Abstract：
:The anti-bacterial activities of three types of di-O-caffeoylquinic acids (diCQAs) in Lonicera japonica flowers, a traditional Chinese medicine (TCM), on Bacillus shigae growth were investigated and compared by microcalorimetry. The three types of diCQAs were 3, 4-di-O-caffeoylquinic acid (3, 4-diCQA), 3, 5-di-O-caffeoylquinic acid (3, 5-diCQA), and 4, 5-di-O-caffeoylquinic acid (4, 5-diCQA). Some qualitative and quantitative information of the effects of the three diCQAs on metabolic power-time curves, growth rate constant k, maximum heat-output power Pm, and the generation time tG, total heat output Qt, and growth inhibitory ratio I of B. shigae were calculated. In accordance with a thermo-kinetic model, the corresponding quantitative relationships of k, Pm, Qt, I and c were established. Also, the half-inhibitory concentrations of the drugs (IC50) were obtained by quantitative analysis. Based on the quantity-activity relationships and the IC50 values, the sequence of inhibitory activity was 3, 5-diCQA > 4, 5-diCQA > 3, 4-diCQA. The results illustrate the possibility that the caffeoyl ester group at C-5 is the principal group that has a higher affinity for the bacterial cell, and that the intramolecular distance of the two caffeoyl ester groups also has an important influence on the anti-bacterial activities of the diCQAs.
journal_name
Chin J Nat Medjournal_title
Chinese journal of natural medicinesauthors
Han J,Lv QY,Jin SY,Zhang TT,Jin SX,Li XY,Yuan HLdoi
10.1016/S1875-5364(14)60017-0subject
Has Abstractpub_date
2014-02-01 00:00:00pages
108-13issue
2eissn
2095-6975issn
1875-5364pii
S1875-5364(14)60017-0journal_volume
12pub_type
杂志文章abstract：:Two new steroidal saponins, named timosaponin P (1) and timosaponin Q (2), were isolated from the rhizome parts of Anemarrhena asphodeloides Bunge using various chromatographic methods. Their structures and absolute configurations were elucidated by a combination of spectroscopic and spectrometric data, including 1D, ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(17)30038-9
更新日期：2017-03-01 00:00:00
abstract：:Polysaccharide from traditional Chinese herb, Saposhnikovia divaricata (Turcz.) Schischk. (SD) was extracted, fractionated and characterized in this work. Four fractions were prepared. Their molecular weight, monosaccharide compositions, linkage modes and structural properties were characterized with SEC-MALS-RI, HPAE...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(19)30096-2
更新日期：2019-10-01 00:00:00
abstract：AIM:To study the chemical constituents and bioactivity of the stem bark of Mitragyna diversifolia. METHOD:Compounds were isolated by various chromatographic methods. Their structures were elucidated on the basis of spectroscopic techniques (IR, UV, MS, and NMR), and they were evaluated for their cytotoxic activities b...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60096-0
更新日期：2014-08-01 00:00:00
abstract：:Atherosclerosis (AS) is a chronic inflammatory disease, the main causes of which include abnormal lipid metabolism, endothelial injury, physical and chemical injury, hemodynamic injury, genetic factors and so on. These causes can lead to inflammatory injury of blood vessels and local dysfunction. Bunao-Fuyuan decoctio...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(21)60004-3
更新日期：2021-01-01 00:00:00
abstract：:In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)30020-6
更新日期：2016-03-01 00:00:00
abstract：:Naodesheng (NDS) formula, which consists of Rhizoma Chuanxiong, Lobed Kudzuvine, Carthamus tinctorius, Radix Notoginseng, and Crataegus pinnatifida, is widely applied for the treatment of cardio/cerebrovascular ischemic diseases, ischemic stroke, and sequelae of cerebral hemorrhage, etc. At present, the studies on NDS...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(18)30029-3
更新日期：2018-01-01 00:00:00
abstract：:D-Glycero-D-mannno-heptose 1β, 7-bisphosphate (HBPβ) is an important intermediate for constructing the core structure of Gram-negative bacterial lipopolysaccharides and was reported as a pathogen-associated molecular pattern (PAMP) that regulates immune responses. HBPβ with 3-O-amyl amine linker and its monophosphate ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(20)30075-3
更新日期：2020-08-01 00:00:00
abstract：:Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(19)30117-7
更新日期：2019-12-01 00:00:00
abstract：:The present study was designed to develop and validate a sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) method to separate and identify the chemical constituents of Qixue Shuangbu Tincture (QXSBT), a classic traditional Chines...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)60007-9
更新日期：2016-02-01 00:00:00
abstract：:The aim of the study was to investigate the effects of Siwu decoction on hyperuricemia, kidney inflammation, and dysfunction in hyperuricemic mice. Siwu decoction at 363.8, 727.5, and 1 455 mg·kg(-1) was orally administered to potassium oxonate-induced hyperuricemic mice for 7 days. Serum urate, creatinine, and blood ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)30059-0
更新日期：2016-07-01 00:00:00
abstract：:Si-Miao-Wan (SMW), a tradiational Chinese medicinal formula consisting of Atractylodis Rhizoma, Phellodendri Chinensis Cortex, Coicis Semen, and Achyranthis Bidentatae Radix, has been used for the treatment of gout and gouty arthritis for many years. In the present study, a liquid chromatography quadrupole-time-of-fli...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(17)30082-1
更新日期：2017-07-01 00:00:00
abstract：AIM:To reveal the profile of astragalosides for better quality evaluation of Radix Astragali, this study was aimed to investigate the transformation of astragalosides under different conditions. METHOD:Seven major astragalosides were selected for evaluation under acidic, neutral and alkaline conditions. The transforma...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60062-5
更新日期：2014-04-01 00:00:00
abstract：:The present study was designed to determine the relationships between the performance of ethanol precipitation and seven process parameters in the ethanol precipitation process of Re Du Ning Injections, including concentrate density, concentrate temperature, ethanol content, flow rate and stir rate in the addition of ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.3724/SP.J.1009.2015.00073
更新日期：2016-01-01 00:00:00
abstract：:The probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia t...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(19)30101-3
更新日期：2019-11-01 00:00:00
abstract：:Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the chemical c...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(20)30015-7
更新日期：2020-02-01 00:00:00
abstract：:Panax notoginseng saponins (PNS) are the major components of Panax notoginseng, with multiple pharmacological activities but poor oral bioavailability. PNS could be metabolized by gut microbiota in vitro, while the exact role of gut microbiota of PNS metabolism in vivo remains poorly understood. In this study, pseudo ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(19)30026-3
更新日期：2019-03-01 00:00:00
abstract：AIM:To study the chemical constituents from the seeds of Griffonia simplicifolia Baill. METHODS:The chemical constituents were isolated and purified by a combination of chromatographic materials including silica gel, Sephadex LH-20, and preparative TLC. Their structures were elucidated on the basis of MS and NMR data ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(13)60059-X
更新日期：2013-07-01 00:00:00
abstract：:Three new phenazine-type compounds, named phenazines SA-SC (1-3), together with four new natural products (4-7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(19)30055-X
更新日期：2019-06-01 00:00:00
abstract：:Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J-N (1-5), together with four known furostanol saponins (6-9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(19)30065-2
更新日期：2019-08-01 00:00:00
abstract：:The present study aimed to establish a pharmacodynamic method using the pySolo software to explore the influence of freeze-dried powders of Shuangxia Decoction (SXD) on the sleep of normal Drosophila melanogaster and the Drosophila melanogaster whose sleep was divested by light. The dose-effect and the time-effect rel...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)30077-2
更新日期：2016-09-01 00:00:00
abstract：:Saposhnikoviae divaricata (Turcz.) Schischk (SD) is a traditional Chinese herb commonly used to treat clinical conditions such as rheumatism and allergic rhinitis. This review article evaluates a collection of works on in vitro and biochemical studies of SD. The discourse on the diverse class of chromones and coumarin...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(17)30042-0
更新日期：2017-04-01 00:00:00
abstract：:Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions. Diosgenin has shown a vast range ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(15)30053-4
更新日期：2015-08-01 00:00:00
abstract：AIM:To investigate the active chloroform fraction of the ethanol extract of Ipomoea carnea flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats. METHOD:Except for the control group, all of the rats were sensitized with intranasal application of 5 μL of 10% toluene diisocyanate (...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60027-3
更新日期：2014-03-01 00:00:00
abstract：:Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(18)30103-1
更新日期：2018-09-01 00:00:00
abstract：:Sophorae Flavescentis Radix (Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma (S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applicati...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(18)30137-7
更新日期：2018-12-01 00:00:00
abstract：:In our previous study, we have elucidated the chemical profile of YGS40, a fraction of Yi-Gan San (YGS), used for the treatment of Alzheimer's disease (AD). Oxidative stress-induced apoptosis is implicated in neurodegenerative disorders such as AD. The aim of the present study was to explore the protective effects of ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(15)30037-6
更新日期：2015-06-01 00:00:00
abstract：AIM:To investigate the effects of feeding phenylalanine (Phe) and tyrosine (Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides (PeGs) to a cell suspension culture of the parasitic plant Cistanche deserticola. METHOD:A cell suspension culture of C. deserticola was established and pr...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60045-5
更新日期：2014-05-01 00:00:00
abstract：:Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of hum...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(17)30085-7
更新日期：2017-08-01 00:00:00
abstract：:The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga ge...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1016/S1875-5364(15)60011-5
更新日期：2015-02-01 00:00:00
abstract：AIM:The compound B19 (C21H22O5) is a newly synthesized, mono-carbonyl analog of curcumin that has exhibited potential antitumor effects. This present study was performed to identify the anti-angiogenic activity of this compound. METHODS AND RESULTS:B19 inhibited migration and tube formation of human umbilical vein end...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60002-9
更新日期：2014-01-01 00:00:00
