Abstract：
:The association between adipose tissue and immunity has been established and fat-associated lymphoid clusters (FALCs) are considered as a source of immune cells. We discovered lymphoid clusters (LCs) in mouse mediastinal fat tissues (MFTs). In Th1-biased C57BL/6N (B6), Th2-biased DBA/2Cr (DBA) and autoimmune-prone MRL/MpJ (MRL) mice strains, LCs without a fibrous capsule and germinal center were observed in white-colored MFTs extending from the diaphragm to the heart. The number and size of the LCs were larger in 12-month-old mice than in 3-month-old mice in all of the examined strains. Moreover, B6 had an especially large number of LCs compared with DBA and MRL. The immune cells in the LCs consisted of mainly T-cells and some B-cells. The majority of T-cells were CD4+ helper T (Th) cells, rather than CD8+ cytotoxic T-cells and no obvious immune cell population difference was present among the strains. Furthermore, high endothelial venules and lymphatic vessels in the LCs were better developed in B6 mice than in the other strains. Interestingly, some CD133+ hematopoietic progenitor cells and some c-Kit+/CD127+ natural helper cells were detected in the LCs. BrdU+ proliferating cells were more abundant in the LCs of B6 mice than in the LCs of the other strains and the number of BrdU+ cells increased with age. This is the first report of LCs in mouse MFTs. We suggest that the mouse genetic background affects LC size and number. We term the LCs "mediastinal fat-associated lymphoid clusters". These clusters can be considered as niches for Th cell production.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Elewa YH,Ichii O,Otsuka S,Hashimoto Y,Kon Ydoi
10.1007/s00441-014-1889-6subject
Has Abstractpub_date
2014-09-01 00:00:00pages
731-41issue
3eissn
0302-766Xissn
1432-0878journal_volume
357pub_type
杂志文章abstract：:We conducted an immunoelectron-microscopic study for histamine (HA) in the enterochromaffin-like (ECL) cells of normal rats and rats given alpha-fluoromethylhistidine (alpha-FMH, 3 mg/kg per hour) via osmotic minipumps over a period of 24 h. The indirect immunoperoxidase procedure utilized a mouse monoclonal antibody ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410100448
更新日期：2001-11-01 00:00:00
abstract：:The so-called 'basement membrane' of arthropod compound eyes is known to be of heterogeneous origin (Odselius and Eloffson 1981). A major contribution in Diptera with open rhabdoms is provided by a pigmented component which lies at the basal end of the extracellular space of each ommatidium and fills it, the glial plu...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00222184
更新日期：1983-01-01 00:00:00
abstract：:This review summarizes findings concerning the unique developmental characteristics of mouse head muscles (mainly the masticatory and tongue muscles) and compares their characteristics with those of other muscles. The developmental origin of the masticatory muscles is the somitomeres, whereas the tongue and other musc...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-005-0019-x
更新日期：2005-11-01 00:00:00
abstract：:The presence of melatonin is demonstrated in the pineal gland, the retina and the Harderian gland in some mammalian and non-mammalian vertebrates, using a specific fluorescence labelled antibody technique. Four different potent antibodies against melatonin have been used and compared. In the pineal gland of hamsters, ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00233830
更新日期：1981-01-01 00:00:00
abstract：:This work describes the origin and development of about 200 tension receptor cells located around the anterior attachment site of the locust ovipositor muscle and their migration to their final position on the muscle fibres. The locust ovipositor muscle is the only insect system in which more than 100 tension receptor...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0498-z
更新日期：2007-12-01 00:00:00
abstract：:Autoradiograms of mouse pituitaries were prepared 30 min after injection of 3H-dexamethasone (3HDM), 3H-corticosterone (3HB) and 3H-cortexolone (3HS) either alone or in the presence of competing unlabelled steroids. 3H-dexamethasone accumulated in cell nuclei of both the pars distalis and the pars nervosa but not in t...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00236423
更新日期：1979-08-01 00:00:00
abstract：:Human gingival fibroblasts were cultured with collagen fibrils. The precise process of collagen phagocytosis and the relationship between acid phosphatase activity and intracellular degradation of collagen were investigated by cytochemical methods at the ultrastructural level. The collagen fibrils were first engulfed ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00213929
更新日期：1986-01-01 00:00:00
abstract：:An ectodermal network of nerve cells has been observed in the echinopluteus. It seems to connect the ectodermal cell bodies with each other and with deeper parts of the nerve system. Together with the neurohumour containing parts of the ventral and oral ciliated bands, the nerve cells probably provide the larva with t...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219793
更新日期：1977-04-07 00:00:00
abstract：:The bilaterally paired cercal nerves of Archimantis brunneriana Sauss. leave the terminal ganglion posteriorly and then turn dorsally through muscles at the rear of the abdomen to enter the cerci, where each splits into two branches; successive branchings occur further distally in each cercus. In the distal nerve bran...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217267
更新日期：1982-01-01 00:00:00
abstract：:Chronic tissue injury with fibrosis results in the disruption of tissue architecture, organ dysfunction and eventual organ failure. Therefore, the development of effective anti-fibrotic therapies is urgently required. During fibrogenesis, complex interplay occurs between cellular and extracellular matrix components of...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-016-2407-9
更新日期：2016-09-01 00:00:00
abstract：:Among heterogeneous S100β-protein-positive (S100β-positive) cells, star-like cells with extended cytoplasmic processes, the so-called folliculo-stellate cells, envelop hormone-producing cells or interconnect homophilically in the anterior pituitary. S100β-positive cells are known, from immunohistochemistry, to emerge ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-015-2256-y
更新日期：2016-02-01 00:00:00
abstract：:Iron loading of hepatocytes was followed through the stages (1-7) of metamorphosis in lamprey (Petromyzon marinus L.) using light- and electron-microscopic histochemistry. Iron is present in ferric and ferrous forms in the hepatocytes of larval lampreys in levels that can only be detected in the electron microscope. D...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217405
更新日期：1983-01-01 00:00:00
abstract：:Thyroid hormone (TH) plays an important role in regulating ovarian development. However, the mechanism involved remains unclear. Evidence suggests that glucose is essential for ovarian development, and its uptake is mediated by several glucose transporter proteins (Glut). We have investigated the effects of TH on Glut...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-016-2453-3
更新日期：2016-11-01 00:00:00
abstract：:Large granular lymphocytes (LGL) comprise a natural defense system in the liver and exert an inhibitory effect on tumor cell metastasis. In order to demonstrate the maturation of LGL in the liver from the morphological aspect, we evaluated electron-microscopically the frequency of 0.2 micron vesicles (rod-cored and "e...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00354799
更新日期：1994-04-01 00:00:00
abstract：:The presence and distribution in the peri-insular region of extracellular matrix, and in particular basement membrane, was investigated in a comparative study comprising pancreata of rat, dog, pig, and man. Basement membrane markers, collagen type-IV and laminin, were determined immunohistochemically. Additional infor...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318700
更新日期：1992-01-01 00:00:00
abstract：:The protonephridial flame cell of the freshwater planarian Bdellocephala brunnea was studied by electron microscopy. This basketlike cell with luminal cilia and fenestrae is known as a cyrtocyte. Careful examination revealed the actual continuity of the fenestrae over the surface of the cell and the microvillous natur...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237973
更新日期：1980-01-01 00:00:00
abstract：:The etiologic basis of Parkinson's disease (PD), the second most common age-related neurodegenerative disorder, is unknown. Recent epidemiological and experimental studies indicate that exposure to environmental agents, including a number of agricultural chemicals, may contribute to the pathogenesis of this disorder. ...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-004-0937-z
更新日期：2004-10-01 00:00:00
abstract：:Black tiger shrimps (Penaeus monodon) are able to survive and can be reared under various salinities, possibly by the cellular adaptation of their excretory system, particularly the antennal gland, which is known to regulate body fluid in crustaceans. We have investigated the morphological and biochemical alterations ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-010-0971-y
更新日期：2010-06-01 00:00:00
abstract：:The opioid peptide dynorphin A (1-17) is the third transmitter identified in the striatonigral projection, the other two being gamma-aminobutyric acid (GABA) and substance P. The ultrastructural features of the dynorphinergic terminals in substantia nigra/pars reticulata were studied using pre-embedding immunocytochem...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00329443
更新日期：1990-07-01 00:00:00
abstract：:Our findings suggest that nitric oxide (NO) acts as peripheral neuromodulator in locusts, in which it is commonly co-localized with RF-like peptide in neurosecretory cells. We also present the first evidence for NO as a cardio-regulator in insects. Putative NO-producing neurones were detected in locust pre-genital fre...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0188-2
更新日期：2006-08-01 00:00:00
abstract：:Electron microscopy of the rat lymph node disclosed reticular cells in close association with bundles of collagenous fibrils 30-45 nm in diameter, and electron lucent "amorphous" substances surrounded by microfibrils 11 nm in diameter, with junctional complexes. The amorphous substances, distinctly revealed by orcein ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210522
更新日期：1981-01-01 00:00:00
abstract：:To identify and describe ovarian follicles committed to undergo follicular degeneration (atresia), immature rats were primed with pregnant mare serum gonadotropin (PMSG). After PMSG treatment, preovulatory follicles develop but subsequently degenerate. Prior to the appearance of pyknotic nuclei (Stage I of atresia), d...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00233727
更新日期：1980-01-01 00:00:00
abstract：:To study the biosynthesis and intracellular migration of glycoproteins in the adrenal gland, adult mice were injected intravenously with L-(3H)-fucose and killed from 10 min to 14 days after injection. Semi-thin sections of the adrenal glands were then processed for radioautography. Incorporation of labeled fucose occ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00232246
更新日期：1979-11-01 00:00:00
abstract：:The projections of ocellar fibres within the brain and thorax of the honey bee, Apis mellifera, were established using a modified cobalt sulphide technique, supplemented by serial sectioning of the brain for the light microscope. The results are: 5 large fibres in each lateral nerve and 12 in the median nerve have wid...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00231405
更新日期：1977-01-24 00:00:00
abstract：:In model experiments with the use of horseradish peroxidase (HRP), two pathways of transport of substances to the adenohypophysis were studied, as well as the distribution of the tracer in the latter organ. The first pathway allows the tracer to penetrate from the intercellular milieu of the median eminence below the ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00214248
更新日期：1984-01-01 00:00:00
abstract：:The distribution and ultrastructure of the mitochondria-rich (MR) cells in the gills of larval (ammocoetes) and adult lampreys (Petromyzon marinus and Geotria australis) have been studied. One type of MR cell, which is found only in ammocoetes, occurs in groups on and between gill lamellae. Freeze-fracture replicas sh...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410051003
更新日期：1998-02-01 00:00:00
abstract：:Post-translational glycosylation of proteins with O-linked β-N-acetylglucosamine (O-GlcNAcylation) and changes of galectin expression profiles are essential in many cellular stress responses. We examine this regulation in the liver tissue of hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus) repr...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-020-03185-x
更新日期：2020-07-01 00:00:00
abstract：:Chorionic binucleate cells (BNC) occur in several ruminants including cow, deer, goat and sheep. They migrate through the chorionic tight junction to fuse with uterine epithelial cells and discharge their granules into maternal connective tissue. We have compared the BNC of near-term, resin-embedded, ovine and bovine ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00331380
更新日期：1994-12-01 00:00:00
abstract：:In humans, pathogenesis in cyclosporine A (CsA)-induced gingival overgrowth (GO) includes the accumulation of extracellular matrix (ECM) constituents, viz., collagen type-1 and type-3 and proteoglycans, in subgingival connective tissue. However, whether this increase is associated with alterations of molecules pivotal...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0200-x
更新日期：2006-09-01 00:00:00
abstract：:The ultrastructural changes induced by the topical application of retinol acetate on hamster cheek pouch epithelium were evaluated using stereological analysis. Electron micrographs were prepared of the basal and superficial regions of the nucleated cell layer of the epithelium obtained from 3 treated and 3 control an...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00214783
更新日期：1982-01-01 00:00:00
