当前位置： SCI文献检索 > Chinese Journal of Natural Medicines期刊下所有文献 > Improved anti-tumor activity and safety profile of a paclitaxel-loaded glycyrrhetinic acid-graft-hyaluronic acid conjugate as a synergistically targeted drug delivery system.

Improved anti-tumor activity and safety profile of a paclitaxel-loaded glycyrrhetinic acid-graft-hyaluronic acid conjugate as a synergistically targeted drug delivery system.

Abstract：

:The present study was designed to develop and evaluate glycyrrhetinic acid-graft-hyaluronic acid (HGA) conjugate for intravenous paclitaxel (PTX) delivery. Lyophilized PTX-loaded self-assembled HGA nanoparticles (PTX/HGAs) were prepared and characterized by dynamic light scattering measurements. Hemolysis test, intravenous irritation assessment, and in vitro and in vivo pharmacodynamic studies were carried out. B16F10 and HepG2 cells were used in the cell apoptosis analysis. The mouse MDA-MB-231 xenograft model was used for the evaluation of in vivo anticancer activity of the drugs, by the analysis of tumor growth and side effects on other tissues. PTX/HGAs showed high stability and good biocompability. Compared with PTX plus GA plus HA solution, PTX/HGAs displayed obvious superiority in inducing the apoptosis of the cancer cells. Following systemic administration, PTX/HGAs efficiently suppressed tumor growth, with mean tumor inhibition ratio (TIR) being 65.08%, which was significantly higher than that of PTX plus GA plus HA treatment. In conclusion, PTX/HGAs demonstrated inhibitory effects tumor growth without unwanted side effects, suggesting that HGA conjugates hold a great potential as a delivery carrier for cancer chemotherapeutics to improve therapeutic efficacy and minimize adverse effects.

journal_name

Chin J Nat Med

journal_title

Chinese journal of natural medicines

authors

Zhang L,Zhou JP,Yao J

doi

10.1016/S1875-5364(15)30097-2

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

915-24

issue

12

eissn

2095-6975

issn

1875-5364

pii

S1875-5364(15)30097-2

journal_volume

13

pub_type

杂志文章

相关文献

Chinese Journal of Natural Medicines文献大全
  • Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κ B inflammatory pathway in the neuroprotective effect of atractylenolide III in corticosterone-induced PC12 cells.

    abstract：:Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanism...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30030-5

    authors： Gong WX,Zhou YZ,Qin XM,DU GH

    更新日期：2019-04-01 00:00:00

  • Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureu.

    abstract：AIM:To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill. METHOD:Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compound...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60104-7

    authors： Fan QY,Yin X,Li ZH,Li Y,Liu JK,Feng T,Zhao BH

    更新日期：2014-09-01 00:00:00

  • Antibacterial constituents from Melodinus suaveolens.

    abstract：:To investigate the non-alkaloidal chemical constituents of the stems and leaves of Melodinus suaveolens and their antibacterial activities. Compounds were isolated and purified by repeated silica gel, Sephadex LH-20, RP18, and preparative HPLC. Their structures were elucidated by comparison with published spectroscopi...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(15)30020-0

    authors： Li JL,Lunga PK,Zhao YL,Qin XJ,Yang XW,Liu YP,Luo XD

    更新日期：2015-04-01 00:00:00

  • Cycloartenol triterpenoid saponins from Cimicifuga simplex (Ranunculaceae) and their biological effects.

    abstract：:The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga ge...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(15)60011-5

    authors： Wu L,Chen ZL,Su Y,Wang QH,Kuang HX

    更新日期：2015-02-01 00:00:00

  • Total synthesis of D-glycero-D-mannno-heptose 1β, 7-bisphosphate with 3-O-amyl amine linker and its monophosphate derivative.

    abstract：:D-Glycero-D-mannno-heptose 1β, 7-bisphosphate (HBPβ) is an important intermediate for constructing the core structure of Gram-negative bacterial lipopolysaccharides and was reported as a pathogen-associated molecular pattern (PAMP) that regulates immune responses. HBPβ with 3-O-amyl amine linker and its monophosphate ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)30075-3

    authors： Zou XP,Qin CJ,Hu J,Fu JJ,Tian GZ,Moscovitz O,Seeberger PH,Yin J

    更新日期：2020-08-01 00:00:00

  • Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection.

    abstract：:Ge Gen Decoction (GGD), a Traditional Chinese Medicine prescription, is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus (IAV) infection. However, the underlying mechanism of GGD against IAV infection remains unclear. In this study, we found that GGD had moderate a...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30079-2

    authors： Geng ZK,Li YQ,Cui QH,DU RK,Tian JZ

    更新日期：2019-09-01 00:00:00

  • Synthesis and evaluation of 2-cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide as a potent anti-inflammatory agent for intervention of LPS-induced acute lung injury.

    abstract：:The present study was designed to synthesize 2-Cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide (1), a lactone derivative of oleanolic acid (OA) and evaluate its anti-inflammatory activity. Compound 1 significantly diminished nitric oxide (NO) production and down-regulated the mRNA expression of iNOS, COX-2, ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30055-9

    authors： Mou Y,Jian YL,Chen T,Huang ZJ,Qiao YX,Peng SX,Zhang DY,Ji H,Zhang YH

    更新日期：2017-05-01 00:00:00

  • Two novel resin glycosides isolated from Ipomoea cairica with α-glucosidase inhibitory activity.

    abstract：:In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)30020-6

    authors： Li JH,Pan JT,Yin YQ

    更新日期：2016-03-01 00:00:00

  • Transformation of astragalosides from radix astragali under acidic, neutral, and alkaline extraction conditions monitored by LC-ESI-TOF/MS.

    abstract：AIM:To reveal the profile of astragalosides for better quality evaluation of Radix Astragali, this study was aimed to investigate the transformation of astragalosides under different conditions. METHOD:Seven major astragalosides were selected for evaluation under acidic, neutral and alkaline conditions. The transforma...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60062-5

    authors： Chu C,Liu EH,Qi LW,Li P

    更新日期：2014-04-01 00:00:00

  • A polysaccharide purified from Radix Adenophorae promotes cell activation and pro-inflammatory cytokine production in murine RAW264.7 macrophages.

    abstract：:Radix Adenophorae, a traditional Chinese medicine, has been reported to have a variety of biological functions. In the present study, a polysaccharide component, Radix Adenophorae Polysaccharide (RAPS), was purified from Radix Adenophorae by decoloring with ADS-7 macroporous adsorption resin, DEAE-52 cellulose ion-exc...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.3724/SP.J.1009.2016.00370

    authors： Li JW,Liu Y,Li BH,Wang YY,Wang H,Zhou CL

    更新日期：2016-05-01 00:00:00

  • Antioxidant and cardioprotective effects of Ilex cornuta on myocardial ischemia injury.

    abstract：:Previous studies have indicated that the Ilex genus exhibits antioxidant, neuroprotective, hepatoprotective, and anti-inflammatory activities. However, the pharmacologic action and mechanisms of Ilex cornuta against cardiac diseases have not yet been explored. The present study was designed to investigate the antioxid...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30025-0

    authors： Yuan Y,Pan S,Yang SL,Liu YL,Xu QM

    更新日期：2017-02-01 00:00:00

  • A new cytochalasin from endophytic Phomopsis sp. IFB-E060.

    abstract：AIM:To study the chemical constituents of the solid culture of the endophyte Phomopsis sp. IFB-E060 in Vatica mangachapoi. METHOD:Isolation and purification were performed through silica gel column chromatography, gel filtration over Sephadex LH-20, ODS column chromatography, and HPLC. Structures of the isolated compo...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60080-7

    authors： Shen L,Luo Q,Shen ZP,Li LY,Zhang XJ,Wei ZQ,Fu Y,Song YC,Tan RX

    更新日期：2014-07-01 00:00:00

  • Protective effect of turmeric extract on ethotrexate-induced intestinal damage and oxidative stress.

    abstract：AIM:The most important side effect of methotrexate (MTX) is mucositis. The purpose of this study was to evaluate the effect of turmeric extract on intestinal damage and oxidative stress in rats receiving methotrexate. METHODS:Experiments were performed on male Wistar albino rats divided into six groups. First group re...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(13)60087-4

    authors： Moghadam AR,Mohajeri D,Namvaran-Abbas-Abad A,Manafi H,Shahi D,Mazani M

    更新日期：2013-09-01 00:00:00

  • Traditional Chinese Medicine: an effective treatment for 2019 novel coronavirus pneumonia (NCP).

    abstract：:The novel coronavirus pneumonia broke out in 2019 and spread rapidly. In 30 different countries, there are over seventy thousand patients have been diagnosed in total. Therefore, it is urgent to develop the effective program to prevent and treat for the novel coronavirus pneumonia. In view of Traditional Chinese Medic...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(20)30022-4

    authors： DU HZ,Hou XY,Miao YH,Huang BS,Liu DH

    更新日期：2020-03-01 00:00:00

  • Enhancement of oral bioavailability and immune response of Ginsenoside Rh2 by co-administration with piperine.

    abstract：:Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30041-4

    authors： Jin ZH,Qiu W,Liu H,Jiang XH,Wang L

    更新日期：2018-02-01 00:00:00

  • Potent anti-angiogenic activity of B19--a mono-carbonyl analogue of curcumin.

    abstract：AIM:The compound B19 (C21H22O5) is a newly synthesized, mono-carbonyl analog of curcumin that has exhibited potential antitumor effects. This present study was performed to identify the anti-angiogenic activity of this compound. METHODS AND RESULTS:B19 inhibited migration and tube formation of human umbilical vein end...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60002-9

    authors： Sun L,Liu J,Lin SS,Shi WT,Zhu J,Liang G,Yuan ST

    更新日期：2014-01-01 00:00:00

  • Chemical profiling of Qixue Shuangbu Tincture by ultra-performance liquid chromatography with electrospray ionization quadrupole-time-of-flight high-definition mass spectrometry (UPLC-QTOF/MS).

    abstract：:The present study was designed to develop and validate a sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) method to separate and identify the chemical constituents of Qixue Shuangbu Tincture (QXSBT), a classic traditional Chines...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)60007-9

    authors： Chen LW,Wang Q,Qin KM,Wang XL,Wang B,Chen DN,Cai BC,Cai T

    更新日期：2016-02-01 00:00:00

  • Characterization and evaluation in vivo of baicalin-nanocrystals prepared by an ultrasonic-homogenization-fluid bed drying method.

    abstract：AIM:To improve the absorption and bioavailability of baicalin using a nanocrystal (or nanosuspension) drug delivery system. METHODS:A tandem, ultrasonic-homogenization-fluid bed drying technology was applied to prepare baicalin-nanocrystal dried powders, and the physicochemical properties of baicalin-nanocrystals were...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60012-1

    authors： Shi-Ying J,Jin H,Shi-Xiao J,Qing-Yuan L,Jin-Xia B,Chen HG,Rui-Sheng L,Wei W,Hai-Long Y

    更新日期：2014-01-01 00:00:00

  • Anti-hypercholesterolemic effect of Pistacia lentiscus fatty oil in egg yolk-fed rabbits: a comparative study with simvastatin.

    abstract：AIM:The current study was undertaken to assess anti-hyperlipidemic activity of Pistacia lentiscus fatty oil (PLFO) in rabbits following a hyperlipidemic diet. METHOD:Twenty healthy female (WNZ) rabbits were divided into four groups of five animals each: (a) normal control (NC group) receiving standard diet, (b) hyperl...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60086-8

    authors： Djerrou Z

    更新日期：2014-08-01 00:00:00

  • Analgesic effects and structural elucidation of two new flavone C-glycosides from Artemisa sacrorum.

    abstract：:The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(15)30080-7

    authors： Wang QH,Han NR,Dai NY,Wu RJ,Wu JS

    更新日期：2015-10-01 00:00:00

  • Flavonoids rather than alkaloids as the diagnostic constituents to distinguish Sophorae Flavescentis Radix from Sophorae Tonkinensis Radix et Rhizoma: an HPLC fingerprint study.

    abstract：:Sophorae Flavescentis Radix (Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma (S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applicati...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30137-7

    authors： Ding PL,He CM,Cheng ZH,Chen DF

    更新日期：2018-12-01 00:00:00

  • Modified Da-chai-hu Decoction regulates the expression of occludin and NF-κB to alleviate organ injury in severe acute pancreatitis rats.

    abstract：:Modified Da-chai-hu Decoction (MDD), a traditional Chinese medicinal formulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis (SAP) for decades. The aim of the present study was to explore its potential organprotective mechanism in SAP. In the present...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30041-X

    authors： Zhao G,Zhuo YZ,Cui LH,Li CX,Chen SY,Li D,Liu JH,Li DH,Cui NQ,Zhang SK

    更新日期：2019-05-20 00:00:00

  • Bioactive phenazines from an earwig-associated Streptomyces sp.

    abstract：:Three new phenazine-type compounds, named phenazines SA-SC (1-3), together with four new natural products (4-7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30055-X

    authors： Han H,Guo ZK,Zhang B,Zhang M,Shi J,Li W,Jiao RH,Tan RX,Ge HM

    更新日期：2019-06-01 00:00:00

  • Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway.

    abstract：:The saponin ginsenoside Rk1 is a major compound isolated from ginseng. Ginsenoside Rk1 has been reported to have anti-inflammatory and anti-tumor properties and to be involved in the regulation of metabolism. However, the effect and mechanism of anti-inflammatory action of ginsenoside Rk1 has not been fully clarified....

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30106-1

    authors： Yu Q,Zeng KW,Ma XL,Jiang Y,Tu PF,Wang XM

    更新日期：2017-10-01 00:00:00

  • Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress.

    abstract：:The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintai...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)60030-9

    authors： Zhu YL,Wang LY,Zhao DP,Wang CL,Zhang R,Fei WT,Wang JX,Zhang JJ

    更新日期：2020-11-01 00:00:00

  • Maslinic acid modulates glycogen metabolism by enhancing the insulin signaling pathway and inhibiting glycogen phosphorylase.

    abstract：AIM:To investigate the molecular signaling mechanism by which the plant-derived, pentacyclic triterpene maslinic acid (MA) exerts anti-diabetic effects. METHOD:HepG2 cells were stimulated with various concentrations of MA. The effects of MA on glycogen phosphorylase a (GPa) activity and the cellular glycogen content w...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60052-2

    authors： Liu J,Wang X,Chen YP,Mao LF,Shang J,Sun HB,Zhang LY

    更新日期：2014-04-01 00:00:00

  • Impact of parameter fluctuations on the performance of ethanol precipitation in production of Re Du Ning Injections, based on HPLC fingerprints and principal component analysis.

    abstract：:The present study was designed to determine the relationships between the performance of ethanol precipitation and seven process parameters in the ethanol precipitation process of Re Du Ning Injections, including concentrate density, concentrate temperature, ethanol content, flow rate and stir rate in the addition of ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.3724/SP.J.1009.2015.00073

    authors： Sun LQ,Wang SY,Li YJ,Wang YX,Wang ZZ,Huang WZ,Wang YS,Bi YA,Ding G,Xiao W

    更新日期：2016-01-01 00:00:00

  • Protease inhibitor in scorpion (Mesobuthus eupeus) venom prolongs the biological activities of the crude venom.

    abstract：:It is hypothesized that protease inhibitors play an essential role in survival of venomous animals through protecting peptide/protein toxins from degradation by proteases in their prey or predators. However, the biological function of protease inhibitors in scorpion venoms remains unknown. In the present study, a tryp...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)30071-1

    authors： Ma H,Xiao-Peng T,Yang SL,Lu QM,Lai R

    更新日期：2016-08-01 00:00:00

  • Advances in the pharmacological activities and mechanisms of diosgenin.

    abstract：:Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions. Diosgenin has shown a vast range ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(15)30053-4

    authors： Chen Y,Tang YM,Yu SL,Han YW,Kou JP,Liu BL,Yu BY

    更新日期：2015-08-01 00:00:00

  • Comprehensive analysis of the chemical constituents in sulfur-fumigated Lonicerae Japonicae Flos using UHPLC-LTQ-Orbitrap mass spectrometry.

    abstract：:Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the chemical c...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)30015-7

    authors： Liu ZH,Wang YQ,Mei XD,Wang F,Yang XZ,Li XD,Jiang F,Zhang JY

    更新日期：2020-02-01 00:00:00