Abstract:
:Wnts are secreted glycoproteins that play multiple roles in early development, including the differentiation of precursor cells. During this period, gradients of Wnts and other morphogens are formed and regulate the differentiation and migration of neural progenitor cells. Afterwards, Wnt signalling cascades participate in the formation of neuronal circuits, playing roles in dendrite and axon development, dendritic spine formation and synaptogenesis. Finally, in the adult brain, Wnts control hippocampal plasticity, regulating synaptic transmission and neurogenesis. In this review, we summarize the reported roles of Wnt signalling cascades in these processes with a particular emphasis on the role of Wnts in neuronal differentiation and development.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Inestrosa NC,Varela-Nallar Ldoi
10.1007/s00441-014-1996-4subject
Has Abstractpub_date
2015-01-01 00:00:00pages
215-23issue
1eissn
0302-766Xissn
1432-0878journal_volume
359pub_type
杂志文章,评审abstract::Enteroendocrine cells containing glucagon-, substance P-, neurotensin- and VIP-like substances have been demonstrated immunocytochemically in the gut of Barbus conchonius. Mainly based on the distribution of the immunoreactive endocrine cells in this and a previous study, at least eight different enteroendocrine cell ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00229200
更新日期:1984-01-01 00:00:00
abstract::Nitric oxide and various neuropeptides in the myenteric plexus regulate esophageal motility. We sought colocalization of nitric oxide synthase and neuropeptides in frozen sections of mid-portion of smooth-muscled opossum esophagus using NADPH-diaphorase activity to mark the synthase and immunoreactivity to detect pept...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00331374
更新日期:1994-12-01 00:00:00
abstract::This study aims to illustrate potential transport mechanisms behind the divergent approaches to nitrogen excretion seen in the ureotelic toadfish (Opsanus beta) and the ammoniotelic plainfin midshipman (Porichthys notatus). Specifically, we wish to confirm the expression of a urea transporter (UT), which is found in t...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1591-0
更新日期:2013-06-01 00:00:00
abstract::Urocortin (UCN) is a 40-amino-acid peptide and a member of the corticotropin-releasing hormone (CRH) family, which includes CRH, urotensin I, sauvagine, UCN2 and UCN3. The biological actions of CRH family peptides are mediated via two types of G-protein-coupled receptors, namely CRH type 1 receptor (CRHR1) and CRH typ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-012-1450-4
更新日期:2012-10-01 00:00:00
abstract::Duck muscle spindles show a large outer capsule enclosing a number of intrafusal muscle fibres which are individually encircled by an inner capsule. The outer capsule consists of a multilayer of 4-6 flattened cells with elongated nuclei, and are usually lined by a basement membrane. They resemble and are linked with p...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00234400
更新日期:1980-01-01 00:00:00
abstract::Enzymatic activities of calcium-magnesium dependent adenosine triphosphatase (Ca-ATPase) and nonspecific alkaline phosphatase (ALPase) were localized at the initial calcification sites of dentin and enamel of rat incisor teeth using electron-microscopic cytochemistry. Ca-ATPase was localized in the Golgi cisternae, cy...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221856
更新日期:1986-01-01 00:00:00
abstract::Dorsal unpaired median (DUM) neurones in the abdominal ganglia of the locust were impaled with microelectrodes and some were injected intracellularly with horseradish peroxidase so that their synapses could be identified in the electron microscope. Simultaneous recordings from DUM neurones in different abdominal gangl...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00307805
更新日期:1995-05-01 00:00:00
abstract::Evidence has already been adduced suggesting that an increase in microtubular number occurs in the tractus hypophyseus of rats stressed by the administration of hypertonic saline, and of rats with congenital diabetes insipidus (CDI). Since the tractus hypophyseus in these animals shows high secretory activity, it seem...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219611
更新日期:1976-06-28 00:00:00
abstract::Myogenesis is a complex process in which committed myogenic cells differentiate and fuse into myotubes that mature into the muscle fibres of adult organisms. This process is initiated by a cascade of myogenic regulatory factors expressed upon entry of the cells into the myogenic differentiation programme. However, ext...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-012-1364-1
更新日期:2012-06-01 00:00:00
abstract::The problem of the blood-brain barrier in the pineal organ of the rainbow trout, Salmo gairdneri, was investigated following intraperitoneal or intracardial injections of several tracers and dyes with different molecular weights. As demonstrated at the light-microscopic level, repeated injections of trypan blue or hor...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219238
更新日期:1985-01-01 00:00:00
abstract::The distribution of neuropeptide Y (NPY)-like immunoreactivity in the brain of the bichir, Polypterus senegalus, was examined immunohistochemically. NPY-like immunoreactivity was distributed widely in the brain, with the highest density in the diencephalon. NPY-positive perikarya were found in various areas, including...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050874
更新日期:1997-08-01 00:00:00
abstract::Spermatozoa from the cauda epididymidis of gossypol-treated rats exhibit distinctive departures from the morphology of spermatozoa from control rats: wrinkled and disorganized cell membrane in the head and tail regions, cell membrane missing from segments of the tail midpiece and principal piece regions, malformed hea...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00210003
更新日期:1981-01-01 00:00:00
abstract::Rab11, a small monomeric GTPase associated with recycling endosomes, is a key molecule in the regulation of vesicular trafficking and is involved in the development and differentiation of many Drosophila tissues through interaction with diverse signaling pathways. In this study, we report for the first time that Rab11...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-016-2500-0
更新日期:2017-02-01 00:00:00
abstract::As luminal fluid moves from the seminiferous tubule and enters the rete testis, its protein concentration declines from approximately 6 mg/ml to 1 mg/ml. It was therefore suggested that protein is either 1) utilized by the spermatozoa, 2) transported across the epithelium of the terminal segment of the seminiferous tu...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00213810
更新日期:1983-01-01 00:00:00
abstract::This study provides information on the rates of DNA synthesis, sites of DNA synthesis, and DNA content of the avian salt gland during the osmotic stressing (plasma membrane synthesis) and destressing (plasma membrane turnover) cycle, in an effort to better understand the relationship of cell turnover to the initial ev...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214782
更新日期:1982-01-01 00:00:00
abstract::Stem cells are an attractive cellular source for regenerative medicine and tissue engineering applications due to their multipotency. Although the elasticity of the extracellular matrix (ECM) has been shown to have crucial impacts in directing stem cell differentiation, it is not the only contributing factor. Many res...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-015-2190-z
更新日期:2015-09-01 00:00:00
abstract::Calcitonin receptor-immunoreactivity (CTR-ir) was found in enteric neurons of the mouse gastrointestinal tract from embryonic day 13.5 (E13.5) to post-natal day 28 (P28). CTR-ir occurred in cell bodies in ganglia of the myenteric plexus extending from the esophagus to the colon and in nerve cells of the submucosal gan...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-011-1303-6
更新日期:2012-02-01 00:00:00
abstract::The glucose transporter 8 (GLUT8) is a recently identified member of the family of sugar transport facilitators. In human tissues GLUT8 is predominantly expressed in testis in a gonadotropin-dependent manner. It is shown here that the onset of mRNA synthesis of GLUT8 during the maturation of mouse testis coincides wit...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-001-0499-2
更新日期:2002-02-01 00:00:00
abstract::Dorsal root ganglia of chick embryos were cultured for one to four weeks on Maximow-slides. Puromycin was added to cultures for a pulse of 30' in a dose of 100 mug/ml medium. Particular interest was given to the ultrastructural features of the glia-neuron relations. Puromycin caused a shrinkage of the glial processes ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00225762
更新日期:1975-07-23 00:00:00
abstract::Exposure of adult brown bullheads Ictalurus nebulosus (120-450 g) to environmental hypercapnia (2% carbon dioxide in air) and subsequent recovery caused transient changes in whole body net sodium flux (JnetNa+) and net chloride flux (JnetCl-) resulting largely from changes in whole body sodium influx (JNa+in) and chlo...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00319161
更新日期:1992-06-01 00:00:00
abstract::Antibodies to smooth muscle and non-muscle myosin allow the development of smooth muscle and its capillary system in the embryonic chicken gizzard to be followed by immunofluorescent techniques. Although smooth muscle development proceeds in a serosal to luminal direction, angiogenetic cell clusters develop independen...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00306123
更新日期:1994-05-01 00:00:00
abstract::Apoptotic and inflammatory processes occur in human arteriosclerotic lesions. We examined the hypothesis whether both processes are possibly associated by studying the colocalization of corresponding markers. In 11 human arteriosclerotic carotid arteries, proapoptotic markers (CPP32 (caspase-3), poly(ADP-ribose) polym...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-005-0024-0
更新日期:2005-12-01 00:00:00
abstract::New genome-editing approaches, such as the CRISPR/Cas system, have opened up great opportunities to insert or delete genes at targeted loci and have revolutionized genetics in model organisms like the zebrafish. The Cre-loxp recombination system is widely used to activate or inactivate genes with high spatial and temp...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2798-x
更新日期:2018-04-01 00:00:00
abstract::Bovine granulosa cells from 3-7 mm follicles were cultured without anchorage in soft agar/methylcellulose solution for 14 days, with or without 50 ng/ml basic fibroblast growth factor. The granulosa cells divided to form colonies of cells. These were analysed by light and electron microscopy, immunohistochemistry and ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00318878
更新日期:1995-12-01 00:00:00
abstract::Autoradiograms of mouse pituitaries were prepared 30 min after injection of 3H-dexamethasone (3HDM), 3H-corticosterone (3HB) and 3H-cortexolone (3HS) either alone or in the presence of competing unlabelled steroids. 3H-dexamethasone accumulated in cell nuclei of both the pars distalis and the pars nervosa but not in t...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00236423
更新日期:1979-08-01 00:00:00
abstract::Examination of pituitaries from young and adult turtles representing four families, reveals that in addition to the abundant juxtaneural pars tuberalis (juxPT) found in this class of reptiles, there is generally a substantial amount of pars tuberalis (PT) tissue closely associated with the pars distalis (PD). The PT f...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218290
更新日期:1982-01-01 00:00:00
abstract::There is general consensus that enteroendocrine cells, EEC, containing the enteric hormone cholecystokinin (CCK) are confined to the small intestine and predominate in the duodenum and jejunum. Contrary to this, EEC that express the gene for CCK have been isolated from the large intestine of the mouse and there is evi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-017-2612-1
更新日期:2017-08-01 00:00:00
abstract::Young rats were injected with 3H-fucose and killed at 10 min, 1, 4 and 24 h thereafter. Samples of the pancreas were processed for light- and electron-microscopic radioautography and then analyzed quantitatively. Fucose label was taken up in the supranuclear region of acinar pancreatic cells that were maximally labele...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222243
更新日期:1983-01-01 00:00:00
abstract::The general ultrastructure of the electrocyte, the basic unit of the electric organs of Electrophorus electricus, is analyzed. Presented herein are detailed observations of the syncytial surface, its fibrillar coat, invaginations of the plasma membrane and synaptic terminals. Using Thiéry's method glycogen granules we...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220681
更新日期:1976-11-10 00:00:00
abstract::Cytochemical methods for the demonstration of p-nitrophenylphosphatase (p-NPPase) at the electron-microscopic level were applied to avian osteoclasts to elucidate some of the functional differences among ruffled border, other membrane systems, and cellular organelles. The localization of p-NPPase activity occurred in ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218381
更新日期:1986-01-01 00:00:00