Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. An enzyme-histochemical study.

Abstract:

:Dichloromethylene diphosphonate can be used for temporary elimination of macrophages in the spleen when administered after entrapment in liposomes. No comparable effect on the macrophages of the spleen was observed with free dichloromethylene diphosphonate or in the case of empty liposomes. Marginal metallophils on the boundary between white pulp and marginal zone as well as macrophages in the marginal zone and red pulp disappeared from the spleen within one day and remained largely absent for about a week. After this time cells reappeared slowly, and at approximately four weeks after injection their presence in the spleen did not differ from that in control animals. Marginal metallophils and macrophages in the spleen were demonstrated by use of enzyme-histochemical methods and by their capacity to ingest carbon particles.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

van Rooijen N,van Nieuwmegen R

doi

10.1007/BF00217308

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

355-8

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

238

pub_type

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