Anticancer activity and underlying mechanism of neogambogic acid.

abstract：:Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability...

journal_title：Chinese journal of natural medicines

authors： Jin ZH,Qiu W,Liu H,Jiang XH,Wang L

更新日期：2018-02-01 00:00:00

abstract：:Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of hum...

journal_title：Chinese journal of natural medicines

authors： Chen L,Wang WL,Song TF,Xie X,Ye XW,Liang Y,Huang HC,Yan SL,Lian XY,Zhang ZZ

更新日期：2017-08-01 00:00:00

abstract：:To investigate the non-alkaloidal chemical constituents of the stems and leaves of Melodinus suaveolens and their antibacterial activities. Compounds were isolated and purified by repeated silica gel, Sephadex LH-20, RP18, and preparative HPLC. Their structures were elucidated by comparison with published spectroscopi...

journal_title：Chinese journal of natural medicines

authors： Li JL,Lunga PK,Zhao YL,Qin XJ,Yang XW,Liu YP,Luo XD

更新日期：2015-04-01 00:00:00

abstract：:Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanism...

journal_title：Chinese journal of natural medicines

authors： Gong WX,Zhou YZ,Qin XM,DU GH

更新日期：2019-04-01 00:00:00

abstract：:Polysaccharides from Chinese medicines are attracting increasing attention to their wide range of valuable biological activities. As these polysaccharides are mostly from edible materials, their safety can be greatly ensured. Therefore, the Chinese medicine polysaccharides have been the focus of research and developme...

journal_title：Chinese journal of natural medicines

authors： Li LF,Wong TL,Han QB

更新日期：2019-12-01 00:00:00

abstract：AIM:To investigate the radioprotective effect of adenine on irradiated lymphocytes and discover the possible mechanisms of protection. METHODS:Lymphocytes were pretreated for 12 h with adenine (0.001-0.1 μmol·L(-1)) and then exposed to 4 Gy radiation. Cell viability was observed by the MTS assay, apoptosis was detecte...

journal_title：Chinese journal of natural medicines

authors： Wang XY,Ma ZC,Shao S,Hong Q,Wang YG,Tan HL,Lu XQ,Dong Z,Gao Y

更新日期：2013-03-01 00:00:00

abstract：:Inflammation is recently recognized as one of the hallmarks of human cancer. Chronic inflammatory response plays a critical role in cancer development, progression, metastasis, and resistance to chemotherapy. Conversely, the oncogenic aberrations also generate an inflammatory microenvironment, enabling the development...

journal_title：Chinese journal of natural medicines

authors： Qin J,Wang W,Zhang R

更新日期：2017-06-01 00:00:00

abstract：:Penicildiones A-D (1-4), four new steroids derivatives together with three known compounds including 16α-methylpregna-17α,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (5), stachybotrylactone B (6) and stachybotrin (7) were isolated from the soft coral-derived fungus Penicillium sp. SCSIO41201, cultured in the...

journal_title：Chinese journal of natural medicines

authors： Long JY,Wang JF,Liao SR,Lin XP,Zhou XF,Li YQ,Yang B,Liu YH

更新日期：2020-04-01 00:00:00

abstract：:Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions. Diosgenin has shown a vast range ...

journal_title：Chinese journal of natural medicines

authors： Chen Y,Tang YM,Yu SL,Han YW,Kou JP,Liu BL,Yu BY

更新日期：2015-08-01 00:00:00

abstract：:The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of ext...

journal_title：Chinese journal of natural medicines

authors： Peng WW,Zheng LX,Ji CJ,Shi XG,Xiong ZH,Shangguan XC

更新日期：2018-07-01 00:00:00

abstract：:Previous studies have indicated that the Ilex genus exhibits antioxidant, neuroprotective, hepatoprotective, and anti-inflammatory activities. However, the pharmacologic action and mechanisms of Ilex cornuta against cardiac diseases have not yet been explored. The present study was designed to investigate the antioxid...

journal_title：Chinese journal of natural medicines

authors： Yuan Y,Pan S,Yang SL,Liu YL,Xu QM

更新日期：2017-02-01 00:00:00

abstract：AIM:To investigate the effects of feeding phenylalanine (Phe) and tyrosine (Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides (PeGs) to a cell suspension culture of the parasitic plant Cistanche deserticola. METHOD:A cell suspension culture of C. deserticola was established and pr...

journal_title：Chinese journal of natural medicines

authors： Hu GS,Jia JM,Kim DH

更新日期：2014-05-01 00:00:00

abstract：:Modified Da-chai-hu Decoction (MDD), a traditional Chinese medicinal formulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis (SAP) for decades. The aim of the present study was to explore its potential organprotective mechanism in SAP. In the present...

journal_title：Chinese journal of natural medicines

authors： Zhao G,Zhuo YZ,Cui LH,Li CX,Chen SY,Li D,Liu JH,Li DH,Cui NQ,Zhang SK

更新日期：2019-05-20 00:00:00

abstract：:Dendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book "Shen Nong's Materia Medica". It's well known that bioactivities are usually related to the ingredients' basis. Based on the previous research, Dend...

journal_title：Chinese journal of natural medicines

authors： Yue H,Zeng H,Ding K

更新日期：2020-01-01 00:00:00

abstract：:It is hypothesized that protease inhibitors play an essential role in survival of venomous animals through protecting peptide/protein toxins from degradation by proteases in their prey or predators. However, the biological function of protease inhibitors in scorpion venoms remains unknown. In the present study, a tryp...

journal_title：Chinese journal of natural medicines

authors： Ma H,Xiao-Peng T,Yang SL,Lu QM,Lai R

更新日期：2016-08-01 00:00:00

abstract：:Several chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease etiology. In the present study, we investigated the melanogenic activity of six structurally distinct compounds, namely, scopoletin, kaempferol, chrysin, vitamin D3, piperine, and 6-benzylaminopurine. We d...

journal_title：Chinese journal of natural medicines

authors： Heriniaina RM,Dong J,Kalavagunta PK,Wu HL,Yan DS,Shang J

更新日期：2018-10-01 00:00:00

abstract：:Polysaccharide from traditional Chinese herb, Saposhnikovia divaricata (Turcz.) Schischk. (SD) was extracted, fractionated and characterized in this work. Four fractions were prepared. Their molecular weight, monosaccharide compositions, linkage modes and structural properties were characterized with SEC-MALS-RI, HPAE...

journal_title：Chinese journal of natural medicines

authors： Meng Y,Yi L,Chen L,Hao J,Li DX,Xue J,Xu NY,Zhang ZQ

更新日期：2019-10-01 00:00:00

abstract：:Ge Gen Decoction (GGD), a Traditional Chinese Medicine prescription, is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus (IAV) infection. However, the underlying mechanism of GGD against IAV infection remains unclear. In this study, we found that GGD had moderate a...

journal_title：Chinese journal of natural medicines

authors： Geng ZK,Li YQ,Cui QH,DU RK,Tian JZ

更新日期：2019-09-01 00:00:00

abstract：AIM:JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities. METHOD:These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo...

journal_title：Chinese journal of natural medicines

authors： Liu MY,Xiao L,Chen GH,Wang YX,Xiong WX,Li F,Liu Y,Huang XL,Deng YF,Zhang Z,Sun HY,Liu QH,Yin M

更新日期：2014-10-01 00:00:00

abstract：:Taurochenodeoxycholic acid (TCDCA) is one of the main effective components of bile acid, playing critical roles in apoptosis and immune responses through the TGR5 receptor. In this study, we reveal the interaction between TCDCA and TGR5 receptor in TGR5-knockdown H1299 cells and the regulation of inflammation via the ...

journal_title：Chinese journal of natural medicines

authors： Qi YC,Duan GZ,Mao W,Liu Q,Zhang YL,Li PF

更新日期：2020-12-01 00:00:00

abstract：:Gut microbiota dysbiosis is a risk factor for colorectal cancer (CRC) in inflammatory bowel disease (IBD). In this study, the effects of Panax notoginseng saponins (PNS) on colitis-associated CRC progression were evaluated on an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. In vivo, PNS significantly re...

journal_title：Chinese journal of natural medicines

authors： Chen L,Chen MY,Shao L,Zhang W,Rao T,Zhou HH,Huang WH

更新日期：2020-07-01 00:00:00

abstract：AIM:The compound B19 (C21H22O5) is a newly synthesized, mono-carbonyl analog of curcumin that has exhibited potential antitumor effects. This present study was performed to identify the anti-angiogenic activity of this compound. METHODS AND RESULTS:B19 inhibited migration and tube formation of human umbilical vein end...

journal_title：Chinese journal of natural medicines

authors： Sun L,Liu J,Lin SS,Shi WT,Zhu J,Liang G,Yuan ST

更新日期：2014-01-01 00:00:00

abstract：:Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol ...

journal_title：Chinese journal of natural medicines

authors： Xu XY,Wang DY,Ku CF,Zhao Y,Cheng H,Liu KL,Rong LJ,Zhang HJ

更新日期：2019-12-01 00:00:00

abstract：:Considering that high levels of nitric oxide (NO) exert anti-cancer effect and the derivatives of oleanolic acid (OA) have shown potent anti-cancer activity, new O2-vinyl diazeniumdiolate-based NO releasing derivatives (5a-l, 11a-l) of OA were designed, synthesized, and biologically evaluated in the present study. The...

journal_title：Chinese journal of natural medicines

authors： Zou Y,Yan C,Liu JC,Huang ZJ,Xu JY,Zhou JP,Zhang HB,Zhang YH

更新日期：2017-12-01 00:00:00

abstract：:The present study was designed to develop and validate a sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) method to separate and identify the chemical constituents of Qixue Shuangbu Tincture (QXSBT), a classic traditional Chines...

journal_title：Chinese journal of natural medicines

authors： Chen LW,Wang Q,Qin KM,Wang XL,Wang B,Chen DN,Cai BC,Cai T

更新日期：2016-02-01 00:00:00

abstract：:The present study was designed to develop and evaluate glycyrrhetinic acid-graft-hyaluronic acid (HGA) conjugate for intravenous paclitaxel (PTX) delivery. Lyophilized PTX-loaded self-assembled HGA nanoparticles (PTX/HGAs) were prepared and characterized by dynamic light scattering measurements. Hemolysis test, intrav...

journal_title：Chinese journal of natural medicines

authors： Zhang L,Zhou JP,Yao J

更新日期：2015-12-01 00:00:00

abstract：:The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga ge...

journal_title：Chinese journal of natural medicines

authors： Wu L,Chen ZL,Su Y,Wang QH,Kuang HX

更新日期：2015-02-01 00:00:00

abstract：AIM:To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae). METHOD:The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis. RESULTS:A new quinoline alkaloid, 5-methoxylrob...

journal_title：Chinese journal of natural medicines

authors： Sun JB,Qu W,Guan FQ,Li LZ,Liang JY

更新日期：2014-03-01 00:00:00

abstract：:The probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia t...

journal_title：Chinese journal of natural medicines

authors： Zhou JC,Zhang XW

更新日期：2019-11-01 00:00:00

abstract：:Panax notoginseng saponins (PNS) are the major components of Panax notoginseng, with multiple pharmacological activities but poor oral bioavailability. PNS could be metabolized by gut microbiota in vitro, while the exact role of gut microbiota of PNS metabolism in vivo remains poorly understood. In this study, pseudo ...

journal_title：Chinese journal of natural medicines

authors： Guo YP,Chen MY,Shao L,Zhang W,Rao T,Zhou HH,Huang WH

更新日期：2019-03-01 00:00:00