Phytochemical progress made in investigations of Angelica sinensis (Oliv.) Diels.

abstract：AIM:To study the chemical constituents in the flowers and fruits of Rabdosia excisa. METHODS:The compounds were isolated and purified by silica gel column chromatography and their structures were identified by spectroscopic methods. RESULTS:Sixteen compounds isolated from the flowers and fruits of this plant were ide...

journal_title：Chinese journal of natural medicines

authors： Wu YX,Zhang W,Li JC,Liu N

更新日期：2012-01-01 00:00:00

abstract：:The probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia t...

journal_title：Chinese journal of natural medicines

authors： Zhou JC,Zhang XW

更新日期：2019-11-01 00:00:00

abstract：:Current study systematically investigated the interaction of two alkaloids, anisodine and monocrotaline, with organic cation transporter OCT1, 2, 3, MATE1 and MATE2-K by using in vitro stably transfected HEK293 cells. Both anisodine and monocrotaline inhibited the OCTs and MATE transporters. The lowest IC50 was 12.9 µ...

journal_title：Chinese journal of natural medicines

authors： Chen JY,Brockmöller J,Tzvetkov MV,Wang LJ,Chen XJ

更新日期：2019-07-01 00:00:00

abstract：AIM:To investigate the effects of feeding phenylalanine (Phe) and tyrosine (Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides (PeGs) to a cell suspension culture of the parasitic plant Cistanche deserticola. METHOD:A cell suspension culture of C. deserticola was established and pr...

journal_title：Chinese journal of natural medicines

authors： Hu GS,Jia JM,Kim DH

更新日期：2014-05-01 00:00:00

abstract：AIM:To investigate the molecular signaling mechanism by which the plant-derived, pentacyclic triterpene maslinic acid (MA) exerts anti-diabetic effects. METHOD:HepG2 cells were stimulated with various concentrations of MA. The effects of MA on glycogen phosphorylase a (GPa) activity and the cellular glycogen content w...

journal_title：Chinese journal of natural medicines

authors： Liu J,Wang X,Chen YP,Mao LF,Shang J,Sun HB,Zhang LY

更新日期：2014-04-01 00:00:00

abstract：AIM:To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae). METHOD:The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis. RESULTS:A new quinoline alkaloid, 5-methoxylrob...

journal_title：Chinese journal of natural medicines

authors： Sun JB,Qu W,Guan FQ,Li LZ,Liang JY

更新日期：2014-03-01 00:00:00

abstract：AIM:To study the chemical constituents from the seeds of Griffonia simplicifolia Baill. METHODS:The chemical constituents were isolated and purified by a combination of chromatographic materials including silica gel, Sephadex LH-20, and preparative TLC. Their structures were elucidated on the basis of MS and NMR data ...

journal_title：Chinese journal of natural medicines

authors： Wang XZ,Wu FH,Qu W,Liang JY

更新日期：2013-07-01 00:00:00

abstract：:Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the chemical c...

journal_title：Chinese journal of natural medicines

authors： Liu ZH,Wang YQ,Mei XD,Wang F,Yang XZ,Li XD,Jiang F,Zhang JY

更新日期：2020-02-01 00:00:00

abstract：:The aim of the study was to investigate the effects of Siwu decoction on hyperuricemia, kidney inflammation, and dysfunction in hyperuricemic mice. Siwu decoction at 363.8, 727.5, and 1 455 mg·kg(-1) was orally administered to potassium oxonate-induced hyperuricemic mice for 7 days. Serum urate, creatinine, and blood ...

journal_title：Chinese journal of natural medicines

authors： Wang R,Ma CH,Zhou F,Kong LD

更新日期：2016-07-01 00:00:00

abstract：:Considering that high levels of nitric oxide (NO) exert anti-cancer effect and the derivatives of oleanolic acid (OA) have shown potent anti-cancer activity, new O2-vinyl diazeniumdiolate-based NO releasing derivatives (5a-l, 11a-l) of OA were designed, synthesized, and biologically evaluated in the present study. The...

journal_title：Chinese journal of natural medicines

authors： Zou Y,Yan C,Liu JC,Huang ZJ,Xu JY,Zhou JP,Zhang HB,Zhang YH

更新日期：2017-12-01 00:00:00

abstract：AIM:To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill. METHOD:Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compound...

journal_title：Chinese journal of natural medicines

authors： Fan QY,Yin X,Li ZH,Li Y,Liu JK,Feng T,Zhao BH

更新日期：2014-09-01 00:00:00

abstract：:A new ursane-type triterpenoid saponin, 2α,3α,24-trihydroxyurs-12,20(30)-dien-28-oic acid β-D-glucopyranosyl ester (1), together with six known triterpenoid saponins, was isolated and characterized from the aerial parts of Clematoclethra scandens subsp. actinidioides. ...

journal_title：Chinese journal of natural medicines

authors： Xiao SJ,Chen F,Ding LS,Zhou Y

更新日期：2015-01-01 00:00:00

abstract：AIM:To study the chemical constituents and bioactivity of the stem bark of Mitragyna diversifolia. METHOD:Compounds were isolated by various chromatographic methods. Their structures were elucidated on the basis of spectroscopic techniques (IR, UV, MS, and NMR), and they were evaluated for their cytotoxic activities b...

journal_title：Chinese journal of natural medicines

authors： Cao XF,Wang JS,Wang PR,Kong LY

更新日期：2014-08-01 00:00:00

abstract：AIM:To reveal the profile of astragalosides for better quality evaluation of Radix Astragali, this study was aimed to investigate the transformation of astragalosides under different conditions. METHOD:Seven major astragalosides were selected for evaluation under acidic, neutral and alkaline conditions. The transforma...

journal_title：Chinese journal of natural medicines

authors： Chu C,Liu EH,Qi LW,Li P

更新日期：2014-04-01 00:00:00

abstract：:Ge Gen Decoction (GGD), a Traditional Chinese Medicine prescription, is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus (IAV) infection. However, the underlying mechanism of GGD against IAV infection remains unclear. In this study, we found that GGD had moderate a...

journal_title：Chinese journal of natural medicines

authors： Geng ZK,Li YQ,Cui QH,DU RK,Tian JZ

更新日期：2019-09-01 00:00:00

abstract：:Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of hum...

journal_title：Chinese journal of natural medicines

authors： Chen L,Wang WL,Song TF,Xie X,Ye XW,Liang Y,Huang HC,Yan SL,Lian XY,Zhang ZZ

更新日期：2017-08-01 00:00:00

abstract：:The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities ...

journal_title：Chinese journal of natural medicines

authors： Wang QH,Han NR,Dai NY,Wu RJ,Wu JS

更新日期：2015-10-01 00:00:00

abstract：:In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 - 11). Their structures were confirmed on the basis of spectro...

journal_title：Chinese journal of natural medicines

authors： Cao D,Wang LQ,Han XM,Guan HR,Lei M,Wei YH,Cheng L,Yang PM,Sun ZL,Gao W,Dai JK

更新日期：2019-02-01 00:00:00

abstract：:Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions. Diosgenin has shown a vast range ...

journal_title：Chinese journal of natural medicines

authors： Chen Y,Tang YM,Yu SL,Han YW,Kou JP,Liu BL,Yu BY

更新日期：2015-08-01 00:00:00

abstract：:Several chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease etiology. In the present study, we investigated the melanogenic activity of six structurally distinct compounds, namely, scopoletin, kaempferol, chrysin, vitamin D3, piperine, and 6-benzylaminopurine. We d...

journal_title：Chinese journal of natural medicines

authors： Heriniaina RM,Dong J,Kalavagunta PK,Wu HL,Yan DS,Shang J

更新日期：2018-10-01 00:00:00

abstract：:In our previous study, we have elucidated the chemical profile of YGS40, a fraction of Yi-Gan San (YGS), used for the treatment of Alzheimer's disease (AD). Oxidative stress-induced apoptosis is implicated in neurodegenerative disorders such as AD. The aim of the present study was to explore the protective effects of ...

journal_title：Chinese journal of natural medicines

authors： Zhao YR,Qu W,Liu WY,Hong H,Feng F,Chen H,Xie N

更新日期：2015-06-01 00:00:00

abstract：AIM:JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities. METHOD:These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo...

journal_title：Chinese journal of natural medicines

authors： Liu MY,Xiao L,Chen GH,Wang YX,Xiong WX,Li F,Liu Y,Huang XL,Deng YF,Zhang Z,Sun HY,Liu QH,Yin M

更新日期：2014-10-01 00:00:00

abstract：:Taurochenodeoxycholic acid (TCDCA) is one of the main effective components of bile acid, playing critical roles in apoptosis and immune responses through the TGR5 receptor. In this study, we reveal the interaction between TCDCA and TGR5 receptor in TGR5-knockdown H1299 cells and the regulation of inflammation via the ...

journal_title：Chinese journal of natural medicines

authors： Qi YC,Duan GZ,Mao W,Liu Q,Zhang YL,Li PF

更新日期：2020-12-01 00:00:00

abstract：:To investigate the non-alkaloidal chemical constituents of the stems and leaves of Melodinus suaveolens and their antibacterial activities. Compounds were isolated and purified by repeated silica gel, Sephadex LH-20, RP18, and preparative HPLC. Their structures were elucidated by comparison with published spectroscopi...

journal_title：Chinese journal of natural medicines

authors： Li JL,Lunga PK,Zhao YL,Qin XJ,Yang XW,Liu YP,Luo XD

更新日期：2015-04-01 00:00:00

abstract：:The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintai...

journal_title：Chinese journal of natural medicines

authors： Zhu YL,Wang LY,Zhao DP,Wang CL,Zhang R,Fei WT,Wang JX,Zhang JJ

更新日期：2020-11-01 00:00:00

abstract：:The stem of Cynomorium songaricum is a traditional Chinese medicine reputed to have tonic effects. C. coccineum growing in northern Africa and the Mediterranean region is regarded in Arabian medical practice as the "treasure of drugs". The major constituents of Cynomorium plants have been revealed to be phenolic compo...

journal_title：Chinese journal of natural medicines

authors： Meng HC,Wang S,Li Y,Kuang YY,Ma CM

更新日期：2013-07-01 00:00:00

abstract：:Previous studies have indicated that the Ilex genus exhibits antioxidant, neuroprotective, hepatoprotective, and anti-inflammatory activities. However, the pharmacologic action and mechanisms of Ilex cornuta against cardiac diseases have not yet been explored. The present study was designed to investigate the antioxid...

journal_title：Chinese journal of natural medicines

authors： Yuan Y,Pan S,Yang SL,Liu YL,Xu QM

更新日期：2017-02-01 00:00:00

abstract：:This study engineered β-carotene ketolase CrtW and β-carotene hydroxylase CrtZ to improve biosynthesis of astaxanthin in Escherichia coli. Firstly, crtW was randomly mutated to increase CrtW activities on conversion from β-carotene to astaxanthin. A crtW* mutant with A6T, T105A and L239M mutations has improved 5.35-fo...

journal_title：Chinese journal of natural medicines

authors： Li D,Li Y,Xu JY,Li QY,Tang JL,Jia SR,Bi CH,Dai ZB,Zhu XN,Zhang XL

更新日期：2020-09-01 00:00:00

abstract：:The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga ge...

journal_title：Chinese journal of natural medicines

authors： Wu L,Chen ZL,Su Y,Wang QH,Kuang HX

更新日期：2015-02-01 00:00:00

abstract：AIM:To improve the absorption and bioavailability of baicalin using a nanocrystal (or nanosuspension) drug delivery system. METHODS:A tandem, ultrasonic-homogenization-fluid bed drying technology was applied to prepare baicalin-nanocrystal dried powders, and the physicochemical properties of baicalin-nanocrystals were...

journal_title：Chinese journal of natural medicines

authors： Shi-Ying J,Jin H,Shi-Xiao J,Qing-Yuan L,Jin-Xia B,Chen HG,Rui-Sheng L,Wei W,Hai-Long Y

更新日期：2014-01-01 00:00:00