Abstract:
AIM:To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae). METHOD:The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis. RESULTS:A new quinoline alkaloid, 5-methoxylrobustine (1), along with five known quinoline alkaloids were obtained, and their structures were identified as dictamnine (2), robustine (3), isopteleine (4), γ-fagarine (5), and skimmianine (6). Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells (MCF7). CONCLUSION:Compound 1 is a new quinoline alkaloid. Alkaloid 3 showed stronger anti-proliferation effect than the other alkaloids.
journal_name
Chin J Nat Medjournal_title
Chinese journal of natural medicinesauthors
Sun JB,Qu W,Guan FQ,Li LZ,Liang JYdoi
10.1016/S1875-5364(14)60037-6subject
Has Abstractpub_date
2014-03-01 00:00:00pages
222-4issue
3eissn
2095-6975issn
1875-5364pii
S1875-5364(14)60037-6journal_volume
12pub_type
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