Abstract:
:Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L-1 and a selective index (SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A (3) and diphyllin (8) demonstrated inhibitory activity against HIV-1 with IC50 values of 4.95 (SI > 6.2) and 0.38 μmol·L-1 (SI = 5.3), respectively.
journal_name
Chin J Nat Medjournal_title
Chinese journal of natural medicinesauthors
Xu XY,Wang DY,Ku CF,Zhao Y,Cheng H,Liu KL,Rong LJ,Zhang HJdoi
10.1016/S1875-5364(19)30117-7subject
Has Abstractpub_date
2019-12-01 00:00:00pages
945-952issue
12eissn
2095-6975issn
1875-5364pii
S1875-5364(19)30117-7journal_volume
17pub_type
杂志文章abstract::It is hypothesized that protease inhibitors play an essential role in survival of venomous animals through protecting peptide/protein toxins from degradation by proteases in their prey or predators. However, the biological function of protease inhibitors in scorpion venoms remains unknown. In the present study, a tryp...
journal_title:Chinese journal of natural medicines
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abstract:AIM:To study the chemical constituents of the fruits of Illicium henryi. METHOD:Chromatographic separations on silica gel, Sephadex LH-20 gel and MCI gel were used to isolate the compounds. The structures were elucidated based on extensive spectroscopic data analyses. RESULTS:Seven compounds were obtained and their s...
journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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更新日期:2020-01-01 00:00:00
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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更新日期:2013-03-01 00:00:00
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更新日期:2014-03-01 00:00:00
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journal_title:Chinese journal of natural medicines
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更新日期:2012-01-01 00:00:00
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journal_title:Chinese journal of natural medicines
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更新日期:2014-07-01 00:00:00
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章,评审
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
abstract::Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability...
journal_title:Chinese journal of natural medicines
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更新日期:2018-02-01 00:00:00