A new ursane-type triterpenoid saponin from the aerial parts of Clematoclethra scandens subsp. actinidioides.

abstract：:Saposhnikoviae divaricata (Turcz.) Schischk (SD) is a traditional Chinese herb commonly used to treat clinical conditions such as rheumatism and allergic rhinitis. This review article evaluates a collection of works on in vitro and biochemical studies of SD. The discourse on the diverse class of chromones and coumarin...

journal_title：Chinese journal of natural medicines

authors： Kreiner J,Pang E,Lenon GB,Yang AWH

更新日期：2017-04-01 00:00:00

abstract：:In this review, we provide a comprehensive overview on the registration of proprietary Chinese medicines (PCMs) in China over the past century by examining published literature and historical data. We will examine this evolving administrative practice for PCMs registration in China, which is divided to the following f...

journal_title：Chinese journal of natural medicines

authors： Yuan L,Wu ZA,Shao ML

更新日期：2017-01-01 00:00:00

abstract：AIM:To improve the absorption and bioavailability of baicalin using a nanocrystal (or nanosuspension) drug delivery system. METHODS:A tandem, ultrasonic-homogenization-fluid bed drying technology was applied to prepare baicalin-nanocrystal dried powders, and the physicochemical properties of baicalin-nanocrystals were...

journal_title：Chinese journal of natural medicines

authors： Shi-Ying J,Jin H,Shi-Xiao J,Qing-Yuan L,Jin-Xia B,Chen HG,Rui-Sheng L,Wei W,Hai-Long Y

更新日期：2014-01-01 00:00:00

abstract：:In our previous study, we have elucidated the chemical profile of YGS40, a fraction of Yi-Gan San (YGS), used for the treatment of Alzheimer's disease (AD). Oxidative stress-induced apoptosis is implicated in neurodegenerative disorders such as AD. The aim of the present study was to explore the protective effects of ...

journal_title：Chinese journal of natural medicines

authors： Zhao YR,Qu W,Liu WY,Hong H,Feng F,Chen H,Xie N

更新日期：2015-06-01 00:00:00

abstract：:The present study was designed to develop and validate a sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) method to separate and identify the chemical constituents of Qixue Shuangbu Tincture (QXSBT), a classic traditional Chines...

journal_title：Chinese journal of natural medicines

authors： Chen LW,Wang Q,Qin KM,Wang XL,Wang B,Chen DN,Cai BC,Cai T

更新日期：2016-02-01 00:00:00

abstract：:This study engineered β-carotene ketolase CrtW and β-carotene hydroxylase CrtZ to improve biosynthesis of astaxanthin in Escherichia coli. Firstly, crtW was randomly mutated to increase CrtW activities on conversion from β-carotene to astaxanthin. A crtW* mutant with A6T, T105A and L239M mutations has improved 5.35-fo...

journal_title：Chinese journal of natural medicines

authors： Li D,Li Y,Xu JY,Li QY,Tang JL,Jia SR,Bi CH,Dai ZB,Zhu XN,Zhang XL

更新日期：2020-09-01 00:00:00

abstract：AIM:To study the chemical constituents from the seeds of Griffonia simplicifolia Baill. METHODS:The chemical constituents were isolated and purified by a combination of chromatographic materials including silica gel, Sephadex LH-20, and preparative TLC. Their structures were elucidated on the basis of MS and NMR data ...

journal_title：Chinese journal of natural medicines

authors： Wang XZ,Wu FH,Qu W,Liang JY

更新日期：2013-07-01 00:00:00

abstract：:Contemporary pharmacological research has demonstrated that puerarin, the most important phytoestrogen extracted from Pueraria lobata(Willd.) Ohwi, has protecting functions on the cardiovascular system, nervous system, osteoporosis, liver injury, and inflammation in vivo and in vitro. Most of these research studies fo...

journal_title：Chinese journal of natural medicines

authors： Wei SY,Chen Y,Xu XY

更新日期：2014-06-01 00:00:00

abstract：:The present study was designed to develop and evaluate glycyrrhetinic acid-graft-hyaluronic acid (HGA) conjugate for intravenous paclitaxel (PTX) delivery. Lyophilized PTX-loaded self-assembled HGA nanoparticles (PTX/HGAs) were prepared and characterized by dynamic light scattering measurements. Hemolysis test, intrav...

journal_title：Chinese journal of natural medicines

authors： Zhang L,Zhou JP,Yao J

更新日期：2015-12-01 00:00:00

abstract：AIM:To investigate the effects of feeding phenylalanine (Phe) and tyrosine (Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides (PeGs) to a cell suspension culture of the parasitic plant Cistanche deserticola. METHOD:A cell suspension culture of C. deserticola was established and pr...

journal_title：Chinese journal of natural medicines

authors： Hu GS,Jia JM,Kim DH

更新日期：2014-05-01 00:00:00

abstract：:Considering that high levels of nitric oxide (NO) exert anti-cancer effect and the derivatives of oleanolic acid (OA) have shown potent anti-cancer activity, new O2-vinyl diazeniumdiolate-based NO releasing derivatives (5a-l, 11a-l) of OA were designed, synthesized, and biologically evaluated in the present study. The...

journal_title：Chinese journal of natural medicines

authors： Zou Y,Yan C,Liu JC,Huang ZJ,Xu JY,Zhou JP,Zhang HB,Zhang YH

更新日期：2017-12-01 00:00:00

abstract：:Several chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease etiology. In the present study, we investigated the melanogenic activity of six structurally distinct compounds, namely, scopoletin, kaempferol, chrysin, vitamin D3, piperine, and 6-benzylaminopurine. We d...

journal_title：Chinese journal of natural medicines

authors： Heriniaina RM,Dong J,Kalavagunta PK,Wu HL,Yan DS,Shang J

更新日期：2018-10-01 00:00:00

abstract：:Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that...

journal_title：Chinese journal of natural medicines

authors： Sun R,Zhang HM,Chen BA

更新日期：2018-09-01 00:00:00

abstract：:Realgar nanoparticles (NPs) are increasingly used as therapeutic agents for their enhanced anti-proliferation effect and cytotoxicity on cancer cells. However, the alteration of particle size may enhance biological reactivity as well as toxicity. A LC/MS and GC/MS based metabolomics approach was employed to explore th...

journal_title：Chinese journal of natural medicines

authors： Zhang MH,Chen JQ,Guo HM,Li RT,Gao YQ,Tian Y,Zhang ZJ,Huang Y

更新日期：2017-09-01 00:00:00

abstract：:Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanism...

journal_title：Chinese journal of natural medicines

authors： Gong WX,Zhou YZ,Qin XM,DU GH

更新日期：2019-04-01 00:00:00

abstract：:Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol ...

journal_title：Chinese journal of natural medicines

authors： Xu XY,Wang DY,Ku CF,Zhao Y,Cheng H,Liu KL,Rong LJ,Zhang HJ

更新日期：2019-12-01 00:00:00

abstract：:The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintai...

journal_title：Chinese journal of natural medicines

authors： Zhu YL,Wang LY,Zhao DP,Wang CL,Zhang R,Fei WT,Wang JX,Zhang JJ

更新日期：2020-11-01 00:00:00

abstract：AIM:To investigate the active chloroform fraction of the ethanol extract of Ipomoea carnea flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats. METHOD:Except for the control group, all of the rats were sensitized with intranasal application of 5 μL of 10% toluene diisocyanate (...

journal_title：Chinese journal of natural medicines

authors： Smita J,Patil UK

更新日期：2014-03-01 00:00:00

abstract：:The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of ext...

journal_title：Chinese journal of natural medicines

authors： Peng WW,Zheng LX,Ji CJ,Shi XG,Xiong ZH,Shangguan XC

更新日期：2018-07-01 00:00:00

abstract：AIM:JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities. METHOD:These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo...

journal_title：Chinese journal of natural medicines

authors： Liu MY,Xiao L,Chen GH,Wang YX,Xiong WX,Li F,Liu Y,Huang XL,Deng YF,Zhang Z,Sun HY,Liu QH,Yin M

更新日期：2014-10-01 00:00:00

abstract：AIM:To investigate the radioprotective effect of adenine on irradiated lymphocytes and discover the possible mechanisms of protection. METHODS:Lymphocytes were pretreated for 12 h with adenine (0.001-0.1 μmol·L(-1)) and then exposed to 4 Gy radiation. Cell viability was observed by the MTS assay, apoptosis was detecte...

journal_title：Chinese journal of natural medicines

authors： Wang XY,Ma ZC,Shao S,Hong Q,Wang YG,Tan HL,Lu XQ,Dong Z,Gao Y

更新日期：2013-03-01 00:00:00

abstract：:The present study was designed to investigate the effects of start codon of nosM on the biosynthesis of nosiheptide. Target genes were amplified by overlap PCR. After homologous recombination to construct engineered strains, nosiheptide production was analyzed by HPLC. Three mutants with different start codon of nosM ...

journal_title：Chinese journal of natural medicines

authors： Jiang L,Xue YJ,Liu WY,Ma M,Wu XR,Wang SZ,Chen YJ

更新日期：2015-11-01 00:00:00

abstract：:Traditional Chinese medicines (TCMs) are in great demand all over the world, especially in the developing world, for primary health care due to their superior merits such as low cost, minimal side effects, better cultural acceptability, and compatibility with humans. However, Chinese medicines consist of several herbs...

journal_title：Chinese journal of natural medicines

authors： Song XY,Li YD,Shi YP,Jin L,Chen J

更新日期：2013-11-01 00:00:00

abstract：:The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga ge...

journal_title：Chinese journal of natural medicines

authors： Wu L,Chen ZL,Su Y,Wang QH,Kuang HX

更新日期：2015-02-01 00:00:00

abstract：AIM:The compound B19 (C21H22O5) is a newly synthesized, mono-carbonyl analog of curcumin that has exhibited potential antitumor effects. This present study was performed to identify the anti-angiogenic activity of this compound. METHODS AND RESULTS:B19 inhibited migration and tube formation of human umbilical vein end...

journal_title：Chinese journal of natural medicines

authors： Sun L,Liu J,Lin SS,Shi WT,Zhu J,Liang G,Yuan ST

更新日期：2014-01-01 00:00:00

abstract：:Dendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book "Shen Nong's Materia Medica". It's well known that bioactivities are usually related to the ingredients' basis. Based on the previous research, Dend...

journal_title：Chinese journal of natural medicines

authors： Yue H,Zeng H,Ding K

更新日期：2020-01-01 00:00:00

abstract：:Guanxinshutong capsule (GXSTC) is an effective and safe traditional Chinese medicine used in the treatment of cardiovascular diseases (CVDs) for many years. However, the targets of this herbal formula and the underlying molecular mechanisms of action involved in the treatment of CVDs are still unclear. In the present ...

journal_title：Chinese journal of natural medicines

authors： Liu F,DU X,Liu PR,Sun YH,Zhang YM

更新日期：2018-04-01 00:00:00

abstract：:Neurodegenerative diseases are the consequences of imbalance between the production of oxidative stress and its nullification by cellular defense mechanisms. Hydrogen peroxide (H2O2), a precursor of deleterious reactive oxygen species, elicits oxidative stress, resulting in severe brain injuries. Bacopa monnieri is we...

journal_title：Chinese journal of natural medicines

authors： Bhatia G,Dhuna V,Dhuna K,Kaur M,Singh J

更新日期：2017-11-01 00:00:00

abstract：:Sophorae Flavescentis Radix (Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma (S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applicati...

journal_title：Chinese journal of natural medicines

authors： Ding PL,He CM,Cheng ZH,Chen DF

更新日期：2018-12-01 00:00:00

abstract：:It is hypothesized that protease inhibitors play an essential role in survival of venomous animals through protecting peptide/protein toxins from degradation by proteases in their prey or predators. However, the biological function of protease inhibitors in scorpion venoms remains unknown. In the present study, a tryp...

journal_title：Chinese journal of natural medicines

authors： Ma H,Xiao-Peng T,Yang SL,Lu QM,Lai R

更新日期：2016-08-01 00:00:00