The insulin receptor is differentially expressed in somatic and visceral primary sensory neurons.

Abstract:

:Recent studies demonstrated the expression of the insulin receptor (InsR) and its functional interaction with the transient receptor potential vanilloid type 1 receptor (TRPV1) in primary sensory neurons (PSNs). The present study was undertaken to reveal the target-specific expression of the InsR and its co-localization with the TRPV1 in rat PSNs. We assessed the localization of the InsR and its co-localization with the TRPV1 in PSNs retrogradely labelled with biotin-conjugated wheat germ agglutinin injected into the dorsal hind paw skin, the gastrocnemius muscle, the pancreas and the urinary bladder wall. The largest proportions of retrogradely labelled InsR-immunoreactive neurons were identified among PSNs serving the pancreas (~ 54%) and the urinary bladder (~ 53%). The proportions of retrogradely labelled InsR-immunoreactive neurons innervating the dorsal hind paw skin and the gastrocnemius muscle amounted to ~ 22 and ~ 21%. TRPV1-immunoreactive neurons amounted to ~ 63, ~ 62, ~ 67 and ~ 65% of retrogradely labelled cutaneous, muscle, pancreatic and urinary bladder PSNs, respectively. Co-localization of the TRPV1 with the InsR was observed in ~ 16, ~ 15, ~ 29 and ~ 30% of retrogradely labelled cutaneous, muscle, pancreatic and urinary bladder PSNs. These quantitative immunohistochemical data demonstrate a preponderance of InsR-immunoreactivity among PSNs, which innervate visceral targets. The present findings suggest that visceral spinal PSNs are more likely to be exposed to the modulatory effects of insulin on sensory functions, including neurotrophic, nociceptive and inflammatory processes.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Lázár BA,Jancsó G,Nagy I,Horváth V,Sántha P

doi

10.1007/s00441-018-2868-0

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

243-249

issue

2

eissn

0302-766X

issn

1432-0878

pii

10.1007/s00441-018-2868-0

journal_volume

374

pub_type

杂志文章
  • Morphology and immunocytochemistry of the turtle pituitary gland with special reference to the pars tuberalis.

    abstract::Examination of pituitaries from young and adult turtles representing four families, reveals that in addition to the abundant juxtaneural pars tuberalis (juxPT) found in this class of reptiles, there is generally a substantial amount of pars tuberalis (PT) tissue closely associated with the pars distalis (PD). The PT f...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00218290

    authors: Pearson AK,Licht P

    更新日期:1982-01-01 00:00:00

  • Phenotypic modulation of parietal epithelial cells of Bowman's capsule in culture.

    abstract::The origin of cobblestone-like polygonal cells (the most numerous in renal glomerular cell culture) remains controversial; they could be either dedifferentiated podocytes or parietal epithelial cells (PECs) of Bowman's capsule. Poor cellular outgrowth from glomeruli devoid of Bowman's capsule (decapsulated glomeruli) ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410100380

    authors: Yaoita E,Kurihara H,Sakai T,Ohshiro K,Yamamoto T

    更新日期:2001-06-01 00:00:00

  • Morphogenesis of tight junctions in the peritoneal mesothelium of the mouse embryo.

    abstract::The peritoneal mesothelium of mouse embryos (12 to 18 day of gestation) was studied by freeze-fracture and in sections in order to reveal the initial formation of the tight junctions. Freeze-fracture observations showed three types of tight junctions. Type I consists of belt-like meshworks of elevations on the P face ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00232008

    authors: Suzuki F,Nagano T

    更新日期:1979-05-18 00:00:00

  • Immunocytochemical distribution of FMRFamide-like substance in the brain of the cloudy dogfish, Scyliorhinus torazame.

    abstract::The distribution of the molluscan cardioexcitatory tetrapeptide FMRFamide (Phe-Met-Arg-Phe-NH2) in the brain of the cloudy dogfish, Scyliorhinus torazame, was examined by immunocytochemistry. FMRFamide-like immunoreactivity was demonstrated to occur extensively in various regions of the dogfish brain, except for the c...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00398072

    authors: Chiba A,Oka S,Honma Y

    更新日期:1991-08-01 00:00:00

  • The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa.

    abstract::The glucose transporter 8 (GLUT8) is a recently identified member of the family of sugar transport facilitators. In human tissues GLUT8 is predominantly expressed in testis in a gonadotropin-dependent manner. It is shown here that the onset of mRNA synthesis of GLUT8 during the maturation of mouse testis coincides wit...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-001-0499-2

    authors: Schürmann A,Axer H,Scheepers A,Doege H,Joost HG

    更新日期:2002-02-01 00:00:00

  • Involvement of contractile elements in control of bioluminescence in Northern krill, Meganyctiphanes norvegica (M. Sars).

    abstract::Inside the light organs of the bioluminescent (light-producing) crustacean Meganyctiphanes norvegica (krill), numerous capillaries drain haemolymph into the light-producing structure (lantern). We have investigated the arrangement and function of filamentous material found around the opening of the capillaries. These ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-009-0774-1

    authors: Krönström J,Karlsson W,Johansson BR,Holmgren S

    更新日期:2009-05-01 00:00:00

  • Ultrastructure of the heart muscle cells of the cuttlefish Rossia macrosoma (Delle Chiaje) (Mollusca: Cephalopoda).

    abstract::The muscle cells of the ventricle, the branchial heart and the branchial heart appendages of Rossia macrosoma (Delle Chiaje) are studied. The ventricle myocardium has three muscle layers, while the other two organs exhibited a loose arrangement of muscle cells. The muscle cells of the ventricle, the branchial heart an...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:

    authors: Jensen H,Tjonneland A

    更新日期:1977-12-13 00:00:00

  • Effect of pimozide on the cytology of the eel pituitary. II. MSH-secreting cells.

    abstract::Pimozide, a specific blocker of dopaminergic receptors, was injected for 4 or 9 days in freshwater (FW) eels or eels acclimated to sea water (SW) for 10 or 30 days. The daily dose was 100 or 200 microgram/100 g. Melanophore index values increase in FW and in 1 month-SW injected eels. All the treated fish react by a to...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00209272

    authors: Olivereau M

    更新日期:1978-05-29 00:00:00

  • Light- and electron-microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone.

    abstract::Substance P (SP) is a neuropeptide that is released from axons of sensory neurons and causes signal transduction through the activation of the neurokinin-1 receptor (NK1-R). The present study demonstrates the distribution of SP-like-immunoreactive (SP-LI) axons and the localization of NK1-Rs in rat bone tissue using t...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410051100

    authors: Goto T,Yamaza T,Kido MA,Tanaka T

    更新日期:1998-07-01 00:00:00

  • Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. An enzyme-histochemical study.

    abstract::Dichloromethylene diphosphonate can be used for temporary elimination of macrophages in the spleen when administered after entrapment in liposomes. No comparable effect on the macrophages of the spleen was observed with free dichloromethylene diphosphonate or in the case of empty liposomes. Marginal metallophils on th...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00217308

    authors: van Rooijen N,van Nieuwmegen R

    更新日期:1984-01-01 00:00:00

  • Evidence for a morphological component in acid-base regulation during environmental hypercapnia in the brown bullhead (Ictalurus nebulosus).

    abstract::Exposure of adult brown bullheads Ictalurus nebulosus (120-450 g) to environmental hypercapnia (2% carbon dioxide in air) and subsequent recovery caused transient changes in whole body net sodium flux (JnetNa+) and net chloride flux (JnetCl-) resulting largely from changes in whole body sodium influx (JNa+in) and chlo...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00319161

    authors: Goss GG,Laurent P,Perry SF

    更新日期:1992-06-01 00:00:00

  • Regulation of spinal motoneuron survival by GDNF during development and following injury.

    abstract::During normal development of many vertebrate species, substantial numbers of neurons in the central and peripheral nervous system undergo naturally occurring (or programmed) cell death. For example, approximately 50% of spinal motoneurons degenerate and die at a time when these cells are establishing synaptic connecti...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410050690

    authors: Houenou LJ,Oppenheim RW,Li L,Lo AC,Prevette D

    更新日期:1996-11-01 00:00:00

  • A comparative scanning electron-microscopical study of endoneurial collagen around normal mouse nerve fibres, nerve fibres following crush injury and nerve fibres of the dystonic mouse mutant (dt/dt).

    abstract::The endoneurial collagen sheath around teased nerve fibres following crush injury was studied by scanning electron microscopy and compared with uninjured sciatic nerve fibres and with fibres from the dystonic mutant mouse. Following crush injury the endoneurial collagen became more abundant than seen in untreated nerv...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00210469

    authors: Moss TH,Lewkowicz SJ

    更新日期:1981-01-01 00:00:00

  • Targeted knock-in of CreER T2 in zebrafish using CRISPR/Cas9.

    abstract::New genome-editing approaches, such as the CRISPR/Cas system, have opened up great opportunities to insert or delete genes at targeted loci and have revolutionized genetics in model organisms like the zebrafish. The Cre-loxp recombination system is widely used to activate or inactivate genes with high spatial and temp...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-018-2798-x

    authors: Kesavan G,Hammer J,Hans S,Brand M

    更新日期:2018-04-01 00:00:00

  • Immunocytochemical detection of mitochondria-rich cells in the brood pouch epithelium of the pipefish, Syngnathus schlegeli: structural comparison with mitochondria-rich cells in the gills and larval epidermis.

    abstract::The brood pouch of the male pipefish (Syngnathus schlegeli) is a ventral organ located on the tail, with the anterior region closely associated with the genital pore. The embryos in the pouch are attached to highly vascularized placenta-like tissue which seals the pouch folds from inside during incubation. The epithel...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410051220

    authors: Watanabe S,Kaneko T,Watanabe Y

    更新日期:1999-01-01 00:00:00

  • Developmental immunohistology of melanotrophs in Xenopus laevis tadpoles.

    abstract::The adenohypophysial primordium of Xenopus laevis tadpoles at stages 33/34 to 46 (Nieuwkoop and Faber, 1956) were examined immunohistologically for alpha-MSH, beta-MSH and ACTH. beta-MSH was demonstrated from stage 37/38 onwards, and alpha-MSH from stage 39. No signs of ACTH production were detected. alpha-MSH and bet...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00231955

    authors: Erik N,Nyholm I,Doerr-Schott J

    更新日期:1977-05-16 00:00:00

  • Electron-microscopic studies on the presence of gap junctions between corneal fibroblasts in rabbits.

    abstract::Corneal fibroblasts, major cellular components of the corneal stroma, are loosely arrayed between collagen lamellae. They play an important role in the metabolic and physiological homeostasis mechanisms by which the cornea is kept transparent. This paper deals with the demonstration of the gap junctions between the co...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00215533

    authors: Ueda A,Nishida T,Otori T,Fujita H

    更新日期:1987-08-01 00:00:00

  • Tritiated thymidine autoradiographic study on the origin and renewal of argentaffin cells in the pyloric gland of hamsters.

    abstract::The origin and renewal of the argentaffin cells in the pyloric glands of hamsters were studied by flash, cumulative and pulse labelling autoradiography with 3H-thymidine. The argentaffin cells were identified by the Diazo Method using Fast Red B Salt. By flash labelling autoradiography, it was shown that the argentaff...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00222771

    authors: Hattori T,Niki H,Fujita S

    更新日期:1977-06-20 00:00:00

  • Astrocytic and neuronal factors affecting axon regeneration in the damaged central nervous system.

    abstract::Whether an axon will regenerate after it is cut depends on the balance between the intrinisic ability of the axon to regrow and the permissiveness of the environment surrounding it. The permissiveness of the environment is determined by the glial cells at the site of injury, and in the CNS both oligodendrocytes and as...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审

    doi:10.1007/s004410050943

    authors: Fawcett JW

    更新日期:1997-11-01 00:00:00

  • Expression of synaptogyrin-1 in T1R2-expressing type II taste cells and type III taste cells of rat circumvallate taste buds.

    abstract::Synaptogyrins are conserved components of the exocytic apparatus and function as regulators of Ca(2+)-dependent exocytosis. The synaptogyrin family comprises three isoforms: two neuronal (synaptogyrin-1 and -3) and one ubiquitous (synaptogyrin-2) form. Although the expression patterns of the exocytic proteins synaptot...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-013-1629-3

    authors: Kotani T,Toyono T,Seta Y,Kitou A,Kataoka S,Toyoshima K

    更新日期:2013-09-01 00:00:00

  • The influence of androgen administration on the structure and function of the brain-pituitary-gonad axis of sexually immature platyfish, Xiphophorus maculatus.

    abstract::This report demonstrates that the administration of testosterone (T) or 11-ketotestosterone (11-KT) to sexually immature (8 wks old) male platyfish (Xiphophorus maculatus) of early- and late-maturing genotypes affects the synthesis and/or release of luteinizing hormone-releasing hormone (LHRH), as assessed by immunocy...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00218552

    authors: Schreibman MP,Margolis-Nunno H,Halpern-Sebold LR,Goos HJ,Perlman PW

    更新日期:1986-01-01 00:00:00

  • Characterization of pars intermedia connections in amphibians by biocytin tract tracing and immunofluorescence aided by confocal microscopy.

    abstract::Biocytin, recently introduced in neuroanatomical studies, was used as a retrograde tract tracer in combination with immunofluorescence in order to analyse the neurochemical characters of some central neuronal projections to the pars intermedia in two amphibian species, the anuran Rana esculenta and the urodele Trituru...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s004410050754

    authors: Jansen K,Fabro C,Artero C,Feuilloley M,Vaudry H,Fasolo A,Franzoni MF

    更新日期:1997-02-01 00:00:00

  • Synaptic development and microtubule organization.

    abstract::Using techniques for enhanced microtubular preservation (albumin pretreatment of Gray) occipital and pyriform cortices of rats were studied by electron microscopy at various stages of development. A close structural relationship was seen between microtubules (mts), focal membrane densities, synaptic vesicles, and pres...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00215777

    authors: Westrum LE,Gray EG,Burgoyne RD,Barron J

    更新日期:1983-01-01 00:00:00

  • Induction by progesterone of a sexual dimorphism of estrogen uptake by anterior pituitary cells in situ.

    abstract::The effects of progesterone pretreatment on in vivo 3H-estrogen uptake by five anterior pituitary cell types was analyzed by means of a quantitative autoradiographic-immunocytochemical technique. Male and female rats castrated for 14 days show nuclear concentration of label in all five cell types one h after injection...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00236250

    authors: Keefer DA

    更新日期:1981-01-01 00:00:00

  • Immunohistochemical localization of laminin, neural cell adhesion molecule, collagen type IV and T-61 antigen in the embryonic retina of the Japanese quail by in vivo injection of antibodies.

    abstract::Antibodies against laminin (LN), fibronectin (FN), collagen type IV (Col IV), neural cell adhesion molecule (N-CAM), T-61 antigen, actin, tubulin and neurofilament protein were injected into the eyes of quail embryos (Coturnix coturnix japonica) of different ages. Twenty h after injection, the heads of the embryos wer...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00217320

    authors: Halfter W,Fua CS

    更新日期:1987-09-01 00:00:00

  • Fine structure of the intestinal epithelium of the colonial ascidian Botryllus schlosseri.

    abstract::In the intestine of the filtering zooids of B. schlosseri three segments can be distinguished. In the intermediate segment the epithelium, which is encrusted by the ampullae of the pyloric gland, shows marked aspects of alteration. In the proximal and distal segments, ciliated mucous, vacuolated and endocrine-like cel...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00219771

    authors: Burighel P,Milanesi C

    更新日期:1977-08-26 00:00:00

  • Microsurgical transection of small nerve fibre bundles in vitro. Effects on axons, growth cones and glial cells.

    abstract::Fibres growing from neurons of explanted dorsal root ganglia from 10 day chick embryos were transected and subsequently observed by light and electron microscopy after periods of a few to fifty minutes. Changes immediately proximal and distal to the cut together with alterations further away from the site of injury on...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/BF00219562

    authors: Bird MM

    更新日期:1978-07-10 00:00:00

  • Neurochemical characterization of nervous elements innervating the body wall of earthworms (Lumbricus, Eisenia): immunohistochemical and pharmacological studies.

    abstract::The distribution and chemical neuroanatomy of nervous elements and certain pharmacological-physiological characteristics of the innervation of the body wall in earthworms are described. Solitary sensory bipolar cells can be found among the epithelial cells. These bipolar cells contain serotonin, tyrosine hydroxylase, ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-005-1134-4

    authors: Csoknya M,Takács B,Koza A,Dénes V,Wilhelm M,Hiripi L,Kaslin J,Elekes K

    更新日期:2005-09-01 00:00:00

  • Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia.

    abstract::This study explores the molecular composition of the tight junction (TJ) in human term placenta from normal women and from patients with preeclampsia, a hypertensive disorder of pregnancy. Maternal endothelial dysfunction is a critical characteristic of preeclampsia; hence, we have analyzed its impact on placental ves...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-005-0135-7

    authors: Liévano S,Alarcón L,Chávez-Munguía B,González-Mariscal L

    更新日期:2006-06-01 00:00:00

  • Retinoic acid enhances leukemia inhibitory factor expression in OLN-93 oligodendrocytes.

    abstract::Brain injuries trigger physiological reactions which are mediated by a number of cytokines including interleukin-6 (IL-6), ciliary neurotrophic factor (CNTF), and leukemia inhibitory factor (LIF). Astrocytes and microglia, the protagonists in these traumatic responses, are known to secrete a variety of paracrine signa...

    journal_title:Cell and tissue research

    pub_type: 杂志文章

    doi:10.1007/s00441-002-0624-x

    authors: Mey J,Henkes L

    更新日期:2002-11-01 00:00:00