Abstract:
:The present study was designed to develop and validate a sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) method to separate and identify the chemical constituents of Qixue Shuangbu Tincture (QXSBT), a classic traditional Chinese medicine (TCM) prescription. Under the optimized UPLC and QTOF/MS conditions, 56 components in QXSBT, including chalcones, triterpenoids, protopanaxatriol, flavones and flavanones were identified and tentatively characterized within a running time of 42 min. The components were identified by comparing the retention times, accurate mass, and mass spectrometric fragmentation characteristic ions, and matching empirical molecular formula with that of the published compounds. In conclusion, the established UPLC-QTOF/MS method was reliable for a rapid identification of complicated components in the TCM prescriptions.
journal_name
Chin J Nat Medjournal_title
Chinese journal of natural medicinesauthors
Chen LW,Wang Q,Qin KM,Wang XL,Wang B,Chen DN,Cai BC,Cai Tdoi
10.1016/S1875-5364(16)60007-9subject
Has Abstractpub_date
2016-02-01 00:00:00pages
141-146issue
2eissn
2095-6975issn
1875-5364pii
S1875-5364(16)60007-9journal_volume
14pub_type
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.3724/SP.J.1009.2015.00073
更新日期:2016-01-01 00:00:00
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(19)30026-3
更新日期:2019-03-01 00:00:00
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更新日期:2014-07-01 00:00:00
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
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更新日期:2017-11-01 00:00:00