Abstract:
:Whether an axon will regenerate after it is cut depends on the balance between the intrinisic ability of the axon to regrow and the permissiveness of the environment surrounding it. The permissiveness of the environment is determined by the glial cells at the site of injury, and in the CNS both oligodendrocytes and astrocytes produce inhibitory molecules. Neurones differ greatly in the ability of their axons to regrow following axotomy. This intrinsic growth ability is greater in embryonic than adult neurones, varies from one neuronal type to another, depends on whether the axon is cut close to or far from the cell body, and can be increased by appropriate neurotrophic molecules.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Fawcett JWdoi
10.1007/s004410050943subject
Has Abstractpub_date
1997-11-01 00:00:00pages
371-7issue
2eissn
0302-766Xissn
1432-0878journal_volume
290pub_type
杂志文章,评审abstract::The ciliary axoneme in photoreceptors from the retina of Xenopus laevis was examined by immunofluorescent staining of tubulin throughout the light/dark cycle. The immunofluorescent axoneme extended along only part of the length of rod outer segments but the entire length of cone outer segments. Both the cone axoneme a...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050632
更新日期:1996-07-01 00:00:00
abstract::Early diplotene oocytes from Necturus maculosus ranging from approximately 0.2 to 0.5 mm in diameter were examined by electron microscopy. In the smallest oocytes of this range, the cytoplasm is largely devoid of membranes, but contains primarily ribosomes and mitochondria. In slightly larger oocytes, smooth-surfaced ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218087
更新日期:1986-01-01 00:00:00
abstract::Considerable evidence indicates that the state of ocular connective tissues and their response in glaucomatous disease affect the degree of glaucoma damage. Both experimental and clinical data suggest that improved diagnostic and prognostic information can be derived from the assessment of the mechanical responsivenes...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-013-1603-0
更新日期:2013-08-01 00:00:00
abstract::In the fish retina, connexon densities of gap junctions in the outer horizontal cells are modulated in response to different light or dark adaptation times and wavelengths. We have examined whether the connexon density is a suitable parameter of gap junction coupling under in situ conditions. Short-term light adaptati...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00318795
更新日期:1992-05-01 00:00:00
abstract::Cobaltous-lysine is transported anterogradely from the optic nerve of the teleost, Lethrinus chrysostomus (Lethrinidae, Perciformes). The marginal optic tract is labelled in longitudinal bands of light and dark staining fibres which persists caudally within the ventral division but not in the dorsal division. This spe...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218889
更新日期:1989-01-01 00:00:00
abstract::The monoamines octopamine and tyramine, which are the invertebrate counterparts of epinephrine and norepinephrine, transmit their action through sets of G protein-coupled receptors. Four different octopamine receptors (Oamb, Octß1R, Octß2R, Octß3R) and 3 different tyramine receptors (TyrR, TyrRII, TyrRIII) are present...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-015-2137-4
更新日期:2015-09-01 00:00:00
abstract::Antibodies raised against the cystic fibrosis transmembrane regulator protein (CFTR) were used to localize CFTR in intestinal tissues of piglets and mice. Positive staining for CFTR was detected in goblet cells of both species. A second population of epithelial cells of unknown phenotype was also labeled by anti-CFTR ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050531
更新日期:1996-02-01 00:00:00
abstract::An antiserum against conjugated histamine and two oligonucleotide probes that detect the mRNA encoding L-histidine decarboxylase (HDC) involved in histamine synthesis were used to study the appearance of histamine and its location in the kidneys of fetal, newborn and young postnatal rats and in the kidneys of pregnant...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00302960
更新日期:1992-02-01 00:00:00
abstract::Enteroendocrine cells containing glucagon-, substance P-, neurotensin- and VIP-like substances have been demonstrated immunocytochemically in the gut of Barbus conchonius. Mainly based on the distribution of the immunoreactive endocrine cells in this and a previous study, at least eight different enteroendocrine cell ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00229200
更新日期:1984-01-01 00:00:00
abstract::An improved technique for fluorescent labelling of heavy meromyosin has made it possible to detect on a light microscopic level the cellular sites of actin localization. Rabbit heavy meromyosin (HMM) was labelled with fluorescein isothiocyanate so that the actin binding site was protected during the reaction. The spec...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00224134
更新日期:1975-08-27 00:00:00
abstract::Elastic cartilage-derived cells cultured two-dimensionally with FGF2 and corticosteroid produce gel-type masses that become mature cartilage when injected into a subcutaneous pocket. This unique method has previously been clinically applied for treatments of nasal augmentation. However, the components of the gel-type ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0438-y
更新日期:2007-09-01 00:00:00
abstract::Morphologically the large intestine of the nutria resembles that of other caviomorphs, notably the guinea pig. The cecum is voluminous: it contributes 8.6% of the total intestinal length and 12.7% of the total intestinal surface area (considering the surface enlargement factor). It contains 27-32% of the wet ingesta a...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214387
更新日期:1988-05-01 00:00:00
abstract::The fine structure, nature and fate of the components of the nucleolus were studied in young (steps 1, 2), intermediate (steps 3, 4, 5) and mature spermatids (steps 6, 7, 8) of man and monkey, by use of several cytochemical techniques (alcoholic PTA; sodium tungstate: EDTA; HAPTA; nuclease-gold complexes; NOR silver s...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00305735
更新日期:1991-04-01 00:00:00
abstract::A major difficulty in the investigation of interstitial cells of Cajal (ICC) is in identifying these cells within intact, living gastrointestinal tissues. To overcome this difficulty we developed a method to visualize ICC in the myenteric plexus region (ICC-MP) of the guinea pig ileum. Cells were identified with Nomar...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-001-0474-y
更新日期:2002-01-01 00:00:00
abstract::The distribution of MAP2 and actin in dendritic spines of the visual and cerebellar cortices, dentate fascia, and hippocampus was determined by using immunogold electron microscopy. By this approach, we have confirmed the presence of MAP2 in dendritic spines and identified substructures within the spine compartment sh...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00225592
更新日期:1989-06-01 00:00:00
abstract::Ultrastructural studies of pancreatic islets have suggested that crinophagy provides a possible mechanism for intracellular degradation of insulin in the insulin-producing B-cells. In the present study, a quantitative estimation of crinophagy in mouse pancreatic islets was attempted by morphometric analysis of lysosom...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00213820
更新日期:1988-04-01 00:00:00
abstract::The rejection of skin allografts by the larval lamprey, Lampetra reissneri, was studied by light- and electron-microscopy, with particular attention to the cell types involved in the reaction. In all allografts, melanophores were destroyed within 20-60 days (the mean survival time, 36 +/- 12 days). Neither the epiderm...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222182
更新日期:1983-01-01 00:00:00
abstract::The glucose transporter 8 (GLUT8) is a recently identified member of the family of sugar transport facilitators. In human tissues GLUT8 is predominantly expressed in testis in a gonadotropin-dependent manner. It is shown here that the onset of mRNA synthesis of GLUT8 during the maturation of mouse testis coincides wit...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-001-0499-2
更新日期:2002-02-01 00:00:00
abstract::The influence of adrenalectomy and administration of hypertonic saline on the amount of vasopressin, oxytocin, and neurophysin contained in the median eminence and the neural lobe of rats was studied by means of the following methods: (i) morphometric and microphotometric analyses of aldehyde fuchsin-stained histologi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00206271
更新日期:1983-01-01 00:00:00
abstract::The localization of (Na+-K+) ATPase in the intact electrocyte of the electric organ of Electrophorus electricus (L.) and its subcellular fractions was investigated by biochemical and cytochemical methods. The distribution of AChE activity in the subcellular fractions was also comparatively analysed with this enzyme se...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00226673
更新日期:1977-11-30 00:00:00
abstract::Proliferating cell nuclear antigen is expressed in cells from late G1 through the S-phase of the cell cycle. Therefore, antibodies directed against this molecule should provide a probe for labeling immunocytochemically the nuclei of proliferating cells. Herein we demonstrate the feasibility and reliability of this tec...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00224731
更新日期:1989-04-01 00:00:00
abstract::Exposure to maternal diabetes during fetal growth is a risk factor for the development of type II diabetes (T2D) in later life. Discovery of the mechanisms involved in this association should provide valuable background for therapeutic treatments. Early embryogenesis involves epigenetic changes including histone modif...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-017-2583-2
更新日期:2017-06-01 00:00:00
abstract::We have previously shown that the chromogranin A (CgA)-derived peptide catestatin (CST: hCgA352-372) inhibits nicotine-induced secretion of catecholamines from the adrenal medulla and chromaffin cells. In the present study, we seek to determine whether CST regulates dense core (DC) vesicle (DCV) quanta (catecholamine ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2956-1
更新日期:2019-04-01 00:00:00
abstract::DNA distribution in mouse, rabbit and bull spermatids was analyzed by electron microscopy, after using a Feulgen-like HCl-osmium ammine procedure, and after immunocytochemistry with anti-DNA antibodies. In addition, nucleic acids were visualized with the intercalating dye ethidium bromide and phosphotungstic acid. The...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00340875
更新日期:1991-09-01 00:00:00
abstract::While Th1 and Th17 T effector cells are pathogenic drivers of glomerulonephritis (GN), regulatory T cells (Tregs) potently protect from renal tissue injury. Recently, it has become evident that different Treg subtypes exist. Among these are lineage specific Treg1 and Treg17 cells, which are specialized to down regulat...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-020-03359-7
更新日期:2020-12-14 00:00:00
abstract::The fine structure of the main excretory duct epithelium (MEDE) of female mouse submandibular gland was investigated by scanning and transmission electron microscopy and the results compared with the previously established structure of male mouse MEDE. A comparative analysis of the subepithelial capillaries of both se...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00300213
更新日期:1994-09-01 00:00:00
abstract::Trichoplax, a member of the phylum Placozoa, is a tiny ciliated marine animal that glides on surfaces feeding on algae and cyanobacteria. It stands out from other animals in that it lacks an internal digestive system and, instead, digests food trapped under its lower surface. Here we review recent work on the phenotyp...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-019-03057-z
更新日期:2019-09-01 00:00:00
abstract::A body of evidence points to the existence of stem cell stores in adult tissues, in addition to the well-known hematopoietic stem cells from bone marrow. Many reports describe the ability of these multipotent cells (developmentally non-compromised with their organs of origin) to give rise to many different cell types ...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-006-0172-x
更新日期:2006-09-01 00:00:00
abstract::A monospecific antibody against beta-1,3-glucan recognition protein (a 62 kDa protein) of the larval silkworm prophenoloxidase activating system was used to study the localization of the protein. Among tissues from 5th instar larvae, only hemocytes and plasma were shown to contain a 62 kDa polypeptide immunoreactive w...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00319149
更新日期:1992-06-01 00:00:00
abstract::Colorectal adenocarcinomas were induced in male Wistar rats, by weekly subcutaneous administration of 1,2-dimethylhydrazine, classified according to the degree of differentiation and submitted to immunocytochemistry for the peptides cholecystokinin (CCK), gastrin, gastric inhibitory polypeptide (GIP), glucagon, neurot...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219019
更新日期:1986-01-01 00:00:00