Expression of mRNA of parathyroid hormone-related peptide in fetal bones of the rat.

Abstract:

:Previous studies have indicated that 19-day-old fetal long bones of the rat contain an adenylyl cyclase-stimulating activity antigenically related to parathyroid hormone-related peptide. To ascertain its origin, Northern blotting and in situ hybridization histochemistry were performed. Results demonstrate that mRNA of parathyroid hormone-related peptide is present in RNA extracted from fetal long bones of the rat and that cells responsible for its production are localized in the periosteum. These cells are not mature osteoblasts because they do not synthesize mRNA of osteocalcin. Thus the present study shows that parathyroid hormone-related peptide could be produced locally, at least in part, in the skeleton of fetal rats.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Karmali R,Schiffmann SN,Vanderwinden JM,Hendy GN,Nys-DeWolf N,Corvilain J,Bergmann P,Vanderhaeghen JJ

doi

10.1007/BF00645063

keywords:

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

597-600

issue

3

eissn

0302-766X

issn

1432-0878

journal_volume

270

pub_type

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