Abstract:
AIM:To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill. METHOD:Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compounds were identified by comparison of their data with those reported. RESULTS:Three mycophenolic acid derivatives, 6-((2E, 6E)-3, 7-dimethyldeca-2, 6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one (1), 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-5, 7-dihydroxy-4-methylphtanlan-1-one (2), and 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one (3) were isolated. CONCLUSION:Among them, compound 1 was new, and compound 2 exhibited moderate cytotoxicity against HL-60, SMMC-7721, A-549, and MCF-7 cells, with IC50 values of 39.1, 31.1, 27.4, and 35.7 μmol·L(-1), respectively.
journal_name
Chin J Nat Medjournal_title
Chinese journal of natural medicinesauthors
Fan QY,Yin X,Li ZH,Li Y,Liu JK,Feng T,Zhao BHdoi
10.1016/S1875-5364(14)60104-7subject
Has Abstractpub_date
2014-09-01 00:00:00pages
685-8issue
9eissn
2095-6975issn
1875-5364pii
S1875-5364(14)60104-7journal_volume
12pub_type
杂志文章abstract::Polysaccharide from traditional Chinese herb, Saposhnikovia divaricata (Turcz.) Schischk. (SD) was extracted, fractionated and characterized in this work. Four fractions were prepared. Their molecular weight, monosaccharide compositions, linkage modes and structural properties were characterized with SEC-MALS-RI, HPAE...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(19)30096-2
更新日期:2019-10-01 00:00:00
abstract::Neokotalanol, a potent α-glucosidase inhibitor isolated from Salacia reticulata, was synthesized through a key coupling reaction between a perbenzylated thiosugar and an appropriately protected perseitol triflate derived from D-mannose. This key step was found to be quite temperature dependent, and a simultaneous cycl...
journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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doi:10.1016/S1875-5364(16)30059-0
更新日期:2016-07-01 00:00:00
abstract::The present study aimed at determining the chemical constituents of Solanum coagulans and their antimicrobial activities. The compounds were isolated by various chromatographic techniques and their structures were elucidated on the basis of extensive spectroscopic analysis, chemical methods, and comparison with report...
journal_title:Chinese journal of natural medicines
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更新日期:2016-04-01 00:00:00
abstract:AIM:To study the chemical constituents and bioactivity of the stem bark of Mitragyna diversifolia. METHOD:Compounds were isolated by various chromatographic methods. Their structures were elucidated on the basis of spectroscopic techniques (IR, UV, MS, and NMR), and they were evaluated for their cytotoxic activities b...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(14)60096-0
更新日期:2014-08-01 00:00:00
abstract:AIM:To study the chemical constituents in the flowers and fruits of Rabdosia excisa. METHODS:The compounds were isolated and purified by silica gel column chromatography and their structures were identified by spectroscopic methods. RESULTS:Sixteen compounds isolated from the flowers and fruits of this plant were ide...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
abstract::In the present report, we review the technical guidelines and principles on impurity research and control for antibiotics established by various agencies, including the International Conference of Harmonization (ICH), the US Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the China Food and...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
abstract::This study engineered β-carotene ketolase CrtW and β-carotene hydroxylase CrtZ to improve biosynthesis of astaxanthin in Escherichia coli. Firstly, crtW was randomly mutated to increase CrtW activities on conversion from β-carotene to astaxanthin. A crtW* mutant with A6T, T105A and L239M mutations has improved 5.35-fo...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Chinese journal of natural medicines
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更新日期:2018-07-01 00:00:00
abstract::Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of hum...
journal_title:Chinese journal of natural medicines
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更新日期:2017-08-01 00:00:00
abstract:AIM:To investigate the radioprotective effect of adenine on irradiated lymphocytes and discover the possible mechanisms of protection. METHODS:Lymphocytes were pretreated for 12 h with adenine (0.001-0.1 μmol·L(-1)) and then exposed to 4 Gy radiation. Cell viability was observed by the MTS assay, apoptosis was detecte...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(13)60040-0
更新日期:2013-03-01 00:00:00
abstract::In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such ...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(16)30020-6
更新日期:2016-03-01 00:00:00
abstract::Radix Adenophorae, a traditional Chinese medicine, has been reported to have a variety of biological functions. In the present study, a polysaccharide component, Radix Adenophorae Polysaccharide (RAPS), was purified from Radix Adenophorae by decoloring with ADS-7 macroporous adsorption resin, DEAE-52 cellulose ion-exc...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.3724/SP.J.1009.2016.00370
更新日期:2016-05-01 00:00:00
abstract::In our previous study, we have elucidated the chemical profile of YGS40, a fraction of Yi-Gan San (YGS), used for the treatment of Alzheimer's disease (AD). Oxidative stress-induced apoptosis is implicated in neurodegenerative disorders such as AD. The aim of the present study was to explore the protective effects of ...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(15)30037-6
更新日期:2015-06-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
abstract:AIM:To investigate the active chloroform fraction of the ethanol extract of Ipomoea carnea flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats. METHOD:Except for the control group, all of the rats were sensitized with intranasal application of 5 μL of 10% toluene diisocyanate (...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(14)60027-3
更新日期:2014-03-01 00:00:00
abstract::The novel coronavirus pneumonia broke out in 2019 and spread rapidly. In 30 different countries, there are over seventy thousand patients have been diagnosed in total. Therefore, it is urgent to develop the effective program to prevent and treat for the novel coronavirus pneumonia. In view of Traditional Chinese Medic...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章,评审
doi:10.1016/S1875-5364(20)30022-4
更新日期:2020-03-01 00:00:00
abstract::The phytochemical progress on Angelica sinensis (Oliv.) Diels over the past decades is summarized. Since 1970s, 165 chemical constituents, including phthalides, phenylpropanoids, terpenoids and essential oils, aromatic compounds, alkaloids, alkynes, sterols, fatty acids, and polysaccharides have been isolated or detec...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章,评审
doi:10.1016/S1875-5364(15)30010-8
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journal_title:Chinese journal of natural medicines
pub_type: 历史文章,杂志文章,评审
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abstract::Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the chemical c...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
abstract::Gut microbiota dysbiosis is a risk factor for colorectal cancer (CRC) in inflammatory bowel disease (IBD). In this study, the effects of Panax notoginseng saponins (PNS) on colitis-associated CRC progression were evaluated on an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. In vivo, PNS significantly re...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(20)30060-1
更新日期:2020-07-01 00:00:00
abstract::Panax notoginseng saponins (PNS) are the major components of Panax notoginseng, with multiple pharmacological activities but poor oral bioavailability. PNS could be metabolized by gut microbiota in vitro, while the exact role of gut microbiota of PNS metabolism in vivo remains poorly understood. In this study, pseudo ...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(19)30026-3
更新日期:2019-03-01 00:00:00
abstract::A new γ-alkylated-γ-butyrolactone, named melongenolide A (1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A (1), (+)-syringaresinol (2), (+)-lyoniresinol (3), 5,5'-dimethoxy lariciresinol (4), (+)-(7R,8R)-4-hydroxy-3,3',5'-tri...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(15)30068-6
更新日期:2015-09-01 00:00:00
abstract::Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanism...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(19)30030-5
更新日期:2019-04-01 00:00:00
abstract::Dendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book "Shen Nong's Materia Medica". It's well known that bioactivities are usually related to the ingredients' basis. Based on the previous research, Dend...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章,评审
doi:10.1016/S1875-5364(20)30001-7
更新日期:2020-01-01 00:00:00
abstract:AIM:To reveal the profile of astragalosides for better quality evaluation of Radix Astragali, this study was aimed to investigate the transformation of astragalosides under different conditions. METHOD:Seven major astragalosides were selected for evaluation under acidic, neutral and alkaline conditions. The transforma...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(14)60062-5
更新日期:2014-04-01 00:00:00
abstract::Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(18)30041-4
更新日期:2018-02-01 00:00:00
abstract:AIM:To improve the absorption and bioavailability of baicalin using a nanocrystal (or nanosuspension) drug delivery system. METHODS:A tandem, ultrasonic-homogenization-fluid bed drying technology was applied to prepare baicalin-nanocrystal dried powders, and the physicochemical properties of baicalin-nanocrystals were...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(14)60012-1
更新日期:2014-01-01 00:00:00
abstract::A new ursane-type triterpenoid saponin, 2α,3α,24-trihydroxyurs-12,20(30)-dien-28-oic acid β-D-glucopyranosyl ester (1), together with six known triterpenoid saponins, was isolated and characterized from the aerial parts of Clematoclethra scandens subsp. actinidioides. ...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(15)60008-5
更新日期:2015-01-01 00:00:00
abstract::Inflammation is recently recognized as one of the hallmarks of human cancer. Chronic inflammatory response plays a critical role in cancer development, progression, metastasis, and resistance to chemotherapy. Conversely, the oncogenic aberrations also generate an inflammatory microenvironment, enabling the development...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章,评审
doi:10.1016/S1875-5364(17)30062-6
更新日期:2017-06-01 00:00:00