Abstract：
:Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability as well as bioactivity of Rh2. The inhibitory effect of piperine on P-gp and CYP3A4 was determined using a Caco-2 monolayer model and a recombinant CYP3A4 metabolic system, respectively. The pharmacokinetics of oral Rh2 (10 mg·kg-1) administered alone or in combination with piperine (10 and 20 mg·kg-1) was performed in rats. The immune boosting effect of Rh2 was assessed in rats by measuring IL-12 level after treated by Rh2 alone or co-administered with piperine. The results indicated that piperine significantly increased the permeability of Rh2 and inhibited the metabolism of Rh2. The pharmacokinetic study results showed that the AUC of Rh2 was significantly increased in combination with piperine at high dose (20 mg·kg-1) when compared to the control group, with relative bioavailability of 196.8%. The increase of Rh2 exposure led to increased serum levels of IL-12. In conclusion, piperine may be used as a bioenhancer to improve pharmacological effect of Rh2 when given orally.
journal_name
Chin J Nat Medjournal_title
Chinese journal of natural medicinesauthors
Jin ZH,Qiu W,Liu H,Jiang XH,Wang Ldoi
10.1016/S1875-5364(18)30041-4subject
Has Abstractpub_date
2018-02-01 00:00:00pages
143-149issue
2eissn
2095-6975issn
1875-5364pii
S1875-5364(18)30041-4journal_volume
16pub_type
杂志文章abstract：AIM:To improve the absorption and bioavailability of baicalin using a nanocrystal (or nanosuspension) drug delivery system. METHODS:A tandem, ultrasonic-homogenization-fluid bed drying technology was applied to prepare baicalin-nanocrystal dried powders, and the physicochemical properties of baicalin-nanocrystals were...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60012-1
更新日期：2014-01-01 00:00:00
abstract：AIM:The most important side effect of methotrexate (MTX) is mucositis. The purpose of this study was to evaluate the effect of turmeric extract on intestinal damage and oxidative stress in rats receiving methotrexate. METHODS:Experiments were performed on male Wistar albino rats divided into six groups. First group re...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(13)60087-4
更新日期：2013-09-01 00:00:00
abstract：:Hybanthus enneaspermus (L.) F. Muell belonging to the family Violaceae, popularly known as Ratanpurus (Hindi) is a herb or a shrub distributed in the tropical and subtropical regions of the world. In the Ayurvedic literature, the plant is reported to cure conditions of "Kapha" and "Pitta", urinary calculi, strangury, ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(13)60017-5
更新日期：2013-05-01 00:00:00
abstract：:In the present report, we review the technical guidelines and principles on impurity research and control for antibiotics established by various agencies, including the International Conference of Harmonization (ICH), the US Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the China Food and...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(15)30044-3
更新日期：2015-07-01 00:00:00
abstract：AIM:To study the chemical constituents of the aerial parts of Cirsium setosum (Willd.) MB.. METHODS:The chemical constituents were isolated and purified by various chromatographic techniques. Their structures were determined on the basis of physical properties and spectroscopic data. RESULTS:A new megastigmane glycos...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(13)60097-7
更新日期：2013-09-01 00:00:00
abstract：AIM:JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities. METHOD:These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60117-5
更新日期：2014-10-01 00:00:00
abstract：:Naodesheng (NDS) formula, which consists of Rhizoma Chuanxiong, Lobed Kudzuvine, Carthamus tinctorius, Radix Notoginseng, and Crataegus pinnatifida, is widely applied for the treatment of cardio/cerebrovascular ischemic diseases, ischemic stroke, and sequelae of cerebral hemorrhage, etc. At present, the studies on NDS...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(18)30029-3
更新日期：2018-01-01 00:00:00
abstract：:Traditional Chinese medicines (TCMs) are in great demand all over the world, especially in the developing world, for primary health care due to their superior merits such as low cost, minimal side effects, better cultural acceptability, and compatibility with humans. However, Chinese medicines consist of several herbs...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(13)60069-2
更新日期：2013-11-01 00:00:00
abstract：:A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester (1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on th...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(17)30018-3
更新日期：2016-12-01 00:00:00
abstract：:It is hypothesized that protease inhibitors play an essential role in survival of venomous animals through protecting peptide/protein toxins from degradation by proteases in their prey or predators. However, the biological function of protease inhibitors in scorpion venoms remains unknown. In the present study, a tryp...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)30071-1
更新日期：2016-08-01 00:00:00
abstract：AIM:To investigate the chemical constituents from the leaves of Broussonetia papyrifera. METHODS:The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatography and preparative HPLC. Their structures were elucidated on the basis of 1D and 2D NMR anal...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(13)60027-8
更新日期：2013-05-01 00:00:00
abstract：AIM:The current study was undertaken to assess anti-hyperlipidemic activity of Pistacia lentiscus fatty oil (PLFO) in rabbits following a hyperlipidemic diet. METHOD:Twenty healthy female (WNZ) rabbits were divided into four groups of five animals each: (a) normal control (NC group) receiving standard diet, (b) hyperl...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60086-8
更新日期：2014-08-01 00:00:00
abstract：:The present study aimed at determining the chemical constituents of Solanum coagulans and their antimicrobial activities. The compounds were isolated by various chromatographic techniques and their structures were elucidated on the basis of extensive spectroscopic analysis, chemical methods, and comparison with report...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)30033-4
更新日期：2016-04-01 00:00:00
abstract：AIM:To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill. METHOD:Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compound...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60104-7
更新日期：2014-09-01 00:00:00
abstract：:The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(15)30080-7
更新日期：2015-10-01 00:00:00
abstract：:In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)30020-6
更新日期：2016-03-01 00:00:00
abstract：AIM:The compound B19 (C21H22O5) is a newly synthesized, mono-carbonyl analog of curcumin that has exhibited potential antitumor effects. This present study was performed to identify the anti-angiogenic activity of this compound. METHODS AND RESULTS:B19 inhibited migration and tube formation of human umbilical vein end...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60002-9
更新日期：2014-01-01 00:00:00
abstract：:The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintai...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(20)60030-9
更新日期：2020-11-01 00:00:00
abstract：:The stem of Cynomorium songaricum is a traditional Chinese medicine reputed to have tonic effects. C. coccineum growing in northern Africa and the Mediterranean region is regarded in Arabian medical practice as the "treasure of drugs". The major constituents of Cynomorium plants have been revealed to be phenolic compo...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(13)60049-7
更新日期：2013-07-01 00:00:00
abstract：:Saposhnikoviae divaricata (Turcz.) Schischk (SD) is a traditional Chinese herb commonly used to treat clinical conditions such as rheumatism and allergic rhinitis. This review article evaluates a collection of works on in vitro and biochemical studies of SD. The discourse on the diverse class of chromones and coumarin...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(17)30042-0
更新日期：2017-04-01 00:00:00
abstract：:The phytochemical progress on Angelica sinensis (Oliv.) Diels over the past decades is summarized. Since 1970s, 165 chemical constituents, including phthalides, phenylpropanoids, terpenoids and essential oils, aromatic compounds, alkaloids, alkynes, sterols, fatty acids, and polysaccharides have been isolated or detec...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(15)30010-8
更新日期：2015-04-01 00:00:00
abstract：:Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J-N (1-5), together with four known furostanol saponins (6-9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(19)30065-2
更新日期：2019-08-01 00:00:00
abstract：:The present study was designed to develop and validate a sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) method to separate and identify the chemical constituents of Qixue Shuangbu Tincture (QXSBT), a classic traditional Chines...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)60007-9
更新日期：2016-02-01 00:00:00
abstract：AIM:To investigate the effects of feeding phenylalanine (Phe) and tyrosine (Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides (PeGs) to a cell suspension culture of the parasitic plant Cistanche deserticola. METHOD:A cell suspension culture of C. deserticola was established and pr...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60045-5
更新日期：2014-05-01 00:00:00
abstract：:Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more promi...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)30039-5
更新日期：2016-06-01 00:00:00
abstract：:Polysaccharide from traditional Chinese herb, Saposhnikovia divaricata (Turcz.) Schischk. (SD) was extracted, fractionated and characterized in this work. Four fractions were prepared. Their molecular weight, monosaccharide compositions, linkage modes and structural properties were characterized with SEC-MALS-RI, HPAE...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(19)30096-2
更新日期：2019-10-01 00:00:00
abstract：:Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions. Diosgenin has shown a vast range ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(15)30053-4
更新日期：2015-08-01 00:00:00
abstract：:Inflammation is recently recognized as one of the hallmarks of human cancer. Chronic inflammatory response plays a critical role in cancer development, progression, metastasis, and resistance to chemotherapy. Conversely, the oncogenic aberrations also generate an inflammatory microenvironment, enabling the development...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(17)30062-6
更新日期：2017-06-01 00:00:00
abstract：AIM:To investigate the molecular signaling mechanism by which the plant-derived, pentacyclic triterpene maslinic acid (MA) exerts anti-diabetic effects. METHOD:HepG2 cells were stimulated with various concentrations of MA. The effects of MA on glycogen phosphorylase a (GPa) activity and the cellular glycogen content w...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60052-2
更新日期：2014-04-01 00:00:00
abstract：:Si-Miao-Wan (SMW), a tradiational Chinese medicinal formula consisting of Atractylodis Rhizoma, Phellodendri Chinensis Cortex, Coicis Semen, and Achyranthis Bidentatae Radix, has been used for the treatment of gout and gouty arthritis for many years. In the present study, a liquid chromatography quadrupole-time-of-fli...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(17)30082-1
更新日期：2017-07-01 00:00:00
