Immunolocalization of inhibin alpha-subunit in the human testis. A light- and electron-microscopy study.

Abstract:

:The localization of inhibin alpha-subunit in the human testis was studied at the light- and electron-microscope level with immunostaining techniques. Antibodies against specific fragments of porcine and human inhibin alpha-subunits were utilized. At light microscopy, inhibin alpha-subunit immunoreactivity was detected in Sertoli cells, spermatocytes and in some Leydig cells. At electron microscopy, gold labeling was found in the cisternae of the Golgi apparatus and in the endoplasmic reticulum of Sertoli and Leydig cells. Gold labeling for inhibin was also found in coated vesicles in the cytoplasm of Sertoli cells as well as in coated pits and coated vesicles in the cytoplasm of some spermatocytes. The results of the present study suggest that, in the human testis, inhibin is produced by Sertoli and Leydig cells and is taken up by spermatocytes, on which it might act in a paracrine manner.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Vannelli GB,Barni T,Forti G,Negro-Vilar A,Vale W,Serio M,Balboni GC

doi

10.1007/BF00319612

keywords:

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

221-7

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

269

pub_type

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