Wnt signalling in neuronal differentiation and development.

Abstract:

:Wnts are secreted glycoproteins that play multiple roles in early development, including the differentiation of precursor cells. During this period, gradients of Wnts and other morphogens are formed and regulate the differentiation and migration of neural progenitor cells. Afterwards, Wnt signalling cascades participate in the formation of neuronal circuits, playing roles in dendrite and axon development, dendritic spine formation and synaptogenesis. Finally, in the adult brain, Wnts control hippocampal plasticity, regulating synaptic transmission and neurogenesis. In this review, we summarize the reported roles of Wnt signalling cascades in these processes with a particular emphasis on the role of Wnts in neuronal differentiation and development.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Inestrosa NC,Varela-Nallar L

doi

10.1007/s00441-014-1996-4

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

215-23

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

359

pub_type

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