Abstract:
:Electron-cytochemical localization of alkaline phosphatase activity was performed on G cells of Necturus maculosus antral mucosa. Alkaline phosphatase activity was localized to the nuclear membrane, the Golgi/endoplasmic reticulum, and the limiting membranes of G cell peptide-secretion vesicles. There was no specific localization of alkaline phosphatase activity to the plasma membrane. Treatment of the tissues with levamisole (an alkaline phosphatase inhibitor) did not markedly reduce the specific alkaline phosphatase activity. Specific lead deposition was reduced by removal of the substrate from the reaction mixture. The results from this study on N. maculosus G cells demonstrate that alkaline phosphatase activity can be found in a non-mammalian gastric endocrine cell and that specific activity was localized primarily to those intracellular structures involved with protein biosynthesis.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Rutten MJ,Garrison RG,Moore CD,Fiskin AM,Cheung LYdoi
10.1007/BF00218867subject
Has Abstractpub_date
1989-12-01 00:00:00pages
555-61issue
3eissn
0302-766Xissn
1432-0878journal_volume
258pub_type
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journal_title:Cell and tissue research
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