当前位置： SCI文献检索 > Chinese Journal of Natural Medicines期刊下所有文献 > Comprehensive analysis of the chemical constituents in sulfur-fumigated Lonicerae Japonicae Flos using UHPLC-LTQ-Orbitrap mass spectrometry.

Comprehensive analysis of the chemical constituents in sulfur-fumigated Lonicerae Japonicae Flos using UHPLC-LTQ-Orbitrap mass spectrometry.

Abstract：

:Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the chemical constituent analysis of organic acids, flavonoids, iridoids and new-generated compounds in sulfur-fumigated LJF (SF-LJF). Based on the accurate mass measurement (< ± 5 ppm), chromatographic behavior and diagnostic product ions (DPIs), 113 constituents were unambiguously or tentatively characterized from SF-LJF extract, including 46 chlorogenic acids, 19 flavonoids, 29 iridoid glycosides and 19 newly-generated compounds (including 17 sulfur-containing derivatives). In addition, 5-CQA (5-caffeoylquinic acid, chlorogenic acid) was chosen to be sulfur-fumigated for the result validation. It was found that the most significant change of LJF after sulfur fumigation was the occurrence of sulfate or sulfite esterification reactions, which resulted in the emergence of many new sulfur-containing components. Our results demonstrated that the established method was a useful and efficient analytical tool to comprehensively characterize the material basis of SF-LJF, and also an excellent guidance of quality control about LJF.

journal_name

Chin J Nat Med

journal_title

Chinese journal of natural medicines

authors

Liu ZH,Wang YQ,Mei XD,Wang F,Yang XZ,Li XD,Jiang F,Zhang JY

doi

10.1016/S1875-5364(20)30015-7

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

148-160

issue

2

eissn

2095-6975

issn

1875-5364

pii

S1875-5364(20)30015-7

journal_volume

18

pub_type

杂志文章

相关文献

Chinese Journal of Natural Medicines文献大全
  • A new sesquiterpene lactone from the fruits of Illicium henryi.

    abstract：AIM:To study the chemical constituents of the fruits of Illicium henryi. METHOD:Chromatographic separations on silica gel, Sephadex LH-20 gel and MCI gel were used to isolate the compounds. The structures were elucidated based on extensive spectroscopic data analyses. RESULTS:Seven compounds were obtained and their s...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60074-1

    authors： Liu JF,Li HJ,Zhang JM,Wang LX,Wang YF,Liu MQ,Bi YF,Zhang YB

    更新日期：2014-06-01 00:00:00

  • A polysaccharide purified from Radix Adenophorae promotes cell activation and pro-inflammatory cytokine production in murine RAW264.7 macrophages.

    abstract：:Radix Adenophorae, a traditional Chinese medicine, has been reported to have a variety of biological functions. In the present study, a polysaccharide component, Radix Adenophorae Polysaccharide (RAPS), was purified from Radix Adenophorae by decoloring with ADS-7 macroporous adsorption resin, DEAE-52 cellulose ion-exc...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.3724/SP.J.1009.2016.00370

    authors： Li JW,Liu Y,Li BH,Wang YY,Wang H,Zhou CL

    更新日期：2016-05-01 00:00:00

  • Guidelines and strategy of the International Conference of Harmonization (ICH) and its member states to overcome existing impurity control problems for antibiotics in China.

    abstract：:In the present report, we review the technical guidelines and principles on impurity research and control for antibiotics established by various agencies, including the International Conference of Harmonization (ICH), the US Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the China Food and...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(15)30044-3

    authors： Jiang Y,Xia JP,Yang JH,Zhang ZF,Hu CQ,Zhang ZR

    更新日期：2015-07-01 00:00:00

  • Novel natural product therapeutics targeting both inflammation and cancer.

    abstract：:Inflammation is recently recognized as one of the hallmarks of human cancer. Chronic inflammatory response plays a critical role in cancer development, progression, metastasis, and resistance to chemotherapy. Conversely, the oncogenic aberrations also generate an inflammatory microenvironment, enabling the development...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(17)30062-6

    authors： Qin J,Wang W,Zhang R

    更新日期：2017-06-01 00:00:00

  • Engineering CrtW and CrtZ for improving biosynthesis of astaxanthin in Escherichia coli.

    abstract：:This study engineered β-carotene ketolase CrtW and β-carotene hydroxylase CrtZ to improve biosynthesis of astaxanthin in Escherichia coli. Firstly, crtW was randomly mutated to increase CrtW activities on conversion from β-carotene to astaxanthin. A crtW* mutant with A6T, T105A and L239M mutations has improved 5.35-fo...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)60005-X

    authors： Li D,Li Y,Xu JY,Li QY,Tang JL,Jia SR,Bi CH,Dai ZB,Zhu XN,Zhang XL

    更新日期：2020-09-01 00:00:00

  • Impact of parameter fluctuations on the performance of ethanol precipitation in production of Re Du Ning Injections, based on HPLC fingerprints and principal component analysis.

    abstract：:The present study was designed to determine the relationships between the performance of ethanol precipitation and seven process parameters in the ethanol precipitation process of Re Du Ning Injections, including concentrate density, concentrate temperature, ethanol content, flow rate and stir rate in the addition of ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.3724/SP.J.1009.2015.00073

    authors： Sun LQ,Wang SY,Li YJ,Wang YX,Wang ZZ,Huang WZ,Wang YS,Bi YA,Ding G,Xiao W

    更新日期：2016-01-01 00:00:00

  • Effects of Bunao-Fuyuan decoction serum on proliferation and migration of vascular smooth muscle cells in atherosclerotic.

    abstract：:Atherosclerosis (AS) is a chronic inflammatory disease, the main causes of which include abnormal lipid metabolism, endothelial injury, physical and chemical injury, hemodynamic injury, genetic factors and so on. These causes can lead to inflammatory injury of blood vessels and local dysfunction. Bunao-Fuyuan decoctio...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(21)60004-3

    authors： Guo HY,Lu ZY,Zhao B,Jiang WW,Xiong YH,Wang K

    更新日期：2021-01-01 00:00:00

  • A new quinoline alkaloid from the roots of Dictamnus angustifolius.

    abstract：AIM:To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae). METHOD:The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis. RESULTS:A new quinoline alkaloid, 5-methoxylrob...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60037-6

    authors： Sun JB,Qu W,Guan FQ,Li LZ,Liang JY

    更新日期：2014-03-01 00:00:00

  • Triterpenes from the stem bark of Mitragyna diversifolia and their cytotoxic activity.

    abstract：AIM:To study the chemical constituents and bioactivity of the stem bark of Mitragyna diversifolia. METHOD:Compounds were isolated by various chromatographic methods. Their structures were elucidated on the basis of spectroscopic techniques (IR, UV, MS, and NMR), and they were evaluated for their cytotoxic activities b...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60096-0

    authors： Cao XF,Wang JS,Wang PR,Kong LY

    更新日期：2014-08-01 00:00:00

  • Difficulties in research of Chinese medicine polysaccharides.

    abstract：:Polysaccharides from Chinese medicines are attracting increasing attention to their wide range of valuable biological activities. As these polysaccharides are mostly from edible materials, their safety can be greatly ensured. Therefore, the Chinese medicine polysaccharides have been the focus of research and developme...

    journal_title：Chinese journal of natural medicines

    pub_type： 社论

    doi：10.1016/S1875-5364(19)30107-4

    authors： Li LF,Wong TL,Han QB

    更新日期：2019-12-01 00:00:00

  • Anti-HIV lignans from Justicia procumbens.

    abstract：:Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30117-7

    authors： Xu XY,Wang DY,Ku CF,Zhao Y,Cheng H,Liu KL,Rong LJ,Zhang HJ

    更新日期：2019-12-01 00:00:00

  • Comparison of anti-bacterial activity of three types of di-O-caffeoylquinic acids in Lonicera japonica flowers based on microcalorimetry.

    abstract：:The anti-bacterial activities of three types of di-O-caffeoylquinic acids (diCQAs) in Lonicera japonica flowers, a traditional Chinese medicine (TCM), on Bacillus shigae growth were investigated and compared by microcalorimetry. The three types of diCQAs were 3, 4-di-O-caffeoylquinic acid (3, 4-diCQA), 3, 5-di-O-caffe...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60017-0

    authors： Han J,Lv QY,Jin SY,Zhang TT,Jin SX,Li XY,Yuan HL

    更新日期：2014-02-01 00:00:00

  • Effects of feeding tyrosine and phenylalanine on the accumulation of phenylethanoid glycosides to Cistanche deserticola cell suspension culture.

    abstract：AIM:To investigate the effects of feeding phenylalanine (Phe) and tyrosine (Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides (PeGs) to a cell suspension culture of the parasitic plant Cistanche deserticola. METHOD:A cell suspension culture of C. deserticola was established and pr...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60045-5

    authors： Hu GS,Jia JM,Kim DH

    更新日期：2014-05-01 00:00:00

  • Anti-colorectal cancer effects of tripolinolate A from Tripolium vulgare.

    abstract：:Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of hum...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30085-7

    authors： Chen L,Wang WL,Song TF,Xie X,Ye XW,Liang Y,Huang HC,Yan SL,Lian XY,Zhang ZZ

    更新日期：2017-08-01 00:00:00

  • A review of isolation methods, structure features and bioactivities of polysaccharides from Dendrobium species.

    abstract：:Dendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book "Shen Nong's Materia Medica". It's well known that bioactivities are usually related to the ingredients' basis. Based on the previous research, Dend...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(20)30001-7

    authors： Yue H,Zeng H,Ding K

    更新日期：2020-01-01 00:00:00

  • Bacopa monnieri extracts prevent hydrogen peroxide-induced oxidative damage in a cellular model of neuroblastoma IMR32 cells.

    abstract：:Neurodegenerative diseases are the consequences of imbalance between the production of oxidative stress and its nullification by cellular defense mechanisms. Hydrogen peroxide (H2O2), a precursor of deleterious reactive oxygen species, elicits oxidative stress, resulting in severe brain injuries. Bacopa monnieri is we...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30017-7

    authors： Bhatia G,Dhuna V,Dhuna K,Kaur M,Singh J

    更新日期：2017-11-01 00:00:00

  • Cytotoxic constituents from the leaves of Broussonetia papyrifera.

    abstract：AIM:To investigate the chemical constituents from the leaves of Broussonetia papyrifera. METHODS:The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatography and preparative HPLC. Their structures were elucidated on the basis of 1D and 2D NMR anal...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(13)60027-8

    authors： Ran XK,Wang XT,Liu PP,Chi YX,Wang BJ,Dou DQ,Kang TG,Xiong W

    更新日期：2013-05-01 00:00:00

  • YGS40, an active fraction of Yi-Gan San, reduces hydrogen peroxide-induced apoptosis in PC12 cells.

    abstract：:In our previous study, we have elucidated the chemical profile of YGS40, a fraction of Yi-Gan San (YGS), used for the treatment of Alzheimer's disease (AD). Oxidative stress-induced apoptosis is implicated in neurodegenerative disorders such as AD. The aim of the present study was to explore the protective effects of ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(15)30037-6

    authors： Zhao YR,Qu W,Liu WY,Hong H,Feng F,Chen H,Xie N

    更新日期：2015-06-01 00:00:00

  • Synthesis and anti-hepatocellular carcinoma activity of novel O2-vinyl diazeniumdiolate-based nitric oxide-releasing derivatives of oleanolic acid.

    abstract：:Considering that high levels of nitric oxide (NO) exert anti-cancer effect and the derivatives of oleanolic acid (OA) have shown potent anti-cancer activity, new O2-vinyl diazeniumdiolate-based NO releasing derivatives (5a-l, 11a-l) of OA were designed, synthesized, and biologically evaluated in the present study. The...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30009-8

    authors： Zou Y,Yan C,Liu JC,Huang ZJ,Xu JY,Zhou JP,Zhang HB,Zhang YH

    更新日期：2017-12-01 00:00:00

  • A new β-carboline alkaloid from the seeds of Griffonia simplicifolia.

    abstract：AIM:To study the chemical constituents from the seeds of Griffonia simplicifolia Baill. METHODS:The chemical constituents were isolated and purified by a combination of chromatographic materials including silica gel, Sephadex LH-20, and preparative TLC. Their structures were elucidated on the basis of MS and NMR data ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(13)60059-X

    authors： Wang XZ,Wu FH,Qu W,Liang JY

    更新日期：2013-07-01 00:00:00

  • Chemical constituents and pharmacologic actions of Cynomorium plants.

    abstract：:The stem of Cynomorium songaricum is a traditional Chinese medicine reputed to have tonic effects. C. coccineum growing in northern Africa and the Mediterranean region is regarded in Arabian medical practice as the "treasure of drugs". The major constituents of Cynomorium plants have been revealed to be phenolic compo...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(13)60049-7

    authors： Meng HC,Wang S,Li Y,Kuang YY,Ma CM

    更新日期：2013-07-01 00:00:00

  • Advances in the pharmacological activities and mechanisms of diosgenin.

    abstract：:Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions. Diosgenin has shown a vast range ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(15)30053-4

    authors： Chen Y,Tang YM,Yu SL,Han YW,Kou JP,Liu BL,Yu BY

    更新日期：2015-08-01 00:00:00

  • Pharmacodynamic study on insomnia-curing effects of Shuangxia Decoction in Drosophila melanogaster.

    abstract：:The present study aimed to establish a pharmacodynamic method using the pySolo software to explore the influence of freeze-dried powders of Shuangxia Decoction (SXD) on the sleep of normal Drosophila melanogaster and the Drosophila melanogaster whose sleep was divested by light. The dose-effect and the time-effect rel...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)30077-2

    authors： Zhang ZQ,Degejin,Geng D,Zhang Q,Tian Y,Xi Y,Wang WQ,Tang HQ,Xu B,Lin HY,Sun YK

    更新日期：2016-09-01 00:00:00

  • Protease inhibitor in scorpion (Mesobuthus eupeus) venom prolongs the biological activities of the crude venom.

    abstract：:It is hypothesized that protease inhibitors play an essential role in survival of venomous animals through protecting peptide/protein toxins from degradation by proteases in their prey or predators. However, the biological function of protease inhibitors in scorpion venoms remains unknown. In the present study, a tryp...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)30071-1

    authors： Ma H,Xiao-Peng T,Yang SL,Lu QM,Lai R

    更新日期：2016-08-01 00:00:00

  • Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4.

    abstract：:The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria (MFMC) on PPARγ (Peroxisome Proliferator Activated Receptor gamma) and GLUT-4 (Glucose transporter-4) with respect to glucose transport. Various concentrations of MFMC ranging from 62.5 to 500 μg·mL(-1) w...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60132-1

    authors： Kumar PM,Venkataranganna MV,Manjunath K,Viswanatha GL,Ashok G

    更新日期：2014-12-01 00:00:00

  • Bioactive phenazines from an earwig-associated Streptomyces sp.

    abstract：:Three new phenazine-type compounds, named phenazines SA-SC (1-3), together with four new natural products (4-7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30055-X

    authors： Han H,Guo ZK,Zhang B,Zhang M,Shi J,Li W,Jiao RH,Tan RX,Ge HM

    更新日期：2019-06-01 00:00:00

  • Quantification of Panax notoginseng saponins metabolites in rat plasma with in vivo gut microbiota-mediated biotransformation by HPLC-MS/MS.

    abstract：:Panax notoginseng saponins (PNS) are the major components of Panax notoginseng, with multiple pharmacological activities but poor oral bioavailability. PNS could be metabolized by gut microbiota in vitro, while the exact role of gut microbiota of PNS metabolism in vivo remains poorly understood. In this study, pseudo ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30026-3

    authors： Guo YP,Chen MY,Shao L,Zhang W,Rao T,Zhou HH,Huang WH

    更新日期：2019-03-01 00:00:00

  • Modified Da-chai-hu Decoction regulates the expression of occludin and NF-κB to alleviate organ injury in severe acute pancreatitis rats.

    abstract：:Modified Da-chai-hu Decoction (MDD), a traditional Chinese medicinal formulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis (SAP) for decades. The aim of the present study was to explore its potential organprotective mechanism in SAP. In the present...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30041-X

    authors： Zhao G,Zhuo YZ,Cui LH,Li CX,Chen SY,Li D,Liu JH,Li DH,Cui NQ,Zhang SK

    更新日期：2019-05-20 00:00:00

  • An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families.

    abstract：:Current study systematically investigated the interaction of two alkaloids, anisodine and monocrotaline, with organic cation transporter OCT1, 2, 3, MATE1 and MATE2-K by using in vitro stably transfected HEK293 cells. Both anisodine and monocrotaline inhibited the OCTs and MATE transporters. The lowest IC50 was 12.9 µ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30070-6

    authors： Chen JY,Brockmöller J,Tzvetkov MV,Wang LJ,Chen XJ

    更新日期：2019-07-01 00:00:00

  • Discovery of novel limonin derivatives as potent anti-inflammatory and analgesic agents.

    abstract：:Novel series of limonin derivatives (V-A-1-V-A-8, V-B-1-V-B-8) were synthesized by adding various tertiary amines onto the C (7)-position of limonin. The synthesized compounds possessed favorable physicochemical property, and the intrinsic solubility of the novel compounds were significantly improved, compared with li...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30052-9

    authors： Wang SC,Yang Y,Liu J,Jiang AD,Chu ZX,Chen SY,Gong GQ,He GW,Xu YG,Zhu QH

    更新日期：2018-03-01 00:00:00