evolution of regeneration in flatworms other than plana...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-020-03302-w
更新日期：2020-11-07 00:00:00
abstract：:Ex-fissiparous planarians produce infertile cocoons or, in very rare cases, cocoons with very low fertility. Here, we describe the features of programmed cell death (PCD) occurring in the hyperplasic ovary of the ex-fissiparous freshwater planarian Dugesia arabica that may explain this infertility. Based on TEM result...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-014-1971-0
更新日期：2014-11-01 00:00:00
abstract：:The octavo-lateral efferent system of several anuran species was studied by means of retrograde transport of horseradish peroxidase. This system is organized similarly in all larval anurans and in all adult aglossids. All have two groups of efferent neurons in the nucleus reticularis medialis between the VIIIth and th...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00214812
更新日期：1982-01-01 00:00:00
abstract：:Synaptogyrins are conserved components of the exocytic apparatus and function as regulators of Ca(2+)-dependent exocytosis. The synaptogyrin family comprises three isoforms: two neuronal (synaptogyrin-1 and -3) and one ubiquitous (synaptogyrin-2) form. Although the expression patterns of the exocytic proteins synaptot...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1629-3
更新日期：2013-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00340875
更新日期：1991-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0558-4
更新日期：2008-04-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237977
更新日期：1980-01-01 00:00:00
abstract：:The interendothelial junctions of all segments of the renal vasculature have been studied in eight species using the freeze-fracture technique. Three types of junctions have been found. Combinations of tight and gap junction elements are characteristic for interlobular arteries and proximal afferent arterioles. Contin...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217224
更新日期：1984-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00232246
更新日期：1979-11-01 00:00:00
abstract：:The present review describes several lines of recent evidence providing new insights into the basic principles and mechanisms of axon projection from the olfactory epithelium to the olfactory bulb. Olfactory sensory neurons are classified into approximately 1000 subtypes according to the expression of specific odorant...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s004410050953
更新日期：1997-11-01 00:00:00
abstract：:Nerves containing the calcium-binding protein calretinin have been reported in several organs but not in female reproductive organs and associated ganglia. This study was undertaken to determine if nerves associated with the uterus contain calretinin and the source(s) of calretinin-synthesizing nerves in the rat (are ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004419900071
更新日期：1999-10-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00331367
更新日期：1994-12-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00384739
更新日期：1992-07-01 00:00:00
abstract：:Many efforts have been made to improve the diagnostic tools used to identify and to estimate the progress of ganglion cell and nerve fibre degeneration in glaucoma. Imaging by optical coherence tomography and measurements of the dimensions of the optic nerve head and the nerve fibre layer in central retinal areas is c...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1602-1
更新日期：2013-08-01 00:00:00
