Abstract:
AIM:To investigate the radioprotective effect of adenine on irradiated lymphocytes and discover the possible mechanisms of protection. METHODS:Lymphocytes were pretreated for 12 h with adenine (0.001-0.1 μmol·L(-1)) and then exposed to 4 Gy radiation. Cell viability was observed by the MTS assay, apoptosis was detected by Annexin V-FITC/PI, DNA ladder, and caspase 3/7 activity. Caspase-9, Bax, and Bcl-2 gene expression was investigated by RT-PCR. RESULTS:Irradiation increased cell death and DNA fragmentation. Pretreatment with adenine significantly reversed this tendency. Furthermore, several anti-apoptotic characteristics of adenine were determined, including the ability to inhibit caspase 3/7, upregulate B-cell lymphoma (Bcl-2) and downregulate Bcl-2- associated X (Bax), capase-9 gene expression in 4 Gy-irradiated AHH-1 cells. CONCLUSION:The results suggest that adenine had a radioprotective effect to inhibit apoptosis in a concentration dependent manner.
journal_name
Chin J Nat Medjournal_title
Chinese journal of natural medicinesauthors
Wang XY,Ma ZC,Shao S,Hong Q,Wang YG,Tan HL,Lu XQ,Dong Z,Gao Ydoi
10.1016/S1875-5364(13)60040-0subject
Has Abstractpub_date
2013-03-01 00:00:00pages
139-44issue
2eissn
2095-6975issn
1875-5364pii
S1875-5364(13)60040-0journal_volume
11pub_type
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pub_type: 历史文章,杂志文章,评审
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journal_title:Chinese journal of natural medicines
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 社论
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更新日期:2019-12-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00