Abstract:
:Previous studies have indicated that 19-day-old fetal long bones of the rat contain an adenylyl cyclase-stimulating activity antigenically related to parathyroid hormone-related peptide. To ascertain its origin, Northern blotting and in situ hybridization histochemistry were performed. Results demonstrate that mRNA of parathyroid hormone-related peptide is present in RNA extracted from fetal long bones of the rat and that cells responsible for its production are localized in the periosteum. These cells are not mature osteoblasts because they do not synthesize mRNA of osteocalcin. Thus the present study shows that parathyroid hormone-related peptide could be produced locally, at least in part, in the skeleton of fetal rats.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Karmali R,Schiffmann SN,Vanderwinden JM,Hendy GN,Nys-DeWolf N,Corvilain J,Bergmann P,Vanderhaeghen JJdoi
10.1007/BF00645063keywords:
subject
Has Abstractpub_date
1992-12-01 00:00:00pages
597-600issue
3eissn
0302-766Xissn
1432-0878journal_volume
270pub_type
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